Ovarian cancer

Common Name(s)

Ovarian cancer, Cancer, Ovarian

Ovarian cancer is a type of cancer that begins in a women’s ovaries. Women have two ovaries that produce eggs as well as the hormones estrogen and progesterone. Ovarian cancer can be hard to diagnose because early-stages of ovarian cancer rarely cause any symptoms and advanced-stage ovarian cancer may cause few and nonspecific symptoms. The symptoms of ovarian cancer may include abdominal bloating, quickly feeling full when eating, weight loss, cramping in the lower stomach, changes in bowel habits, and a frequent need to urinate.

The cause of ovarian cancer is unclear. In general, cancer is caused by genetic mutations that turn normal cells into abnormal cancer cells that quickly multiply, forming a mass (tumor). The type of cell where the cancer begins determines the type of ovarian cancer. These types included epithelial tumor, stromal tumor, and germ cell tumor. Certain factors may increase your risk of ovarian cancer. These include age (most common in women ages 50 to 60), estrogen hormone replacement therapy, age when menstruation starts and ends (starting before age 12 or undergoing menopause after age 52), never being pregnant, fertility treatment, smoking, and polycystic ovary syndrome. About 10% to 20% of all ovarian cancer is caused by an inherited change (mutation) in either the BRCA1 or BRCA2 gene.

A doctor will use a combination of methods to diagnose ovarian cancer, including a pelvic exam, imaging (ultrasound or CT scans) to look at the ovaries, blood tests, and surgery to remove a tissue sample and abdominal fluid to confirm the diagnosis. Treatment of ovarian cancer usually involves a combination of surgery and chemotherapy. It is important to talk to your doctor to learn about the most up-to-date treatment options. If more than one person in your family has been diagnosed with ovarian cancer, it may be helpful to talk with a genetic counselor about hereditary cancer and genetic testing options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ovarian cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

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Basser Research Center for BRCA

The Basser Research Center for BRCA provides education and support for individuals and families with BRCA1 and BRCA2 mutations. Our mission is to deliver cutting edge research in basic and clinical sciences to advance the care of individuals who carry BRCA mutations. The Basser Center is part of the Abramson Cancer Center at Penn Medicine.

Last Updated: 29 Oct 2014

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Bay Area Cancer Connections

We support people touched by breast and ovarian cancer by providing comprehensive, personalized services in an atmosphere of warmth and compassion.

Last Updated: 21 May 2015

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Breast Friends

Breast Friends ensures that no woman goes through cancer alone. We are a unique resource for women, their family, friends, co-workers and community minimizing the fear and isolation of cancer. For over a decade our programs have empowered thousands with emotional support and hope. We are survivors and professionals helping others celebrate the joy of life.

Last Updated: 25 Mar 2013

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

Last Updated: 26 Dec 2012

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Conversations!

The mission of Conversations! is to provide information to people who are diagnosed with gynecologic cancers, their families, and caregivers.

Last Updated: 29 Jan 2013

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FORCE: Facing Our Risk of Cancer Empowered

FORCE is a national nonprofit dedicated to fighting hereditary breast and ovarian cancer. With 50 outreach groups throughout the U.S., and international affiliates, FORCE programs provide support, education, advocacy, awareness and research specific to hereditary cancers. Our programs serve anyone with a BRCA mutation or a family history of cancer. FORCE was founded on the principle that no one should have to face hereditary breast and ovarian cancer alone.

Last Updated: 5 May 2014

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Gilda Radner Familial Ovarian Cancer Registry

The Gilda Radner Ovarian Cancer Registry is looking for families with two or more diagnoses of ovarian cancer to join the Registry. Research conducted by the Registry will help the scientific and medical communities learn more about ovarian cancer and identify new genes associated with familial ovarian cancer.

Last Updated: 24 Nov 2009

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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National Ovarian Cancer Coalition, Inc.

To raise awareness and promote education about ovarian cancer. The Coalition is committed to improving the survival rate and quality of life for women with ovarian cancer.

Last Updated: 30 Oct 2012

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Norma Livingston Ovarian Cancer Foundation

The mission of the Norma Livingston Ovarian Cancer Foundation is to raise funds for ovarian cancer research and to increase awareness about the risks, symptoms and treatments of this disease.

Last Updated: 20 Feb 2013

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Ovarian Cancer National Alliance

Our mission is to advance the interests of women with ovarian cancer.

Last Updated: 30 Nov 2014

View Details
SHARE

SHARE helps people through breast or ovarian cancer, from diagnosis through treatment and post-treatment, offering the unique support of survivors who've been there. All of SHARE's services are free of charge and include telephone support, educational programs, support groups, and public-health initiatives. Visit us at www.sharecancersupport.org or call our toll-free helplines at 866-891-2392.

