Osteosarcoma

Common Name(s)

Osteosarcoma

Osteosarcoma is the most common cancerous (malignant) bone tumor in youth. The average age at diagnosis is 15. Boys and girls have a similar incidence of this tumor until late adolescence, at which time boys are more commonly affected. In rare cases, osteosarcoma occurs in adults. The cause of osteosarcoma is not known. In some cases, it runs in families, and at least one gene has been linked to increased risk. Although osteosarcoma tends to occur in the larger bones, such as the shin (near the knee), thigh (near the knee) and upper arm (near the shoulder), it can occur in any bone. A number of variants of osteosarcoma exist, including conventional types (osteoblastic, chondroblastic, and fibroblastic), telangiectatic, multifocal, parosteal, and periosteal.  Treatment usually starts after a biopsy of the tumor and includes chemotherapy followed by surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

View Details

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteosarcoma" returned 2008 free, full-text research articles on human participants. First 3 results:

Chondroblastic osteosarcoma of the distal tibia: a rare case report.
 

Author(s): Aymen Ben Fredj, Lassaad Hassini, Aymen Fekih, Mohamed Allagui, Issam Aloui, Abderrazek Abid

Journal:

 

Chondroblastic osteosarcoma, representing about 25% of osteosarcoma, is a fatal primary malignancy of the skeleton if not diagnosed and treated appropriately. It most commonly occurs in the long bones of the extremities near the metaphyseal growth plates. In this report, we describe ...

Last Updated: 27 Jul 2017

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In vitro effect of microRNA-107 targeting Dkk-1 by regulation of Wnt/β-catenin signaling pathway in osteosarcoma.
 

Author(s): Zhi-Cai Zhang, Jian-Xiang Liu, Zeng-Wu Shao, Fei-Fei Pu, Bai-Chuan Wang, Qiang Wu, Yu-Kun Zhang, Xian-Lin Zeng, Xiao-Dong Guo, Shu-Hua Yang, Tong-Chuan He

Journal: Medicine (Baltimore). 2017 Jul;96(27):e7245.

 

The aim of the study was to explore the effects of microRNA-107 (miR-107) by targeting Dkk-1 on osteosarcoma (OS) via the Wnt/β-catenin signaling pathway.

Last Updated: 6 Jul 2017

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Wogonin suppresses stem cell-like traits of CD133 positive osteosarcoma cell via inhibiting matrix metallopeptidase-9 expression.
 

Author(s): Do Luong Huynh, Taeho Kwon, Jiao Jiao Zhang, Neelesh Sharma, Meeta Gera, Mrinmoy Ghosh, Nameun Kim, Somi Kim Cho, Dong Sun Lee, Yang Ho Park, Dong Kee Jeong

Journal:

 

Several efforts have been deployed to cure osteosarcoma, a high-grade malignant bone tumour in children and adolescents. However, some challenges such as drug resistance, relapse, and tumour metastasis remain owing to the existence of cancer stem cells (CSC). There is an urgent need ...

Last Updated: 13 Jun 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteosarcoma" returned 109 free, full-text review articles on human participants. First 3 results:

P16 protein expression as a useful predictive biomarker for neoadjuvant chemotherapy response in patients with high-grade osteosarcoma: A systematic meta-analysis under guideline of PRISMA.
 

Author(s): Yin Tang, Changchun Yang, Zonghui Guo, Youwei Fu, Xiao Yu, Binggen Liu, Haier Zhou, Junjie Wang, Weilong Li, Qingjiang Pang

Journal: Medicine (Baltimore). 2017 May;96(19):e6714.

 

Neoadjuvant chemotherapy for patients with high-grade osteosarcoma has highly improved the clinical survival. However, the prognostic and predictive role of P16 expression after neoadjuvant chemotherapy remains unclear. We first determined whether P16 expression can become a potential ...

Last Updated: 10 May 2017

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Tumor lysis syndrome in an extraskeletal osteosarcoma: a case report and review of the literature.
 

Author(s): Vito Emanuele Catania, Michele Vecchio, Michele Malaguarnera, Roberto Madeddu, Giulia Malaguarnera, Saverio Latteri

Journal:

 

This case report describes a spontaneous tumor lysis syndrome due to a rare solid tumor.

Last Updated: 24 Mar 2017

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What Is New in the miRNA World Regarding Osteosarcoma and Chondrosarcoma?
 

Author(s): Gaia Palmini, Francesca Marini, Maria Luisa Brandi

Journal:

 

Despite the availability of multimodal and aggressive therapies, currently patients with skeletal sarcomas, including osteosarcoma and chondrosarcoma, often have a poor prognosis. In recent decades, advances in sequencing technology have revealed the presence of RNAs without coding ...

Last Updated: 8 Mar 2017

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Biology of Osteosarcoma (BOOST) Registry and Biobank
 

Status: Recruiting

Condition Summary: Osteosarcoma

 

Last Updated: 21 Jul 2017

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Last Updated: 17 Mar 2017

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Last Updated: 9 Mar 2017

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