Osteosarcoma

Common Name(s)

Osteosarcoma

Osteosarcoma is the most common cancerous (malignant) bone tumor in youth. The average age at diagnosis is 15. Boys and girls have a similar incidence of this tumor until late adolescence, at which time boys are more commonly affected. In rare cases, osteosarcoma occurs in adults. The cause of osteosarcoma is not known. In some cases, it runs in families, and at least one gene has been linked to increased risk. Although osteosarcoma tends to occur in the larger bones, such as the shin (near the knee), thigh (near the knee) and upper arm (near the shoulder), it can occur in any bone. A number of variants of osteosarcoma exist, including conventional types (osteoblastic, chondroblastic, and fibroblastic), telangiectatic, multifocal, parosteal, and periosteal.  Treatment usually starts after a biopsy of the tumor and includes chemotherapy followed by surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteosarcoma" returned 1904 free, full-text research articles on human participants. First 3 results:

(Z)-3,4,3',5'-tetramethoxystilbene, a natural product, induces apoptosis and reduces viability of paclitaxel-and cisplatin-resistant osteosarcoma cells.
 

Author(s): Huiqing Xu

Journal: J Cancer Res Ther. ;12(4):1261-1265.

 

Osteosarcoma is a common bone tumor and the development of drug resistance in therapy of osteosarcoma is a general rule. The natural compounds isolated from medicinal plants represent a valuable resource for anticancer therapeutics. (Z)-3,4,3', '-tetramethoxystilbene is one of them. ...

Last Updated: 7 Feb 2017

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Transcription Factor SOX9 Promotes Osteosarcoma Cell Growth by Repressing Claudin-8 Expression.
 

Author(s): Jin Qi, Yaoqi Yang, Ping Hao, Jianqiang Xu

Journal: Tohoku J. Exp. Med.. 2017 ;241(1):55-63.

 

Osteosarcoma is a malignant bone cancer that mainly affects children. SOX9 plays a key role in bone formation and osteosarcoma, and Claudin-8 (CLDN8), a tight junction protein, contributes to proliferation of osteosarcoma cells. The aim of this study was to investigate the relationship ...

Last Updated: 26 Jan 2017

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Sacral Reconstruction with a 3D-Printed Implant after Hemisacrectomy in a Patient with Sacral Osteosarcoma: 1-Year Follow-Up Result.
 

Author(s): Doyoung Kim, Jun Young Lim, Kyu Won Shim, Jung Woo Han, Seong Yi, Do Heum Yoon, Keung Nyun Kim, Yoon Ha, Gyu Yeul Ji, Dong Ah Shin

Journal: Yonsei Med. J.. 2017 Mar;58(2):453-457.

 

Pelvic reconstruction after sacral resection is challenging in terms of anatomical complexity, excessive loadbearing, and wide defects. Nevertheless, the technological development of 3D-printed implants enables us to overcome these difficulties. Here, we present a case of sacral osteosarcoma ...

Last Updated: 25 Jan 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteosarcoma" returned 97 free, full-text review articles on human participants. First 3 results:

Parathyroid hormone/parathyroid hormone-related peptide regulate osteosarcoma cell functions: Focus on the extracellular matrix (Review).
 

Author(s): Dragana Nikitovic, Rafaela-Maria Kavasi, Aikaterini Berdiaki, Dionysios J Papachristou, John Tsiaoussis, Demetrios A Spandidos, Aristides M Tsatsakis, George N Tzanakakis

Journal: Oncol. Rep.. 2016 Oct;36(4):1787-92.

 

Osteosarcoma (OS) is a primary bone tumor of mesenchymal origin mostly affecting children and adolescents. The OS extracellular matrix (ECM) is extensively altered as compared to physiological bone tissue. Indeed, the main characteristic of the most common osteoblastic subtype of ...

Last Updated: 16 Sep 2016

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HER-2 expression in biopsy and surgical specimen on prognosis of osteosarcoma: A systematic review and meta-analysis of 16 studies.
 

Author(s): Qingyu Zhang, Fanxiao Liu, Bomin Wang, Zhenfeng Li, Dongsheng Zhou, Qiang Yang, Jinlei Dong, Jianmin Li

Journal: Medicine (Baltimore). 2016 Jun;95(23):e3661.

 

Numerous original clinical studies have attempted to investigate the prognostic value of HER-2 overexpression in osteosarcoma, but the results of these studies are not consistent. This meta-analysis and systematic review was performed to further assess the correlation between HER-2 ...

Last Updated: 10 Jun 2016

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Present Advances and Future Perspectives of Molecular Targeted Therapy for Osteosarcoma.
 

Author(s): Atik Badshah Shaikh, Fangfei Li, Min Li, Bing He, Xiaojuan He, Guofen Chen, Baosheng Guo, Defang Li, Feng Jiang, Lei Dang, Shaowei Zheng, Chao Liang, Jin Liu, Cheng Lu, Biao Liu, Jun Lu, Luyao Wang, Aiping Lu, Ge Zhang

Journal:

 

Osteosarcoma (OS) is a bone cancer mostly occurring in pediatric population. Current treatment regime of surgery and intensive chemotherapy could cure about 60%-75% patients with primary osteosarcoma, however only 15% to 30% can be cured when pulmonary metastasis or relapse has taken ...

Last Updated: 9 Apr 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 17 Mar 2017

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Last Updated: 9 Mar 2017

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Last Updated: 8 Feb 2016

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