Osteonecrosis

Common Name(s)

Osteonecrosis

Osteonecrosis is a disease caused by reduced blood flow to the bones. In healthy people, new bone is constantly growing to replace old bone. In people affected by osteonecrosis, new bone is not able to grow and replace old bones because of the reduced blood supply. This leads to a reduction in the amount of bone, which causes pain and limits mobility in joints. Osteonecrosis can affect anyone, but people who are between age 30-50 are most often affected.

The cause of osteonecrosis is reduced blood flow, but the cause of the reduction in blood flow is not always known. Some common causes include alcohol use, steroid medications, injury, and increased pressure in the bones. Major risk factors for osteonecrosis include having undergone chemotherapy and radiation treatments and having had an organ transplant. Certain diseases, such as cancer, lupus, HIV, and many others, also increase the risk for osteonecrosis. Others will develop osteonecrosis due to unknown causes, even without these risk factors.

The symptoms of osteonecrosis are joint pain and, depending on the severity, inability to use a joint. The disease may show no symptoms at all in the early stages, and worsening pain will result as the disease progresses. Treatment is usually based around maintaining function of the affected joints. Without any treatment, the disease will cause progressive loss of mobility. Seeking treatment as soon as possible is important to maintain joint function. Research is currently being done to learn more about the disease. Support groups are also available for more resources and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteonecrosis" for support, advocacy or research.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteonecrosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteonecrosis" returned 576 free, full-text research articles on human participants. First 3 results:

[Proximal humerus fractures: clinical assessment and functional outcome in patients with osteonecrosis of the humeral head].
 

Author(s): J G Gómez-Mont Landerreche, F Gil-Orbezo, H Morales-Domínguez, A Flores-Carrillo, G Levy-Holden, P Capuano-Tripp

Journal: Acta Ortop Mex. ;29(2):88-96.

 

Fractures of the proximal humerus resulting in three or more fragments represent a high risk of necrosis. The former is the second most frequent site of necrosis, only after the femur, due to either traumatic or nontraumatic causes. The former are the most common, with an incidence ...

Last Updated: 25 Mar 2016

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[Clinical features of osteonecrosis of jaws after bisphosphonates therapy for bone metastasis of breast cancer].
 

Author(s): Yu-xing Guo, Dian-can Wang, Yang Wang, Xin Peng, Chi Mao, Chuan-bin Guo

Journal: Beijing Da Xue Xue Bao. 2016 Feb;48(1):80-3.

 

To understand the clinical features of osteonecrosis of the jaw after bisphosphonates use for therapy of breast cancer patients with bone metastasis.

Last Updated: 18 Feb 2016

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Establishment of an Animal Model of Bisphosphonate-Related Osteonecrosis of the Jaws in Spontaneously Diabetic Torii Rats.
 

Author(s): Kazuki Takaoka, Michiyo Yamamura, Toshihiro Nishioka, Tetsuya Abe, Joji Tamaoka, Emi Segawa, Masami Shinohara, Haruyasu Ueda, Hiromitsu Kishimoto, Masahiro Urade

Journal:

 

We evaluated the side effects of bisphosphonate (BP) on tooth extraction socket healing in spontaneously diabetic Torii (SDT) rats, an established model of non-obese type 2 diabetes mellitus, to develop an animal model of BP-related osteonecrosis of the jaws (BRONJ).

Last Updated: 15 Dec 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteonecrosis" returned 71 free, full-text review articles on human participants. First 3 results:

Understanding bisphosphonates and osteonecrosis of the jaw: uses and risks.
 

Author(s): S Rosini, S Rosini, I Bertoldi, B Frediani

Journal: Eur Rev Med Pharmacol Sci. 2015 Sep;19(17):3309-17.

 

Bisphosphonates are chemically stable analogs of pyrophosphate compounds, which have been used to treat multiple disorders of calcium metabolism. Although bisphosphonates have been employed for many years and have demonstrated an excellent safety profile, severe osteonecrosis of the ...

Last Updated: 24 Sep 2015

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The role of "cell therapy" in osteonecrosis of the femoral head. A systematic review of the literature and meta-analysis of 7 studies.
 

Author(s): Costas Papakostidis, Theodoros H Tosounidis, Elena Jones, Peter V Giannoudis

Journal: Acta Orthop. 2016 Feb;87(1):72-8.

 

The value of core decrompression for treatment of osteonecrosis of the femoral head (ONFH) is unclear. We investigated by a literature review whether implantation of autologous bone marrow aspirate, containing high concentrations of pluripotent mesenchymal stem cells, into the core ...

Last Updated: 5 Jan 2016

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Genetic association between methylenetetrahydrofolate reductase gene polymorphism and risk of osteonecrosis of the femoral head.
 

Author(s): Wei Chai, Zhendong Zhang, Ming Ni, Peiliang Geng, Zijian Lian, Guoqiang Zhang, Lewis L Shi, Jiying Chen

Journal: Biomed Res Int. 2015 ;2015():196495.

 

Methylenetetrahydrofolate reductase (MTHFR) SNP rs1801133 has been frequently investigated in recent years. Relevant candidate gene association studies with this SNP and osteonecrosis of the femoral head (ONFH) reported conflicting results. Meta-analysis provides a method to combine ...

Last Updated: 17 Feb 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Osteonecrosis of the Hip and Bisphosphonate Treatment
 

Status: Recruiting

Condition Summary: Osteonecrosis

 

Last Updated: 11 Jan 2013

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Osteonecrosis in Children With Acute Lymphoblastic Leukemia
 

Status: Recruiting

Condition Summary: Osteonecrosis; Acute Lymphoblastic Leukemia

 

Last Updated: 14 Apr 2010

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Osteonecroses in Pediatric Patients With ALL
 

Status: Recruiting

Condition Summary: Osteonecrosis; Acute Lymphoblastic Leukaemia; Lymphoblastic Lymphoma

 

Last Updated: 4 Mar 2014

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