Ovarian cancer

Common Name(s)

Ovarian cancer, Cancer, Ovarian

Ovarian cancer occurs when a cancerous tumor forms in a women’s ovary. Most commonly, there is no known cause for the growth of the cancerous tumor. If the ovarian tumor is malignant, then the cancer cells can spread to other organs in the pelvis and abdomen or metastasize through the bloodstream to other regions of the body. Symptoms might include ongoing pain in the belly or back, atypical vaginal bleeding, and nausea. Treatment options may include surgery or chemotherapy depending on the stage of the cancer. The different stages can be defined as: Stage I: Cancer limited to one or both ovaries Stage II: Cancer spreads to other pelvic structures Stage III: Cancer has metastasized to lining of the abdomen or cancer has spread to the lymph nodes Stage IV: Cancer has spread to the liver or lungs

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ovarian cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

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Basser Research Center for BRCA

The Basser Research Center for BRCA provides education and support for individuals and families with BRCA1 and BRCA2 mutations. Our mission is to deliver cutting edge research in basic and clinical sciences to advance the care of individuals who carry BRCA mutations. The Basser Center is part of the Abramson Cancer Center at Penn Medicine.

Last Updated: 29 Oct 2014

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Breast Cancer Connections

We support people touched by breast or ovarian cancer by providing comprehensive, personalized services in an atmosphere of warmth and compassion.

Last Updated: 22 Apr 2014

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Breast Friends

Breast Friends ensures that no woman goes through cancer alone. We are a unique resource for women, their family, friends, co-workers and community minimizing the fear and isolation of cancer. For over a decade our programs have empowered thousands with emotional support and hope. We are survivors and professionals helping others celebrate the joy of life.

Last Updated: 25 Mar 2013

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

Last Updated: 26 Dec 2012

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Conversations!

The mission of Conversations! is to provide information to people who are diagnosed with gynecologic cancers, their families, and caregivers.

Last Updated: 29 Jan 2013

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FORCE: Facing Our Risk of Cancer Empowered

FORCE is a national nonprofit dedicated to fighting hereditary breast and ovarian cancer. With 50 outreach groups throughout the U.S., and international affiliates, FORCE programs provide support, education, advocacy, awareness and research specific to hereditary cancers. Our programs serve anyone with a BRCA mutation or a family history of cancer. FORCE was founded on the principle that no one should have to face hereditary breast and ovarian cancer alone.

Last Updated: 5 May 2014

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Gilda Radner Familial Ovarian Cancer Registry

The Gilda Radner Ovarian Cancer Registry is looking for families with two or more diagnoses of ovarian cancer to join the Registry. Research conducted by the Registry will help the scientific and medical communities learn more about ovarian cancer and identify new genes associated with familial ovarian cancer.

Last Updated: 24 Nov 2009

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 27 Apr 2015

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National Ovarian Cancer Coalition, Inc.

To raise awareness and promote education about ovarian cancer. The Coalition is committed to improving the survival rate and quality of life for women with ovarian cancer.

Last Updated: 30 Oct 2012

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Norma Livingston Ovarian Cancer Foundation

The mission of the Norma Livingston Ovarian Cancer Foundation is to raise funds for ovarian cancer research and to increase awareness about the risks, symptoms and treatments of this disease.

Last Updated: 20 Feb 2013

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Ovarian Cancer National Alliance

Our mission is to advance the interests of women with ovarian cancer.

Last Updated: 30 Nov 2014

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SHARE

SHARE helps people through breast or ovarian cancer, from diagnosis through treatment and post-treatment, offering the unique support of survivors who've been there. All of SHARE's services are free of charge and include telephone support, educational programs, support groups, and public-health initiatives. Visit us at www.sharecancersupport.org or call our toll-free helplines at 866-891-2392.

Last Updated: 20 Feb 2013

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Sharsheret

Sharsheret is a national not-for-profit organization supporting young Jewish women and their families facing breast cancer. Our mission is to offer a community of support to women, of all Jewish backgrounds, diagnosed with breast cancer or at increased genetic risk, by fostering culturally-relevant individualized connections with networks of peers, health professionals, and related resources.

