Osteosarcoma

Common Name(s)

Osteosarcoma

Osteosarcoma is the most common cancerous (malignant) bone tumor in youth. The average age at diagnosis is 15. Boys and girls have a similar incidence of this tumor until late adolescence, at which time boys are more commonly affected. In rare cases, osteosarcoma occurs in adults. The cause of osteosarcoma is not known. In some cases, it runs in families, and at least one gene has been linked to increased risk. Although osteosarcoma tends to occur in the larger bones, such as the shin (near the knee), thigh (near the knee) and upper arm (near the shoulder), it can occur in any bone. A number of variants of osteosarcoma exist, including conventional types (osteoblastic, chondroblastic, and fibroblastic), telangiectatic, multifocal, parosteal, and periosteal.  Treatment usually starts after a biopsy of the tumor and includes chemotherapy followed by surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

View Details
Logo
Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

View Details
Logo
Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteosarcoma" returned 1903 free, full-text research articles on human participants. First 3 results:

A Rare Cause of Bowel Obstruction: Peritoneal Metastases in Osteosarcoma at the Tibia in a Young Female Patient with Brain Metastasis. Case Report.
 

Author(s): Dumitru Cristinel Badiu, Cristina Alexandra Manea, Vlad Porojan, Marius Paraschiv, Claudia Mehedintu, Ionut Simion Coman, Valentin Titus Grigorean

Journal: Chirurgia (Bucur). ;111(3):274-8.

 

Osteosarcomas are the most frequent primary malignant bone tumors in children and adolescents. Like brain metastases in osteosarcomas, the bowel metastases are very rare. We present the case of a 23-year-old female patient, diagnosed and operated in 2008 of osteosarcoma at the tibia, ...

Last Updated: 25 Jul 2016

Go To URL
Hippo/YAP signaling pathway is involved in osteosarcoma chemoresistance.
 

Author(s): Dong-Yu Wang, Ya-Nan Wu, Jun-Qi Huang, Wei Wang, Meng Xu, Jin-Peng Jia, Gang Han, Bei-Bei Mao, Wen-Zhi Bi

Journal:

 

Osteosarcoma is the most common bone malignancy in children and adolescents, and 20%-30% of the patients suffer from poor prognosis because of individual chemoresistance. The Hippo/yes-associated protein (YAP) signaling pathway has been shown to play a role in tumor chemoresistance, ...

Last Updated: 21 May 2016

Go To URL
Decreased microRNA-452 expression and its prognostic significance in human osteosarcoma.
 

Author(s): Ren-zeng Li, Li-min Wang

Journal:

 

MicroRNA-452 (miR-452) was previously reported to be dysregulated in several types of human cancers and involved in tumor progression. The aim of this study was to investigate the clinical significance and prognostic value of miR-452 expression in human osteosarcoma.

Last Updated: 19 May 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteosarcoma" returned 94 free, full-text review articles on human participants. First 3 results:

Present Advances and Future Perspectives of Molecular Targeted Therapy for Osteosarcoma.
 

Author(s): Atik Badshah Shaikh, Fangfei Li, Min Li, Bing He, Xiaojuan He, Guofen Chen, Baosheng Guo, Defang Li, Feng Jiang, Lei Dang, Shaowei Zheng, Chao Liang, Jin Liu, Cheng Lu, Biao Liu, Jun Lu, Luyao Wang, Aiping Lu, Ge Zhang

Journal:

 

Osteosarcoma (OS) is a bone cancer mostly occurring in pediatric population. Current treatment regime of surgery and intensive chemotherapy could cure about 60%-75% patients with primary osteosarcoma, however only 15% to 30% can be cured when pulmonary metastasis or relapse has taken ...

Last Updated: 9 Apr 2016

Go To URL
Total hip arthroplasty-related osteogenic osteosarcoma: case report and review of the literature.
 

Author(s): Rajko Kavalar, Samo K Fokter, Janez Lamovec

Journal:

 

Orthopedic implant-related sarcoma is an exceedingly rare, but a known complication of total hip arthroplasty (THA).

Last Updated: 2 Mar 2016

Go To URL
Osteosarcoma of larynx: A rare case report with review of literature.
 

Author(s): Amit Bahl, Philip George, Tapesh Bhattacharyya, Sushmita Ghoshal, Jaymanti Bakshi, Ashim Das

Journal: J Cancer Res Ther. ;11(4):1038.

 

Laryngeal osteosarcoma is an extremely rare and aggressive malignancy. Only very few cases of primary laryngeal osteosarcomas are reported in literature, and all have a dismal prognosis. A 50-year-old male presented with recurrent hoarseness of voice and was evaluated and diagnosed ...

Last Updated: 17 Feb 2016

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 2 Mar 2016

Go to URL

Last Updated: 8 Feb 2016

Go to URL
Combination of External Beam Radiotherapy With 153Sm-EDTMP to Treat High Risk Osteosarcoma
 

Status: Recruiting

Condition Summary: Metastatic Osteosarcoma

 

Last Updated: 20 Apr 2016

Go to URL