Aplastic Anemia

Common Name(s)

Aplastic Anemia

Aplastic anemia is failure of the bone marrow to make enough blood cells. All blood cell types are affected. It can be caused by injury to blood stem cells due to exposure to certain drugs, chemotherapy, congenital disorders, drug therapy to suppress the immune system, pregnancy, radiation therapy, or toxins such as benzene or arsenic. When the cause is unknown, it is referred to as idiopathic aplastic anemia. In about half of all cases, no cause can be found. The condition can be acute or chronic.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Aplastic Anemia" for support, advocacy or research.

Dyskeratosis Congenita Outreach, Inc.

Our mission is to provide information and support services to families affected by Dyskeratosis Congenita, a Telomere Biology Disorder worldwide, to encourage the medical community's research in finding causes and effective treatments, and to facilitate improved diagnosis by educating medical providers.

Last Updated: 1 Nov 2014

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Aplastic Anemia & MDS International Foundation

The Aplastic Anemia & MDS International Foundation (AA&MDSIF) is the world's leading nonprofit health organization dedicated to supporting patients and families living with aplastic anemia, myelodysplastic syndromes (MDS), paroxysmal nocturnal hemoglobinuria (PNH), and related bone marrow failure diseases. AA&MDSIF provides answers, support and hope to thousands of patients and their families around the world.

Last Updated: 29 Apr 2014

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APLASTIC ANEMIA AND OMID'S MISSION FOUNDATION

ONE MOTHER.. ONE SON... ONE MISSION! AT AAOMF.ORG WE EDUCATE, SUPPORT PATIENTS, CAREGIVERS. AND BRING GLOBAL AWARENESS.OF THIS LIFE THREATENING BONE MARROW FAILURE BLOOD DISEASE. MILLIONS OF CHILDREN WORLDWIDE ARE SUFFERING WITH APLASTIC ANEMIA. WE PROVIDE UPDATED INFORMATION RELATED TO NEW RESEARCH, TREATMENTS AND NEW FINDINGS FROM THE NATIONAL INSTITUTE OF HEALTH. (NIH) WE ARE ADVOCATES THAT LOOK OUT FOR PATIENT'S RIGHTS. OUR MISSION IS TO HELP RESEARCHERS FIND A CURE FOR APLASTIC ANEMIA DYSKERATOSIS CONGENITA. AAOMF.ORG HAS BEEN PROACTIVE AND RECOGNIZED BY LARGE CORPORATIONS SUCH AS MACY'S, CITGO, TDBANK, STARBUCKS, CARMAX AND MUCH MORE. WE CAN TACKLE APLASTIC ANEMIA BY WORKING TOGETHER.

Last Updated: 15 Feb 2013

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Aplastic Anemia" for support, advocacy or research.

Dyskeratosis Congenita Outreach, Inc.

Our mission is to provide information and support services to families affected by Dyskeratosis Congenita, a Telomere Biology Disorder worldwide, to encourage the medical community's research in finding causes and effective treatments, and to facilitate improved diagnosis by educating medical providers.

http://www.dcoutreach.com

Last Updated: 1 Nov 2014

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Aplastic Anemia & MDS International Foundation

The Aplastic Anemia & MDS International Foundation (AA&MDSIF) is the world's leading nonprofit health organization dedicated to supporting patients and families living with aplastic anemia, myelodysplastic syndromes (MDS), paroxysmal nocturnal hemoglobinuria (PNH), and related bone marrow failure diseases. AA&MDSIF provides answers, support and hope to thousands of patients and their families around the world.

http://www.aamds.org/

Last Updated: 29 Apr 2014

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APLASTIC ANEMIA AND OMID'S MISSION FOUNDATION

ONE MOTHER.. ONE SON... ONE MISSION! AT AAOMF.ORG WE EDUCATE, SUPPORT PATIENTS, CAREGIVERS. AND BRING GLOBAL AWARENESS.OF THIS LIFE THREATENING BONE MARROW FAILURE BLOOD DISEASE. MILLIONS OF CHILDREN WORLDWIDE ARE SUFFERING WITH APLASTIC ANEMIA. WE PROVIDE UPDATED INFORMATION RELATED TO NEW RESEARCH, TREATMENTS AND NEW FINDINGS FROM THE NATIONAL INSTITUTE OF HEALTH. (NIH) WE ARE ADVOCATES THAT LOOK OUT FOR PATIENT'S RIGHTS. OUR MISSION IS TO HELP RESEARCHERS FIND A CURE FOR APLASTIC ANEMIA DYSKERATOSIS CONGENITA. AAOMF.ORG HAS BEEN PROACTIVE AND RECOGNIZED BY LARGE CORPORATIONS SUCH AS MACY'S, CITGO, TDBANK, STARBUCKS, CARMAX AND MUCH MORE. WE CAN TACKLE APLASTIC ANEMIA BY WORKING TOGETHER.

