Aplastic Anemia

Common Name(s)

Aplastic Anemia

Aplastic anemia is failure of the bone marrow to make enough blood cells. All blood cell types are affected. It can be caused by injury to blood stem cells due to exposure to certain drugs, chemotherapy, congenital disorders, drug therapy to suppress the immune system, pregnancy, radiation therapy, or toxins such as benzene or arsenic. When the cause is unknown, it is referred to as idiopathic aplastic anemia. In about half of all cases, no cause can be found. The condition can be acute or chronic.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Aplastic Anemia" for support, advocacy or research.

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Aplastic Anemia & MDS International Foundation

The Aplastic Anemia & MDS International Foundation (AA&MDSIF) is the world's leading nonprofit health organization dedicated to supporting patients and families living with aplastic anemia, myelodysplastic syndromes (MDS), paroxysmal nocturnal hemoglobinuria (PNH), and related bone marrow failure diseases. AA&MDSIF provides answers, support and hope to thousands of patients and their families around the world.

Last Updated: 29 Apr 2014

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APLASTIC ANEMIA AND OMID'S MISSION FOUNDATION

ONE MOTHER.. ONE SON... ONE MISSION! AT AAOMF.ORG WE EDUCATE, SUPPORT PATIENTS, CAREGIVERS. AND BRING GLOBAL AWARENESS.OF THIS LIFE THREATENING BONE MARROW FAILURE BLOOD DISEASE. MILLIONS OF CHILDREN WORLDWIDE ARE SUFFERING WITH APLASTIC ANEMIA. WE PROVIDE UPDATED INFORMATION RELATED TO NEW RESEARCH, TREATMENTS AND NEW FINDINGS FROM THE NATIONAL INSTITUTE OF HEALTH. (NIH) WE ARE ADVOCATES THAT LOOK OUT FOR PATIENT'S RIGHTS. OUR MISSION IS TO HELP RESEARCHERS FIND A CURE FOR APLASTIC ANEMIA DYSKERATOSIS CONGENITA. AAOMF.ORG HAS BEEN PROACTIVE AND RECOGNIZED BY LARGE CORPORATIONS SUCH AS MACY'S, CITGO, TDBANK, STARBUCKS, CARMAX AND MUCH MORE. WE CAN TACKLE APLASTIC ANEMIA BY WORKING TOGETHER.

Last Updated: 15 Feb 2013

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Aplastic Anemia" for support, advocacy or research.

Logo
Aplastic Anemia & MDS International Foundation

The Aplastic Anemia & MDS International Foundation (AA&MDSIF) is the world's leading nonprofit health organization dedicated to supporting patients and families living with aplastic anemia, myelodysplastic syndromes (MDS), paroxysmal nocturnal hemoglobinuria (PNH), and related bone marrow failure diseases. AA&MDSIF provides answers, support and hope to thousands of patients and their families around the world.

http://www.aamds.org/

Last Updated: 29 Apr 2014

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APLASTIC ANEMIA AND OMID'S MISSION FOUNDATION

ONE MOTHER.. ONE SON... ONE MISSION! AT AAOMF.ORG WE EDUCATE, SUPPORT PATIENTS, CAREGIVERS. AND BRING GLOBAL AWARENESS.OF THIS LIFE THREATENING BONE MARROW FAILURE BLOOD DISEASE. MILLIONS OF CHILDREN WORLDWIDE ARE SUFFERING WITH APLASTIC ANEMIA. WE PROVIDE UPDATED INFORMATION RELATED TO NEW RESEARCH, TREATMENTS AND NEW FINDINGS FROM THE NATIONAL INSTITUTE OF HEALTH. (NIH) WE ARE ADVOCATES THAT LOOK OUT FOR PATIENT'S RIGHTS. OUR MISSION IS TO HELP RESEARCHERS FIND A CURE FOR APLASTIC ANEMIA DYSKERATOSIS CONGENITA. AAOMF.ORG HAS BEEN PROACTIVE AND RECOGNIZED BY LARGE CORPORATIONS SUCH AS MACY'S, CITGO, TDBANK, STARBUCKS, CARMAX AND MUCH MORE. WE CAN TACKLE APLASTIC ANEMIA BY WORKING TOGETHER.

http://www.aaomf.org

Last Updated: 15 Feb 2013

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Aplastic Anemia" returned 536 free, full-text research articles on human participants. First 3 results:

High-dose immunosuppressive therapy combined with cord blood infusion and non-myeloablative peripheral blood stem cell transplantation for patients with severe aplastic anemia.
 

