Palmoplantar Keratoderma

Common Name(s)

Palmoplantar Keratoderma

Palmoplantar keratoderma (PPK) is a group of conditions characterized by thickening of the palms and soles of the feet. PPK can also be an associated feature of different syndromes. In rare forms of palmoplantar keratoderma, other organs in the body may be affected in addition to the skin. PPK can either be inherited or acquired. Acquired palmoplantar keratodermas may arise as a result of infections, internal disease or cancer, inflammatory skin conditions, or medications. The hereditary palmoplantar keratodermas are caused by a gene abnormality that results in abnormal skin protein (keratin). They can be inherited in an autosomal dominant or autosomal recessive patterns.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Palmoplantar Keratoderma" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Palmoplantar Keratoderma" returned 80 free, full-text research articles on human participants. First 3 results:

Unique autosomal recessive variant of palmoplantar keratoderma associated with hearing loss not caused by known mutations.
 

Author(s): Moustafa Abdelaal Hegazi, Sommen Manou, Hazem Sakr, Guy Van Camp

Journal: An Bras Dermatol. 2017 ;92(5 Suppl 1):154-158.

 

Inherited Palmoplantar Keratodermas are rare disorders of genodermatosis that are conventionally regarded as autosomal dominant in inheritance with extensive clinical and genetic heterogeneity. This is the first report of a unique autosomal recessive Inherited Palmoplantar keratoderma ...

Last Updated: 31 Dec 1969

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Multiple Primary Acral Lentiginous Melanoma on the Feet Developing in Lesions of Nagashima-type Palmoplantar Keratoderma.
 

Author(s): Akimasa Adachi, Mayumi Komine, Takeo Maekawa, Satoru Murata, Aiko Shiohama, Akiharu Kubo, Mamitaro Ohtsuki

Journal: Acta Derm. Venereol.. 2017 06;97(6):756-758.

 

Last Updated: 31 Dec 1969

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Mutations in desmoglein 1 cause diverse inherited palmoplantar keratoderma phenotypes: implications for genetic screening.
 

Author(s): M-L Lovgren, M A McAleer, A D Irvine, N J Wilson, S Tavadia, M E Schwartz, C Cole, A Sandilands, F J D Smith, M Zamiri

Journal: Br. J. Dermatol.. 2017 May;176(5):1345-1350.

 

The inherited palmoplantar keratodermas (PPKs) are a heterogeneous group of genodermatoses, characterized by thickening of the epidermis of the palms and soles. No classification system satisfactorily unites clinical presentation, pathology and molecular pathogenesis. There are four ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Palmoplantar Keratoderma" returned 3 free, full-text review articles on human participants. First 3 results:

PIGO deficiency: palmoplantar keratoderma and novel mutations.
 

Author(s): Marie-Anne Morren, Jaak Jaeken, Gepke Visser, Isabelle Salles, Chris Van Geet, , Ilenia Simeoni, Ernest Turro, Kathleen Freson

Journal:

 

Several genetic defects have been identified in the glycosylphosphatidylinositol (GPI) anchor synthesis, including mutations in PIGO encoding phosphatidylinositol glycan anchor biosynthesis class O protein. These defects constitute a subgroup of the congenital disorders of glycosylation ...

Last Updated: 31 Dec 1969

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Desmoplakin mutations with palmoplantar keratoderma, woolly hair and cardiomyopathy.
 

Author(s): Manuela Pigors, Agnes Schwieger-Briel, Rodica Cosgarea, Adriana Diaconeasa, Leena Bruckner-Tuderman, Thilo Fleck, Cristina Has

Journal: Acta Derm. Venereol.. 2015 Mar;95(3):337-40.

 

Mutations in genes encoding for desmosomal components are associated with a broad spectrum of phenotypes comprising skin and hair abnormalities and account for 45-50% of cases of arrhythmogenic right ventricular cardiomyopathy. Today, more than 120 dominant and recessive desmoplakin ...

Last Updated: 31 Dec 1969

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Palmoplantar keratoderma (PPK): acquired and genetic causes of a not so rare disease.
 

Author(s): Stina Schiller, Christina Seebode, Hans Christian Hennies, Kathrin Giehl, Steffen Emmert

Journal: J Dtsch Dermatol Ges. 2014 Sep;12(9):781-8.

 

Palmoplantar keratodermas (PPK) comprise a heterogeneous group of keratinization disorders with hyperkeratotic thickening of palms and soles. Sporadic or acquired forms of PPKs and genetic or hereditary forms exist. Differentiation between acquired and hereditary forms is essential ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.