Aplastic Anemia

Common Name(s)

Aplastic Anemia

Aplastic anemia is failure of the bone marrow to make enough blood cells. All blood cell types are affected. It can be caused by injury to blood stem cells due to exposure to certain drugs, chemotherapy, congenital disorders, drug therapy to suppress the immune system, pregnancy, radiation therapy, or toxins such as benzene or arsenic. When the cause is unknown, it is referred to as idiopathic aplastic anemia. In about half of all cases, no cause can be found. The condition can be acute or chronic.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Aplastic Anemia" for support, advocacy or research.

Dyskeratosis Congenita Outreach, Inc.

Our mission is to provide information and support services to families affected by Dyskeratosis Congenita, a Telomere Biology Disorder worldwide, to encourage the medical community's research in finding causes and effective treatments, and to facilitate improved diagnosis by educating medical providers.

Last Updated: 1 Nov 2014

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Aplastic Anemia & MDS International Foundation

The Aplastic Anemia & MDS International Foundation (AA&MDSIF) is the world's leading nonprofit health organization dedicated to supporting patients and families living with aplastic anemia, myelodysplastic syndromes (MDS), paroxysmal nocturnal hemoglobinuria (PNH), and related bone marrow failure diseases. AA&MDSIF provides answers, support and hope to thousands of patients and their families around the world.

Last Updated: 29 Apr 2014

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APLASTIC ANEMIA AND OMID'S MISSION FOUNDATION

ONE MOTHER.. ONE SON... ONE MISSION! AT AAOMF.ORG WE EDUCATE, SUPPORT PATIENTS, CAREGIVERS. AND BRING GLOBAL AWARENESS.OF THIS LIFE THREATENING BONE MARROW FAILURE BLOOD DISEASE. MILLIONS OF CHILDREN WORLDWIDE ARE SUFFERING WITH APLASTIC ANEMIA. WE PROVIDE UPDATED INFORMATION RELATED TO NEW RESEARCH, TREATMENTS AND NEW FINDINGS FROM THE NATIONAL INSTITUTE OF HEALTH. (NIH) WE ARE ADVOCATES THAT LOOK OUT FOR PATIENT'S RIGHTS. OUR MISSION IS TO HELP RESEARCHERS FIND A CURE FOR APLASTIC ANEMIA DYSKERATOSIS CONGENITA. AAOMF.ORG HAS BEEN PROACTIVE AND RECOGNIZED BY LARGE CORPORATIONS SUCH AS MACY'S, CITGO, TDBANK, STARBUCKS, CARMAX AND MUCH MORE. WE CAN TACKLE APLASTIC ANEMIA BY WORKING TOGETHER.

Last Updated: 15 Feb 2013

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Aplastic Anemia" for support, advocacy or research.

Dyskeratosis Congenita Outreach, Inc.

Our mission is to provide information and support services to families affected by Dyskeratosis Congenita, a Telomere Biology Disorder worldwide, to encourage the medical community's research in finding causes and effective treatments, and to facilitate improved diagnosis by educating medical providers.

http://www.dcoutreach.com

Last Updated: 1 Nov 2014

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Aplastic Anemia & MDS International Foundation

The Aplastic Anemia & MDS International Foundation (AA&MDSIF) is the world's leading nonprofit health organization dedicated to supporting patients and families living with aplastic anemia, myelodysplastic syndromes (MDS), paroxysmal nocturnal hemoglobinuria (PNH), and related bone marrow failure diseases. AA&MDSIF provides answers, support and hope to thousands of patients and their families around the world.

http://www.aamds.org/

Last Updated: 29 Apr 2014

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APLASTIC ANEMIA AND OMID'S MISSION FOUNDATION

ONE MOTHER.. ONE SON... ONE MISSION! AT AAOMF.ORG WE EDUCATE, SUPPORT PATIENTS, CAREGIVERS. AND BRING GLOBAL AWARENESS.OF THIS LIFE THREATENING BONE MARROW FAILURE BLOOD DISEASE. MILLIONS OF CHILDREN WORLDWIDE ARE SUFFERING WITH APLASTIC ANEMIA. WE PROVIDE UPDATED INFORMATION RELATED TO NEW RESEARCH, TREATMENTS AND NEW FINDINGS FROM THE NATIONAL INSTITUTE OF HEALTH. (NIH) WE ARE ADVOCATES THAT LOOK OUT FOR PATIENT'S RIGHTS. OUR MISSION IS TO HELP RESEARCHERS FIND A CURE FOR APLASTIC ANEMIA DYSKERATOSIS CONGENITA. AAOMF.ORG HAS BEEN PROACTIVE AND RECOGNIZED BY LARGE CORPORATIONS SUCH AS MACY'S, CITGO, TDBANK, STARBUCKS, CARMAX AND MUCH MORE. WE CAN TACKLE APLASTIC ANEMIA BY WORKING TOGETHER.

http://www.aaomf.org

Last Updated: 15 Feb 2013

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Aplastic Anemia" returned 667 free, full-text research articles on human participants. First 3 results:

Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.
 

