Osteosarcoma

Common Name(s)

Osteosarcoma

Osteosarcoma is the most common cancerous (malignant) bone tumor in youth. The average age at diagnosis is 15. Boys and girls have a similar incidence of this tumor until late adolescence, at which time boys are more commonly affected. In rare cases, osteosarcoma occurs in adults. The cause of osteosarcoma is not known. In some cases, it runs in families, and at least one gene has been linked to increased risk. Although osteosarcoma tends to occur in the larger bones, such as the shin (near the knee), thigh (near the knee) and upper arm (near the shoulder), it can occur in any bone. A number of variants of osteosarcoma exist, including conventional types (osteoblastic, chondroblastic, and fibroblastic), telangiectatic, multifocal, parosteal, and periosteal.  Treatment usually starts after a biopsy of the tumor and includes chemotherapy followed by surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteosarcoma" returned 1330 free, full-text research articles on human participants. First 3 results:

Last Updated: 5 Jun 2015

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[Ganoderic acid A suppresses proliferation and invasion and induces apoptosis in human osteosarcoma cells].
 

Author(s): Jianli Shao, Zhizhong Li, Genlong Jiao, Guodong Sun, Zhigang Zhou

Journal: Nan Fang Yi Ke Da Xue Xue Bao. 2015 May;35(5):619-24.

 

To investigate the effect of ganoderic acid A (GA-A) on the biological behaviors of human osteosarcoma cells in vitro.

Last Updated: 28 May 2015

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Patterns of care and outcomes of adult osteosarcoma in a tertiary care cancer centre in Pakistan.
 

Author(s): Saba Imtiaz, Ather Kazmi

Journal: J Pak Med Assoc. 2014 Oct;64(10):1166-70.

 

To present our experience of treatment outcomes in adult osteosarcoma patients.

Last Updated: 31 Mar 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteosarcoma" returned 59 free, full-text review articles on human participants. First 3 results:

Aurora-A kinase: potential tumor marker of osteosarcoma.
 

Author(s): Xiaozhong Zhu, Jiong Mei, Zhiyuan Wang

Journal: J Cancer Res Ther. 2014 Nov;10 Suppl():C102-7.

 

Aurora kinase family is a group of serine/threonine protein kinase. It is the main regulator in mitosis, including centrosome regulation, spindle formation, and chromosome separation. Aurora-A is an oncogene that is highly expressed in various human tumors, including osteosarcoma. ...

Last Updated: 2 Dec 2014

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Prognostic value of p53 alterations in human osteosarcoma: a meta analysis.
 

Author(s): Dong Yao, Guo-Hong Cai, Jing Chen, Rui Ling, Sheng-Xi Wu, Yong-Ping Li

Journal:

 

Tumor suppressor gene p53 functions as the guardian of the human genome and mutations in p53 contribute to cancer development. However, studies that investigated the potential of p53 as a prognostic marker in osteosarcoma patients have yielded inconclusive results. Based on recommendation ...

Last Updated: 17 Nov 2014

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P16INK4a overexpression and survival in osteosarcoma patients: a meta analysis.
 

Author(s): Jie Bu, Hui Li, Li-Hong Liu, Yu-Rong Ouyang, Hong-Bin Guo, Xiao-Yang Li, Tao Xiao

Journal:

 

Osteosarcoma is one of the most common primary bone malignancies. Although there is a significant improvement of survival on osteosarcoma patients in the past decades, treatment of osteosarcoma is still unsatisfactory for the development of pulmonary metastasis. The potential prognostic ...

Last Updated: 22 Oct 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Blood Samples From Patients With Osteosarcoma
 

Status: Recruiting

Condition Summary: Localized Osteosarcoma; Metastatic Osteosarcoma; Recurrent Osteosarcoma

 

Last Updated: 12 May 2015

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Denosumab in Treating Patients With Recurrent or Refractory Osteosarcoma
 

Status: Not yet recruiting

Condition Summary: Childhood Osteosarcoma; Metastatic Osteosarcoma; Recurrent Osteosarcoma

 

Last Updated: 10 Jun 2015

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Study of Pazopanib in the Treatment of Osteosarcoma Metastatic to the Lung
 

Status: Recruiting

Condition Summary: Osteosarcoma; Metastatic Osteosarcoma

 

Last Updated: 6 Jul 2015

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