Palmoplantar Keratoderma

Common Name(s)

Palmoplantar Keratoderma

Palmoplantar keratoderma (PPK) is a group of conditions characterized by thickening of the palms and soles of the feet. PPK can also be an associated feature of different syndromes. In rare forms of palmoplantar keratoderma, other organs in the body may be affected in addition to the skin. PPK can either be inherited or acquired. Acquired palmoplantar keratodermas may arise as a result of infections, internal disease or cancer, inflammatory skin conditions, or medications. The hereditary palmoplantar keratodermas are caused by a gene abnormality that results in abnormal skin protein (keratin). They can be inherited in an autosomal dominant or autosomal recessive patterns.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Palmoplantar Keratoderma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Palmoplantar Keratoderma" returned 72 free, full-text research articles on human participants. First 3 results:

Connexin26 Mutations Causing Palmoplantar Keratoderma and Deafness Interact with Connexin43, Modifying Gap Junction and Hemichannel Properties.
 

Author(s): Zunaira Shuja, Leping Li, Shashank Gupta, Gülistan Meşe, Thomas W White

Journal: J. Invest. Dermatol.. 2016 Jan;136(1):225-35.

 

Mutations in GJB2 (connexin [Cx]26) cause either deafness or deafness associated with skin diseases. That different disorders can be caused by distinct mutations within the same gene suggests that unique channel activities are influenced by each class of mutation. We have examined ...

Last Updated: 14 Jan 2016

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Papillon-Lèfevre syndrome with palmoplantar keratoderma and periodontitis, a rare cause of pyrexia of unknown origin: a case report.
 

Author(s): Somia Iqtadar, Sami Ullah Mumtaz, Sajid Abaidullah

Journal:

 

Papillon-Lefèvre Syndrome is a rare autosomal recessive disorder characterized by diffuse, transgradient palmoplantar keratoderma, destructive periodontitis beginning in childhood, premature loss of primary teeth, and frequent cutaneous and systemic pyogenic infections. Pyogenic ...

Last Updated: 19 Dec 2015

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Comment on Zhao et al. "Palmoplantar keratoderma of the Gamborg-Nielsen type is caused by mutations in the SLURP1 gene and represents a variant of Mal de Meleda".
 

Author(s): Ruud G L Nellen, Peter M Steijlen, Michel van Geel, Maurice A M van Steensel

Journal: Acta Derm. Venereol.. 2015 Nov;95(8):1034-5.

 

Last Updated: 4 Nov 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Palmoplantar Keratoderma" returned 2 free, full-text review articles on human participants. First 3 results:

Desmoplakin mutations with palmoplantar keratoderma, woolly hair and cardiomyopathy.
 

Author(s): Manuela Pigors, Agnes Schwieger-Briel, Rodica Cosgarea, Adriana Diaconeasa, Leena Bruckner-Tuderman, Thilo Fleck, Cristina Has

Journal: Acta Derm. Venereol.. 2015 Mar;95(3):337-40.

 

Mutations in genes encoding for desmosomal components are associated with a broad spectrum of phenotypes comprising skin and hair abnormalities and account for 45-50% of cases of arrhythmogenic right ventricular cardiomyopathy. Today, more than 120 dominant and recessive desmoplakin ...

Last Updated: 10 Mar 2015

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Palmoplantar keratoderma (PPK): acquired and genetic causes of a not so rare disease.
 

Author(s): Stina Schiller, Christina Seebode, Hans Christian Hennies, Kathrin Giehl, Steffen Emmert

Journal: J Dtsch Dermatol Ges. 2014 Sep;12(9):781-8.

 

Palmoplantar keratodermas (PPK) comprise a heterogeneous group of keratinization disorders with hyperkeratotic thickening of palms and soles. Sporadic or acquired forms of PPKs and genetic or hereditary forms exist. Differentiation between acquired and hereditary forms is essential ...

Last Updated: 1 Sep 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.