Aplastic Anemia

Common Name(s)

Aplastic Anemia

Aplastic anemia is failure of the bone marrow to make enough blood cells. All blood cell types are affected. It can be caused by injury to blood stem cells due to exposure to certain drugs, chemotherapy, congenital disorders, drug therapy to suppress the immune system, pregnancy, radiation therapy, or toxins such as benzene or arsenic. When the cause is unknown, it is referred to as idiopathic aplastic anemia. In about half of all cases, no cause can be found. The condition can be acute or chronic.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Aplastic Anemia" for support, advocacy or research.

Dyskeratosis Congenita Outreach, Inc.

Our mission is to provide information and support services to families affected by Dyskeratosis Congenita, a Telomere Biology Disorder worldwide, to encourage the medical community's research in finding causes and effective treatments, and to facilitate improved diagnosis by educating medical providers.

Last Updated: 1 Nov 2014

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Aplastic Anemia & MDS International Foundation

The Aplastic Anemia & MDS International Foundation (AA&MDSIF) is the world's leading nonprofit health organization dedicated to supporting patients and families living with aplastic anemia, myelodysplastic syndromes (MDS), paroxysmal nocturnal hemoglobinuria (PNH), and related bone marrow failure diseases. AA&MDSIF provides answers, support and hope to thousands of patients and their families around the world.

Last Updated: 29 Apr 2014

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APLASTIC ANEMIA AND OMID'S MISSION FOUNDATION

ONE MOTHER.. ONE SON... ONE MISSION! AT AAOMF.ORG WE EDUCATE, SUPPORT PATIENTS, CAREGIVERS. AND BRING GLOBAL AWARENESS.OF THIS LIFE THREATENING BONE MARROW FAILURE BLOOD DISEASE. MILLIONS OF CHILDREN WORLDWIDE ARE SUFFERING WITH APLASTIC ANEMIA. WE PROVIDE UPDATED INFORMATION RELATED TO NEW RESEARCH, TREATMENTS AND NEW FINDINGS FROM THE NATIONAL INSTITUTE OF HEALTH. (NIH) WE ARE ADVOCATES THAT LOOK OUT FOR PATIENT'S RIGHTS. OUR MISSION IS TO HELP RESEARCHERS FIND A CURE FOR APLASTIC ANEMIA DYSKERATOSIS CONGENITA. AAOMF.ORG HAS BEEN PROACTIVE AND RECOGNIZED BY LARGE CORPORATIONS SUCH AS MACY'S, CITGO, TDBANK, STARBUCKS, CARMAX AND MUCH MORE. WE CAN TACKLE APLASTIC ANEMIA BY WORKING TOGETHER.

Last Updated: 15 Feb 2013

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Aplastic Anemia" for support, advocacy or research.

Dyskeratosis Congenita Outreach, Inc.

Our mission is to provide information and support services to families affected by Dyskeratosis Congenita, a Telomere Biology Disorder worldwide, to encourage the medical community's research in finding causes and effective treatments, and to facilitate improved diagnosis by educating medical providers.

http://www.dcoutreach.com

Last Updated: 1 Nov 2014

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Aplastic Anemia & MDS International Foundation

The Aplastic Anemia & MDS International Foundation (AA&MDSIF) is the world's leading nonprofit health organization dedicated to supporting patients and families living with aplastic anemia, myelodysplastic syndromes (MDS), paroxysmal nocturnal hemoglobinuria (PNH), and related bone marrow failure diseases. AA&MDSIF provides answers, support and hope to thousands of patients and their families around the world.

http://www.aamds.org/

Last Updated: 29 Apr 2014

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APLASTIC ANEMIA AND OMID'S MISSION FOUNDATION

ONE MOTHER.. ONE SON... ONE MISSION! AT AAOMF.ORG WE EDUCATE, SUPPORT PATIENTS, CAREGIVERS. AND BRING GLOBAL AWARENESS.OF THIS LIFE THREATENING BONE MARROW FAILURE BLOOD DISEASE. MILLIONS OF CHILDREN WORLDWIDE ARE SUFFERING WITH APLASTIC ANEMIA. WE PROVIDE UPDATED INFORMATION RELATED TO NEW RESEARCH, TREATMENTS AND NEW FINDINGS FROM THE NATIONAL INSTITUTE OF HEALTH. (NIH) WE ARE ADVOCATES THAT LOOK OUT FOR PATIENT'S RIGHTS. OUR MISSION IS TO HELP RESEARCHERS FIND A CURE FOR APLASTIC ANEMIA DYSKERATOSIS CONGENITA. AAOMF.ORG HAS BEEN PROACTIVE AND RECOGNIZED BY LARGE CORPORATIONS SUCH AS MACY'S, CITGO, TDBANK, STARBUCKS, CARMAX AND MUCH MORE. WE CAN TACKLE APLASTIC ANEMIA BY WORKING TOGETHER.

http://www.aaomf.org

Last Updated: 15 Feb 2013

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Aplastic Anemia" returned 692 free, full-text research articles on human participants. First 3 results:

Impaired Autophagy in Adult Bone Marrow CD34+ Cells of Patients with Aplastic Anemia: Possible Pathogenic Significance.
 

