Osteonecrosis

Common Name(s)

Osteonecrosis

Osteonecrosis is when there is a lack of blood flow to bones in the joints. Osteonecrosis is most common in people ages 30-50. In healthy people, new bone is always replacing old bone. However those with osteonecrosis, have a breakdown of old bone faster than formation of new bone because of reduced blood flow. Osteonecrosis is most common in the upper leg, but also occurs in the upper arm, knees, shoulders, and ankles. The cause of osteonecrosis is unknown but risk factors include long-term steroid treatment, alcohol abuse, joint injuries, arthritis, and some cancers.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteonecrosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteonecrosis" returned 441 free, full-text research articles on human participants. First 3 results:

Huogu I formula prevents steroid-induced osteonecrosis in rats by down-regulating PPARgamma expression and activating wnt/LRP5/ beta-catenin signaling.
 

Author(s): Yini Jiang, Daobing Liu, Xiangying Kong, Ying Xu, Weiheng Chen, Na Lin

Journal: J Tradit Chin Med. 2014 Jun;34(3):342-50.

 

To investigate the effects of Huogu I formula on regulation of lipid metabolism in steroid-induced osteonecrosis of the femoral head (SONFH) rats and verify our hypothesis that Huogu I formula regulates lipid metabolism by down-regulating peroxisome proliferator-activated receptor ...

Last Updated: 4 Jul 2014

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Osteonecrosis with the use of polymethylmethacrylate cement for hip replacement: thermal-induced damage evidenced in vivo by decreased osteocyte viability.
 

Author(s): M R Whitehouse, N S Atwal, M Pabbruwe, A W Blom, G C Bannister

Journal:

 

Thermal damage to host bone is a possible source of compromise of fixation in patients undergoing cemented total hip replacement (THR). Data on the subject to date are derived from mathematical modelling powered by animal studies. The aim of this study was to assess the effect of ...

Last Updated: 27 Jan 2014

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The effect of postoperative corticosteroid administration on free vascularized fibular grafting for treating osteonecrosis of the femoral head.
 

Author(s): Hao Ding, Sheng-Bao Chen, Sen Lin, You-Shui Gao, Chang-Qing Zhang

Journal:

 

Free vascularized fibular grafting (FVFG) has been reported to be an effective method of treating osteonecrosis of the femoral head (ONFH). This study evaluated whether postoperative maintenance doses of corticosteroids had an adverse effect on FVFG outcomes in patients with corticosteroid-induced ...

Last Updated: 10 Dec 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteonecrosis" returned 53 free, full-text review articles on human participants. First 3 results:

Bisphosphonate related osteonecrosis of the jaws: spontaneous or dental origin?
 

Author(s): Sarina E C Pichardo, J P Richard van Merkesteyn

Journal: Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Sep;116(3):287-92.

 

Bisphosphonates are frequently used worldwide mostly in osteoporosis and skeletal bone metastases. However, a serious side-effect is bisphosphonate related osteonecrosis of the jaws (BRONJ). The mechanism behind BRONJ remains unclear. In literature several origins are suggested. Presence ...

Last Updated: 19 Aug 2013

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C-terminal cross-linking telopeptide as a serologic marker for bisphosphonate-related osteonecrosis of the jaw: review of 2 cases.
 

Author(s): Michael Pasoff

Journal: J Can Dent Assoc. 2013 ;79():d51.

 

With the increasing use of the bisphosphonate class of drugs, dental professionals are encountering more cases of bisphosphonate-related osteonecrosis of the jaw (BRONJ). The C-terminal cross-linking telopeptide (CTX) assay is a serologic test to predict the risk of BRONJ. This paper ...

Last Updated: 7 Aug 2013

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[Osteonecrosis of the jaw associated with bisphosphonate therapy in primary osteoporosis. Review of the literature].
 

Author(s): A Outeiriño-Fernández

Journal: An Sist Sanit Navar. ;36(1):87-97.

 

The aim of this review was to study risk factors involved in osteonecrosis of the jaw after oral surgery in patients treated with bisphosphonates due to primary osteoporosis.

Last Updated: 7 May 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Osteonecroses in Pediatric Patients With ALL
 

Status: Recruiting

Condition Summary: Osteonecrosis; Acute Lymphoblastic Leukaemia; Lymphoblastic Lymphoma

 

Last Updated: 4 Mar 2014

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Osteonecrosis of the Hip and Bisphosphonate Treatment
 

Status: Recruiting

Condition Summary: Osteonecrosis

 

Last Updated: 11 Jan 2013

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Osteonecrosis in Children With Acute Lymphoblastic Leukemia
 

Status: Recruiting

Condition Summary: Osteonecrosis; Acute Lymphoblastic Leukemia

 

Last Updated: 14 Apr 2010

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