Osteosarcoma

Common Name(s)

Osteosarcoma

Osteosarcoma is the most common cancerous (malignant) bone tumor in youth. The average age at diagnosis is 15. Boys and girls have a similar incidence of this tumor until late adolescence, at which time boys are more commonly affected. In rare cases, osteosarcoma occurs in adults. The cause of osteosarcoma is not known. In some cases, it runs in families, and at least one gene has been linked to increased risk. Although osteosarcoma tends to occur in the larger bones, such as the shin (near the knee), thigh (near the knee) and upper arm (near the shoulder), it can occur in any bone. A number of variants of osteosarcoma exist, including conventional types (osteoblastic, chondroblastic, and fibroblastic), telangiectatic, multifocal, parosteal, and periosteal.  Treatment usually starts after a biopsy of the tumor and includes chemotherapy followed by surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteosarcoma" returned 1870 free, full-text research articles on human participants. First 3 results:

A Rare Cause of Bowel Obstruction: Peritoneal Metastases in Osteosarcoma at the Tibia in a Young Female Patient with Brain Metastasis. Case Report.
 

Author(s): Dumitru Cristinel Badiu, Cristina Alexandra Manea, Vlad Porojan, Marius Paraschiv, Claudia Mehedintu, Ionut Simion Coman, Valentin Titus Grigorean

Journal: Chirurgia (Bucur). ;111(3):274-8.

 

Osteosarcomas are the most frequent primary malignant bone tumors in children and adolescents. Like brain metastases in osteosarcomas, the bowel metastases are very rare. We present the case of a 23-year-old female patient, diagnosed and operated in 2008 of osteosarcoma at the tibia, ...

Last Updated: 25 Jul 2016

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Improvement in High-Grade Osteosarcoma Survival: Results from 202 Patients Treated at a Single Institution in Taiwan.
 

Author(s): Giun-Yi Hung, Hsiu-Ju Yen, Chueh-Chuan Yen, Po-Kuei Wu, Cheng-Fong Chen, Paul C-H Chen, Hung-Ta H Wu, Hong-Jen Chiou, Wei-Ming Chen

Journal: Medicine (Baltimore). 2016 Apr;95(15):e3420.

 

The aim of this study was to compare survival before and after 2004 and define the prognostic factors for high-grade osteosarcomas beyond those of typical young patients with localized extremity disease. Few studies have reported the long-term treatment outcomes of high-grade osteosarcoma ...

Last Updated: 16 Apr 2016

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Serum CEACAM1 Level Is Associated with Diagnosis and Prognosis in Patients with Osteosarcoma.
 

Author(s): Haiying Yu, Jian Yu, Yanjun Ren, Yun Yang, Xing Xiao

Journal:

 

Carcinoembryonic antigen related cell adhesion molecule 1 (CEACAM1) is a trans-membrane multifunctional cell adhesion molecule associated with tumor cell proliferation, apoptosis, angiogenesis, invasion, and migration during tumor development. In the present study, we evaluated serum ...

Last Updated: 14 Apr 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteosarcoma" returned 91 free, full-text review articles on human participants. First 3 results:

Prognostic significance of CD44V6 expression in osteosarcoma: a meta-analysis.
 

Author(s): Yunyuan Zhang, Chunming Ding, Jing Wang, Guirong Sun, Yongxian Cao, Longqiang Xu, Lan Zhou, Xian Chen

Journal:

 

Numerous individual studies evaluating the relationship between CD44V6 over-expression and prognostic impact in patients with osteosarcoma (OS) have yielded in conclusive results. This meta-analysis aimed to determine the value of cell adhesion molecule CD44V6 in prognosis of OS by ...

Last Updated: 24 Dec 2015

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Prognostic Significance of Serum Alkaline Phosphatase Level in Osteosarcoma: A Meta-Analysis of Published Data.
 

Author(s): Hai-Yong Ren, Ling-Ling Sun, Heng-Yuan Li, Zhao-Ming Ye

Journal: Biomed Res Int. 2015 ;2015():160835.

 

Serum alkaline phosphatase (SALP) is commonly elevated in osteosarcoma patients. A number of studies have investigated the prognostic role of SALP level in patients with osteosarcoma but yielded inconsistent results.

Last Updated: 30 Nov 2015

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Efficacy and safety of ifosfamide-based chemotherapy for osteosarcoma: a meta-analysis.
 

Author(s): Xiao-Liang Fan, Guo-Ping Cai, Liu-Long Zhu, Guo-Ming Ding

Journal:

 

The efficacy of ifosfamide-based chemotherapy in the treatment of osteosarcoma has been investigated; however, results are inconsistent. Therefore, we reviewed the relevant studies and conducted a meta-analysis to assess the efficacy of ifosfamide-based chemotherapy in patients with osteosarcoma.

Last Updated: 25 Nov 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Cabozantinib-s-malate in Treating Patients With Relapsed Osteosarcoma or Ewing Sarcoma
 

Status: Recruiting

Condition Summary: Metastatic Ewing Sarcoma; Metastatic Osteosarcoma; Recurrent Ewing Sarcoma; Recurrent Osteosarcoma; Stage IVA Osteosarcoma; Stage IVB Osteosarcoma

 

Last Updated: 27 Jun 2016

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Denosumab in Treating Patients With Recurrent or Refractory Osteosarcoma
 

Status: Recruiting

Condition Summary: Childhood Osteosarcoma; Metastatic Osteosarcoma; Recurrent Osteosarcoma

 

Last Updated: 8 Jul 2016

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Study of Pazopanib in the Treatment of Osteosarcoma Metastatic to the Lung
 

Status: Recruiting

Condition Summary: Osteosarcoma; Metastatic Osteosarcoma

 

Last Updated: 25 Jul 2016

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