Author(s): Jinbo Huang, Meili Ge, Shihong Lu, Jun Shi, Wei Yu, Xingxin Li, Min Wang, Jizhou Zhang, Sizhou Feng, Shuxu Dong, Xuelian Cheng, Yizhou Zheng

Journal:

 

Aplastic anemia (AA) is a bone marrow failure syndrome that is caused largely by profound quantitative and qualitative defects of hematopoietic stem and progenitor cells. However, the mechanisms underlying these defects remain unclear. Under conditions of stress, autophagy acts as ...

Last Updated: 2 Mar 2016

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Successful Allogeneic Stem Cell Transplantation for Severe Aplastic Anemia after Treatment of Lymphoproliferative Disorder Caused by Rabbit Antithymocyte Globulin.
 

Author(s): Shokichi Tsukamoto, Yuhei Nagao, Atsuko Yamazaki, Yasumasa Sugita, Tomoya Muto, Shio Sakai, Yusuke Takeda, Naoya Mimura, Masahiro Takeuchi, Chikako Ohwada, Emiko Sakaida, Koutaro Yokote, Tohru Iseki, Chiaki Nakaseko

Journal: Intern. Med.. 2015 ;54(24):3197-200.

 

Immunosuppressive therapy (IST) with a combination of antithymocyte globulin (ATG) and cyclosporine (CsA) is an effective therapeutic modality for patients with aplastic anemia (AA) who are not eligible for allogeneic stem cell transplantation (Allo-SCT) from a human leukocyte antigen-identical ...

Last Updated: 15 Dec 2015

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Disrupted lymphocyte homeostasis in hepatitis-associated acquired aplastic anemia is associated with short telomeres.
 

Author(s): Daria V Babushok, Anne-Laure Grignon, Yimei Li, Jamie Atienza, Hongbo M Xie, Ho-Sun Lam, Helge Hartung, Monica Bessler, Timothy S Olson

Journal: Am. J. Hematol.. 2016 Feb;91(2):243-7.

 

Hepatitis-associated aplastic anemia (HAA) is a variant of acquired aplastic anemia (AA) in which immune-mediated bone marrow failure (BMF) develops following an acute episode of seronegative hepatitis. Dyskeratosis congenita (DC) is an inherited BMF syndrome characterized by the ...

Last Updated: 23 Jan 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Aplastic Anemia" returned 43 free, full-text review articles on human participants. First 3 results:

Concurrent Epstein-Barr virus associated NK/T cell lymphoma after immunosuppressive therapy for aplastic anemia: report of a case and review of literature.
 

Author(s): Guangli Yin, Ying Ni, Zhengrui Xiao, Guangsheng He, Kourong Miao

Journal:

 

Aplastic anemia (AA) patients with prolonged immunosuppression have a risk of development of lymphoproliferative disorders (LPDs), especially combined with Epstein-Barr virus (EBV) infection. However, development of nature killer/T (NK/T) cell lymphoma, in a nontransplantation setting, ...

Last Updated: 11 Aug 2015

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[Defectiveness of bone marrow mesenchymal stem cells in acquired aplastic anemia].
 

Author(s): Jing-Liao Zhang, Xiao-Fan Zhu

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2015 Jan;17(1):100-6.

 

The defectiveness of bone marrow mesenchymal stem cells (BM-MSCs) in acquired aplastic anemia (AA) has been a frequent research topic in recent years. This review summarizes the defectiveness of BM-MSCs which is responsible for the mechanism of acquired AA and the prospective application ...

Last Updated: 24 Jan 2015

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Eltrombopag in aplastic anemia.
 

Author(s): Ronan Desmond, Danielle M Townsley, Cynthia Dunbar, Neal S Young

Journal: Semin. Hematol.. 2015 Jan;52(1):31-7.

 

The treatment of aplastic anemia is currently with immunosuppressive therapy (IST) with anti-thymocyte globulin (ATG) and cyclosporine, to which two thirds of patients respond. However, a significant proportion of these responders relapse and many have persistent cytopenias. The management ...

Last Updated: 12 Jan 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Eltrombopag for Moderate Aplastic Anemia
 

Status: Recruiting

Condition Summary: Eltrombopag; Aplastic Anemia; Aplastic Anemia Treatment; Moderate Aplastic Anemia; Moderate Aplastic Anemia Treatment; Unilineage Bone Marrow Failure Disorders

 

Last Updated: 20 Sep 2016

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NMA Haplo or MUD BMT for Newly Diagnosed Severe Aplastic Anemia
 

Status: Recruiting

Condition Summary: Severe Aplastic Anemia; Aplastic Anemia; Bone Marrow Failure; Immunosuppression

 

Last Updated: 29 Aug 2016

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Study of Romiplostim(AMG531) in Subjects With Aplastic Anemia
 

Status: Recruiting

Condition Summary: Aplastic Anemia

 

Last Updated: 13 May 2016

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