Osteosarcoma

Common Name(s)

Osteosarcoma

Osteosarcoma is the most common cancerous (malignant) bone tumor in youth. The average age at diagnosis is 15. Boys and girls have a similar incidence of this tumor until late adolescence, at which time boys are more commonly affected. In rare cases, osteosarcoma occurs in adults. The cause of osteosarcoma is not known. In some cases, it runs in families, and at least one gene has been linked to increased risk. Although osteosarcoma tends to occur in the larger bones, such as the shin (near the knee), thigh (near the knee) and upper arm (near the shoulder), it can occur in any bone. A number of variants of osteosarcoma exist, including conventional types (osteoblastic, chondroblastic, and fibroblastic), telangiectatic, multifocal, parosteal, and periosteal.  Treatment usually starts after a biopsy of the tumor and includes chemotherapy followed by surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

View Details

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteosarcoma" returned 2028 free, full-text research articles on human participants. First 3 results:

Pulmonary Metastases from Chondroblastic Osteosarcoma.
 

Author(s): Hirva Mamdani, Sara J Grethlein

Journal: N. Engl. J. Med.. 2018 Apr;378(15):1429.

 

Last Updated: 31 Dec 1969

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Primary, cardiac, fibroblastic osteosarcoma: A case report.
 

Author(s): Yangyang Li, Teng Ye, Qianru Gu, Lei Dong, Guorong Chen, Shanshan Lu

Journal: Medicine (Baltimore). 2018 Jan;97(1):e9543.

 

Primary cardiac osteosarcoma is a rare tumor. To our knowledge, only 15 cases have been reported in the literature in the past 10 years. We describe a case of primary, cardiac, fibroblastic osteosarcoma in a 42-year-old woman.

Last Updated: 31 Dec 1969

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Long Non-Coding RNA TUG1 Promotes Proliferation and Inhibits Apoptosis of Osteosarcoma Cells by Sponging miR-132-3p and Upregulating SOX4 Expression.
 

Author(s): Gang Li, Keyu Liu, Xinhui Du

Journal: Yonsei Med. J.. 2018 Mar;59(2):226-235.

 

Long non-coding RNA taurine upregulated gene 1 (TUG1) is reported to be a vital regulator of the progression of various cancers. This study aimed to explore the exact roles and molecular mechanisms of TUG1 in osteosarcoma (OS) development.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteosarcoma" returned 108 free, full-text review articles on human participants. First 3 results:

Primary osteosarcoma of frontal bone: A case report and review of literature.
 

Author(s): Guangyong Wu, Qi Liang, Yu Liu

Journal: Medicine (Baltimore). 2017 Dec;96(51):e9392.

 

Primary osteosarcomas of the skull and skull base are rare, comprising <2% of all skull tumors. Primary osteosarcomas of the skull are aggressive neoplasms composed of spindle cells producing osteoid which have poor outcome.

Last Updated: 31 Dec 1969

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Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics.
 

Author(s): Siobhan Simpson, Mark David Dunning, Simone de Brot, Llorenç Grau-Roma, Nigel Patrick Mongan, Catrin Sian Rutland

Journal:

 

Osteosarcoma (OSA) is a rare cancer in people. However OSA incidence rates in dogs are 27 times higher than in people. Prognosis in both species is relatively poor, with 5 year OSA survival rates in people not having improved in decades. For dogs, 1 year survival rates are only ...

Last Updated: 31 Dec 1969

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Application of Long Noncoding RNAs in Osteosarcoma: Biomarkers and Therapeutic Targets.
 

Author(s): Zhihong Li, Pengcheng Dou, Tang Liu, Shasha He

Journal: Cell. Physiol. Biochem.. 2017 ;42(4):1407-1419.

 

Osteosarcoma is the most common primary bone malignancy in children and adolescents. Although improvements in therapeutic strategies were achieved, the outcome remains poor for most patients with metastatic or recurrent osteosarcoma. Therefore, it is imperative to identify novel and ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Osteosarcoma Biobank in Peking University People's Hospital
 

Status: Not yet recruiting

Condition Summary: Osteosarcoma

 

Last Updated: 2 Dec 2017

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Biology of Osteosarcoma (BOOST) Registry and Biobank
 

Status: Recruiting

Condition Summary: Osteosarcoma

 

Last Updated: 21 Jul 2017

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A Phase II Trial of Avelumab in Patients With Recurrent or Progressive Osteosarcoma
 

Status: Recruiting

Condition Summary: Osteosarcoma

 

Last Updated: 27 Mar 2018

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