Author(s): Neal S Young, Seishi Ogawa

Journal: N. Engl. J. Med.. 2015 Oct;373(17):1675-6.

 

Last Updated: 22 Oct 2015

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Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.
 

Author(s): Tetsuichi Yoshizato, Bogdan Dumitriu, Kohei Hosokawa, Hideki Makishima, Kenichi Yoshida, Danielle Townsley, Aiko Sato-Otsubo, Yusuke Sato, Delong Liu, Hiromichi Suzuki, Colin O Wu, Yuichi Shiraishi, Michael J Clemente, Keisuke Kataoka, Yusuke Shiozawa, Yusuke Okuno, Kenichi Chiba, Hiroko Tanaka, Yasunobu Nagata, Takamasa Katagiri, Ayana Kon, Masashi Sanada, Phillip Scheinberg, Satoru Miyano, Jaroslaw P Maciejewski, Shinji Nakao, Neal S Young, Seishi Ogawa

Journal: N. Engl. J. Med.. 2015 Jul;373(1):35-47.

 

In patients with acquired aplastic anemia, destruction of hematopoietic cells by the immune system leads to pancytopenia. Patients have a response to immunosuppressive therapy, but myelodysplastic syndromes and acute myeloid leukemia develop in about 15% of the patients, usually many ...

Last Updated: 3 Jul 2015

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[Hepatitis E virus-associated aplastic anemia. Report of a case].
 

Author(s): Marcelo Zylberman, Karina Turdó, Andrea Odzak, Florencia Arcondo, Nancy Altabert, Silvina Munné

Journal: Medicina (B Aires). 2015 ;75(3):175-7.

 

Hepatitis-associated aplastic anemia (HAAA) is a well-recognized clinical syndrome in which marrow failure follows the development of hepatitis; it can be observed in up to 5% in the aplastic anemia in West Europe and North American countries and 10% in the East Asia. Although hepatotropic ...

Last Updated: 29 Jun 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Aplastic Anemia" returned 53 free, full-text review articles on human participants. First 3 results:

Timing of allogeneic stem cell transplantation for myelodysplastic syndromes and aplastic anemia.
 

Author(s): Corey Cutler

Journal: Hematology Am Soc Hematol Educ Program. 2014 Dec;2014(1):77-81.

 

Allogeneic hematopoietic stem cell transplantation (HSCT) for myelodysplastic syndrome (MDS) is a potentially curative procedure, but is associated with a significant risk of morbidity and mortality. With the recent approval of disease-modifying agents, the appropriate timing of allogeneic ...

Last Updated: 20 Feb 2015

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[Defectiveness of bone marrow mesenchymal stem cells in acquired aplastic anemia].
 

Author(s): Jing-Liao Zhang, Xiao-Fan Zhu

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2015 Jan;17(1):100-6.

 

The defectiveness of bone marrow mesenchymal stem cells (BM-MSCs) in acquired aplastic anemia (AA) has been a frequent research topic in recent years. This review summarizes the defectiveness of BM-MSCs which is responsible for the mechanism of acquired AA and the prospective application ...

Last Updated: 24 Jan 2015

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Eltrombopag in aplastic anemia.
 

Author(s): Ronan Desmond, Danielle M Townsley, Cynthia Dunbar, Neal S Young

Journal: Semin. Hematol.. 2015 Jan;52(1):31-7.

 

The treatment of aplastic anemia is currently with immunosuppressive therapy (IST) with anti-thymocyte globulin (ATG) and cyclosporine, to which two thirds of patients respond. However, a significant proportion of these responders relapse and many have persistent cytopenias. The management ...

Last Updated: 12 Jan 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Efficacy and Safety of Eltrombopag In Patients With Severe and Very Severe Aplastic Anemia
 

Status: Recruiting

Condition Summary: Severe Aplastic Anemia; Very Severe Aplastic Anemia; Moderate Aplastic Anemia

 

Last Updated: 25 Jan 2016

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Hematopoietic Stem Cell Transplant for Dyskeratosis Congenita or Severe Aplastic Anemia
 

Status: Recruiting

Condition Summary: Dyskeratosis Congenita; Aplastic Anemia

 

Last Updated: 21 Jan 2016

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Last Updated: 6 Nov 2014

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