Palmoplantar Keratoderma

Common Name(s)

Palmoplantar Keratoderma

Palmoplantar keratoderma (PPK) is a group of conditions characterized by thickening of the palms and soles of the feet. PPK can also be an associated feature of different syndromes. In rare forms of palmoplantar keratoderma, other organs in the body may be affected in addition to the skin. PPK can either be inherited or acquired. Acquired palmoplantar keratodermas may arise as a result of infections, internal disease or cancer, inflammatory skin conditions, or medications. The hereditary palmoplantar keratodermas are caused by a gene abnormality that results in abnormal skin protein (keratin). They can be inherited in an autosomal dominant or autosomal recessive patterns.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Palmoplantar Keratoderma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Palmoplantar Keratoderma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Palmoplantar Keratoderma" returned 67 free, full-text research articles on human participants. First 3 results:

A spontaneous KRT16 mutation in a dog breed: a model for human focal non-epidermolytic palmoplantar keratoderma (FNEPPK).
 

Author(s): Jocelyn Plassais, Eric Guaguère, Laetitia Lagoutte, Anne-Sophie Guillory, Caroline Dufaure de Citres, Frédérique Degorce-Rubiales, Maxence Delverdier, Amaury Vaysse, Pascale Quignon, Céline Bleuart, Christophe Hitte, Alain Fautrel, Cecile Kaerle, Pascale Bellaud, Emmanuel Bensignor, Guillaume Queney, Emmanuelle Bourrat, Anne Thomas, Catherine André

Journal: J. Invest. Dermatol.. 2015 Apr;135(4):1187-90.

 

Last Updated: 19 Mar 2015

Go To URL
Possible anticipation in familial epidermolytic palmoplantar keratoderma with the p.R163W mutation of Keratin 9.
 

Author(s): Y Guo, M Shi, Z P Tan, X L Shi

Journal:

 

Epidermolytic palmoplantar keratoderma (EPPK) is an autosomal dominant disease characterized by diffuse hyperkeratosis of the epidermis of the palm and sole with an erythematous margin. The Keratin 9 (KRT9) and Keratin 1 genes are responsible for EPPK. Several previous studies have ...

Last Updated: 10 Oct 2014

Go To URL
A gain-of-function mutation in TRPV3 causes focal palmoplantar keratoderma in a Chinese family.
 

Author(s): Yuqing He, Kang Zeng, Xibao Zhang, Qiaolin Chen, Jiang Wu, Hong Li, Yong Zhou, Gustavo Glusman, Jared Roach, Alton Etheridge, Shizhen Qing, Qiang Tian, Inyoul Lee, Xin Tian, Xiaoning Wang, Zhihua Wu, Leroy Hood, Yuanlin Ding, Kai Wang

Journal: J. Invest. Dermatol.. 2015 Mar;135(3):907-9.

 

Last Updated: 10 Feb 2015

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Palmoplantar Keratoderma" returned 2 free, full-text review articles on human participants. First 3 results:

Desmoplakin mutations with palmoplantar keratoderma, woolly hair and cardiomyopathy.
 

Author(s): Manuela Pigors, Agnes Schwieger-Briel, Rodica Cosgarea, Adriana Diaconeasa, Leena Bruckner-Tuderman, Thilo Fleck, Cristina Has

Journal: Acta Derm. Venereol.. 2015 Mar;95(3):337-40.

 

Mutations in genes encoding for desmosomal components are associated with a broad spectrum of phenotypes comprising skin and hair abnormalities and account for 45-50% of cases of arrhythmogenic right ventricular cardiomyopathy. Today, more than 120 dominant and recessive desmoplakin ...

Last Updated: 10 Mar 2015

Go To URL
Palmoplantar keratoderma (PPK): acquired and genetic causes of a not so rare disease.
 

Author(s): Stina Schiller, Christina Seebode, Hans Christian Hennies, Kathrin Giehl, Steffen Emmert

Journal: J Dtsch Dermatol Ges. 2014 Sep;12(9):781-8.

 

Palmoplantar keratodermas (PPK) comprise a heterogeneous group of keratinization disorders with hyperkeratotic thickening of palms and soles. Sporadic or acquired forms of PPKs and genetic or hereditary forms exist. Differentiation between acquired and hereditary forms is essential ...

Last Updated: 1 Sep 2014

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.