Osteonecrosis

Common Name(s)

Osteonecrosis

Osteonecrosis is a disease caused by reduced blood flow to the bones. In healthy people, new bone is constantly growing to replace old bone. In people affected by osteonecrosis, new bone is not able to grow and replace old bones because of the reduced blood supply. This leads to a reduction in the amount of bone, which causes pain and limits mobility in joints. Osteonecrosis can affect anyone, but people who are between age 30-50 are most often affected.

The cause of osteonecrosis is reduced blood flow, but the cause of the reduction in blood flow is not always known. Some common causes include alcohol use, steroid medications, injury, and increased pressure in the bones. Major risk factors for osteonecrosis include having undergone chemotherapy and radiation treatments and having had an organ transplant. Certain diseases, such as cancer, lupus, HIV, and many others, also increase the risk for osteonecrosis. Others will develop osteonecrosis due to unknown causes, even without these risk factors.

The symptoms of osteonecrosis are joint pain and, depending on the severity, inability to use a joint. The disease may show no symptoms at all in the early stages, and worsening pain will result as the disease progresses. Treatment is usually based around maintaining function of the affected joints. Without any treatment, the disease will cause progressive loss of mobility. Seeking treatment as soon as possible is important to maintain joint function. Research is currently being done to learn more about the disease. Support groups are also available for more resources and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteonecrosis" for support, advocacy or research.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteonecrosis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteonecrosis" returned 654 free, full-text research articles on human participants. First 3 results:

A new 3D printed titanium metal trabecular bone reconstruction system for early osteonecrosis of the femoral head.
 

Author(s): Ying Zhang, Leilei Zhang, Ruibo Sun, Yudong Jia, Xiantao Chen, Youwen Liu, Hong Oyang, Lizhi Feng

Journal: Medicine (Baltimore). 2018 Jun;97(26):e11088.

 

Presently, biomechanical support therapy for the femoral head has become an important approach in the treatment of early osteonecrosis of the femoral head (ONFH). Previous studies have reported that the titanium metal trabecular bone reconstruction systems (TMTBRS) achieved satisfactory ...

Last Updated: 31 Dec 1969

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A CARE-compliant article: Biomechanics of treating early-stage femoral-head osteonecrosis by using a β-tricalcium phosphate bioceramic rod system: a 3-dimensional finite-element analysis.
 

Author(s): Bo Li, RuYin Hu, Li Sun, Rui Luo, JinMin Zhao, XiaoBin Tian

Journal: Medicine (Baltimore). 2018 Jun;97(25):e10808.

 

The effect of implanting a β-TCP bioceramic rod system (BRS) can be observed with using the 3-dimensional (3D) finite-element method on the biomechanics of early-stage osteonecrosis of the femoral head (ONFH), to provide a theoretical basis for the biomechanics of applying the β-TCP ...

Last Updated: 31 Dec 1969

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Comment on: Medication-related osteonecrosis of the jaw in osteoporotic patients: prevention and management.
 

Author(s): Choon Lai Toh, Andrew Dutton

Journal: Singapore Med J. 2018 05;59(5):287.

 

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteonecrosis" returned 92 free, full-text review articles on human participants. First 3 results:

Chinese herbal medicine formulas as adjuvant therapy for osteonecrosis of the femoral head: A systematic review and meta-analysis of randomized controlled trials.
 

Author(s): Qingwen Zhang, Fan Yang, Yaolong Chen, Haibin Wang, Delong Chen, Wei He, Peng Chen

Journal: Medicine (Baltimore). 2018 Sep;97(36):e12196.

 

Osteonecrosis of femoral head (ONFH) is a disabling clinical entity affecting mainly young adults. Although Chinese Herbal Medicine (CHM) has been widely used as an adjunct therapy for ONFH in China, its effectiveness is not well defined. The purpose of this systematic review is to ...

Last Updated: 31 Dec 1969

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Oral Methotrexate-related Lymphoproliferative Disease Presenting with Severe Osteonecrosis of the Jaw: A Case Report and Literature Review.
 

Author(s): Sachiko Furukawa, Kazunari Oobu, Masafumi Moriyama, Shintaro Kawano, Saori Sako, Jun-Nosuke Hayashida, Ryota Matsubara, Ken-Ichi Ogata, Tamotsu Kiyoshima, Seiji Nakamura

Journal: Intern. Med.. 2018 Feb;57(4):575-581.

 

Long-term methotrexate (MTX) treatment can cause MTX-related lymphoproliferative disorder (MTX-LPD). We experienced a case of MTX-LPD that was associated with severe osteonecrosis of the jaw mimicking medication-related osteonecrosis of the jaw. The patient was an 81-year-old woman ...

Last Updated: 31 Dec 1969

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Corticosteroid-induced Osteonecrosis of the Femoral Head: Detection, Diagnosis, and Treatment in Earlier Stages.
 

Author(s): Li-Hua Liu, Qing-Yu Zhang, Wei Sun, Zi-Rong Li, Fu-Qiang Gao

Journal: Chin. Med. J.. 2017 Nov;130(21):2601-2607.

 

This review aimed to provide a current recommendation to multidisciplinary physicians for early detection, diagnosis, and treatment of corticosteroid-induced osteonecrosis of the femoral head (ONFH) based on a comprehensive analysis of the clinical literature.

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Imaging of Osteonecrosis With Ferumoxytol-Enhanced MRI
 

Status: Recruiting

Condition Summary: Osteonecrosis

 

Last Updated: 17 Apr 2018

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The British Osteonecrosis Study
 

Status: Recruiting

Condition Summary: Osteonecrosis

 

Last Updated: 12 Mar 2018

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Use of Adipose Derived Regenerative Cells in Bilateral Femoral Head Osteonecrosis
 

Status: Recruiting

Condition Summary: Osteonecrosis

 

Last Updated: 9 Jul 2018

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