Osteosarcoma

Common Name(s)

Osteosarcoma

Osteosarcoma is the most common cancerous (malignant) bone tumor in youth. The average age at diagnosis is 15. Boys and girls have a similar incidence of this tumor until late adolescence, at which time boys are more commonly affected. In rare cases, osteosarcoma occurs in adults. The cause of osteosarcoma is not known. In some cases, it runs in families, and at least one gene has been linked to increased risk. Although osteosarcoma tends to occur in the larger bones, such as the shin (near the knee), thigh (near the knee) and upper arm (near the shoulder), it can occur in any bone. A number of variants of osteosarcoma exist, including conventional types (osteoblastic, chondroblastic, and fibroblastic), telangiectatic, multifocal, parosteal, and periosteal.  Treatment usually starts after a biopsy of the tumor and includes chemotherapy followed by surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Logo
Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Logo
Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteosarcoma" returned 1313 free, full-text research articles on human participants. First 3 results:

Patterns of care and outcomes of adult osteosarcoma in a tertiary care cancer centre in Pakistan.
 

Author(s): Saba Imtiaz, Ather Kazmi

Journal: J Pak Med Assoc. 2014 Oct;64(10):1166-70.

 

To present our experience of treatment outcomes in adult osteosarcoma patients.

Last Updated: 31 Mar 2015

Go To URL
Late recurrence of osteosarcoma: a report of two cases.
 

Author(s): Kentaro Igarashi, Norio Yamamoto, Toshiharu Shirai, Hideji Nishida, Katsuhiro Hayashi, Yoshikazu Tanzawa, Hiroaki Kimura, Akihiko Takeuchi, Shinji Miwa, Hiroyuki Inatani, Shingo Shimozaki, Takashi Kato, Hiroyuki Tsuchiya

Journal: J Orthop Surg (Hong Kong). 2014 Dec;22(3):415-9.

 

We report 2 cases of late recurrence of osteosarcoma after 6 and 7 years. One patient had pulmonary metastasis, and the other had soft tissue recurrence. Both patients underwent complete resection and chemotherapy. The first patient achieved complete remission and remained disease-free ...

Last Updated: 31 Dec 2014

Go To URL
Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma.
 

Author(s): Jennifer A Perry, Adam Kiezun, Peter Tonzi, Eliezer M Van Allen, Scott L Carter, Sylvan C Baca, Glenn S Cowley, Ami S Bhatt, Esther Rheinbay, Chandra Sekhar Pedamallu, Elena Helman, Amaro Taylor-Weiner, Aaron McKenna, David S DeLuca, Michael S Lawrence, Lauren Ambrogio, Carrie Sougnez, Andrey Sivachenko, Loren D Walensky, Nikhil Wagle, Jaume Mora, Carmen de Torres, Cinzia Lavarino, Simone Dos Santos Aguiar, Jose Andres Yunes, Silvia Regina Brandalise, Gabriela Elisa Mercado-Celis, Jorge Melendez-Zajgla, Rocío Cárdenas-Cardós, Liliana Velasco-Hidalgo, Charles W M Roberts, Levi A Garraway, Carlos Rodriguez-Galindo, Stacey B Gabriel, Eric S Lander, Todd R Golub, Stuart H Orkin, Gad Getz, Katherine A Janeway

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2014 Dec;111(51):E5564-73.

 

Osteosarcoma is the most common primary bone tumor, yet there have been no substantial advances in treatment or survival in three decades. We examined 59 tumor/normal pairs by whole-exome, whole-genome, and RNA-sequencing. Only the TP53 gene was mutated at significant frequency across ...

Last Updated: 24 Dec 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteosarcoma" returned 57 free, full-text review articles on human participants. First 3 results:

Gemcitabine for the treatment of patients with osteosarcoma.
 

Author(s): Mei-Yang Wei, Yan-Feng Zhuang, Wan-Ming Wang

Journal: Asian Pac. J. Cancer Prev.. 2014 ;15(17):7159-62.

 

Patients with recurrent or refractory osteosarcoma are considered to have a very poor prognosis, and new regimens are needed to improve the prognosis in this setting. Gemcitabine, a nucleoside antimetabolite, is an analog of deoxycytidine which mainly inhibits DNA synthesis through ...

Last Updated: 17 Sep 2014

Go To URL
Advances in targeted therapy for osteosarcoma.
 

Author(s): Wenya Zhou, Mengze Hao, Xiaoling Du, Kexin Chen, Guowen Wang, Jilong Yang

Journal: Discov Med. 2014 Jun;17(96):301-7.

 

Osteosarcoma is an aggressive cancer in skeletal system with unknown molecular mechanisms of etiology and pathogenesis, therefore it remains a challenge for current therapeutic strategies to effectively treat osteosarcoma. The aim of this review is to give an overview of the molecular ...

Last Updated: 1 Jul 2014

Go To URL
Canine osteosarcoma: a naturally occurring disease to inform pediatric oncology.
 

Author(s): Joelle M Fenger, Cheryl A London, William C Kisseberth

Journal: ILAR J. 2014 ;55(1):69-85.

 

Osteosarcoma (OSA) is the most common form of malignant bone cancer in children and dogs, although the disease occurs in dogs approximately 10 times more frequently than in people. Multidrug chemotherapy and aggressive surgical techniques have improved survival; however, new therapies ...

Last Updated: 17 Jun 2014

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Blood Samples From Patients With Osteosarcoma
 

Status: Recruiting

Condition Summary: Localized Osteosarcoma; Metastatic Osteosarcoma; Recurrent Osteosarcoma

 

Last Updated: 12 May 2015

Go to URL
Denosumab in Treating Patients With Recurrent or Refractory Osteosarcoma
 

Status: Not yet recruiting

Condition Summary: Childhood Osteosarcoma; Metastatic Osteosarcoma; Recurrent Osteosarcoma

 

Last Updated: 10 Jun 2015

Go to URL
Study of Pazopanib in the Treatment of Osteosarcoma Metastatic to the Lung
 

Status: Recruiting

Condition Summary: Osteosarcoma; Metastatic Osteosarcoma

 

Last Updated: 10 Jun 2015

Go to URL