Osteonecrosis

Common Name(s)

Osteonecrosis

Osteonecrosis is a disease caused by reduced blood flow to the bones. In healthy people, new bone is constantly growing to replace old bone. In people affected by osteonecrosis, new bone is not able to grow and replace old bones because of the reduced blood supply. This leads to a reduction in the amount of bone, which causes pain and limits mobility in joints. Osteonecrosis can affect anyone, but people who are between age 30-50 are most often affected.

The cause of osteonecrosis is reduced blood flow, but the cause of the reduction in blood flow is not always known. Some common causes include alcohol use, steroid medications, injury, and increased pressure in the bones. Major risk factors for osteonecrosis include having undergone chemotherapy and radiation treatments and having had an organ transplant. Certain diseases, such as cancer, lupus, HIV, and many others, also increase the risk for osteonecrosis. Others will develop osteonecrosis due to unknown causes, even without these risk factors.

The symptoms of osteonecrosis are joint pain and, depending on the severity, inability to use a joint. The disease may show no symptoms at all in the early stages, and worsening pain will result as the disease progresses. Treatment is usually based around maintaining function of the affected joints. Without any treatment, the disease will cause progressive loss of mobility. Seeking treatment as soon as possible is important to maintain joint function. Research is currently being done to learn more about the disease. Support groups are also available for more resources and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteonecrosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteonecrosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteonecrosis" returned 569 free, full-text research articles on human participants. First 3 results:

Significant Associations of SOX9 Gene Polymorphism and Gene Expression with the Risk of Osteonecrosis of the Femoral Head in a Han Population in Northern China.
 

Author(s): Yang Song, Zhenwu Du, Ming Ren, Qiwei Yang, Yujie Sui, Qingyu Wang, Ao Wang, Haiyue Zhao, Jincheng Wang, Guizhen Zhang

Journal: Biomed Res Int. 2016 ;2016():5695317.

 

Sex determining region Y-box 9 (SOX9) is a key transcription factor involved in cartilage formation during the embryonic development stage and cartilage growth and repair after birth. To explore the roles of polymorphism and expression of the SOX9 gene in the development of osteonecrosis ...

Last Updated: 16 Jan 2017

Go To URL
Single-nucleotide polymorphisms of MMP2 in MMP/TIMP pathways associated with the risk of alcohol-induced osteonecrosis of the femoral head in Chinese males: A case-control study.
 

Author(s): Yan Yu, Zhilan Xie, Jihan Wang, Chu Chen, Shuli Du, Peng Chen, Bin Li, Tianbo Jin, Heping Zhao

Journal: Medicine (Baltimore). 2016 Dec;95(49):e5407.

 

The proportion of alcohol-induced osteonecrosis of the femoral head (ONFH) in all ONFH patients was 30.7%, with males prevailing among the ONFH patients in mainland China (70.1%). Matrix metalloproteinase 2 (MMP2), a member of the MMP gene family, encodes the enzyme MMP2, which can ...

Last Updated: 8 Dec 2016

Go To URL
Treatment of osteonecrosis of the femoral head with free vascularized fibular grafting: Results of 7.6-year follow-up.
 

Author(s): Mehmet Bekir Ünal, Eren Cansu, Fatih Parmaksızoğlu, Hakan Cift, Serkan Gürcan

Journal: Acta Orthop Traumatol Turc. 2016 Oct;50(5):501-506.

 

The aim of this study was to determine long term follow up of the patients who had femoral head osteonecrosis and had been treated with free vascularized fibular grafting.

Last Updated: 20 Nov 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteonecrosis" returned 70 free, full-text review articles on human participants. First 3 results:

Stem Cell Therapy for the Treatment of Hip Osteonecrosis: A 30-Year Review of Progress.
 

Author(s): Philippe Hernigou, Matthieu Trousselier, François Roubineau, Charlie Bouthors, Nathalie Chevallier, Helene Rouard, Charles-Henri Flouzat-Lachaniette

Journal: Clin Orthop Surg. 2016 Mar;8(1):1-8.

 

Avascular necrosis of the femoral head is caused by a multitude of etiologic factors and is associated with collapse with a risk of hip arthroplasty in younger populations. A focus on early disease management with the use of stem cells was proposed as early as 1985 by the senior author ...

Last Updated: 1 Mar 2016

Go To URL
Prevention of medication-related osteonecrosis of the jaws secondary to tooth extractions. A systematic review.
 

Author(s): Márcio Diniz-Freitas, Jacobo Limeres

Journal:

 

A study was made to identify the most effective protocol for reducing the risk of osteonecrosis of the jaws (ONJ) following tooth extraction in patients subjected to treatment with antiresorptive or antiangiogenic drugs.

Last Updated: 28 Feb 2016

Go To URL
Bisphosphonates, vitamin D, parathyroid hormone, and osteonecrosis of the jaw. Could there be a missing link?
 

Author(s): Ignacio-Osoitz Leizaola-Cardesa, Antonio Aguilar-Salvatierra, Maximino Gonzalez-Jaranay, Gerardo Moreu, María-José Sala-Romero, Gerardo Gómez-Moreno

Journal:

 

It is estimated that over 190 million bisphosphonates have been prescribed worldwide. But this drug can produce adverse effects, of which osteonecrosis of the jaw and severe hypocalcemia are the most serious. It is evident that bisphosphonate administration affects multiple and diverse ...

Last Updated: 28 Feb 2016

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Imaging of Osteonecrosis With Ferumoxytol-Enhanced MRI
 

Status: Recruiting

Condition Summary: Osteonecrosis

 

Last Updated: 2 Sep 2016

Go to URL
The British Osteonecrosis Study
 

Status: Not yet recruiting

Condition Summary: Osteonecrosis

 

Last Updated: 18 May 2016

Go to URL
Randomized Clinical Trial for the Treatment of Osteonecrosis of the Femoral Head
 

Status: Recruiting

Condition Summary: Osteonecrosis

 

Last Updated: 7 Mar 2016

Go to URL