Last Updated: 5 Mar 2013

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Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

Last Updated: 6 Nov 2012

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ovarian cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

View Details
Basser Research Center for BRCA

The Basser Research Center for BRCA provides education and support for individuals and families with BRCA1 and BRCA2 mutations. Our mission is to deliver cutting edge research in basic and clinical sciences to advance the care of individuals who carry BRCA mutations. The Basser Center is part of the Abramson Cancer Center at Penn Medicine.

http://www.basser.org

Last Updated: 29 Oct 2014

View Details
Logo
Breast Cancer Connections

We support people touched by breast or ovarian cancer by providing comprehensive, personalized services in an atmosphere of warmth and compassion.

http://www.bcconnections.org

Last Updated: 22 Apr 2014

View Details
Breast Friends

Breast Friends ensures that no woman goes through cancer alone. We are a unique resource for women, their family, friends, co-workers and community minimizing the fear and isolation of cancer. For over a decade our programs have empowered thousands with emotional support and hope. We are survivors and professionals helping others celebrate the joy of life.

http://www.breastfriends.org

Last Updated: 25 Mar 2013

View Details
Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

http://www.jewishgenetics.org

Last Updated: 26 Dec 2012

View Details
Logo
Conversations!

The mission of Conversations! is to provide information to people who are diagnosed with gynecologic cancers, their families, and caregivers.

http://www.ovarian-news.org

Last Updated: 29 Jan 2013

View Details
FORCE: Facing Our Risk of Cancer Empowered

FORCE is a national nonprofit dedicated to fighting hereditary breast and ovarian cancer. With 50 outreach groups throughout the U.S., and international affiliates, FORCE programs provide support, education, advocacy, awareness and research specific to hereditary cancers. Our programs serve anyone with a BRCA mutation or a family history of cancer. FORCE was founded on the principle that no one should have to face hereditary breast and ovarian cancer alone.

http://www.facingourrisk.org

Last Updated: 5 May 2014

View Details
Logo
Gilda Radner Familial Ovarian Cancer Registry

The Gilda Radner Ovarian Cancer Registry is looking for families with two or more diagnoses of ovarian cancer to join the Registry. Research conducted by the Registry will help the scientific and medical communities learn more about ovarian cancer and identify new genes associated with familial ovarian cancer.

http://www.ovariancancer.com

Last Updated: 24 Nov 2009

View Details
HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 27 Apr 2015

View Details
National Ovarian Cancer Coalition, Inc.

To raise awareness and promote education about ovarian cancer. The Coalition is committed to improving the survival rate and quality of life for women with ovarian cancer.

http://www.ovarian.org

Last Updated: 30 Oct 2012

View Details
Logo
Norma Livingston Ovarian Cancer Foundation

The mission of the Norma Livingston Ovarian Cancer Foundation is to raise funds for ovarian cancer research and to increase awareness about the risks, symptoms and treatments of this disease.

http://www.nlovca.org

Last Updated: 20 Feb 2013

View Details
Ovarian Cancer National Alliance

Our mission is to advance the interests of women with ovarian cancer.

http://ovariancancer.org/

Last Updated: 30 Nov 2014

View Details
SHARE

SHARE helps people through breast or ovarian cancer, from diagnosis through treatment and post-treatment, offering the unique support of survivors who've been there. All of SHARE's services are free of charge and include telephone support, educational programs, support groups, and public-health initiatives. Visit us at www.sharecancersupport.org or call our toll-free helplines at 866-891-2392.

http://www.sharecancersupport.org

Last Updated: 20 Feb 2013

View Details
Sharsheret

Sharsheret is a national not-for-profit organization supporting young Jewish women and their families facing breast cancer. Our mission is to offer a community of support to women, of all Jewish backgrounds, diagnosed with breast cancer or at increased genetic risk, by fostering culturally-relevant individualized connections with networks of peers, health professionals, and related resources.

http://www.sharsheret.org

Last Updated: 5 Mar 2013

View Details
Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

http://stupidcancer.org

Last Updated: 6 Nov 2012

View Details

 

General Support Organizations

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General Resources

NOCC Resources Links

Publication, Video & Resource Links

Updated 9 Oct 2012

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Ovarian Cancer Symptom Diary App

The Ovarian Cancer Symptom Diary App will help you learn about the risks, signs and symptoms of ovarian cancer. This first-of-its-kind application allows a woman to track symptoms that could indicate ovarian cancer.

