Pancreatic cancer

Common Name(s)

Pancreatic cancer

Pancreatic cancer occurs when cells of the pancreas grow abnormally to form a tumor. The pancreas is a gland that normally makes juices that help break down food and produces insulin and other hormones. Pancreatic cancer usually doesn't cause symptoms right away, but can cause yellowing of the skin and eyes, pain in the abdomen and back, weight loss, and fatigue. Some risk factors for developing pancreatic cancer include smoking, long-term diabetes, chronic pancreatitis, and certain hereditary disorders. Because pancreatic cancer is often found late and it spreads quickly, it can be hard to treat. Possible treatments include surgery, radiation, and chemotherapy.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pancreatic cancer" for support, advocacy or research.

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Pancreatic Cancer Action Network

The Pancreatic Cancer Action Network is a nationwide network of people dedicated to working together to advance research, support patients and create hope for those affected by pancreatic cancer.

Last Updated: 20 Feb 2013

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The Lustgarten Foundation

The Lustgarten Foundation is committed to advancing the scientific and medical research related to the diagnosis, treatment, cure and prevention of pancreatic cancer.

Last Updated: 20 Feb 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pancreatic cancer" for support, advocacy or research.

Logo
Pancreatic Cancer Action Network

The Pancreatic Cancer Action Network is a nationwide network of people dedicated to working together to advance research, support patients and create hope for those affected by pancreatic cancer.

http://www.pancan.org

Last Updated: 20 Feb 2013

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The Lustgarten Foundation

The Lustgarten Foundation is committed to advancing the scientific and medical research related to the diagnosis, treatment, cure and prevention of pancreatic cancer.

http://www.lustgarten.org

Last Updated: 20 Feb 2013

View Details

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pancreatic cancer" returned 3585 free, full-text research articles on human participants. First 3 results:

Anti-tumor effect of the extract from qingyihuaji formula on pancreatic cancer by down-regulating Notch-4 and Jagged-1.
 

Author(s): Yanli Xu, Feiye Zhu, Shan Xu, Luming Liu

Journal: J Tradit Chin Med. 2015 Feb;35(1):77-83.

 

To investigate, in terms of Notch signaling pathway, the effect on pancreatic cancer of the extract of an anti-tumor prescription--Qingyi-huaji formula (QYHJ)--from Traditional Chinese Medicine (TCM).

Last Updated: 6 Apr 2015

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Synergistic antitumor interactions between MK-1775 and panobinostat in preclinical models of pancreatic cancer.
 

Author(s): Guan Wang, Xiaojia Niu, Wenbo Zhang, J Timothy Caldwell, Holly Edwards, Wei Chen, Jeffrey W Taub, Lijing Zhao, Yubin Ge

Journal: Cancer Lett.. 2015 Jan;356(2 Pt B):656-68.

 

Pancreatic cancer remains a clinical challenge, thus new therapies are urgently needed. The selective Wee1 inhibitor MK-1775 has demonstrated promising results when combined with DNA damaging agents, and more recently with CHK1 inhibitors in various malignancies. We have previously ...

Last Updated: 8 Dec 2014

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Surgical treatment of the pancreatic stump: preventive strategies of pancreatic fistula after pancreatoduodenectomy for cancer.
 

Author(s): R Tersigni, M Capaldi, P Ialongo, L R Grillo, A Anselmo

Journal: G Chir. ;35(9-10):213-22.

 

The institutions with high volume of pancreatic surgery report morbidity rate from 30% to 50% and mortality less than 5% after pancreaticoduodenectomy (PD). At the present, the most significant cause of morbidity and mortality is pancreatic fistula (PF).

Last Updated: 25 Nov 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pancreatic cancer" returned 484 free, full-text review articles on human participants. First 3 results:

Blood glucose concentration and risk of pancreatic cancer: systematic review and dose-response meta-analysis.
 

Author(s): Wei-Chih Liao, Yu-Kang Tu, Ming-Shiang Wu, Jaw-Town Lin, Hsiu-Po Wang, Kuo-Liong Chien

Journal:

 

To evaluate potential linear and non-linear dose-response relations between blood glucose and risk of pancreatic cancer.

Last Updated: 5 Jan 2015

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K-ras mutational status in cytohistological tissue as a molecular marker for the diagnosis of pancreatic cancer: a systematic review and meta-analysis.
 

Author(s): Jing Yang, Jingjing Li, Rong Zhu, Huawei Zhang, Yuanyuan Zheng, Weiqi Dai, Fan Wang, Miao Shen, Kan Chen, Ping Cheng, Yan Zhang, Chengfen Wang, Junshan Wang, Yujing Xia, Jie Lu, Yingqun Zhou, Chuanyong Guo

Journal: Dis. Markers. 2014 ;2014():573783.

 

More clinically meaningful diagnostic tests are needed in pancreatic cancer (PC). K-ras mutations are the most frequently acquired genetic alteration.

Last Updated: 10 Oct 2014

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Interleukin-6: a villain in the drama of pancreatic cancer development and progression.
 

Author(s): Reinhild Holmer, Freya A Goumas, Georg H Waetzig, Stefan Rose-John, Holger Kalthoff

Journal: HBPD INT. 2014 Aug;13(4):371-80.

 

Pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy with a poor prognosis and little treatment options. The development and progression of the disease is fostered by inflammatory cells and cytokines. One of these cytokines is interleukin-6 (IL-6), which plays an important ...

Last Updated: 7 Aug 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Gemcitabine and CT-011 for Resected Pancreatic Cancer
 

Status: Recruiting

Condition Summary: Pancreatic Neoplasms; Cancer of the Pancreas; Neoplasms Pancreatic; Pancreatic Cancer; Pancreas Cancer

 

Last Updated: 12 Aug 2014

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Weekly Dosing of an Integrative Chemotherapy Combination to Treat Advanced Pancreatic Cancer
 

Status: Recruiting

Condition Summary: Adenocarincoma of Pancreas; Stage III Pancreatic Cancer; Stage IVA Pancreatic Cancer; Stage IVB Pancreatic Cancer

 

Last Updated: 7 May 2007

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A Study of Vantictumab (OMP-18R5) in Combination With Nab-Paclitaxel and Gemcitabine in Previously Untreated Stage IV Pancreatic Cancer
 

Status: Recruiting

Condition Summary: Pancreatic Cancer; Stage IV Pancreatic Cancer

 

Last Updated: 8 May 2014

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