Osteosarcoma

Common Name(s)

Osteosarcoma

Osteosarcoma is the most common cancerous (malignant) bone tumor in youth. The average age at diagnosis is 15. Boys and girls have a similar incidence of this tumor until late adolescence, at which time boys are more commonly affected. In rare cases, osteosarcoma occurs in adults. The cause of osteosarcoma is not known. In some cases, it runs in families, and at least one gene has been linked to increased risk. Although osteosarcoma tends to occur in the larger bones, such as the shin (near the knee), thigh (near the knee) and upper arm (near the shoulder), it can occur in any bone. A number of variants of osteosarcoma exist, including conventional types (osteoblastic, chondroblastic, and fibroblastic), telangiectatic, multifocal, parosteal, and periosteal.  Treatment usually starts after a biopsy of the tumor and includes chemotherapy followed by surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

View Details

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteosarcoma" returned 1669 free, full-text research articles on human participants. First 3 results:

Extraskeletal Osteosarcoma of the Omentum with Aggressive Development.
 

Author(s): Y Asenov, B Stefanov, B Korukov, V Tihtchev, V Hadzhiysca, D Damianov

Journal: Chirurgia (Bucur). ;110(4):384-6.

 

For the first time extraskeletal osteosarcomas (ESOS) were described by Wilson in 1941. They are extremely rare neoplasms, presenting 4% of all osteosarcomas and 1,2% of all soft-tissue sarcomas. About 300 cases have been reported in the literature up to date. We present a 66-year-old ...

Last Updated: 26 Aug 2015

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Comments on Bu et al. "P16(INK₄a) overexpression and survival in osteosarcoma patients: a meta analysis".
 

Author(s): Ming-Ming Yan, Jiang-Dong Ni

Journal:

 

Recently, we read the article "P16(INK4a) overexpression and survival in osteosarcoma patients: a meta analysis" by Jie Bu and his colleagues, published in the recent issue of International Journal Of Experimental Pathology. This research performed a meta-analysis to uncover the role ...

Last Updated: 11 Aug 2015

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Osteoprotegerin activates osteosarcoma cells that co-express RANK and RANKL.
 

Author(s): Kevin Marley, Shay Bracha, Bernard Seguin

Journal: Exp. Cell Res.. 2015 Oct;338(1):32-8.

 

Osteosarcoma (OS) is an aggressive and often fatal cancer that afflicts over 1000 humans and 10,000 dogs per year in the United States. Recent evidence suggests deregulation in the signaling triad, receptor activator of nuclear factor kappa B (RANK), its activating ligand (RANKL), ...

Last Updated: 29 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteosarcoma" returned 82 free, full-text review articles on human participants. First 3 results:

Systemic therapy for osteosarcoma and Ewing sarcoma.
 

Author(s): Paul A Meyers

Journal: Am Soc Clin Oncol Educ Book. 2015 ;():e644-7.

 

Curative therapy for both osteosarcoma and Ewing sarcoma requires the combination of effective systemic therapy and local control of all macroscopic tumors. Systemic therapy for osteosarcoma consists of multiagent chemotherapy. The most common regimen uses cisplatin, doxorubicin, ...

Last Updated: 21 May 2015

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Correlations of ezrin expression with pathological characteristics and prognosis of osteosarcoma: a meta-analysis.
 

Author(s): Da-Hang Zhao, Jiang Zhu, Wen-Bo Wang, Feng Dong, Qiao Zhang, Hong-Wu Fan, Jing-Zhe Zhang, Yong-Ming Wang

Journal: ScientificWorldJournal. 2014 ;2014():837543.

 

We conducted a meta-analysis to comprehensively evaluate the correlations of ezrin expression with pathological characteristics and the prognosis of osteosarcoma. The MEDLINE (1966-2013), the Cochrane Library Database, EMBASE, CINAHL, Web of Science (1945-2013), and the Chinese Biomedical ...

Last Updated: 29 Dec 2014

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Aurora-A kinase: potential tumor marker of osteosarcoma.
 

Author(s): Xiaozhong Zhu, Jiong Mei, Zhiyuan Wang

Journal: J Cancer Res Ther. 2014 Nov;10 Suppl():C102-7.

 

Aurora kinase family is a group of serine/threonine protein kinase. It is the main regulator in mitosis, including centrosome regulation, spindle formation, and chromosome separation. Aurora-A is an oncogene that is highly expressed in various human tumors, including osteosarcoma. ...

Last Updated: 2 Dec 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Blood Samples From Patients With Osteosarcoma
 

Status: Recruiting

Condition Summary: Localized Osteosarcoma; Metastatic Osteosarcoma; Recurrent Osteosarcoma

 

Last Updated: 16 Nov 2015

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Denosumab in Treating Patients With Recurrent or Refractory Osteosarcoma
 

Status: Recruiting

Condition Summary: Childhood Osteosarcoma; Metastatic Osteosarcoma; Recurrent Osteosarcoma

 

Last Updated: 7 Jan 2016

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Study of Pazopanib in the Treatment of Osteosarcoma Metastatic to the Lung
 

Status: Recruiting

Condition Summary: Osteosarcoma; Metastatic Osteosarcoma

 

Last Updated: 5 Jan 2016

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