Osteonecrosis

Common Name(s)

Osteonecrosis

Osteonecrosis is when there is a lack of blood flow to bones in the joints. Osteonecrosis is most common in people ages 30-50. In healthy people, new bone is always replacing old bone. However those with osteonecrosis, have a breakdown of old bone faster than formation of new bone because of reduced blood flow. Osteonecrosis is most common in the upper leg, but also occurs in the upper arm, knees, shoulders, and ankles. The cause of osteonecrosis is unknown but risk factors include long-term steroid treatment, alcohol abuse, joint injuries, arthritis, and some cancers.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteonecrosis" for support, advocacy or research.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteonecrosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteonecrosis" returned 472 free, full-text research articles on human participants. First 3 results:

Last Updated: 11 Jun 2015

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Treatment with acetylsalicylic acid prevents short to mid-term radiographic progression of nontraumatic osteonecrosis of the femoral head: a pilot study.
 

Author(s): Anthony Albers, Alberto Carli, Bertrand Routy, Edward J Harvey, Chantal Séguin

Journal: Can J Surg. 2015 Jun;58(3):198-205.

 

Nontraumatic osteonecrosis of the femoral head (ONFH) is a progressive disease in young adults producing substantial morbidity and frequently resulting in total hip arthroplasty. Although hip-preserving surgical procedures represent the current mainstay of treatment for early disease, ...

Last Updated: 27 May 2015

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Temporal Trends in Characteristics of Newly Diagnosed Nontraumatic Osteonecrosis of the Femoral Head From 1997 to 2011: A Hospital-Based Sentinel Monitoring System in Japan.
 

Author(s): Shinji Takahashi, Wakaba Fukushima, Takuaki Yamamoto, Yukihide Iwamoto, Toshikazu Kubo, Nobuhiko Sugano, Yoshio Hirota,

Journal: J Epidemiol. 2015 ;25(6):437-44.

 

Nontraumatic osteonecrosis of the femoral head (ONFH) is a rare disorder caused by ischemic necrosis of unknown etiology. A few studies have demonstrated trends in the number of patients with ONFH. However, there are no data on temporal trends in characteristics such as age, gender, ...

Last Updated: 30 Jul 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteonecrosis" returned 60 free, full-text review articles on human participants. First 3 results:

Efficacy of alendronate for preventing collapse of femoral head in adult patients with nontraumatic osteonecrosis.
 

Author(s): Yu-Cai Hong, Ru-Bin Luo, Tiao Lin, Hui-Ming Zhong, Jian-Bin Shi

Journal: Biomed Res Int. 2014 ;2014():716538.

 

The purpose of the current review was to determine the efficacy of alendronate for preventing collapse of femoral head in adult patients with nontraumatic avascular osteonecrosis of femoral head (ANFH). Five randomized controlled trials (RCTs) involving 305 hips were included in this ...

Last Updated: 23 Dec 2014

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Management and treatment of osteonecrosis in children and adolescents with acute lymphoblastic leukemia.
 

Author(s): Mariël L Te Winkel, Rob Pieters, Ernst-Jan D Wind, J H J M Gert Bessems, Marry M van den Heuvel-Eibrink

Journal: Haematologica. 2014 Mar;99(3):430-6.

 

There is no consensus regarding how to manage osteonecrosis in pediatric acute lymphoblastic leukemia patients. Therefore, we performed a quality assessment of the literature with the result of a search strategy using the MESH terms osteonecrosis, children, childhood cancer, surgery, ...

Last Updated: 6 Mar 2014

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Epidemiology, clinical manifestations, risk reduction and treatment strategies of jaw osteonecrosis in cancer patients exposed to antiresorptive agents.
 

Author(s): Giuseppina Campisi, Stefano Fedele, Vittorio Fusco, Giuseppe Pizzo, Olga Di Fede, Alberto Bedogni

Journal: Future Oncol. 2014 Feb;10(2):257-75.

 

 Osteonecrosis of the jaws (ONJ) is an adverse side event of bisphosphonates and denosumab, antiresorptive agents that effectively reduce the incidence of skeletal-related events in patients with metastatic bone cancer and multiple myeloma. Available data suggest that 0-27.5% of ...

Last Updated: 4 Feb 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Osteonecrosis of the Hip and Bisphosphonate Treatment
 

Status: Recruiting

Condition Summary: Osteonecrosis

 

Last Updated: 11 Jan 2013

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Osteonecrosis in Children With Acute Lymphoblastic Leukemia
 

Status: Recruiting

Condition Summary: Osteonecrosis; Acute Lymphoblastic Leukemia

 

Last Updated: 14 Apr 2010

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Osteonecroses in Pediatric Patients With ALL
 

Status: Recruiting

Condition Summary: Osteonecrosis; Acute Lymphoblastic Leukaemia; Lymphoblastic Lymphoma

 

Last Updated: 4 Mar 2014

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