Osteosarcoma

Common Name(s)

Osteosarcoma

Osteosarcoma is the most common cancerous (malignant) bone tumor in youth. The average age at diagnosis is 15. Boys and girls have a similar incidence of this tumor until late adolescence, at which time boys are more commonly affected. In rare cases, osteosarcoma occurs in adults. The cause of osteosarcoma is not known. In some cases, it runs in families, and at least one gene has been linked to increased risk. Although osteosarcoma tends to occur in the larger bones, such as the shin (near the knee), thigh (near the knee) and upper arm (near the shoulder), it can occur in any bone. A number of variants of osteosarcoma exist, including conventional types (osteoblastic, chondroblastic, and fibroblastic), telangiectatic, multifocal, parosteal, and periosteal.  Treatment usually starts after a biopsy of the tumor and includes chemotherapy followed by surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteosarcoma" returned 2048 free, full-text research articles on human participants. First 3 results:

The prognostic value of PCNA expression in patients with osteosarcoma: A meta-analysis of 16 studies.
 

Author(s): Xing Wang, Dong Wang, Na Yuan, Fanxiao Liu, Fu Wang, Bomin Wang, Dongsheng Zhou

Journal: Medicine (Baltimore). 2017 Oct;96(41):e8254.

 

Numerous studies have attempted to determine the prognostic role of proliferating cell nuclear antigen (PCNA) expression in patients with osteosarcoma with no consistent conclusion. We performed this meta-analysis to systematically elucidate the association in a more precise manner.The ...

Last Updated: 11 Oct 2017

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Quercetin Inhibits Cell Migration and Invasion in Human Osteosarcoma Cells.
 

Author(s): Haifeng Lan, Wei Hong, Pan Fan, Dongyang Qian, Jianwei Zhu, Bo Bai

Journal: Cell. Physiol. Biochem.. 2017 ;43(2):553-567.

 

Osteosarcoma is a malignant tumor associated with high mortality; however, no effective therapies for the disease have been developed. Several studies have focused on elucidating the pathogenesis of osteosarcoma and have aimed to develop novel therapies for the disease. Quercetin ...

Last Updated: 1 Oct 2017

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MicroRNA-125a Regulates Cell Proliferation Via Directly Targeting E2F2 in Osteosarcoma.
 

Author(s): Tieying Tao, Qinrong Shen, Jianmin Luo, Yang Xu, Wenqing Liang

Journal: Cell. Physiol. Biochem.. 2017 ;43(2):768-774.

 

Increasing evidence has shown that miR-125a plays important role in human cancer progression. However, little is known about the function of miR-125a in osteosarcoma.

Last Updated: 26 Sep 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteosarcoma" returned 112 free, full-text review articles on human participants. First 3 results:

Application of Long Noncoding RNAs in Osteosarcoma: Biomarkers and Therapeutic Targets.
 

Author(s): Zhihong Li, Pengcheng Dou, Tang Liu, Shasha He

Journal: Cell. Physiol. Biochem.. 2017 ;42(4):1407-1419.

 

Osteosarcoma is the most common primary bone malignancy in children and adolescents. Although improvements in therapeutic strategies were achieved, the outcome remains poor for most patients with metastatic or recurrent osteosarcoma. Therefore, it is imperative to identify novel and ...

Last Updated: 17 Jul 2017

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P16 protein expression as a useful predictive biomarker for neoadjuvant chemotherapy response in patients with high-grade osteosarcoma: A systematic meta-analysis under guideline of PRISMA.
 

Author(s): Yin Tang, Changchun Yang, Zonghui Guo, Youwei Fu, Xiao Yu, Binggen Liu, Haier Zhou, Junjie Wang, Weilong Li, Qingjiang Pang

Journal: Medicine (Baltimore). 2017 May;96(19):e6714.

 

Neoadjuvant chemotherapy for patients with high-grade osteosarcoma has highly improved the clinical survival. However, the prognostic and predictive role of P16 expression after neoadjuvant chemotherapy remains unclear. We first determined whether P16 expression can become a potential ...

Last Updated: 10 May 2017

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Tumor lysis syndrome in an extraskeletal osteosarcoma: a case report and review of the literature.
 

Author(s): Vito Emanuele Catania, Michele Vecchio, Michele Malaguarnera, Roberto Madeddu, Giulia Malaguarnera, Saverio Latteri

Journal:

 

This case report describes a spontaneous tumor lysis syndrome due to a rare solid tumor.

Last Updated: 24 Mar 2017

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Biology of Osteosarcoma (BOOST) Registry and Biobank
 

Status: Recruiting

Condition Summary: Osteosarcoma

 

Last Updated: 21 Jul 2017

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Last Updated: 17 Mar 2017

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Last Updated: 9 Mar 2017

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