Osteosarcoma

Common Name(s)

Osteosarcoma

Osteosarcoma is the most common cancerous (malignant) bone tumor in youth. The average age at diagnosis is 15. Boys and girls have a similar incidence of this tumor until late adolescence, at which time boys are more commonly affected. In rare cases, osteosarcoma occurs in adults. The cause of osteosarcoma is not known. In some cases, it runs in families, and at least one gene has been linked to increased risk. Although osteosarcoma tends to occur in the larger bones, such as the shin (near the knee), thigh (near the knee) and upper arm (near the shoulder), it can occur in any bone. A number of variants of osteosarcoma exist, including conventional types (osteoblastic, chondroblastic, and fibroblastic), telangiectatic, multifocal, parosteal, and periosteal.  Treatment usually starts after a biopsy of the tumor and includes chemotherapy followed by surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Logo
Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteosarcoma" returned 1323 free, full-text research articles on human participants. First 3 results:

[Ganoderic acid A suppresses proliferation and invasion and induces apoptosis in human osteosarcoma cells].
 

Author(s): Jianli Shao, Zhizhong Li, Genlong Jiao, Guodong Sun, Zhigang Zhou

Journal: Nan Fang Yi Ke Da Xue Xue Bao. 2015 May;35(5):619-24.

 

To investigate the effect of ganoderic acid A (GA-A) on the biological behaviors of human osteosarcoma cells in vitro.

Last Updated: 28 May 2015

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Late recurrence of osteosarcoma: a report of two cases.
 

Author(s): Kentaro Igarashi, Norio Yamamoto, Toshiharu Shirai, Hideji Nishida, Katsuhiro Hayashi, Yoshikazu Tanzawa, Hiroaki Kimura, Akihiko Takeuchi, Shinji Miwa, Hiroyuki Inatani, Shingo Shimozaki, Takashi Kato, Hiroyuki Tsuchiya

Journal: J Orthop Surg (Hong Kong). 2014 Dec;22(3):415-9.

 

We report 2 cases of late recurrence of osteosarcoma after 6 and 7 years. One patient had pulmonary metastasis, and the other had soft tissue recurrence. Both patients underwent complete resection and chemotherapy. The first patient achieved complete remission and remained disease-free ...

Last Updated: 31 Dec 2014

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Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma.
 

Author(s): Jennifer A Perry, Adam Kiezun, Peter Tonzi, Eliezer M Van Allen, Scott L Carter, Sylvan C Baca, Glenn S Cowley, Ami S Bhatt, Esther Rheinbay, Chandra Sekhar Pedamallu, Elena Helman, Amaro Taylor-Weiner, Aaron McKenna, David S DeLuca, Michael S Lawrence, Lauren Ambrogio, Carrie Sougnez, Andrey Sivachenko, Loren D Walensky, Nikhil Wagle, Jaume Mora, Carmen de Torres, Cinzia Lavarino, Simone Dos Santos Aguiar, Jose Andres Yunes, Silvia Regina Brandalise, Gabriela Elisa Mercado-Celis, Jorge Melendez-Zajgla, Rocío Cárdenas-Cardós, Liliana Velasco-Hidalgo, Charles W M Roberts, Levi A Garraway, Carlos Rodriguez-Galindo, Stacey B Gabriel, Eric S Lander, Todd R Golub, Stuart H Orkin, Gad Getz, Katherine A Janeway

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2014 Dec;111(51):E5564-73.

 

Osteosarcoma is the most common primary bone tumor, yet there have been no substantial advances in treatment or survival in three decades. We examined 59 tumor/normal pairs by whole-exome, whole-genome, and RNA-sequencing. Only the TP53 gene was mutated at significant frequency across ...

Last Updated: 24 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteosarcoma" returned 59 free, full-text review articles on human participants. First 3 results:

Prognostic value of p53 alterations in human osteosarcoma: a meta analysis.
 

Author(s): Dong Yao, Guo-Hong Cai, Jing Chen, Rui Ling, Sheng-Xi Wu, Yong-Ping Li

Journal:

 

Tumor suppressor gene p53 functions as the guardian of the human genome and mutations in p53 contribute to cancer development. However, studies that investigated the potential of p53 as a prognostic marker in osteosarcoma patients have yielded inconclusive results. Based on recommendation ...

Last Updated: 17 Nov 2014

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P16INK4a overexpression and survival in osteosarcoma patients: a meta analysis.
 

Author(s): Jie Bu, Hui Li, Li-Hong Liu, Yu-Rong Ouyang, Hong-Bin Guo, Xiao-Yang Li, Tao Xiao

Journal:

 

Osteosarcoma is one of the most common primary bone malignancies. Although there is a significant improvement of survival on osteosarcoma patients in the past decades, treatment of osteosarcoma is still unsatisfactory for the development of pulmonary metastasis. The potential prognostic ...

Last Updated: 22 Oct 2014

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Gemcitabine for the treatment of patients with osteosarcoma.
 

Author(s): Mei-Yang Wei, Yan-Feng Zhuang, Wan-Ming Wang

Journal: Asian Pac. J. Cancer Prev.. 2014 ;15(17):7159-62.

 

Patients with recurrent or refractory osteosarcoma are considered to have a very poor prognosis, and new regimens are needed to improve the prognosis in this setting. Gemcitabine, a nucleoside antimetabolite, is an analog of deoxycytidine which mainly inhibits DNA synthesis through ...

Last Updated: 17 Sep 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Blood Samples From Patients With Osteosarcoma
 

Status: Recruiting

Condition Summary: Localized Osteosarcoma; Metastatic Osteosarcoma; Recurrent Osteosarcoma

 

Last Updated: 12 May 2015

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Denosumab in Treating Patients With Recurrent or Refractory Osteosarcoma
 

Status: Not yet recruiting

Condition Summary: Childhood Osteosarcoma; Metastatic Osteosarcoma; Recurrent Osteosarcoma

 

Last Updated: 10 Jun 2015

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Study of Pazopanib in the Treatment of Osteosarcoma Metastatic to the Lung
 

Status: Recruiting

Condition Summary: Osteosarcoma; Metastatic Osteosarcoma

 

Last Updated: 6 Jul 2015

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