Osteonecrosis

Common Name(s)

Osteonecrosis

Osteonecrosis is a disease caused by reduced blood flow to the bones. In healthy people, new bone is constantly growing to replace old bone. In people affected by osteonecrosis, new bone is not able to grow and replace old bones because of the reduced blood supply. This leads to a reduction in the amount of bone, which causes pain and limits mobility in joints. Osteonecrosis can affect anyone, but people who are between age 30-50 are most often affected.

The cause of osteonecrosis is reduced blood flow, but the cause of the reduction in blood flow is not always known. Some common causes include alcohol use, steroid medications, injury, and increased pressure in the bones. Major risk factors for osteonecrosis include having undergone chemotherapy and radiation treatments and having had an organ transplant. Certain diseases, such as cancer, lupus, HIV, and many others, also increase the risk for osteonecrosis. Others will develop osteonecrosis due to unknown causes, even without these risk factors.

The symptoms of osteonecrosis are joint pain and, depending on the severity, inability to use a joint. The disease may show no symptoms at all in the early stages, and worsening pain will result as the disease progresses. Treatment is usually based around maintaining function of the affected joints. Without any treatment, the disease will cause progressive loss of mobility. Seeking treatment as soon as possible is important to maintain joint function. Research is currently being done to learn more about the disease. Support groups are also available for more resources and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteonecrosis" for support, advocacy or research.

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteonecrosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteonecrosis" returned 582 free, full-text research articles on human participants. First 3 results:

A 10-Year Follow-Up of Two-Incision and Modified Watson-Jones Total Hip Arthroplasty in Patients with Osteonecrosis of the Femoral Head.
 

Author(s): Shih-Jie Lin, Tsan-Wen Huang, Po-Chun Lin, Feng-Chih Kuo, Kuo-Ti Peng, Kuo-Chin Huang, Mel S Lee

Journal: Biomed Res Int. 2017 ;2017():8915104.

 

Long-term data and information indicating whether minimally invasive surgery (MIS) approaches are safe and effective with total hip arthroplasty (THA) are lacking. Between 2004 and 2006, 75 patients with alcohol-related osteonecrosis of the femoral head (ONFH) who underwent 75 THAs ...

Last Updated: 7 Apr 2017

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[Clinical analysis of bisphosphonate-related osteonecrosis of the jaw].
 

Author(s): Gong Jiaxing, Wang Huiming

Journal: Hua Xi Kou Qiang Yi Xue Za Zhi. 2016 Aug;34(4):358-363.

 

The study aims to analyze patients with bisphosphonate-related osteonecrosis of the jaw (BRONJ).

Last Updated: 20 Mar 2017

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Significant Associations of SOX9 Gene Polymorphism and Gene Expression with the Risk of Osteonecrosis of the Femoral Head in a Han Population in Northern China.
 

Author(s): Yang Song, Zhenwu Du, Ming Ren, Qiwei Yang, Yujie Sui, Qingyu Wang, Ao Wang, Haiyue Zhao, Jincheng Wang, Guizhen Zhang

Journal: Biomed Res Int. 2016 ;2016():5695317.

 

Sex determining region Y-box 9 (SOX9) is a key transcription factor involved in cartilage formation during the embryonic development stage and cartilage growth and repair after birth. To explore the roles of polymorphism and expression of the SOX9 gene in the development of osteonecrosis ...

Last Updated: 16 Jan 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteonecrosis" returned 71 free, full-text review articles on human participants. First 3 results:

[Research progress on bisphosphonate-related osteonecrosis of the jaws].
 

Author(s): Pan Jian, Wang Qizhang, Liu Jiyuan

Journal: Hua Xi Kou Qiang Yi Xue Za Zhi. 2017 Feb;35(1):29-36.

 

Bisphosphonates (BPs), as potent drugs inhibiting bone resorption, have been widely used for treatment of several diseases. In recent years, dentists and oral and maxillofacial surgeons reported continuously increasing cases of bisphosphonate-related osteonecrosis of the jaws (BRONJ). ...

Last Updated: 22 Mar 2017

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Extracorporeal shockwave therapy in osteonecrosis of femoral head: A systematic review of now available clinical evidences.
 

Author(s): Qingyu Zhang, Lihua Liu, Wei Sun, Fuqiang Gao, Liming Cheng, Zirong Li

Journal: Medicine (Baltimore). 2017 Jan;96(4):e5897.

 

Osteonecrosis is an incapacitating disorder with high morbidity. Though extracorporeal shockwave therapy (ESWT) provides a noninvasive treatment option, controversial subjects still exist about its effectiveness, indications, and mechanism of action.

Last Updated: 25 Jan 2017

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Stem Cell Therapy for the Treatment of Hip Osteonecrosis: A 30-Year Review of Progress.
 

Author(s): Philippe Hernigou, Matthieu Trousselier, Fran├žois Roubineau, Charlie Bouthors, Nathalie Chevallier, Helene Rouard, Charles-Henri Flouzat-Lachaniette

Journal: Clin Orthop Surg. 2016 Mar;8(1):1-8.

 

Avascular necrosis of the femoral head is caused by a multitude of etiologic factors and is associated with collapse with a risk of hip arthroplasty in younger populations. A focus on early disease management with the use of stem cells was proposed as early as 1985 by the senior author ...

Last Updated: 1 Mar 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Imaging of Osteonecrosis With Ferumoxytol-Enhanced MRI
 

Status: Recruiting

Condition Summary: Osteonecrosis

 

Last Updated: 2 Sep 2016

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The British Osteonecrosis Study
 

Status: Not yet recruiting

Condition Summary: Osteonecrosis

 

Last Updated: 18 May 2016

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Randomized Clinical Trial for the Treatment of Osteonecrosis of the Femoral Head
 

Status: Recruiting

Condition Summary: Osteonecrosis

 

Last Updated: 7 Mar 2016

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