Osteonecrosis

Common Name(s)

Osteonecrosis

Osteonecrosis is a disease caused by reduced blood flow to the bones. In healthy people, new bone is constantly growing to replace old bone. In people affected by osteonecrosis, new bone is not able to grow and replace old bones because of the reduced blood supply. This leads to a reduction in the amount of bone, which causes pain and limits mobility in joints. Osteonecrosis can affect anyone, but people who are between age 30-50 are most often affected.

The cause of osteonecrosis is reduced blood flow, but the cause of the reduction in blood flow is not always known. Some common causes include alcohol use, steroid medications, injury, and increased pressure in the bones. Major risk factors for osteonecrosis include having undergone chemotherapy and radiation treatments and having had an organ transplant. Certain diseases, such as cancer, lupus, HIV, and many others, also increase the risk for osteonecrosis. Others will develop osteonecrosis due to unknown causes, even without these risk factors.

The symptoms of osteonecrosis are joint pain and, depending on the severity, inability to use a joint. The disease may show no symptoms at all in the early stages, and worsening pain will result as the disease progresses. Treatment is usually based around maintaining function of the affected joints. Without any treatment, the disease will cause progressive loss of mobility. Seeking treatment as soon as possible is important to maintain joint function. Research is currently being done to learn more about the disease. Support groups are also available for more resources and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteonecrosis" for support, advocacy or research.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteonecrosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteonecrosis" returned 619 free, full-text research articles on human participants. First 3 results:

The genetic association between PON1 polymorphisms and osteonecrosis of femoral head: A case-control study.
 

Author(s): Jian-Mei Li, Yi Li, Lu Wang

Journal: Medicine (Baltimore). 2017 Oct;96(42):e8198.

 

The purpose of this study was to investigate the relationship between Paraoxonase-1 (PON1) gene rs662, rs854555 polymorphisms and osteonecrosis of the femoral head (ONFH) in Han population, northern China.Polymerase chain reaction-restriction fragment length polymorphism was used ...

Last Updated: 19 Oct 2017

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Association between plasminogen activator inhibitor gene polymorphisms and osteonecrosis of the femoral head susceptibility: A case-control study.
 

Author(s): Yi Li, Feng-Xia Liu, Chao Yuan, Lingguo Meng

Journal: Medicine (Baltimore). 2017 Oct;96(42):e7047.

 

This study aimed to analyze the correlation of the plasminogen activator inhibitor (PAI-1) gene polymorphisms (rs6092 and rs7242) with susceptibility of osteonecrosis of the femoral head (ONFH).This case-control study included 106 ONFH patients and 151 healthy controls. PAI-1 polymorphisms ...

Last Updated: 19 Oct 2017

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Heterotopic ossification related to the use of recombinant human BMP-2 in osteonecrosis of femoral head.
 

Author(s): Lijun Shi, Wei Sun, Fuqiang Gao, Liming Cheng, Zirong Li

Journal: Medicine (Baltimore). 2017 Jul;96(27):e7413.

 

Despite the wide use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in bone defect, its application in treating osteonecrosis of femoral head (ONFH) is yet to be elucidated. The heterotopic ossification (HO) after rhBMP-2 usage in some orthopedic surgeries has been reported ...

Last Updated: 6 Jul 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteonecrosis" returned 78 free, full-text review articles on human participants. First 3 results:

Association of ABCB1 C3435T polymorphism with the susceptibility to osteonecrosis of the femoral head: A meta-analysis.
 

Author(s): Yu Zhang, Hui Xie, Dewei Zhao, Benjie Wang, Lei Yang, Qingyu Meng

Journal: Medicine (Baltimore). 2017 May;96(20):e6049.

 

The exploration for the etiology of osteonecrosis of the femoral head (ONFH) has got some promising findings, but the morbidity of ONFH is still not under control. The C3435T polymorphism of ATP-binding cassette subfamily B member 1 (ABCB1) gene has been reported to possess significant ...

Last Updated: 17 May 2017

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The use of anticoagulants for prevention and treatment of osteonecrosis of the femoral head: A systematic review.
 

Author(s): Peipei Guo, Fuqiang Gao, Yanhua Wang, Zhenkun Zhang, Wei Sun, Baoguo Jiang, Bailiang Wang, Zirong Li

Journal: Medicine (Baltimore). 2017 Apr;96(16):e6646.

 

Osteonecrosis of the femoral head (ONFH) is a progressive disease, which mainly affects young adults and often necessitates total hip arthroplasty (THA), so early interventions are critical to successfully protect hip joint from THA. In this review, our purpose was to determine the ...

Last Updated: 19 Apr 2017

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[Research progress on bisphosphonate-related osteonecrosis of the jaws].
 

Author(s): Pan Jian, Wang Qizhang, Liu Jiyuan

Journal: Hua Xi Kou Qiang Yi Xue Za Zhi. 2017 Feb;35(1):29-36.

 

Bisphosphonates (BPs), as potent drugs inhibiting bone resorption, have been widely used for treatment of several diseases. In recent years, dentists and oral and maxillofacial surgeons reported continuously increasing cases of bisphosphonate-related osteonecrosis of the jaws (BRONJ). ...

Last Updated: 22 Mar 2017

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Imaging of Osteonecrosis With Ferumoxytol-Enhanced MRI
 

Status: Recruiting

Condition Summary: Osteonecrosis

 

Last Updated: 18 Oct 2017

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The British Osteonecrosis Study
 

Status: Recruiting

Condition Summary: Osteonecrosis

 

Last Updated: 29 Aug 2017

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Last Updated: 14 Nov 2017

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