Ovarian small cell carcinoma

Common Name(s)

Ovarian small cell carcinoma

Ovarian small cell carcinoma is a rare type of cancer of the ovaries that primarily affects young women. Carcinoma is a cancer that affects the cells that line organs in the body; these cells are called epithelial cells. People with ovarian small cell carcinoma often have high calcium levels in their blood (hypercalcemia). This situation can be dangerous because the calcium levels will be low in the bones and can affect the heart and brain. Cancer can be very dangerous, and early diagnosis is very important.

The symptoms include stomach bloating, abdominal pain, difficulty eating, feeling full quickly, frequent urination, or sudden, urgent need for urination. Additionally, affected individuals may experience fatigue, indigestion, back pain, constipation, or menstruation irregularities. A history of cancer in your family may increase your risk of developing ovarian small cell carcinoma. The presence of a change (mutation) in the BRCA genes may also increase your risk of ovarian or breast cancer.

In order to diagnose ovarian small cell carcinoma, a doctor may begin by performing a physical pelvic or rectal exam. They may also use blood tests and a vaginal ultrasound to help in diagnosis. The first step for treatment may be surgery to remove as much of the mass as possible. Treatment options may vary between individuals so it is important to talk to your doctor about which treatments are right for you. Support groups are also a good source of information and support for people or families with ovarian small cell carcinoma.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ovarian small cell carcinoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ovarian small cell carcinoma" returned 12 free, full-text research articles on human participants. First 3 results:

c-Met inhibitors attenuate tumor growth of small cell hypercalcemic ovarian carcinoma (SCCOHT) populations.
 

Author(s): Anna Otte, Finn Rauprich, Juliane von der Ohe, Yuanyuan Yang, Friedrich Kommoss, Friedrich Feuerhake, Peter Hillemanns, Ralf Hass

Journal: Oncotarget. 2015 Oct;6(31):31640-58.

 

A cellular model (SCCOHT-1) of the aggressive small cell hypercalcemic ovarian carcinoma demonstrated constitutive chemokine and growth factor production including HGF. A simultaneous presence of c-Met in 41% SCCOHT-1 cells suggested an autocrine growth mechanism. Expression of c-Met ...

Last Updated: 27 Oct 2015

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Germline SMARCA4 mutations in patients with ovarian small cell carcinoma of hypercalcemic type.
 

Author(s): Joanna Moes-Sosnowska, Lukasz Szafron, Dorota Nowakowska, Agnieszka Dansonka-Mieszkowska, Agnieszka Budzilowska, Bozena Konopka, Joanna Plisiecka-Halasa, Agnieszka Podgorska, Iwona K Rzepecka, Jolanta Kupryjanczyk

Journal:

 

SMARCA4 mutations have recently been identified as driving lesions of the ovarian small cell carcinoma of hypercalcemic type (SCCHT). Familial occurrence of this neoplasm was described previously.

Last Updated: 18 Apr 2015

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Squamous cell carcinoma arising from ovarian mature cystic teratoma and causing small bowel obstruction.
 

Author(s): Hooman Yarmohammadi, Bahar Mansoori, Vince Wong, Vania Tacher, Luke R Wilkins, Peter G Pavlidakey, John R Haaga

Journal: J Cancer Res Ther. ;10(3):770-2.

 

Malignant transformation of mature cystic teratoma (MCT) is a rare phenomenon with incidence of approximately 1-3%. We report a 48-year-old woman who presented to the emergency room with symptoms of bowel obstruction. She underwent computed tomography scan for the evaluation of obstruction, ...

Last Updated: 15 Oct 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ovarian small cell carcinoma" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

International Ovarian & Testicular Stromal Tumor Registry
 

Status: Recruiting

Condition Summary: Ovarian Stromal Tumor; Testicular Stromal Tumors; Ovarian Small Cell Carcinoma

 

Last Updated: 1 Nov 2016

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LCL161 Plus Topotecan for Patients With Relapsed/Refractory Small Cell Lung Cancer and Select Gynecologic Malignancies
 

Status: Recruiting

Condition Summary: Small Cell Lung Cancer; Ovarian Cancer

 

Last Updated: 26 Sep 2016

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RRx-001 in Small, Non-small Cell Lung Cancer, Ovarian Cancer and Neuroendocrine Tumors Prior to Re-administration of Platinum Based Doublet Regimens (QUADRUPLE THREAT)
 

Status: Recruiting

Condition Summary: Small Cell Lung Carcinoma; Carcinoma, Non-Small-Cell Lung; Neuroendocrine Tumors; Ovarian Epithelial Cancer

 

Last Updated: 7 Aug 2016

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