Pancreatic cancer

Common Name(s)

Pancreatic cancer

Pancreatic cancer occurs when cells of the pancreas grow abnormally to form a tumor. The pancreas is a gland that normally makes juices that help break down food and produces insulin and other hormones. Pancreatic cancer usually doesn't cause symptoms right away, but can cause yellowing of the skin and eyes, pain in the abdomen and back, weight loss, and fatigue. Some risk factors for developing pancreatic cancer include smoking, long-term diabetes, chronic pancreatitis, and certain hereditary disorders. Because pancreatic cancer is often found late and it spreads quickly, it can be hard to treat. Possible treatments include surgery, radiation, and chemotherapy.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pancreatic cancer" for support, advocacy or research.

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Pancreatic Cancer Action Network

The Pancreatic Cancer Action Network is a nationwide network of people dedicated to working together to advance research, support patients and create hope for those affected by pancreatic cancer.

Last Updated: 20 Feb 2013

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The Lustgarten Foundation

The Lustgarten Foundation is committed to advancing the scientific and medical research related to the diagnosis, treatment, cure and prevention of pancreatic cancer.

Last Updated: 20 Feb 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pancreatic cancer" for support, advocacy or research.

Logo
Pancreatic Cancer Action Network

The Pancreatic Cancer Action Network is a nationwide network of people dedicated to working together to advance research, support patients and create hope for those affected by pancreatic cancer.

http://www.pancan.org

Last Updated: 20 Feb 2013

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The Lustgarten Foundation

The Lustgarten Foundation is committed to advancing the scientific and medical research related to the diagnosis, treatment, cure and prevention of pancreatic cancer.

http://www.lustgarten.org

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pancreatic cancer" returned 3460 free, full-text research articles on human participants. First 3 results:

Genistein potentiates the antitumor effect of 5-Fluorouracil by inducing apoptosis and autophagy in human pancreatic cancer cells.
 

Author(s): Rei Suzuki, Ya'an Kang, Xinqun Li, David Roife, Ran Zhang, Jason B Fleming

Journal: Anticancer Res.. 2014 Sep;34(9):4685-92.

 

Although 5-fluorouracil (5-FU)-based combination chemotherapy (i.e. FOLFIRINOX) has demonstrated effectiveness against pancreatic cancer, novel therapeutic strategies must be developed to increase the therapeutic window of these cytotoxic agents. Genistein is a soy-derived isoflavone ...

Last Updated: 9 Sep 2014

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Stromal response to Hedgehog signaling restrains pancreatic cancer progression.
 

Author(s): John J Lee, Rushika M Perera, Huaijun Wang, Dai-Chen Wu, X Shawn Liu, Shiwei Han, Julien Fitamant, Phillip D Jones, Krishna S Ghanta, Sally Kawano, Julia M Nagle, Vikram Deshpande, Yves Boucher, Tomoyo Kato, James K Chen, Jürgen K Willmann, Nabeel Bardeesy, Philip A Beachy

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2014 Jul;111(30):E3091-100.

 

Pancreatic ductal adenocarcinoma (PDA) is the most lethal of common human malignancies, with no truly effective therapies for advanced disease. Preclinical studies have suggested a therapeutic benefit of targeting the Hedgehog (Hh) signaling pathway, which is activated throughout ...

Last Updated: 30 Jul 2014

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Nitric oxide increases the invasion of pancreatic cancer cells via activation of the PI3K-AKT and RhoA pathways after carbon ion irradiation.
 

Author(s): Mayumi Fujita, Kaori Imadome, Satoshi Endo, Yoshimi Shoji, Shigeru Yamada, Takashi Imai

Journal: FEBS Lett.. 2014 Aug;588(17):3240-50.

 

Previous studies have shown that serine proteases and Rho-associated kinase contribute to carbon ion radiation-enhanced invasion of the human pancreatic cancer cell line PANC-1. The results presented here show that nitric oxide synthase (NOS) also plays a critical role in this process. ...

Last Updated: 18 Aug 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pancreatic cancer" returned 438 free, full-text review articles on human participants. First 3 results:

The role of PAM4 in the management of pancreatic cancer: diagnosis, radioimmunodetection, and radioimmunotherapy.
 

Author(s): Suxia Han, Guihua Jin, Lijuan Wang, Meng Li, Chenchen He, Xijing Guo, Qing Zhu

Journal: J Immunol Res. 2014 ;2014():268479.

 

PAM4, a new monoclonal antibody (MAb) known as clivatuzumab, is highly reactive with pancreatic cancer and precursor lesions. It is absent from the normal tissues and has limited reactivity with nonpancreatic cancer. The detailed characteristic of the PAM4 epitope is unknown but recent ...

Last Updated: 12 May 2014

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Precursor lesions for sporadic pancreatic cancer: PanIN, IPMN, and MCN.
 

Author(s): M Distler, D Aust, J Weitz, C Pilarsky, Robert Grützmann

Journal: Biomed Res Int. 2014 ;2014():474905.

 

Pancreatic cancer is still a dismal disease. The high mortality rate is mainly caused by the lack of highly sensitive and specific diagnostic tools, and most of the patients are diagnosed in an advanced and incurable stage. Knowledge about precursor lesions for pancreatic cancer has ...

Last Updated: 30 Apr 2014

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Oncogenic KRAS signalling in pancreatic cancer.
 

Author(s): S Eser, A Schnieke, G Schneider, D Saur

Journal: Br. J. Cancer. 2014 Aug;111(5):817-22.

 

Pancreatic ductal adenocarcinoma (PDAC) is almost universally fatal. The annual number of deaths equals the number of newly diagnosed cases, despite maximal treatment. The overall 5-year survival rate of <5% has remained stubbornly unchanged over the last 30 years, despite tremendous ...

Last Updated: 27 Aug 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Gemcitabine and CT-011 for Resected Pancreatic Cancer
 

Status: Recruiting

Condition Summary: Pancreatic Neoplasms; Cancer of the Pancreas; Neoplasms Pancreatic; Pancreatic Cancer; Pancreas Cancer

 

Last Updated: 12 Aug 2014

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Neoadjuvant FOLFIRINOX Regimen in Patients With Non-metastatic Pancrease Cancer
 

Status: Recruiting

Condition Summary: Pancreas Cancer; Localized Pancreas Cancer; Non-metastatic Pancreas Cancer

 

Last Updated: 3 Mar 2014

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Phase I Study of Stereotactic Body Radiation Therapy and FOLFIRINOX in the Neoadjuvant Therapy of Pancreatic Cancer
 

Status: Recruiting

Condition Summary: Cancer of Pancreas; Cancer of the Pancreas; Neoplasms, Pancreatic; Pancreas Cancer; Pancreas Neoplasms

 

Last Updated: 24 Sep 2014

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