Osteosarcoma

Common Name(s)

Osteosarcoma

Osteosarcoma is the most common cancerous (malignant) bone tumor in youth. The average age at diagnosis is 15. Boys and girls have a similar incidence of this tumor until late adolescence, at which time boys are more commonly affected. In rare cases, osteosarcoma occurs in adults. The cause of osteosarcoma is not known. In some cases, it runs in families, and at least one gene has been linked to increased risk. Although osteosarcoma tends to occur in the larger bones, such as the shin (near the knee), thigh (near the knee) and upper arm (near the shoulder), it can occur in any bone. A number of variants of osteosarcoma exist, including conventional types (osteoblastic, chondroblastic, and fibroblastic), telangiectatic, multifocal, parosteal, and periosteal.  Treatment usually starts after a biopsy of the tumor and includes chemotherapy followed by surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteosarcoma" returned 1758 free, full-text research articles on human participants. First 3 results:

Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency.
 

Author(s): Michal Kovac, Claudia Blattmann, Sebastian Ribi, Jan Smida, Nikola S Mueller, Florian Engert, Francesc Castro-Giner, Joachim Weischenfeldt, Monika Kovacova, Andreas Krieg, Dimosthenis Andreou, Per-Ulf Tunn, Hans Roland Dürr, Hans Rechl, Klaus-Dieter Schaser, Ingo Melcher, Stefan Burdach, Andreas Kulozik, Katja Specht, Karl Heinimann, Simone Fulda, Stefan Bielack, Gernot Jundt, Ian Tomlinson, Jan O Korbel, Michaela Nathrath, Daniel Baumhoer

Journal:

 

Osteosarcomas are aggressive bone tumours with a high degree of genetic heterogeneity, which has historically complicated driver gene discovery. Here we sequence exomes of 31 tumours and decipher their evolutionary landscape by inferring clonality of the individual mutation events. ...

Last Updated: 3 Dec 2015

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CORR Insights(®): Transcriptional Profiling Identifies the Signaling Axes of IGF and Transforming Growth Factor-β as Involved in the Pathogenesis of Osteosarcoma.
 

Author(s): Elisabeth F P Peterse, Judith V M G Bovée

Journal: Clin. Orthop. Relat. Res.. 2016 Jan;474(1):190-2.

 

Last Updated: 22 Dec 2015

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[Low grade parosteal osteosarcoma. Clinical and oncological outcomes].
 

Author(s): José I Albergo, Germán L Farfalli, Miguel A Ayerza, Domingo L Muscolo, Luis A Aponte-Tinao

Journal: Medicina (B Aires). 2015 ;75(5):303-6.

 

The objective of the study was to analyze a group of patients with low grade parosteal osteosarcoma treated with limb salvage surgery and reconstructed with bone allograft. A retrospective review from our oncologic data base between 1980 and 2010 was done and all patients with diagnosis ...

Last Updated: 27 Oct 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteosarcoma" returned 86 free, full-text review articles on human participants. First 3 results:

Advances in osteosarcoma stem cell research and opportunities for novel therapeutic targets.
 

Author(s): Guang-Ning Yan, Yang-Fan Lv, Qiao-Nan Guo

Journal: Cancer Lett.. 2016 Jan;370(2):268-74.

 

Osteosarcoma is the most common type of bone cancer, especially in children and young adults. The primary treatment for osteosarcoma is a combination of surgery and chemotherapy, however prognoses remain poor due to chemoresistance and early metastases. Osteosarcoma stem cells appear ...

Last Updated: 18 Dec 2015

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Low-grade extraskeletal osteosarcoma of the mediastinum: report of a case and review of literature.
 

Author(s): Hong Yu, Zhendong Wu, Yongan Cui, Junxing Huang

Journal:

 

Extraskeletal osteosarcoma (ESOS) is a rare soft tissue sarcoma, typically characterized by a bone-producing neoplasm. Low-grade extraskeletal osteosarcoma (LGESOS) is an extremely rare soft tissue tumor, and patients with LGESOS tend to have a better prognosis. Here, we reported ...

Last Updated: 5 Jun 2015

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[Synchronous multicentric osteosarcoma: with multiple primary tumors or metastatic disease. Report of one case and literature review].
 

Author(s): L A Rossier-Guillot, R Tecualt-Gómez, R Amaya-Cepeda, M I Barrera-García

Journal: Acta Ortop Mex. ;28(3):179-82.

 

Synchronous multicentric osteosarcoma, is a tumor with presentation in two or more sites without the appearance of lung metastasis. The incidence is 1 to 3% of all osteosarcomas and only less than 100 cases have been documented in the literature. In our case, we are presenting a six ...

Last Updated: 29 May 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Denosumab in Treating Patients With Recurrent or Refractory Osteosarcoma
 

Status: Recruiting

Condition Summary: Childhood Osteosarcoma; Metastatic Osteosarcoma; Recurrent Osteosarcoma

 

Last Updated: 7 Jan 2016

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Study of Pazopanib in the Treatment of Osteosarcoma Metastatic to the Lung
 

Status: Recruiting

Condition Summary: Osteosarcoma; Metastatic Osteosarcoma

 

Last Updated: 5 Jan 2016

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Cabozantinib-s-malate in Treating Patients With Relapsed Osteosarcoma or Ewing Sarcoma
 

Status: Recruiting

Condition Summary: Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Metastatic Osteosarcoma; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Osteosarcoma

 

Last Updated: 5 Apr 2016

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