Author(s): Z Yu, F Zhou, L -Fu Ge, X-M Liu, Y Fang, L Xie, F-S Kong, N-X Song

Journal: Eur Rev Med Pharmacol Sci. 2013 Oct;17(19):2613-8.

 

The aim of this study was to compare the clinical effective rates of high-dose immunosuppressive therapy combined with cord blood infusion (IS + CBI) and non-myeloablative peripheral blood stem cell transplantation (NSCT) for severe aplastic anemia (SAA).

Last Updated: 21 Oct 2013

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[The relationship of telomere and telomerase activity with outcome of aplastic anemia after immunosuppressive therapy].
 

Author(s): Jia-yin Song, Li-ping Kuang, Yang Wang, Yong-hua Li, Jiu-long Wu, Hang Zhang, Li Li, Yao-chun Wang, Zu-jun Jiang, Yang Xiao

Journal: Zhonghua Xue Ye Xue Za Zhi. 2013 Sep;34(9):771-6.

 

To observe the changes of telomere length and telomerase activity in patients with aplastic anemia (AA), and relationship with immunosuppressive therapy (IST) efficacy, to explore the pathogenesis of AA and the role of telomere length in evaluating immunosuppressive therapy efficacy.

Last Updated: 9 Oct 2013

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Antithymocyte globulin induced posterior reversible encephalopathy in aplastic anemia.
 

Author(s): Aniruddha Dayama, Tulika Seth, Pravas Mishra, Manoranjan Mahapatra

Journal: Neurol India. ;61(4):430-1.

 

Last Updated: 5 Sep 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Aplastic Anemia" returned 36 free, full-text review articles on human participants. First 3 results:

[High-dose cyclophosphamide for severe aplastic anemia associated with β-thalassemia: a case report and literatures review].
 

Author(s): Xin Zhao, Yuan Li, Kang Zhou, Li Zhang, Li-ping Jing, Lei Ye, Guang-xin Peng, Yang Li, Jian-ping Li, Hui-hui Fan, Lin Song, Feng-kui Zhang

Journal: Zhonghua Xue Ye Xue Za Zhi. 2013 Jun;34(6):532-5.

 

To investigate the clinical features and therapeutic method for severe aplastic anemia (SAA) associated with β-thalassemia, and to improve the recognition of the disease.

Last Updated: 5 Jul 2013

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[Advances in allogeneic hematopoietic stem cell transplantation for severe aplastic anemia].
 

Author(s): Xin Chen, Si-zhou Feng

Journal: Zhonghua Xue Ye Xue Za Zhi. 2012 Nov;33(11):963-7.

 

Last Updated: 31 Jan 2013

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Aplastic anemia: therapeutic updates in immunosuppression and transplantation.
 

Author(s): Phillip Scheinberg

Journal: Hematology Am Soc Hematol Educ Program. 2012 ;2012():292-300.

 

Advances in hematopoietic stem cell transplantation (HSCT) and immunosuppressive therapy (IST) have improved survival in severe aplastic anemia (SAA) from 10%-20% in the 1960s to 80%-90% today. A matched sibling HSCT is the treatment of choice in younger patients, whereas IST is often ...

Last Updated: 12 Dec 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Eltrombopag for Moderate Aplastic Anemia
 

Status: Recruiting

Condition Summary: Eltrombopag; Aplastic Anemia; Aplastic Anemia Treatment; Moderate Aplastic Anemia; Moderate Aplastic Anemia Treatment

 

Last Updated: 11 Jun 2014

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Efficacy and Safety of Eltrombopag In Patients With Severe and Very Severe Aplastic Anemia
 

Status: Recruiting

Condition Summary: Severe Aplastic Anemia; Very Severe Aplastic Anemia; Moderate Aplastic Anemia

 

Last Updated: 7 Mar 2013

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Alemtuzumab to Treat Severe Aplastic Anemia
 

Status: Recruiting

Condition Summary: Relapsed or Refractory Severe Aplastic Anemia; Severe Aplastic Anemia

 

Last Updated: 15 Aug 2014

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