Osteonecrosis

Common Name(s)

Osteonecrosis

Osteonecrosis is a disease caused by reduced blood flow to the bones. In healthy people, new bone is constantly growing to replace old bone. In people affected by osteonecrosis, new bone is not able to grow and replace old bones because of the reduced blood supply. This leads to a reduction in the amount of bone, which causes pain and limits mobility in joints. Osteonecrosis can affect anyone, but people who are between age 30-50 are most often affected.

The cause of osteonecrosis is reduced blood flow, but the cause of the reduction in blood flow is not always known. Some common causes include alcohol use, steroid medications, injury, and increased pressure in the bones. Major risk factors for osteonecrosis include having undergone chemotherapy and radiation treatments and having had an organ transplant. Certain diseases, such as cancer, lupus, HIV, and many others, also increase the risk for osteonecrosis. Others will develop osteonecrosis due to unknown causes, even without these risk factors.

The symptoms of osteonecrosis are joint pain and, depending on the severity, inability to use a joint. The disease may show no symptoms at all in the early stages, and worsening pain will result as the disease progresses. Treatment is usually based around maintaining function of the affected joints. Without any treatment, the disease will cause progressive loss of mobility. Seeking treatment as soon as possible is important to maintain joint function. Research is currently being done to learn more about the disease. Support groups are also available for more resources and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteonecrosis" for support, advocacy or research.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteonecrosis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteonecrosis" returned 577 free, full-text research articles on human participants. First 3 results:

[Proximal humerus fractures: clinical assessment and functional outcome in patients with osteonecrosis of the humeral head].
 

Author(s): J G Gómez-Mont Landerreche, F Gil-Orbezo, H Morales-Domínguez, A Flores-Carrillo, G Levy-Holden, P Capuano-Tripp

Journal: Acta Ortop Mex. ;29(2):88-96.

 

Fractures of the proximal humerus resulting in three or more fragments represent a high risk of necrosis. The former is the second most frequent site of necrosis, only after the femur, due to either traumatic or nontraumatic causes. The former are the most common, with an incidence ...

Last Updated: 25 Mar 2016

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Clinical outcomes of osteonecrosis of the femoral head after autologous bone marrow stem cell implantation: a meta-analysis of seven case-control studies.
 

Author(s): Heng-Feng Yuan, Jing Zhang, Chang-An Guo, Zuo-Qin Yan

Journal: Clinics (Sao Paulo). 2016 Feb;71(2):110-3.

 

The purpose of this study was to evaluate the clinical outcomes of osteonecrosis of the femoral head after autologous bone marrow stem cell implantation. We searched the PubMed, Embase and Web of Science databases and included all case-control trials that reported on the clinical ...

Last Updated: 3 Mar 2016

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Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws.
 

Author(s): Ana Carolina Fragoso Motta, Leandro Dorigan de Macedo, Gisele Guimarães Santos, Carlos Tostes Guerreiro, Tatiane Ferrari, Thais Feitosa Leitão de Oliveira, Paulo Sérgio da Silva Santos, Christiano de Oliveira-Santos, Hilton Marcos Alves Ricz, Samuel Porfírio Xavier, Odilon Iannetta

Journal: Braz Oral Res. 2015 ;29(1):S1806-83242015000100301.

 

Patients with bisphosphonate-related osteonecrosis of the jaws (BRONJ) who received intravenous or oral bisphosphonates (BP) were selected for determination of their bone microarchitecture as a risk predictor of BRONJ development. The diagnosis of BRONJ was made based on clinical ...

Last Updated: 19 Feb 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteonecrosis" returned 73 free, full-text review articles on human participants. First 3 results:

Pathophysiology of Osteonecrosis of the Jaws.
 

Author(s): Tara Aghaloo, Renna Hazboun, Sotirios Tetradis

Journal: Oral Maxillofac Surg Clin North Am. 2015 Nov;27(4):489-96.

 

Osteonecrosis of the jaw (ONJ) is a multifactorial disease in patients with primary or metastatic bone malignancy or osteoporosis undergoing systemic antiresorptive therapy, where pathophysiology has not yet been fully determined. The staging of ONJ is based on severity of symptoms ...

Last Updated: 30 Oct 2015

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Understanding bisphosphonates and osteonecrosis of the jaw: uses and risks.
 

Author(s): S Rosini, S Rosini, I Bertoldi, B Frediani

Journal: Eur Rev Med Pharmacol Sci. 2015 Sep;19(17):3309-17.

 

Bisphosphonates are chemically stable analogs of pyrophosphate compounds, which have been used to treat multiple disorders of calcium metabolism. Although bisphosphonates have been employed for many years and have demonstrated an excellent safety profile, severe osteonecrosis of the ...

Last Updated: 24 Sep 2015

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The role of "cell therapy" in osteonecrosis of the femoral head. A systematic review of the literature and meta-analysis of 7 studies.
 

Author(s): Costas Papakostidis, Theodoros H Tosounidis, Elena Jones, Peter V Giannoudis

Journal: Acta Orthop. 2016 Feb;87(1):72-8.

 

The value of core decrompression for treatment of osteonecrosis of the femoral head (ONFH) is unclear. We investigated by a literature review whether implantation of autologous bone marrow aspirate, containing high concentrations of pluripotent mesenchymal stem cells, into the core ...

Last Updated: 5 Jan 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Imaging of Osteonecrosis With Ferumoxytol-Enhanced MRI
 

Status: Recruiting

Condition Summary: Osteonecrosis

 

Last Updated: 2 Sep 2016

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The British Osteonecrosis Study
 

Status: Not yet recruiting

Condition Summary: Osteonecrosis

 

Last Updated: 18 May 2016

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Randomized Clinical Trial for the Treatment of Osteonecrosis of the Femoral Head
 

Status: Recruiting

Condition Summary: Osteonecrosis

 

Last Updated: 7 Mar 2016

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