Ovarian epithelial cancer

Common Name(s)

Ovarian epithelial cancer

Ovarian cancer, the leading cause of death from gynecologic malignancy, is characterized by advanced presentation with loco-regional dissemination in the peritoneal cavity and the rare incidence of visceral metastases ({6:Chi et al., 2001}). These typical features relate to the biology of the disease, which is a principal determinant of outcome ({1:Auersperg et al., 2001}). Epithelial ovarian cancer is the most common form and encompasses 5 major histologic subtypes: papillary serous, endometrioid, mucinous, clear cell, and transitional cell. Epithelial ovarian cancer arises as a result of genetic alterations sustained by the ovarian surface epithelium ({44:Stany et al., 2008}; {43:Soslow, 2008}).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ovarian epithelial cancer" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ovarian epithelial cancer" returned 672 free, full-text research articles on human participants. First 3 results:

A phase II study of paclitaxel and carboplatin with a biweekly schedule in patients with epithelial ovarian cancer: Gynecologic Cancer Network trial.
 

Author(s): Koichi Yoneyama, Hideki Konishi, Tetsuro Yahata, Kazuyuki Fujita, Yoichi Aoki, Daisuke Doi, Takashi Matsushima, Shoji Kodama, Shigeru Honma, Hisamori Kato, Hiroki Nakayama, Seiryu Kamoi, Hirobumi Asakura, Toshiyuki Takeshita, Kenichi Tanaka

Journal: J Nippon Med Sch. 2014 ;81(1):28-34.

 

The objective of this multicenter phase II study was to evaluate the effects of biweekly paclitaxel and carboplatin combination chemotherapy on response rate and toxicities in patients with epithelial ovarian cancer.

Last Updated: 11 Mar 2014

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An mDia2/ROCK signaling axis regulates invasive egress from epithelial ovarian cancer spheroids.
 

Author(s): Krista M Pettee, Kaitlyn M Dvorak, Andrea L Nestor-Kalinoski, Kathryn M Eisenmann

Journal:

 

Multi-cellular spheroids are enriched in ascites of epithelial ovarian cancer (OvCa) patients. They represent an invasive and chemoresistant cellular population fundamental to metastatic dissemination. The molecular mechanisms triggering single cell invasive egress from spheroids ...

Last Updated: 3 Mar 2014

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Targeted methylation of the epithelial cell adhesion molecule (EpCAM) promoter to silence its expression in ovarian cancer cells.
 

Author(s): Suneetha Nunna, Richard Reinhardt, Sergey Ragozin, Albert Jeltsch

Journal:

 

The Epithelial Cell Adhesion Molecule (EpCAM) is overexpressed in many cancers including ovarian cancer and EpCAM overexpression correlates with decreased survival of patients. It was the aim of this study to achieve a targeted methylation of the EpCAM promoter and silence EpCAM gene ...

Last Updated: 3 Feb 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ovarian epithelial cancer" returned 59 free, full-text review articles on human participants. First 3 results:

Recurrent epithelial ovarian cancer: an update on treatment.
 

Author(s): Olivia W Foley, J Alejandro Rauh-Hain, Marcela G del Carmen

Journal: Oncology (Williston Park, N.Y.). 2013 Apr;27(4):288-94, 298.

 

An estimated 85% of patients with epithelial ovarian cancer who achieve a full remission following first-line therapy will develop recurrent disease. Although each subsequent line of therapy is characterized by shorter disease-free intervals, median survival for these patients ranges ...

Last Updated: 20 Jun 2013

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Immunity of human epithelial ovarian carcinoma: the paradigm of immune suppression in cancer.
 

Author(s): Vincent Lavoué, Aurélie Thédrez, Jean Levêque, Fabrice Foucher, Sébastien Henno, Vincent Jauffret, Marc-Antoine Belaud-Rotureau, Veronique Catros, Florian Cabillic

Journal:

 

Epithelial ovarian cancer (EOC) is a significant cause of cancer-related mortality in women, and there has been no substantial decrease in the death rates due to EOC in the last three decades. Thus, basic knowledge regarding ovarian tumor cell biology is urgently needed to allow the ...

Last Updated: 17 Jun 2013

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Interval debulking surgery for advanced epithelial ovarian cancer.
 

Author(s): Siriwan Tangjitgamol, Sumonmal Manusirivithaya, Malinee Laopaiboon, Pisake Lumbiganon, Andrew Bryant

Journal:

 

Interval debulking surgery (IDS), following induction or neoadjuvant chemotherapy, may have a role in treating advanced epithelial ovarian cancer (stage III to IV) where primary debulking surgery is not an option.

Last Updated: 1 May 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase II Study DCVAC/OvCa Added to First Line Carboplatin and Paclitaxel Newly Diagnosed Epithelial Ovarian Carcinoma
 

Status: Recruiting

Condition Summary: Ovarian Neoplasms; Ovarian Epithelial Cancer

 

Last Updated: 12 May 2014

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Vaccine Therapy in Treating Patients With Stage IIIC-IV Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cavity Cancer Following Surgery and Chemotherapy
 

Status: Recruiting

Condition Summary: Ovarian Clear Cell Cystadenocarcinoma; Ovarian Endometrioid Adenocarcinoma; Ovarian Mixed Epithelial Carcinoma; Ovarian Mucinous Cystadenocarcinoma; Ovarian Serous Cystadenocarcinoma; Ovarian Undifferentiated Adenocarcinoma; Recurrent Fallopian Tube Cancer; Recurrent Ovarian Epithelial Cancer; Recurrent Primary Peritoneal Cavity Cancer; Stage IIIC Fallopian Tube Cancer; Stage IIIC Ovarian Epithelial Cancer; Stage IIIC Primary Peritoneal Cavity Cancer; Stage IV Fallopian Tube Cancer; Stage IV Ovarian Epithelial Cancer; Stage IV Primary Peritoneal Cavity Cancer

 

Last Updated: 18 Sep 2014

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