Aplastic Anemia

Common Name(s)

Aplastic Anemia

Aplastic anemia is failure of the bone marrow to make enough blood cells. All blood cell types are affected. It can be caused by injury to blood stem cells due to exposure to certain drugs, chemotherapy, congenital disorders, drug therapy to suppress the immune system, pregnancy, radiation therapy, or toxins such as benzene or arsenic. When the cause is unknown, it is referred to as idiopathic aplastic anemia. In about half of all cases, no cause can be found. The condition can be acute or chronic.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Aplastic Anemia" for support, advocacy or research.

Dyskeratosis Congenita Outreach, Inc.

Our mission is to provide information and support services to families affected by Dyskeratosis Congenita, a Telomere Biology Disorder worldwide, to encourage the medical community's research in finding causes and effective treatments, and to facilitate improved diagnosis by educating medical providers.

Last Updated: 1 Nov 2014

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Aplastic Anemia & MDS International Foundation

The Aplastic Anemia & MDS International Foundation (AA&MDSIF) is the world's leading nonprofit health organization dedicated to supporting patients and families living with aplastic anemia, myelodysplastic syndromes (MDS), paroxysmal nocturnal hemoglobinuria (PNH), and related bone marrow failure diseases. AA&MDSIF provides answers, support and hope to thousands of patients and their families around the world.

Last Updated: 29 Apr 2014

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APLASTIC ANEMIA AND OMID'S MISSION FOUNDATION

ONE MOTHER.. ONE SON... ONE MISSION! AT AAOMF.ORG WE EDUCATE, SUPPORT PATIENTS, CAREGIVERS. AND BRING GLOBAL AWARENESS.OF THIS LIFE THREATENING BONE MARROW FAILURE BLOOD DISEASE. MILLIONS OF CHILDREN WORLDWIDE ARE SUFFERING WITH APLASTIC ANEMIA. WE PROVIDE UPDATED INFORMATION RELATED TO NEW RESEARCH, TREATMENTS AND NEW FINDINGS FROM THE NATIONAL INSTITUTE OF HEALTH. (NIH) WE ARE ADVOCATES THAT LOOK OUT FOR PATIENT'S RIGHTS. OUR MISSION IS TO HELP RESEARCHERS FIND A CURE FOR APLASTIC ANEMIA DYSKERATOSIS CONGENITA. AAOMF.ORG HAS BEEN PROACTIVE AND RECOGNIZED BY LARGE CORPORATIONS SUCH AS MACY'S, CITGO, TDBANK, STARBUCKS, CARMAX AND MUCH MORE. WE CAN TACKLE APLASTIC ANEMIA BY WORKING TOGETHER.

Last Updated: 15 Feb 2013

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Aplastic Anemia" for support, advocacy or research.

Dyskeratosis Congenita Outreach, Inc.

Our mission is to provide information and support services to families affected by Dyskeratosis Congenita, a Telomere Biology Disorder worldwide, to encourage the medical community's research in finding causes and effective treatments, and to facilitate improved diagnosis by educating medical providers.

http://www.dcoutreach.com

Last Updated: 1 Nov 2014

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Aplastic Anemia & MDS International Foundation

The Aplastic Anemia & MDS International Foundation (AA&MDSIF) is the world's leading nonprofit health organization dedicated to supporting patients and families living with aplastic anemia, myelodysplastic syndromes (MDS), paroxysmal nocturnal hemoglobinuria (PNH), and related bone marrow failure diseases. AA&MDSIF provides answers, support and hope to thousands of patients and their families around the world.

http://www.aamds.org/

Last Updated: 29 Apr 2014

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APLASTIC ANEMIA AND OMID'S MISSION FOUNDATION

ONE MOTHER.. ONE SON... ONE MISSION! AT AAOMF.ORG WE EDUCATE, SUPPORT PATIENTS, CAREGIVERS. AND BRING GLOBAL AWARENESS.OF THIS LIFE THREATENING BONE MARROW FAILURE BLOOD DISEASE. MILLIONS OF CHILDREN WORLDWIDE ARE SUFFERING WITH APLASTIC ANEMIA. WE PROVIDE UPDATED INFORMATION RELATED TO NEW RESEARCH, TREATMENTS AND NEW FINDINGS FROM THE NATIONAL INSTITUTE OF HEALTH. (NIH) WE ARE ADVOCATES THAT LOOK OUT FOR PATIENT'S RIGHTS. OUR MISSION IS TO HELP RESEARCHERS FIND A CURE FOR APLASTIC ANEMIA DYSKERATOSIS CONGENITA. AAOMF.ORG HAS BEEN PROACTIVE AND RECOGNIZED BY LARGE CORPORATIONS SUCH AS MACY'S, CITGO, TDBANK, STARBUCKS, CARMAX AND MUCH MORE. WE CAN TACKLE APLASTIC ANEMIA BY WORKING TOGETHER.

http://www.aaomf.org

Last Updated: 15 Feb 2013

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Aplastic Anemia" returned 555 free, full-text research articles on human participants. First 3 results:

Busuishengxue ranules mediate their effects upon non-severe aplastic anemia via mitogen-activated protein kinase/extracellular signal-regulated kinase pathway.
 

