Osteosarcoma

Common Name(s)

Osteosarcoma

Osteosarcoma is the most common cancerous (malignant) bone tumor in youth. The average age at diagnosis is 15. Boys and girls have a similar incidence of this tumor until late adolescence, at which time boys are more commonly affected. In rare cases, osteosarcoma occurs in adults. The cause of osteosarcoma is not known. In some cases, it runs in families, and at least one gene has been linked to increased risk. Although osteosarcoma tends to occur in the larger bones, such as the shin (near the knee), thigh (near the knee) and upper arm (near the shoulder), it can occur in any bone. A number of variants of osteosarcoma exist, including conventional types (osteoblastic, chondroblastic, and fibroblastic), telangiectatic, multifocal, parosteal, and periosteal.  Treatment usually starts after a biopsy of the tumor and includes chemotherapy followed by surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Logo
Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteosarcoma" returned 1233 free, full-text research articles on human participants. First 3 results:

Knee reconstruction with endoprosthesis after extra-articular and intra-articular resection of osteosarcoma.
 

Author(s): Makoto Ieguchi, Manabu Hoshi, Masanari Aono, Jun Takada, Naoto Ohebisu, Ikuo Kudawara, Hiroaki Nakamura

Journal: Jpn. J. Clin. Oncol.. 2014 Sep;44(9):812-7.

 

Extra-articular resection is necessary to obtain a wide margin for primary osteosarcomas invading the knee joint, and the limb is often reconstructed using a prosthesis. Here, outcomes of extra-articular and intra-articular procedures were compared.

Last Updated: 26 Aug 2014

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Meta-analysis of differentially expressed genes in osteosarcoma based on gene expression data.
 

Author(s): Zuozhang Yang, Yongbin Chen, Yu Fu, Yihao Yang, Ya Zhang, Yanjin Chen, Dongqi Li

Journal:

 

To uncover the genes involved in the development of osteosarcoma (OS), we performed a meta-analysis of OS microarray data to identify differentially expressed genes (DEGs) and biological functions associated with gene expression changes between OS and normal control (NC) tissues.

Last Updated: 25 Jul 2014

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SAOS-2 osteosarcoma cells bind fibroblasts via ICAM-1 and this is increased by tumour necrosis factor-α.
 

Author(s): Manu S David, Elizabeth Kelly, Ivan Cheung, Munira Xaymardan, Malcolm A S Moore, Hans Zoellner

Journal:

 

We recently reported exchange of membrane and cytoplasmic markers between SAOS-2 osteosarcoma cells and human gingival fibroblasts (h-GF) without comparable exchange of nuclear markers, while similar h-GF exchange was seen for melanoma and ovarian carcinoma cells. This process of ...

Last Updated: 1 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteosarcoma" returned 55 free, full-text review articles on human participants. First 3 results:

Advances in targeted therapy for osteosarcoma.
 

Author(s): Wenya Zhou, Mengze Hao, Xiaoling Du, Kexin Chen, Guowen Wang, Jilong Yang

Journal: Discov Med. 2014 Jun;17(96):301-7.

 

Osteosarcoma is an aggressive cancer in skeletal system with unknown molecular mechanisms of etiology and pathogenesis, therefore it remains a challenge for current therapeutic strategies to effectively treat osteosarcoma. The aim of this review is to give an overview of the molecular ...

Last Updated: 1 Jul 2014

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Canine osteosarcoma: a naturally occurring disease to inform pediatric oncology.
 

Author(s): Joelle M Fenger, Cheryl A London, William C Kisseberth

Journal: ILAR J. 2014 ;55(1):69-85.

 

Osteosarcoma (OSA) is the most common form of malignant bone cancer in children and dogs, although the disease occurs in dogs approximately 10 times more frequently than in people. Multidrug chemotherapy and aggressive surgical techniques have improved survival; however, new therapies ...

Last Updated: 17 Jun 2014

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Small-cell extraskeletal osteosarcoma: case report and literature review.
 

Author(s): Ming Zhang, Wei Zhang, Qiang Li, Jian-Li Qu, Guo-Feng Zhang

Journal:

 

Small-cell extraskeletal osteosarcoma is extremely rare and consists of sheets of small round cells with variable amounts of osteoid. This tumor is often difficult to diagnose when tissue samples do not include recognizable osteoid. Only four cases have been reported in English and ...

Last Updated: 19 Feb 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Blood Samples From Patients With Osteosarcoma
 

Status: Recruiting

Condition Summary: Localized Osteosarcoma; Metastatic Osteosarcoma; Recurrent Osteosarcoma

 

Last Updated: 5 Aug 2014

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Study of Pazopanib in the Treatment of Osteosarcoma Metastatic to the Lung
 

Status: Recruiting

Condition Summary: Osteosarcoma; Metastatic Osteosarcoma

 

Last Updated: 17 Dec 2014

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Cabozantinib-s-malate in Treating Patients With Relapsed Osteosarcoma or Ewing Sarcoma
 

Status: Recruiting

Condition Summary: Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Metastatic Osteosarcoma; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Osteosarcoma

 

Last Updated: 29 Jan 2015

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