Pancreatic cancer

Common Name(s)

Pancreatic cancer

Pancreatic cancer occurs when cells of the pancreas grow abnormally to form a tumor. The pancreas is a gland that normally makes juices that help break down food and produces insulin and other hormones. Pancreatic cancer usually doesn't cause symptoms right away, but can cause yellowing of the skin and eyes, pain in the abdomen and back, weight loss, and fatigue. Some risk factors for developing pancreatic cancer include smoking, long-term diabetes, chronic pancreatitis, and certain hereditary disorders. Because pancreatic cancer is often found late and it spreads quickly, it can be hard to treat. Possible treatments include surgery, radiation, and chemotherapy.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pancreatic cancer" for support, advocacy or research.

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Pancreatic Cancer Action Network

The Pancreatic Cancer Action Network is a nationwide network of people dedicated to working together to advance research, support patients and create hope for those affected by pancreatic cancer.

Last Updated: 20 Feb 2013

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The Lustgarten Foundation

The Lustgarten Foundation is committed to advancing the scientific and medical research related to the diagnosis, treatment, cure and prevention of pancreatic cancer.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pancreatic cancer" for support, advocacy or research.

Logo
Pancreatic Cancer Action Network

The Pancreatic Cancer Action Network is a nationwide network of people dedicated to working together to advance research, support patients and create hope for those affected by pancreatic cancer.

http://www.pancan.org

Last Updated: 20 Feb 2013

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The Lustgarten Foundation

The Lustgarten Foundation is committed to advancing the scientific and medical research related to the diagnosis, treatment, cure and prevention of pancreatic cancer.

http://www.lustgarten.org

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pancreatic cancer" returned 3523 free, full-text research articles on human participants. First 3 results:

Synergistic antitumor interactions between MK-1775 and panobinostat in preclinical models of pancreatic cancer.
 

Author(s): Guan Wang, Xiaojia Niu, Wenbo Zhang, J Timothy Caldwell, Holly Edwards, Wei Chen, Jeffrey W Taub, Lijing Zhao, Yubin Ge

Journal: Cancer Lett.. 2015 Jan;356(2 Pt B):656-68.

 

Pancreatic cancer remains a clinical challenge, thus new therapies are urgently needed. The selective Wee1 inhibitor MK-1775 has demonstrated promising results when combined with DNA damaging agents, and more recently with CHK1 inhibitors in various malignancies. We have previously ...

Last Updated: 8 Dec 2014

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Neoadjuvant chemoradiation therapy with gemcitabine/cisplatin and surgery versus immediate surgery in resectable pancreatic cancer: results of the first prospective randomized phase II trial.
 

Author(s): Henriette Golcher, Thomas B Brunner, Helmut Witzigmann, Lukas Marti, Wolf-Otto Bechstein, Christiane Bruns, Henry Jungnickel, Stefan Schreiber, Gerhard G Grabenbauer, Thomas Meyer, Susanne Merkel, Rainer Fietkau, Werner Hohenberger

Journal: Strahlenther Onkol. 2015 Jan;191(1):7-16.

 

In nonrandomized trials, neoadjuvant treatment was reported to prolong survival in patients with pancreatic cancer. As neoadjuvant chemoradiation is established for the treatment of rectal cancer we examined the value of neoadjuvant chemoradiotherapy in pancreatic cancer in a randomized ...

Last Updated: 10 Jan 2015

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IER3 supports KRASG12D-dependent pancreatic cancer development by sustaining ERK1/2 phosphorylation.
 

Author(s): Maria Noé Garcia, Daniel Grasso, Maria Belen Lopez-Millan, Tewfik Hamidi, Celine Loncle, Richard Tomasini, Gwen Lomberk, Françoise Porteu, Raul Urrutia, Juan L Iovanna

Journal: J. Clin. Invest.. 2014 Nov;124(11):4709-22.

 

Activating mutations in the KRAS oncogene are prevalent in pancreatic ductal adenocarcinoma (PDAC). We previously demonstrated that pancreatic intraepithelial neoplasia (PanIN) formation, which precedes malignant transformation, associates with the expression of immediate early response ...

Last Updated: 4 Nov 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pancreatic cancer" returned 454 free, full-text review articles on human participants. First 3 results:

Blood glucose concentration and risk of pancreatic cancer: systematic review and dose-response meta-analysis.
 

Author(s): Wei-Chih Liao, Yu-Kang Tu, Ming-Shiang Wu, Jaw-Town Lin, Hsiu-Po Wang, Kuo-Liong Chien

Journal:

 

To evaluate potential linear and non-linear dose-response relations between blood glucose and risk of pancreatic cancer.

Last Updated: 5 Jan 2015

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Association between pancreatitis and subsequent risk of pancreatic cancer: a systematic review of epidemiological studies.
 

Author(s): Gui-Xian Tong, Qing-Qing Geng, Jing Chai, Jing Cheng, Peng-Lai Chen, Han Liang, Xing-Rong Shen, De-Bin Wang

Journal: Asian Pac. J. Cancer Prev.. 2014 ;15(12):5029-34.

 

This study aimed to summarize published epidemiological evidence for the relationship between pancreatitis and subsequent risk of pancreatic cancer (PC). We searched Medline and Embase for epidemiological studies published by February 5th, 2014 examining the risk of PC in pancreatitis ...

Last Updated: 7 Jul 2014

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Chemotherapy regimens for advanced pancreatic cancer: a systematic review and network meta-analysis.
 

Author(s): Gillian K Gresham, George A Wells, Sharlene Gill, Christopher Cameron, Derek J Jonker

Journal:

 

Advanced pancreatic cancer confers poor prognosis and treatment advancement has been slow. Recent randomized clinical trials (RCTs) have demonstrated survival benefits for combination therapy compared to gemcitabine alone. However, the comparative benefits and harms of available combination ...

Last Updated: 15 Jul 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Gemcitabine and CT-011 for Resected Pancreatic Cancer
 

Status: Recruiting

Condition Summary: Pancreatic Neoplasms; Cancer of the Pancreas; Neoplasms Pancreatic; Pancreatic Cancer; Pancreas Cancer

 

Last Updated: 12 Aug 2014

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Weekly Dosing of an Integrative Chemotherapy Combination to Treat Advanced Pancreatic Cancer
 

Status: Recruiting

Condition Summary: Adenocarincoma of Pancreas; Stage III Pancreatic Cancer; Stage IVA Pancreatic Cancer; Stage IVB Pancreatic Cancer

 

Last Updated: 7 May 2007

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A Study of Vantictumab (OMP-18R5) in Combination With Nab-Paclitaxel and Gemcitabine in Previously Untreated Stage IV Pancreatic Cancer
 

Status: Recruiting

Condition Summary: Pancreatic Cancer; Stage IV Pancreatic Cancer

 

Last Updated: 8 May 2014

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