Osteosarcoma

Common Name(s)

Osteosarcoma

Osteosarcoma is the most common cancerous (malignant) bone tumor in youth. The average age at diagnosis is 15. Boys and girls have a similar incidence of this tumor until late adolescence, at which time boys are more commonly affected. In rare cases, osteosarcoma occurs in adults. The cause of osteosarcoma is not known. In some cases, it runs in families, and at least one gene has been linked to increased risk. Although osteosarcoma tends to occur in the larger bones, such as the shin (near the knee), thigh (near the knee) and upper arm (near the shoulder), it can occur in any bone. A number of variants of osteosarcoma exist, including conventional types (osteoblastic, chondroblastic, and fibroblastic), telangiectatic, multifocal, parosteal, and periosteal.  Treatment usually starts after a biopsy of the tumor and includes chemotherapy followed by surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Logo
Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteosarcoma" returned 1237 free, full-text research articles on human participants. First 3 results:

Meta-analysis of differentially expressed genes in osteosarcoma based on gene expression data.
 

Author(s): Zuozhang Yang, Yongbin Chen, Yu Fu, Yihao Yang, Ya Zhang, Yanjin Chen, Dongqi Li

Journal:

 

To uncover the genes involved in the development of osteosarcoma (OS), we performed a meta-analysis of OS microarray data to identify differentially expressed genes (DEGs) and biological functions associated with gene expression changes between OS and normal control (NC) tissues.

Last Updated: 25 Jul 2014

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Reticulated hyperpigmentation following chemotherapy for radiation-induced osteosarcoma.
 

Author(s): Catherine A Necessary, David Roffwarg, Darrel Ellis

Journal: J. Am. Acad. Dermatol.. 2014 Jul;71(1):e23-4.

 

Last Updated: 20 Jun 2014

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Structuring osteosarcoma knowledge: an osteosarcoma-gene association database based on literature mining and manual annotation.
 

Author(s): Kathrin Poos, Jan Smida, Michaela Nathrath, Doris Maugg, Daniel Baumhoer, Anna Neumann, Eberhard Korsching

Journal:

 

Osteosarcoma (OS) is the most common primary bone cancer exhibiting high genomic instability. This genomic instability affects multiple genes and microRNAs to a varying extent depending on patient and tumor subtype. Massive research is ongoing to identify genes including their gene ...

Last Updated: 28 May 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteosarcoma" returned 55 free, full-text review articles on human participants. First 3 results:

Extraskeletal osteosarcoma: a case report and review of the literature.
 

Author(s): Michael Hoch, Sayed Ali, Shefali Agrawal, Congli Wang, Jasvir S Khurana

Journal:

 

We report an instructive case of extraskeletal osteosarcoma in a 63-year-old African American male who presented after an episode of recent trauma, with clinical and radiological features characteristic of this neoplasm. Osteosarcoma is the most common primary malignant tumor of bone ...

Last Updated: 14 Jan 2014

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Osteosarcoma tumor thrombus: a case report with a review of the literature.
 

Author(s): Pournima Navalkele, Sarah M Jones, Jason K Jones, Jorge D Salazar, Patrick C Toy, Rathi V Iyer, Betty Herrington

Journal: Tex Heart Inst J. 2013 ;40(1):75-8.

 

Tumor thrombus arising from osteosarcoma is rare. We report the case of a 20-year-old man with proximal humerus osteosarcoma, accompanied by an extensive intravascular tumor thrombus extending into the heart. Our review of the literature found 14 previous reports on osteosarcoma with ...

Last Updated: 7 Mar 2013

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Synchronous multifocal osteosarcoma with hypocalcemia.
 

Author(s): Li-Feng Qin, Han Fang, Li-Hua Qin, Xiao-ning Guo, Dan Peng

Journal: Libyan J Med. 2013 ;8():.

 

Last Updated: 6 Mar 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Blood Samples From Patients With Osteosarcoma
 

Status: Recruiting

Condition Summary: Localized Osteosarcoma; Metastatic Osteosarcoma; Recurrent Osteosarcoma

 

Last Updated: 5 Aug 2014

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Biomarker Expression in Tissue Samples From Patients With Bone Sarcomas
 

Status: Recruiting

Condition Summary: Localized Osteosarcoma; Metastatic Osteosarcoma; Recurrent Osteosarcoma

 

Last Updated: 5 Aug 2014

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Study of Pazopanib in the Treatment of Osteosarcoma Metastatic to the Lung
 

Status: Recruiting

Condition Summary: Osteosarcoma; Metastatic Osteosarcoma

 

Last Updated: 17 Jun 2014

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