Updated 20 Dec 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ovarian cancer" returned 4812 free, full-text research articles on human participants. First 3 results:

Adjuvant ovarian suppression in premenopausal breast cancer.
 

Author(s): Prudence A Francis, Meredith M Regan, Gini F Fleming

Journal: N. Engl. J. Med.. 2015 Apr;372(17):1673.

 

Last Updated: 23 Apr 2015

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Intake of cruciferous vegetables is associated with reduced risk of ovarian cancer: a meta-analysis.
 

Author(s): Jiyi Hu, Yiwang Hu, Yeting Hu, Shu Zheng

Journal: Asia Pac J Clin Nutr. 2015 ;24(1):101-9.

 

Epidemiological studies on the association between cruciferous vegetable (CV) consumption and the risk of ovarian cancer have demonstrated inconsistent results. We conducted a meta-analysis on CV consumption and ovarian cancer risk.

Last Updated: 5 Mar 2015

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Iron alters cell survival in a mitochondria-dependent pathway in ovarian cancer cells.
 

Author(s): Kyle Bauckman, Edward Haller, Nicholas Taran, Stephanie Rockfield, Abigail Ruiz-Rivera, Meera Nanjundan

Journal: Biochem. J.. 2015 Mar;466(2):401-13.

 

The role of iron in the development of cancer remains unclear. We previously reported that iron reduces cell survival in a Ras/mitogen-activated protein kinase (MAPK)-dependent manner in ovarian cells; however, the underlying downstream pathway leading to reduced survival was unclear. ...

Last Updated: 20 Feb 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ovarian cancer" returned 427 free, full-text review articles on human participants. First 3 results:

[Association between obesity and ovarian cancer].
 

Author(s): Macarena Valladares, Gino Corsini, Carmen Romero

Journal: Rev Med Chil. 2014 May;142(5):593-8.

 

Obesity is a risk factor for cancer. Epidemiological evidences associate ovarian cancer with obesity. Epithelial ovarian cancer (EOC) is the most common type of ovarian cancer and accounts for a high rate of mortality. The association between ovarian cancer and obesity could be explained ...

Last Updated: 27 Nov 2014

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Role of nerve growth factor and its TRKA receptor in normal ovarian and epithelial ovarian cancer angiogenesis.
 

Author(s): Carolina Vera, Verónica Tapia, Margarita Vega, Carmen Romero

Journal:

 

In normal ovarian function a controlled angiogenesis is essential. Several growth factors are involved in this process, such as the vascular endothelial growth factor (VEGF) and nerve growth factor (NGF). The angiogenesis process in the normal ovary is a tightly controlled process ...

Last Updated: 10 Oct 2014

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Development of nanoscale approaches for ovarian cancer therapeutics and diagnostics.
 

Author(s): Sarah A Engelberth, Nadine Hempel, Magnus Bergkvist

Journal: Crit Rev Oncog. 2014 ;19(3-4):281-315.

 

Ovarian cancer is the deadliest of all gynecological cancers and the fifth leading cause of death due to cancer in women. This is largely due to late-stage diagnosis, poor prognosis related to advanced-stage disease, and the high recurrence rate associated with development of chemoresistance. ...

Last Updated: 2 Oct 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Interactive Educational Website for Women With Ovarian Cancer & Caregivers
 

Status: Recruiting

Condition Summary: Stage III Ovarian Cancer; Stage IV Ovarian Cancer; Recurrent Ovarian Cancer; Fallopian Tube Cancer

 

Last Updated: 21 Aug 2014

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Low-Dose Fractionated Whole Abdominal Radiation Therapy (LDFWART) With Carboplatin and Docetaxel in Patients With Recurrent Ovarian Cancer
 

Status: Recruiting

Condition Summary: Ovarian Cancer; Ovarian Carcinoma; Recurrent Ovarian Cancer; Recurrent Ovarian Carcinoma

 

Last Updated: 13 Feb 2015

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Slowed Carboplatin Infusion for Ovarian Cancer Patients Receiving Carboplatin Re-Treatment
 

Status: Recruiting

Condition Summary: Recurrent Ovarian Cancer; Platinum Sensitive Ovarian Cancer

 

Last Updated: 15 Sep 2014

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