Osteosarcoma

Common Name(s)

Osteosarcoma

Osteosarcoma is the most common cancerous (malignant) bone tumor in youth. The average age at diagnosis is 15. Boys and girls have a similar incidence of this tumor until late adolescence, at which time boys are more commonly affected. In rare cases, osteosarcoma occurs in adults. The cause of osteosarcoma is not known. In some cases, it runs in families, and at least one gene has been linked to increased risk. Although osteosarcoma tends to occur in the larger bones, such as the shin (near the knee), thigh (near the knee) and upper arm (near the shoulder), it can occur in any bone. A number of variants of osteosarcoma exist, including conventional types (osteoblastic, chondroblastic, and fibroblastic), telangiectatic, multifocal, parosteal, and periosteal.  Treatment usually starts after a biopsy of the tumor and includes chemotherapy followed by surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Logo
Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteosarcoma" returned 1280 free, full-text research articles on human participants. First 3 results:

Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma.
 

Author(s): Jennifer A Perry, Adam Kiezun, Peter Tonzi, Eliezer M Van Allen, Scott L Carter, Sylvan C Baca, Glenn S Cowley, Ami S Bhatt, Esther Rheinbay, Chandra Sekhar Pedamallu, Elena Helman, Amaro Taylor-Weiner, Aaron McKenna, David S DeLuca, Michael S Lawrence, Lauren Ambrogio, Carrie Sougnez, Andrey Sivachenko, Loren D Walensky, Nikhil Wagle, Jaume Mora, Carmen de Torres, Cinzia Lavarino, Simone Dos Santos Aguiar, Jose Andres Yunes, Silvia Regina Brandalise, Gabriela Elisa Mercado-Celis, Jorge Melendez-Zajgla, Rocío Cárdenas-Cardós, Liliana Velasco-Hidalgo, Charles W M Roberts, Levi A Garraway, Carlos Rodriguez-Galindo, Stacey B Gabriel, Eric S Lander, Todd R Golub, Stuart H Orkin, Gad Getz, Katherine A Janeway

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2014 Dec;111(51):E5564-73.

 

Osteosarcoma is the most common primary bone tumor, yet there have been no substantial advances in treatment or survival in three decades. We examined 59 tumor/normal pairs by whole-exome, whole-genome, and RNA-sequencing. Only the TP53 gene was mutated at significant frequency across ...

Last Updated: 24 Dec 2014

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Cytotoxic effects of curcumin in osteosarcoma cells.
 

Author(s): J M Moran, F J Rodriguez-Velasco, R Roncero-Martin, V Vera, J D Pedrera-Zamorano

Journal:

 

Last Updated: 8 Dec 2014

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A-770041 reverses paclitaxel and doxorubicin resistance in osteosarcoma cells.
 

Author(s): Zhenfeng Duan, Jianming Zhang, Shunan Ye, Jacson Shen, Edwin Choy, Gregory Cote, David Harmon, Henry Mankin, Yingqi Hua, Yu Zhang, Nathanael S Gray, Francis J Hornicek

Journal:

 

Reversing multidrug resistance (MDR) has been an important goal for clinical and investigational oncologists. In the last few decades, significant effort has been made to search for inhibitors to reverse MDR by targeting ATP-binding cassette (ABC) transporters (Pgp, MRP) directly, ...

Last Updated: 24 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteosarcoma" returned 56 free, full-text review articles on human participants. First 3 results:

Advances in targeted therapy for osteosarcoma.
 

Author(s): Wenya Zhou, Mengze Hao, Xiaoling Du, Kexin Chen, Guowen Wang, Jilong Yang

Journal: Discov Med. 2014 Jun;17(96):301-7.

 

Osteosarcoma is an aggressive cancer in skeletal system with unknown molecular mechanisms of etiology and pathogenesis, therefore it remains a challenge for current therapeutic strategies to effectively treat osteosarcoma. The aim of this review is to give an overview of the molecular ...

Last Updated: 1 Jul 2014

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Canine osteosarcoma: a naturally occurring disease to inform pediatric oncology.
 

Author(s): Joelle M Fenger, Cheryl A London, William C Kisseberth

Journal: ILAR J. 2014 ;55(1):69-85.

 

Osteosarcoma (OSA) is the most common form of malignant bone cancer in children and dogs, although the disease occurs in dogs approximately 10 times more frequently than in people. Multidrug chemotherapy and aggressive surgical techniques have improved survival; however, new therapies ...

Last Updated: 17 Jun 2014

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Dose-intensive versus dose-control chemotherapy for high-grade osteosarcoma: a meta-analysis.
 

Author(s): W Wang, Z-c Wang, H Shen, J-j Xie, H Lu

Journal: Eur Rev Med Pharmacol Sci. 2014 ;18(9):1383-90.

 

Tumor necrosis might be a consequence of innate sensitivity of tumor cells to changed dosage instead of the increased dosage of chemotherapeutics in the treatment of osteosarcoma patients.

Last Updated: 28 May 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Blood Samples From Patients With Osteosarcoma
 

Status: Recruiting

Condition Summary: Localized Osteosarcoma; Metastatic Osteosarcoma; Recurrent Osteosarcoma

 

Last Updated: 12 May 2015

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Study of Pazopanib in the Treatment of Osteosarcoma Metastatic to the Lung
 

Status: Recruiting

Condition Summary: Osteosarcoma; Metastatic Osteosarcoma

 

Last Updated: 30 Apr 2015

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Cabozantinib-s-malate in Treating Patients With Relapsed Osteosarcoma or Ewing Sarcoma
 

Status: Recruiting

Condition Summary: Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Metastatic Osteosarcoma; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Osteosarcoma

 

Last Updated: 9 Apr 2015

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