Osteosarcoma

Common Name(s)

Osteosarcoma

Osteosarcoma is the most common cancerous (malignant) bone tumor in youth. The average age at diagnosis is 15. Boys and girls have a similar incidence of this tumor until late adolescence, at which time boys are more commonly affected. In rare cases, osteosarcoma occurs in adults. The cause of osteosarcoma is not known. In some cases, it runs in families, and at least one gene has been linked to increased risk. Although osteosarcoma tends to occur in the larger bones, such as the shin (near the knee), thigh (near the knee) and upper arm (near the shoulder), it can occur in any bone. A number of variants of osteosarcoma exist, including conventional types (osteoblastic, chondroblastic, and fibroblastic), telangiectatic, multifocal, parosteal, and periosteal.  Treatment usually starts after a biopsy of the tumor and includes chemotherapy followed by surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteosarcoma" returned 1942 free, full-text research articles on human participants. First 3 results:

Long-term survival after sporadic and delayed metastases of conventional osteosarcoma: A case report.
 

Author(s): Tadahiko Kubo, Taisuke Furuta, Muhammad P Johan, Masaaki Yoshizuka, Mitsuo Ochi, Nobuo Adachi

Journal: Medicine (Baltimore). 2017 May;96(18):e6824.

 

Histologically conventional osteosarcoma, once metastasized to the lung, generally causes a rapid and fatal outcome. Osteosarcoma metastasis to the gastrointestinal tract is extremely rare.We report herein a case of osteoblastic osteosarcoma with exceptionally unique features: sporadic ...

Last Updated: 4 May 2017

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Distinct activity of the bone-targeted gallium compound KP46 against osteosarcoma cells - synergism with autophagy inhibition.
 

Author(s): Bernd Kubista, Thomas Schoefl, Lisa Mayr, Sushilla van Schoonhoven, Petra Heffeter, Reinhard Windhager, Bernhard K Keppler, Walter Berger

Journal:

 

Osteosarcoma is the most frequent primary malignant bone tumor. Although survival has distinctly increased due to neoadjuvant chemotherapy in the past, patients with metastatic disease and poor response to chemotherapy still have an adverse prognosis. Hence, development of new therapeutic ...

Last Updated: 13 Apr 2017

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A case report of apatinib in treating osteosarcoma with pulmonary metastases.
 

Author(s): Yong Zhou, Wengeng Zhang, Fan Tang, Yi Luo, Li Min, Wenli Zhang, Rui Shi, Hong Duan, Chongqi Tu

Journal: Medicine (Baltimore). 2017 Apr;96(15):e6578.

 

Osteosarcoma is the most common malignant bone tumor in children and adolescents. Pulmonary metastases lead to a significantly increased risk of death. Apatinib, a new potent oral small-molecule tyrosine kinase inhibitor targeting the intracellular domain of vascular endothelial growth ...

Last Updated: 13 Apr 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteosarcoma" returned 106 free, full-text review articles on human participants. First 3 results:

P16 protein expression as a useful predictive biomarker for neoadjuvant chemotherapy response in patients with high-grade osteosarcoma: A systematic meta-analysis under guideline of PRISMA.
 

Author(s): Yin Tang, Changchun Yang, Zonghui Guo, Youwei Fu, Xiao Yu, Binggen Liu, Haier Zhou, Junjie Wang, Weilong Li, Qingjiang Pang

Journal: Medicine (Baltimore). 2017 May;96(19):e6714.

 

Neoadjuvant chemotherapy for patients with high-grade osteosarcoma has highly improved the clinical survival. However, the prognostic and predictive role of P16 expression after neoadjuvant chemotherapy remains unclear. We first determined whether P16 expression can become a potential ...

Last Updated: 10 May 2017

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What Is New in the miRNA World Regarding Osteosarcoma and Chondrosarcoma?
 

Author(s): Gaia Palmini, Francesca Marini, Maria Luisa Brandi

Journal:

 

Despite the availability of multimodal and aggressive therapies, currently patients with skeletal sarcomas, including osteosarcoma and chondrosarcoma, often have a poor prognosis. In recent decades, advances in sequencing technology have revealed the presence of RNAs without coding ...

Last Updated: 8 Mar 2017

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A meta-analysis of randomized control trials of surgical methods with osteosarcoma outcomes.
 

Author(s): Xiaojun He, Zhenzhen Gao, Hongwei Xu, Zhongwei Zhang, Peng Fu

Journal:

 

Osteosarcoma is a high malignant neoplasm, and conflicting findings have been reported on the survival and function recovery of osteosarcoma patients experiencing limb salvage or amputation. In the present study, we compared limb salvage surgery (LSS) with amputation in clinical outcomes ...

Last Updated: 14 Jan 2017

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 17 Mar 2017

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Last Updated: 9 Mar 2017

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Combination of External Beam Radiotherapy With 153Sm-EDTMP to Treat High Risk Osteosarcoma
 

Status: Recruiting

Condition Summary: Metastatic Osteosarcoma

 

Last Updated: 21 Mar 2017

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