Author(s): Jinhuan Wang, Feng Sun, Weizheng Sun, Haitao Shi, Yanli Yong, Sijia Liu, Limei Liu

Journal: J Tradit Chin Med. 2014 Feb;34(1):23-9.

 

To observe the clinical efficacy of Busuishengxue granules on non-severe aplastic anemia (NSAA) and investigate its effect on the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway.

Last Updated: 8 Aug 2014

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[Telomere length and telomerase mutations in peripheral blood leukocytes of children with chronic aplastic anemia].
 

Author(s): Xi-Ge Wang, Xuan Wang, Song Liu, Yu-Jie Zhou, Dan-Feng Wang

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2014 Apr;16(4):375-9.

 

To investigate the change in telomere length and TERC and TERT mutations in peripheral blood leukocytes of children with chronic aplastic anemia (CAA).

Last Updated: 22 Apr 2014

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Granulocyte transfusion combined with granulocyte colony stimulating factor in severe infection patients with severe aplastic anemia: a single center experience from China.
 

Author(s): Huaquan Wang, Yuhong Wu, Rong Fu, Wen Qu, Erbao Ruan, Guojin Wang, Hong Liu, Jia Song, Limin Xing, Jing Guan, Lijuan Li, Chunyan Liu, Zonghong Shao

Journal:

 

To investigate the efficacy and safety of granulocyte transfusion combined with granulocyte colony stimulating factor (G-CSF) in severe infection patients with severe aplastic anemia (SAA).

Last Updated: 7 Feb 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Aplastic Anemia" returned 40 free, full-text review articles on human participants. First 3 results:

Aplastic anemia in adolescents and young adults.
 

Author(s): Amy E DeZern, Eva C Guinan

Journal: Acta Haematol.. 2014 ;132(3-4):331-9.

 

Adolescent and young adult patient presentations of aplastic anemia require a particular perspective on both diagnosis and treatment. This unique age group necessitates a thorough diagnostic evaluation to ensure the etiology, acquired or inherited, is sufficiently determined. The ...

Last Updated: 17 Sep 2014

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Management of the refractory aplastic anemia patient: what are the options?
 

Author(s): Judith C W Marsh, Austin G Kulasekararaj

Journal: Blood. 2013 Nov;122(22):3561-7.

 

Refractory aplastic anemia (AA) is defined as a lack of response to first-line immunosuppressive therapy (IST) with antithymocyte globulin and cyclosporin and is manifested as persistence of severe cytopenias at 6 months after IST. Although supportive care is critical for AA patients, ...

Last Updated: 22 Nov 2013

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[High-dose cyclophosphamide for severe aplastic anemia associated with β-thalassemia: a case report and literatures review].
 

Author(s): Xin Zhao, Yuan Li, Kang Zhou, Li Zhang, Li-ping Jing, Lei Ye, Guang-xin Peng, Yang Li, Jian-ping Li, Hui-hui Fan, Lin Song, Feng-kui Zhang

Journal: Zhonghua Xue Ye Xue Za Zhi. 2013 Jun;34(6):532-5.

 

To investigate the clinical features and therapeutic method for severe aplastic anemia (SAA) associated with β-thalassemia, and to improve the recognition of the disease.

Last Updated: 5 Jul 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Eltrombopag for Moderate Aplastic Anemia
 

Status: Recruiting

Condition Summary: Eltrombopag; Aplastic Anemia; Aplastic Anemia Treatment; Moderate Aplastic Anemia; Moderate Aplastic Anemia Treatment

 

Last Updated: 22 Nov 2014

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Efficacy and Safety of Eltrombopag In Patients With Severe and Very Severe Aplastic Anemia
 

Status: Recruiting

Condition Summary: Severe Aplastic Anemia; Very Severe Aplastic Anemia; Moderate Aplastic Anemia

 

Last Updated: 7 Mar 2013

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Alemtuzumab to Treat Severe Aplastic Anemia
 

Status: Recruiting

Condition Summary: Relapsed or Refractory Severe Aplastic Anemia; Severe Aplastic Anemia

 

Last Updated: 4 Nov 2014

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