Osteonecrosis

Common Name(s)

Osteonecrosis

Osteonecrosis is a disease caused by reduced blood flow to the bones. In healthy people, new bone is constantly growing to replace old bone. In people affected by osteonecrosis, new bone is not able to grow and replace old bones because of the reduced blood supply. This leads to a reduction in the amount of bone, which causes pain and limits mobility in joints. Osteonecrosis can affect anyone, but people who are between age 30-50 are most often affected.

The cause of osteonecrosis is reduced blood flow, but the cause of the reduction in blood flow is not always known. Some common causes include alcohol use, steroid medications, injury, and increased pressure in the bones. Major risk factors for osteonecrosis include having undergone chemotherapy and radiation treatments and having had an organ transplant. Certain diseases, such as cancer, lupus, HIV, and many others, also increase the risk for osteonecrosis. Others will develop osteonecrosis due to unknown causes, even without these risk factors.

The symptoms of osteonecrosis are joint pain and, depending on the severity, inability to use a joint. The disease may show no symptoms at all in the early stages, and worsening pain will result as the disease progresses. Treatment is usually based around maintaining function of the affected joints. Without any treatment, the disease will cause progressive loss of mobility. Seeking treatment as soon as possible is important to maintain joint function. Research is currently being done to learn more about the disease. Support groups are also available for more resources and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteonecrosis" for support, advocacy or research.

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteonecrosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteonecrosis" returned 580 free, full-text research articles on human participants. First 3 results:

[Proximal humerus fractures: clinical assessment and functional outcome in patients with osteonecrosis of the humeral head].
 

Author(s): J G Gómez-Mont Landerreche, F Gil-Orbezo, H Morales-Domínguez, A Flores-Carrillo, G Levy-Holden, P Capuano-Tripp

Journal: Acta Ortop Mex. ;29(2):88-96.

 

Fractures of the proximal humerus resulting in three or more fragments represent a high risk of necrosis. The former is the second most frequent site of necrosis, only after the femur, due to either traumatic or nontraumatic causes. The former are the most common, with an incidence ...

Last Updated: 25 Mar 2016

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The Role of (99m)Tc-Annexin V Apoptosis Scintigraphy in Visualizing Early Stage Glucocorticoid-Induced Femoral Head Osteonecrosis in the Rabbit.
 

Author(s): Xiaolong Wang, Yu Liu, Xuemei Wang, Rui Liu, Jianbo Li, Guoliang Zhang, Qiang Li, Lei Wang, Zhigang Bai, Jianmin Zhao

Journal: Biomed Res Int. 2016 ;2016():7067259.

 

To validate the ability of (99m)Tc-Annexin V to visualize early stage of glucocorticoid-induced femoral head necrosis by comparing with (99m)Tc-MDP bone scanning.

Last Updated: 18 Mar 2016

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Clinical outcomes of osteonecrosis of the femoral head after autologous bone marrow stem cell implantation: a meta-analysis of seven case-control studies.
 

Author(s): Heng-Feng Yuan, Jing Zhang, Chang-An Guo, Zuo-Qin Yan

Journal: Clinics (Sao Paulo). 2016 Feb;71(2):110-3.

 

The purpose of this study was to evaluate the clinical outcomes of osteonecrosis of the femoral head after autologous bone marrow stem cell implantation. We searched the PubMed, Embase and Web of Science databases and included all case-control trials that reported on the clinical ...

Last Updated: 3 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteonecrosis" returned 74 free, full-text review articles on human participants. First 3 results:

Stem Cell Therapy for the Treatment of Hip Osteonecrosis: A 30-Year Review of Progress.
 

Author(s): Philippe Hernigou, Matthieu Trousselier, François Roubineau, Charlie Bouthors, Nathalie Chevallier, Helene Rouard, Charles-Henri Flouzat-Lachaniette

Journal: Clin Orthop Surg. 2016 Mar;8(1):1-8.

 

Avascular necrosis of the femoral head is caused by a multitude of etiologic factors and is associated with collapse with a risk of hip arthroplasty in younger populations. A focus on early disease management with the use of stem cells was proposed as early as 1985 by the senior author ...

Last Updated: 1 Mar 2016

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Prevention of medication-related osteonecrosis of the jaws secondary to tooth extractions. A systematic review.
 

Author(s): Márcio Diniz-Freitas, Jacobo Limeres

Journal:

 

A study was made to identify the most effective protocol for reducing the risk of osteonecrosis of the jaws (ONJ) following tooth extraction in patients subjected to treatment with antiresorptive or antiangiogenic drugs.

Last Updated: 28 Feb 2016

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Bisphosphonates, vitamin D, parathyroid hormone, and osteonecrosis of the jaw. Could there be a missing link?
 

Author(s): Ignacio-Osoitz Leizaola-Cardesa, Antonio Aguilar-Salvatierra, Maximino Gonzalez-Jaranay, Gerardo Moreu, María-José Sala-Romero, Gerardo Gómez-Moreno

Journal:

 

It is estimated that over 190 million bisphosphonates have been prescribed worldwide. But this drug can produce adverse effects, of which osteonecrosis of the jaw and severe hypocalcemia are the most serious. It is evident that bisphosphonate administration affects multiple and diverse ...

Last Updated: 28 Feb 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Imaging of Osteonecrosis With Ferumoxytol-Enhanced MRI
 

Status: Recruiting

Condition Summary: Osteonecrosis

 

Last Updated: 2 Sep 2016

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The British Osteonecrosis Study
 

Status: Not yet recruiting

Condition Summary: Osteonecrosis

 

Last Updated: 18 May 2016

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Randomized Clinical Trial for the Treatment of Osteonecrosis of the Femoral Head
 

Status: Recruiting

Condition Summary: Osteonecrosis

 

Last Updated: 7 Mar 2016

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