Osteonecrosis

Common Name(s)

Osteonecrosis

Osteonecrosis is a disease caused by reduced blood flow to the bones. In healthy people, new bone is constantly growing to replace old bone. In people affected by osteonecrosis, new bone is not able to grow and replace old bones because of the reduced blood supply. This leads to a reduction in the amount of bone, which causes pain and limits mobility in joints. Osteonecrosis can affect anyone, but people who are between age 30-50 are most often affected.

The cause of osteonecrosis is reduced blood flow, but the cause of the reduction in blood flow is not always known. Some common causes include alcohol use, steroid medications, injury, and increased pressure in the bones. Major risk factors for osteonecrosis include having undergone chemotherapy and radiation treatments and having had an organ transplant. Certain diseases, such as cancer, lupus, HIV, and many others, also increase the risk for osteonecrosis. Others will develop osteonecrosis due to unknown causes, even without these risk factors.

The symptoms of osteonecrosis are joint pain and, depending on the severity, inability to use a joint. The disease may show no symptoms at all in the early stages, and worsening pain will result as the disease progresses. Treatment is usually based around maintaining function of the affected joints. Without any treatment, the disease will cause progressive loss of mobility. Seeking treatment as soon as possible is important to maintain joint function. Research is currently being done to learn more about the disease. Support groups are also available for more resources and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteonecrosis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteonecrosis" returned 602 free, full-text research articles on human participants. First 3 results:

Clinical analysis of 23 cases of steroid-associated osteonecrosis of the femoral head with normal initial magnetic resonance imaging presentation.
 

Author(s): Feng-Chao Zhao, Huai-Xia Hu, Xin Zheng, Ding-Wei Cang, Xiaoyun Liu, Jian-Zhi Zhang, Kai-Jin Guo

Journal: Medicine (Baltimore). 2017 Dec;96(49):e8834.

 

To explore the clinical characteristics of steroid-associated osteonecrosis of the femoral head (ONFH) presenting initially normal magnetic resonance imaging (MRI) results.This retrospective study examined data from 23 cases that suffered from ONFH but presented a normal image at ...

Last Updated: 31 Dec 1969

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BOLD-MRI early detect femoral head osteonecrosis following steroid-treated patients.
 

Author(s): Jing Li, Jingjing Wang, Jihua Zhao, Bin Yuan, Liming Xing, Fengming Tang, Lei Liu, Mingming Lu, Quan Zhang, Jun Zhao, Peng Gu, Jianhui Li, Zhuoli Zhang, Chong Sun, Yu Zhang, Fei Yuan

Journal: Medicine (Baltimore). 2017 Nov;96(44):e8401.

 

The purpose of the study is to evaluate the feasibility of blood oxygenation level-dependent MRI (BOLD-MRI) to early detect the femoral head osteonecrosis (FHON). One hundred twelve patients were recruited who had received steroid treatment. The normal control group included 10 volunteers ...

Last Updated: 31 Dec 1969

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The genetic association between PON1 polymorphisms and osteonecrosis of femoral head: A case-control study.
 

Author(s): Jian-Mei Li, Yi Li, Lu Wang

Journal: Medicine (Baltimore). 2017 Oct;96(42):e8198.

 

The purpose of this study was to investigate the relationship between Paraoxonase-1 (PON1) gene rs662, rs854555 polymorphisms and osteonecrosis of the femoral head (ONFH) in Han population, northern China.Polymerase chain reaction-restriction fragment length polymorphism was used ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteonecrosis" returned 86 free, full-text review articles on human participants. First 3 results:

Underlying Mechanisms and Therapeutic Strategies for Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ).
 

Author(s): Yasuo Endo, Hiroyuki Kumamoto, Masanori Nakamura, Shunji Sugawara, Teruko Takano-Yamamoto, Keiichi Sasaki, Tetsu Takahashi

Journal: Biol. Pharm. Bull.. 2017 ;40(6):739-750.

 

Bisphosphonates (BPs), with a non-hydrolysable P-C-P structure, are cytotoxic analogues of pyrophosphate, bind strongly to bone, are taken into osteoclasts during bone-resorption and exhibit long-acting anti-bone-resorptive effects. Among the BPs, nitrogen-containing BPs (N-BPs) have ...

Last Updated: 31 Dec 1969

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Drug-induced osteonecrosis of the jaw: the state of the art.
 

Author(s): A Fassio, F Bertoldo, L Idolazzi, O Viapiana, M Rossini, D Gatti

Journal:

 

Osteonecrosis of the jaw (ONJ) is a rare adverse event of antiresorptive drugs such as bisphosphonates (BP) and denosumab (DMAb). The diagnosis of ONJ is considered in cases where exposed bone in the maxillofacial region does not heal within 8 weeks in a patient previously treated ...

Last Updated: 31 Dec 1969

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Association of ABCB1 C3435T polymorphism with the susceptibility to osteonecrosis of the femoral head: A meta-analysis.
 

Author(s): Yu Zhang, Hui Xie, Dewei Zhao, Benjie Wang, Lei Yang, Qingyu Meng

Journal: Medicine (Baltimore). 2017 May;96(20):e6049.

 

The exploration for the etiology of osteonecrosis of the femoral head (ONFH) has got some promising findings, but the morbidity of ONFH is still not under control. The C3435T polymorphism of ATP-binding cassette subfamily B member 1 (ABCB1) gene has been reported to possess significant ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Imaging of Osteonecrosis With Ferumoxytol-Enhanced MRI
 

Status: Recruiting

Condition Summary: Osteonecrosis

 

Last Updated: 17 Apr 2018

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The British Osteonecrosis Study
 

Status: Recruiting

Condition Summary: Osteonecrosis

 

Last Updated: 12 Mar 2018

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Use of Adipose Derived Regenerative Cells in Bilateral Femoral Head Osteonecrosis
 

Status: Recruiting

Condition Summary: Osteonecrosis

 

Last Updated: 5 Jan 2018

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