Osteosarcoma

Common Name(s)

Osteosarcoma

Osteosarcoma is the most common cancerous (malignant) bone tumor in youth. The average age at diagnosis is 15. Boys and girls have a similar incidence of this tumor until late adolescence, at which time boys are more commonly affected. In rare cases, osteosarcoma occurs in adults. The cause of osteosarcoma is not known. In some cases, it runs in families, and at least one gene has been linked to increased risk. Although osteosarcoma tends to occur in the larger bones, such as the shin (near the knee), thigh (near the knee) and upper arm (near the shoulder), it can occur in any bone. A number of variants of osteosarcoma exist, including conventional types (osteoblastic, chondroblastic, and fibroblastic), telangiectatic, multifocal, parosteal, and periosteal.  Treatment usually starts after a biopsy of the tumor and includes chemotherapy followed by surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteosarcoma" returned 2083 free, full-text research articles on human participants. First 3 results:

Andrographolide Induces Autophagic Cell Death and Inhibits Invasion and Metastasis of Human Osteosarcoma Cells in An Autophagy-Dependent Manner.
 

Author(s): Ying Liu, Yan Zhang, Jilong Zou, Lixin Yan, Xiufeng Yu, Peng Lu, Xiaomeng Wu, Qiaozhi Li, Rui Gu, Daling Zhu

Journal: Cell. Physiol. Biochem.. 2017 ;44(4):1396-1410.

 

Osteosarcoma (OS) is the most common primary malignant tumor of bone tissue. Although treatment effectiveness has improved, the OS survival rate has fluctuated in recent years. Andrographolide (AG) has been reported to have antitumor activity against a variety of tumors. Our aim was ...

Last Updated: 31 Dec 1969

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[Breast osteosarcoma originating in a phyllodes tumor. Report of one case].
 

Author(s): Tereza Nieto-Coronel, Jessica Elizabeth Salazar-Campos, David Cantú de León, Raúl Díaz-Molina, Rafael Vázquez-Romo, Enrique Bargalló-Rocha

Journal: Rev Med Chil. 2017 Aug;145(8):1076-1082.

 

Phyllodes tumors account for less than 1% of tumors of the mammary gland, have both epithelial and stromal components and are classified as benign, borderline and malignant. The malignant tumors are highly heterogeneous: they can differentiate to liposarcomas, fibrosarcomas, rhabdomyosarcomas, ...

Last Updated: 31 Dec 1969

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Therapeutic effect of neoadjuvant chemotherapy combined with curettage to treat distal femoral osteosarcoma: A case report.
 

Author(s): Qi Lai, Conglin Ye, Tian Gao, Jun Xiao, An Xie, Xuqiang Liu, Xiaolong Yu, Jun Liu, Min Dai, Hucheng Liu, Bin Zhang

Journal: Medicine (Baltimore). 2017 Nov;96(46):e8672.

 

Osteosarcoma is the most common malignant bone tumor in children and adolescents. Metastasis occurs early, the mortality rate is high, and the tumor results in a tremendous physical, mental, and economic burden on patients. Therefore, the treatment of osteosarcoma has been important ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteosarcoma" returned 114 free, full-text review articles on human participants. First 3 results:

Application of Long Noncoding RNAs in Osteosarcoma: Biomarkers and Therapeutic Targets.
 

Author(s): Zhihong Li, Pengcheng Dou, Tang Liu, Shasha He

Journal: Cell. Physiol. Biochem.. 2017 ;42(4):1407-1419.

 

Osteosarcoma is the most common primary bone malignancy in children and adolescents. Although improvements in therapeutic strategies were achieved, the outcome remains poor for most patients with metastatic or recurrent osteosarcoma. Therefore, it is imperative to identify novel and ...

Last Updated: 31 Dec 1969

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P16 protein expression as a useful predictive biomarker for neoadjuvant chemotherapy response in patients with high-grade osteosarcoma: A systematic meta-analysis under guideline of PRISMA.
 

Author(s): Yin Tang, Changchun Yang, Zonghui Guo, Youwei Fu, Xiao Yu, Binggen Liu, Haier Zhou, Junjie Wang, Weilong Li, Qingjiang Pang

Journal: Medicine (Baltimore). 2017 May;96(19):e6714.

 

Neoadjuvant chemotherapy for patients with high-grade osteosarcoma has highly improved the clinical survival. However, the prognostic and predictive role of P16 expression after neoadjuvant chemotherapy remains unclear. We first determined whether P16 expression can become a potential ...

Last Updated: 31 Dec 1969

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Tumor lysis syndrome in an extraskeletal osteosarcoma: a case report and review of the literature.
 

Author(s): Vito Emanuele Catania, Michele Vecchio, Michele Malaguarnera, Roberto Madeddu, Giulia Malaguarnera, Saverio Latteri

Journal:

 

This case report describes a spontaneous tumor lysis syndrome due to a rare solid tumor.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Osteosarcoma Biobank in Peking University People's Hospital
 

Status: Not yet recruiting

Condition Summary: Osteosarcoma

 

Last Updated: 2 Dec 2017

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Biology of Osteosarcoma (BOOST) Registry and Biobank
 

Status: Recruiting

Condition Summary: Osteosarcoma

 

Last Updated: 21 Jul 2017

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Last Updated: 9 Mar 2017

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