http://www.aaomf.org

Last Updated: 15 Feb 2013

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Aplastic Anemia" returned 608 free, full-text research articles on human participants. First 3 results:

[Measurement of Foxp3 and NFAT1 in children with aplastic anemia].
 

Author(s): Yi-Ming Cao, Xi-Ge Wang, Ping Chen, Wen-Hai Yan, Xiao-Ming Zhao

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2015 Mar;17(3):258-61.

 

To study the expression of Foxp3 and NFAT1 protein in peripheral blood (PB) in children with aplastic anemia (AA) and their roles in the pathogenesis of AA.

Last Updated: 30 Mar 2015

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CXCR4 expression on pathogenic T cells facilitates their bone marrow infiltration in a mouse model of aplastic anemia.
 

Author(s): Christina Arieta Kuksin, Gabriela Gonzalez-Perez, Lisa M Minter

Journal: Blood. 2015 Mar;125(13):2087-94.

 

Aplastic anemia (AA) is a disease characterized by T-cell-mediated destruction of bone marrow (BM) hematopoietic stem and progenitor cells. Physiologically, T cells migrate to the BM in response to chemokines, such as SDF-1α, the ligand for CXCR4. However, how T cells traffic to ...

Last Updated: 27 Mar 2015

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[Kaposi sarcoma complicating aplastic anemia].
 

Author(s): Mouna Lamchahab, Bouchra Oukkache, Sofia Marouan, Asmae Quessar, Said Benchekroun

Journal:

 

Last Updated: 25 Nov 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Aplastic Anemia" returned 49 free, full-text review articles on human participants. First 3 results:

[Defectiveness of bone marrow mesenchymal stem cells in acquired aplastic anemia].
 

Author(s): Jing-Liao Zhang, Xiao-Fan Zhu

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2015 Jan;17(1):100-6.

 

The defectiveness of bone marrow mesenchymal stem cells (BM-MSCs) in acquired aplastic anemia (AA) has been a frequent research topic in recent years. This review summarizes the defectiveness of BM-MSCs which is responsible for the mechanism of acquired AA and the prospective application ...

Last Updated: 24 Jan 2015

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Recent advances in treatment of aplastic anemia.
 

Author(s): Seung Hwan Shin, Sung Eun Lee, Jong Wook Lee

Journal: Korean J. Intern. Med.. 2014 Nov;29(6):713-26.

 

Recent advances in the treatment of aplastic anemia (AA) made most of patients to expect to achieve a long-term survival. Allogeneic stem cell transplantation (SCT) from HLA-matched sibling donor (MSD-SCT) is a preferred first-line treatment option for younger patients with severe ...

Last Updated: 7 Nov 2014

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Aplastic anemia in adolescents and young adults.
 

Author(s): Amy E DeZern, Eva C Guinan

Journal: Acta Haematol.. 2014 ;132(3-4):331-9.

 

Adolescent and young adult patient presentations of aplastic anemia require a particular perspective on both diagnosis and treatment. This unique age group necessitates a thorough diagnostic evaluation to ensure the etiology, acquired or inherited, is sufficiently determined. The ...

Last Updated: 17 Sep 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Eltrombopag for Moderate Aplastic Anemia
 

Status: Recruiting

Condition Summary: Eltrombopag; Aplastic Anemia; Aplastic Anemia Treatment; Moderate Aplastic Anemia; Moderate Aplastic Anemia Treatment

 

Last Updated: 30 Apr 2015

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Efficacy and Safety of Eltrombopag In Patients With Severe and Very Severe Aplastic Anemia
 

Status: Recruiting

Condition Summary: Severe Aplastic Anemia; Very Severe Aplastic Anemia; Moderate Aplastic Anemia

 

Last Updated: 11 Aug 2015

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Hematopoietic Stem Cell Transplant for Dyskeratosis Congenita or Severe Aplastic Anemia
 

Status: Recruiting

Condition Summary: Dyskeratosis Congenita; Aplastic Anemia

 

Last Updated: 22 Apr 2015

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