Osteosarcoma

Common Name(s)

Osteosarcoma

Osteosarcoma is the most common cancerous (malignant) bone tumor in youth. The average age at diagnosis is 15. Boys and girls have a similar incidence of this tumor until late adolescence, at which time boys are more commonly affected. In rare cases, osteosarcoma occurs in adults. The cause of osteosarcoma is not known. In some cases, it runs in families, and at least one gene has been linked to increased risk. Although osteosarcoma tends to occur in the larger bones, such as the shin (near the knee), thigh (near the knee) and upper arm (near the shoulder), it can occur in any bone. A number of variants of osteosarcoma exist, including conventional types (osteoblastic, chondroblastic, and fibroblastic), telangiectatic, multifocal, parosteal, and periosteal.  Treatment usually starts after a biopsy of the tumor and includes chemotherapy followed by surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

View Details
Logo
Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

View Details
Logo
Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteosarcoma" returned 2140 free, full-text research articles on human participants. First 3 results:

MiRNA-221 from tissue may predict the prognosis of patients with osteosarcoma.
 

Author(s): Ningji Gong, Mingzhi Gong

Journal: Medicine (Baltimore). 2018 Jul;97(29):e11100.

 

This study was aimed to investigate the relationship between miR-221 expression and prognosis in patients with osteosarcoma.miR-221 expression in 69 osteosarcoma specimens and corresponding noncancer tissues were characterized by quantitative reverse transcription polymerase chain ...

Last Updated: 31 Dec 1969

Go To URL
Codelivery of doxorubicin and JIP1 siRNA with novel EphA2-targeted PEGylated cationic nanoliposomes to overcome osteosarcoma multidrug resistance.
 

Author(s): Fateme Haghiralsadat, Ghasem Amoabediny, Samira Naderinezhad, Behrouz Zandieh-Doulabi, Tymour Forouzanfar, Marco N Helder

Journal:

 

Osteosarcoma (OS) mostly affects children and young adults, and has only a 20%-30% 5-year survival rate when metastasized. We aimed to create dual-targeted (extracellular against EphA2 and intracellular against JNK-interacting protein 1 [JIP1]), doxorubicin (DOX)-loaded liposomes ...

Last Updated: 31 Dec 1969

Go To URL
Lumbar spinal canal osteosarcoma: A case report.
 

Author(s): De-Jian Chen, Qi Lai, Jianghao Zhu, Zongmiao Wan, Hucheng Liu, Min Dai, Runsheng Guo, Bin Zhang

Journal: Medicine (Baltimore). 2018 Jun;97(25):e11210.

 

Osteosarcoma is a rare neoplasm in the lumbar spine. Although osteosarcoma can arise in any portion of the skeleton, it very rarely arises in the spinal canal, which accounts for <0.1% of all cases of adult sarcomas. Here, we describe a case of osteosarcoma arising in the L4-5 spinal canal.

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteosarcoma" returned 116 free, full-text review articles on human participants. First 3 results:

Meta-analysis of serum lactate dehydrogenase and prognosis for osteosarcoma.
 

Author(s): Yucheng Fu, Tao Lan, Hongliu Cai, Anwei Lu, Wei Yu

Journal: Medicine (Baltimore). 2018 May;97(19):e0741.

 

A large number of studies have reported the relationships between serum lactate dehydrogenase (LDH) and prognosis of osteosarcoma. However, the result is still controversial and no consensus has been reached. Therefore, we performed a meta-analysis to evaluate the prognostic role ...

Last Updated: 31 Dec 1969

Go To URL
Primary osteosarcoma of frontal bone: A case report and review of literature.
 

Author(s): Guangyong Wu, Qi Liang, Yu Liu

Journal: Medicine (Baltimore). 2017 Dec;96(51):e9392.

 

Primary osteosarcomas of the skull and skull base are rare, comprising <2% of all skull tumors. Primary osteosarcomas of the skull are aggressive neoplasms composed of spindle cells producing osteoid which have poor outcome.

Last Updated: 31 Dec 1969

Go To URL
2-Methoxyestradiol Reverses the Pro-Carcinogenic Effect of L-Lactate in Osteosarcoma 143B Cells.
 

Author(s): Magdalena Gorska-Ponikowska, Alicja Kuban-Jankowska, Agnieszka Daca, Stephan Nussberger

Journal: Cancer Genomics Proteomics. ;14(6):483-493.

 

According to the reverse Warburg effect, tumor cells may metabolize lactate as an energy source and shuttle L-lactate to neighboring cancer cells, adjacent stroma, and vascular endothelial cells, thus inducing metabolic reprogramming. An increased tumor L-lactate level strictly correlates ...

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

The Osteosarcoma Biobank in Peking University People's Hospital
 

Status: Not yet recruiting

Condition Summary: Osteosarcoma

 

Last Updated: 2 Dec 2017

Go to URL
Biology of Osteosarcoma (BOOST) Registry and Biobank
 

Status: Recruiting

Condition Summary: Osteosarcoma

 

Last Updated: 21 Jul 2017

Go to URL
A Phase II Trial of Avelumab in Patients With Recurrent or Progressive Osteosarcoma
 

Status: Recruiting

Condition Summary: Osteosarcoma

 

Last Updated: 20 Jun 2018

Go to URL