Last Updated: 20 Feb 2013

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Sharsheret

Sharsheret is a national not-for-profit organization supporting young Jewish women and their families facing breast cancer. Our mission is to offer a community of support to women, of all Jewish backgrounds, diagnosed with breast cancer or at increased genetic risk, by fostering culturally-relevant individualized connections with networks of peers, health professionals, and related resources.

Last Updated: 5 Mar 2013

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Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

Last Updated: 6 Nov 2012

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ovarian cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

View Details
Basser Research Center for BRCA

The Basser Research Center for BRCA provides education and support for individuals and families with BRCA1 and BRCA2 mutations. Our mission is to deliver cutting edge research in basic and clinical sciences to advance the care of individuals who carry BRCA mutations. The Basser Center is part of the Abramson Cancer Center at Penn Medicine.

http://www.basser.org

Last Updated: 29 Oct 2014

View Details
Logo
Bay Area Cancer Connections

We support people touched by breast and ovarian cancer by providing comprehensive, personalized services in an atmosphere of warmth and compassion.

http://www.bcconnections.org

Last Updated: 21 May 2015

View Details
Breast Friends

Breast Friends ensures that no woman goes through cancer alone. We are a unique resource for women, their family, friends, co-workers and community minimizing the fear and isolation of cancer. For over a decade our programs have empowered thousands with emotional support and hope. We are survivors and professionals helping others celebrate the joy of life.

http://www.breastfriends.org

Last Updated: 25 Mar 2013

View Details
Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

http://www.jewishgenetics.org

Last Updated: 26 Dec 2012

View Details
Logo
Conversations!

The mission of Conversations! is to provide information to people who are diagnosed with gynecologic cancers, their families, and caregivers.

http://www.ovarian-news.org

Last Updated: 29 Jan 2013

View Details
FORCE: Facing Our Risk of Cancer Empowered

FORCE is a national nonprofit dedicated to fighting hereditary breast and ovarian cancer. With 50 outreach groups throughout the U.S., and international affiliates, FORCE programs provide support, education, advocacy, awareness and research specific to hereditary cancers. Our programs serve anyone with a BRCA mutation or a family history of cancer. FORCE was founded on the principle that no one should have to face hereditary breast and ovarian cancer alone.

http://www.facingourrisk.org

Last Updated: 5 May 2014

View Details
Logo
Gilda Radner Familial Ovarian Cancer Registry

The Gilda Radner Ovarian Cancer Registry is looking for families with two or more diagnoses of ovarian cancer to join the Registry. Research conducted by the Registry will help the scientific and medical communities learn more about ovarian cancer and identify new genes associated with familial ovarian cancer.

http://www.ovariancancer.com

Last Updated: 24 Nov 2009

View Details
HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

View Details
National Ovarian Cancer Coalition, Inc.

To raise awareness and promote education about ovarian cancer. The Coalition is committed to improving the survival rate and quality of life for women with ovarian cancer.

http://www.ovarian.org

Last Updated: 30 Oct 2012

View Details
Logo
Norma Livingston Ovarian Cancer Foundation

The mission of the Norma Livingston Ovarian Cancer Foundation is to raise funds for ovarian cancer research and to increase awareness about the risks, symptoms and treatments of this disease.

http://www.nlovca.org

Last Updated: 20 Feb 2013

View Details
Ovarian Cancer National Alliance

Our mission is to advance the interests of women with ovarian cancer.

http://ovariancancer.org/

Last Updated: 30 Nov 2014

View Details
SHARE

SHARE helps people through breast or ovarian cancer, from diagnosis through treatment and post-treatment, offering the unique support of survivors who've been there. All of SHARE's services are free of charge and include telephone support, educational programs, support groups, and public-health initiatives. Visit us at www.sharecancersupport.org or call our toll-free helplines at 866-891-2392.

http://www.sharecancersupport.org

Last Updated: 20 Feb 2013

View Details
Sharsheret

Sharsheret is a national not-for-profit organization supporting young Jewish women and their families facing breast cancer. Our mission is to offer a community of support to women, of all Jewish backgrounds, diagnosed with breast cancer or at increased genetic risk, by fostering culturally-relevant individualized connections with networks of peers, health professionals, and related resources.

http://www.sharsheret.org

Last Updated: 5 Mar 2013

View Details
Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

http://stupidcancer.org

Last Updated: 6 Nov 2012

View Details

 

General Support Organizations

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General Resources

NOCC Resources Links

Publication, Video & Resource Links

Updated 9 Oct 2012

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Ovarian Cancer Symptom Diary App

The Ovarian Cancer Symptom Diary App will help you learn about the risks, signs and symptoms of ovarian cancer. This first-of-its-kind application allows a woman to track symptoms that could indicate ovarian cancer.

Updated 20 Dec 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ovarian cancer" returned 6205 free, full-text research articles on human participants. First 3 results:

Cediranib in patients with relapsed platinum-sensitive ovarian cancer (ICON6): a randomised, double-blind, placebo-controlled phase 3 trial.
 

