Pancreatic cancer

Common Name(s)

Pancreatic cancer

Pancreatic cancer occurs when cells of the pancreas grow abnormally to form a tumor. The pancreas is a gland that normally makes juices that help break down food and produces insulin and other hormones. Pancreatic cancer usually doesn't cause symptoms right away, but can cause yellowing of the skin and eyes, pain in the abdomen and back, weight loss, and fatigue. Some risk factors for developing pancreatic cancer include smoking, long-term diabetes, chronic pancreatitis, and certain hereditary disorders. Because pancreatic cancer is often found late and it spreads quickly, it can be hard to treat. Possible treatments include surgery, radiation, and chemotherapy.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pancreatic cancer" for support, advocacy or research.

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Pancreatic Cancer Action Network

The Pancreatic Cancer Action Network is a nationwide network of people dedicated to working together to advance research, support patients and create hope for those affected by pancreatic cancer.

Last Updated: 20 Feb 2013

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The Lustgarten Foundation

The Lustgarten Foundation is committed to advancing the scientific and medical research related to the diagnosis, treatment, cure and prevention of pancreatic cancer.

Last Updated: 20 Feb 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pancreatic cancer" for support, advocacy or research.

Logo
Pancreatic Cancer Action Network

The Pancreatic Cancer Action Network is a nationwide network of people dedicated to working together to advance research, support patients and create hope for those affected by pancreatic cancer.

http://www.pancan.org

Last Updated: 20 Feb 2013

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The Lustgarten Foundation

The Lustgarten Foundation is committed to advancing the scientific and medical research related to the diagnosis, treatment, cure and prevention of pancreatic cancer.

http://www.lustgarten.org

Last Updated: 20 Feb 2013

View Details

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pancreatic cancer" returned 3422 free, full-text research articles on human participants. First 3 results:

Nitric oxide increases the invasion of pancreatic cancer cells via activation of the PI3K-AKT and RhoA pathways after carbon ion irradiation.
 

Author(s): Mayumi Fujita, Kaori Imadome, Satoshi Endo, Yoshimi Shoji, Shigeru Yamada, Takashi Imai

Journal: FEBS Lett.. 2014 Aug;588(17):3240-50.

 

Previous studies have shown that serine proteases and Rho-associated kinase contribute to carbon ion radiation-enhanced invasion of the human pancreatic cancer cell line PANC-1. The results presented here show that nitric oxide synthase (NOS) also plays a critical role in this process. ...

Last Updated: 18 Aug 2014

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Antitumor effect of Kanglaite® injection in human pancreatic cancer xenografts.
 

Author(s): Ying Liu, Wei Zhang, Xiao-Jie Wang, Shi Liu

Journal:

 

Kanglaite® injection (KLT), with a main ingredient of Coix seed oil (a traditional Chinese medicine), has been widely used for cancer treatment in China. KLT has an inhibitory effect on many kinds of tumors and PI3K/Akt/mTOR signaling promotes cell survival, proliferation, and progression ...

Last Updated: 22 Jul 2014

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Synthesis, characterization, and evaluation of poly (D,L-lactide-co-glycolide)-based nanoformulation of miRNA-150: potential implications for pancreatic cancer therapy.
 

Author(s): Sumit Arora, Suresh K Swaminathan, Ameya Kirtane, Sanjeev K Srivastava, Arun Bhardwaj, Seema Singh, Jayanth Panyam, Ajay P Singh

Journal:

 

MicroRNAs are small (18-22 nucleotide long) noncoding RNAs that play important roles in biological processes through posttranscriptional regulation of gene expression. Their aberrant expression and functional significance are reported in several human malignancies, including pancreatic ...

Last Updated: 27 Jun 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pancreatic cancer" returned 436 free, full-text review articles on human participants. First 3 results:

Oncogenic KRAS signalling in pancreatic cancer.
 

Author(s): S Eser, A Schnieke, G Schneider, D Saur

Journal: Br. J. Cancer. 2014 Aug;111(5):817-22.

 

Pancreatic ductal adenocarcinoma (PDAC) is almost universally fatal. The annual number of deaths equals the number of newly diagnosed cases, despite maximal treatment. The overall 5-year survival rate of <5% has remained stubbornly unchanged over the last 30 years, despite tremendous ...

Last Updated: 27 Aug 2014

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The role of quantitative mass spectrometry in the discovery of pancreatic cancer biomarkers for translational science.
 

Author(s): Daniel Ansari, Linus Aronsson, Agata Sasor, Charlotte Welinder, Melinda Rezeli, György Marko-Varga, Roland Andersson

Journal:

 

In the post-genomic era, it has become evident that genetic changes alone are not sufficient to understand most disease processes including pancreatic cancer. Genome sequencing has revealed a complex set of genetic alterations in pancreatic cancer such as point mutations, chromosomal ...

Last Updated: 25 Apr 2014

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Nab-paclitaxel for metastatic pancreatic cancer: clinical outcomes and potential mechanisms of action.
 

Author(s): Salah-Eddin Al-Batran, Michael Geissler, Thomas Seufferlein, Helmut Oettle

Journal: Oncol Res Treat. 2014 ;37(3):128-34.

 

For almost 15 years there has been stagnation in the systemic treatment of patients with pancreatic ductal adenocarcinoma (PDAC). Recently, several developments seem to indicate clinically relevant improvements in the treatment of patients with metastatic disease. One of these developments ...

Last Updated: 1 Apr 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Gemcitabine and CT-011 for Resected Pancreatic Cancer
 

Status: Recruiting

Condition Summary: Pancreatic Neoplasms; Cancer of the Pancreas; Neoplasms Pancreatic; Pancreatic Cancer; Pancreas Cancer

 

Last Updated: 12 Aug 2014

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Neoadjuvant FOLFIRINOX Regimen in Patients With Non-metastatic Pancrease Cancer
 

Status: Recruiting

Condition Summary: Pancreas Cancer; Localized Pancreas Cancer; Non-metastatic Pancreas Cancer

 

Last Updated: 3 Mar 2014

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Phase I Study of Stereotactic Body Radiation Therapy and FOLFIRINOX in the Neoadjuvant Therapy of Pancreatic Cancer
 

Status: Recruiting

Condition Summary: Cancer of Pancreas; Cancer of the Pancreas; Neoplasms, Pancreatic; Pancreas Cancer; Pancreas Neoplasms

 

Last Updated: 24 Sep 2014

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