Author(s): Jonathan A Ledermann, Andrew C Embleton, Fharat Raja, Timothy J Perren, Gordon C Jayson, Gordon J S Rustin, Stan B Kaye, Hal Hirte, Elizabeth Eisenhauer, Michelle Vaughan, Michael Friedlander, Antonio González-Martín, Daniel Stark, Elizabeth Clark, Laura Farrelly, Ann Marie Swart, Adrian Cook, Richard S Kaplan, Mahesh K B Parmar,

Journal: Lancet. 2016 Mar;387(10023):1066-74.

 

Angiogenesis is a validated clinical target in advanced epithelial ovarian cancer. Cediranib is an oral antiangiogenic vascular endothelial growth factor receptor 1-3 inhibitor that has shown antitumour activity in recurrent ovarian cancer. We assessed efficacy and safety of cediranib ...

Last Updated: 30 Mar 2016

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Actualities in Ovarian Cancer in the Perspective of 2015 (ASCO and ECCO).
 

Author(s): Dana Lucia Stanculeanu, Daniela Mosoiu, Alecu Mihnea, Laurentiu Simion,

Journal: Chirurgia (Bucur). ;111(1):9-11.

 

Ovarian cancer represents the 4-th reason of cancer related death in women, the majority of patients being diagnosed in advanced stages of the disease, (III-IV). The loco-regional advanced ovarian cancer should be considered a chronic disease, with multiple evolutionary relapses and ...

Last Updated: 18 Mar 2016

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Prognostic Value of KIF2A and HER2-Neu Overexpression in Patients With Epithelial Ovarian Cancer.
 

Author(s): Di Wang, Huijun Zhu, Qing Ye, Chenyi Wang, Yunzhao Xu

Journal: Medicine (Baltimore). 2016 Feb;95(8):e2803.

 

Kinesin family member 2A (KIF2A) is a member of Kinesin-13 family and involved in cell migration and cell signaling. Human epidermal growth factor receptor 2 (HER2-neu) is implicated in the development of many cancers. Both of these 2 proteins are upstream inducer of PI3K/AKT signaling ...

Last Updated: 4 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ovarian cancer" returned 588 free, full-text review articles on human participants. First 3 results:

Morphologic, Immunophenotypic, and Molecular Features of Epithelial Ovarian Cancer.
 

Author(s): Preetha Ramalingam

Journal: Oncology (Williston Park, N.Y.). 2016 Feb;30(2):166-76.

 

Epithelial ovarian cancer comprises a heterogeneous group of tumors. The four most common subtypes are serous, endometrioid, clear cell, and mucinous carcinoma. Less common are transitional cell tumors, including transitional cell carcinoma and malignant Brenner tumor. While in the ...

Last Updated: 19 Feb 2016

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[Dualistic classification of epithelial ovarian cancer: Is it clinically relevant?].
 

Author(s): Mojgan Devouassoux-Shisheboran, Catherine Genestie, Isabelle Ray-Coquard

Journal: Bull Cancer. 2016 Mar;103(3):252-8.

 

Malignant epithelial tumors (carcinomas) are the most common ovarian cancers and the most lethal gynecological malignancies. Based on their heterogeneous morphology, a dualistic model of carcinogenesis was proposed in 2004. Type I carcinomas, composed of low grade serous, endometrioid, ...

Last Updated: 13 Mar 2016

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[Ovarian cancer - from biology to clinic].
 

Author(s): Katarzyna Aleksandra Kujawa, Katarzyna Marta Lisowska

Journal:

 

Ovarian cancer is the most frequent cause of deaths from among gynecologic malignancies. Due to its asymptomatic development the disease is frequently diagnosed at an advanced, incurable stages. Although ovarian cancers usually respond well to the first line chemotherapy based on ...

Last Updated: 16 Dec 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pembrolizumab in Combination With Chemotherapy in Frontline Ovarian Cancer
 

Status: Recruiting

Condition Summary: Ovarian Cancer; Metastatic Ovarian Cancer

 

Last Updated: 5 Jul 2016

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Slowed Carboplatin Infusion for Ovarian Cancer Patients Receiving Carboplatin Re-Treatment
 

Status: Recruiting

Condition Summary: Recurrent Ovarian Cancer; Platinum Sensitive Ovarian Cancer

 

Last Updated: 21 Sep 2015

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Specimen and Data Study for Ovarian Cancer Early Detection and Prevention
 

Status: Recruiting

Condition Summary: Cervical Cancer; Endometrial Cancer; Fallopian Tube Cancer; Hereditary Breast/Ovarian Cancer (brca1, brca2); Ovarian Cancer; Sarcoma; Uterine Leiomyomata; Vaginal Cancer; Vulvar Cancer

 

Last Updated: 7 Jul 2015

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