Osteonecrosis

Common Name(s)

Osteonecrosis

Osteonecrosis is a disease caused by reduced blood flow to the bones. In healthy people, new bone is constantly growing to replace old bone. In people affected by osteonecrosis, new bone is not able to grow and replace old bones because of the reduced blood supply. This leads to a reduction in the amount of bone, which causes pain and limits mobility in joints. Osteonecrosis can affect anyone, but people who are between age 30-50 are most often affected.

The cause of osteonecrosis is reduced blood flow, but the cause of the reduction in blood flow is not always known. Some common causes include alcohol use, steroid medications, injury, and increased pressure in the bones. Major risk factors for osteonecrosis include having undergone chemotherapy and radiation treatments and having had an organ transplant. Certain diseases, such as cancer, lupus, HIV, and many others, also increase the risk for osteonecrosis. Others will develop osteonecrosis due to unknown causes, even without these risk factors.

The symptoms of osteonecrosis are joint pain and, depending on the severity, inability to use a joint. The disease may show no symptoms at all in the early stages, and worsening pain will result as the disease progresses. Treatment is usually based around maintaining function of the affected joints. Without any treatment, the disease will cause progressive loss of mobility. Seeking treatment as soon as possible is important to maintain joint function. Research is currently being done to learn more about the disease. Support groups are also available for more resources and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteonecrosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteonecrosis" returned 563 free, full-text research articles on human participants. First 3 results:

Correlation Between Residual Displacement and Osteonecrosis of the Femoral Head Following Cannulated Screw Fixation of Femoral Neck Fractures.
 

Author(s): Chen Wang, Gui-Jun Xu, Zhe Han, Xuan Jiang, Cheng-Bao Zhang, Qiang Dong, Jian-Xiong Ma, Xin-Long Ma

Journal: Medicine (Baltimore). 2015 Nov;94(47):e2139.

 

The aim of the study was to introduce a new method for measuring the residual displacement of the femoral head after internal fixation and explore the relationship between residual displacement and osteonecrosis with femoral head, and to evaluate the risk factors associated with osteonecrosis ...

Last Updated: 4 Dec 2015

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VEGF, eNOS, and ABCB1 genetic polymorphisms may increase the risk of osteonecrosis of the femoral head.
 

Author(s): Z C Zhou, S Z Gu, J Wu, Q W Liang

Journal:

 

We investigated the associations between vascular endothelial growth factors (VEGF), endothelial nitric oxide synthase (eNOS), and ATP-binding cassette subfamily B member 1 transporter (ABCB1) polymorphisms and the risk of osteonecrosis of the femoral head (ONFH). Published studies ...

Last Updated: 5 Nov 2015

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Key pathway to prevent the collapse of femoral head in osteonecrosis.
 

Author(s): W-L Gou, Q Lu, X Wang, Y Wang, J Peng, S-B Lu

Journal: Eur Rev Med Pharmacol Sci. 2015 Aug;19(15):2766-74.

 

Osteonecrosis of the femoral head (ONFH) is a multifactorial disease, with unclear pathogenesis. The collapse of the femoral head is an important turning point in ONFH, especially for young patients. Many methods have been proposed, but the best treatment lacks consensus among orthopedic ...

Last Updated: 5 Aug 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteonecrosis" returned 69 free, full-text review articles on human participants. First 3 results:

Genetic association between methylenetetrahydrofolate reductase gene polymorphism and risk of osteonecrosis of the femoral head.
 

Author(s): Wei Chai, Zhendong Zhang, Ming Ni, Peiliang Geng, Zijian Lian, Guoqiang Zhang, Lewis L Shi, Jiying Chen

Journal: Biomed Res Int. 2015 ;2015():196495.

 

Methylenetetrahydrofolate reductase (MTHFR) SNP rs1801133 has been frequently investigated in recent years. Relevant candidate gene association studies with this SNP and osteonecrosis of the femoral head (ONFH) reported conflicting results. Meta-analysis provides a method to combine ...

Last Updated: 17 Feb 2015

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Efficacy of alendronate for preventing collapse of femoral head in adult patients with nontraumatic osteonecrosis.
 

Author(s): Yu-Cai Hong, Ru-Bin Luo, Tiao Lin, Hui-Ming Zhong, Jian-Bin Shi

Journal: Biomed Res Int. 2014 ;2014():716538.

 

The purpose of the current review was to determine the efficacy of alendronate for preventing collapse of femoral head in adult patients with nontraumatic avascular osteonecrosis of femoral head (ANFH). Five randomized controlled trials (RCTs) involving 305 hips were included in this ...

Last Updated: 23 Dec 2014

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Diabetes as a risk factor for medication-related osteonecrosis of the jaw.
 

Author(s): A Peer, M Khamaisi

Journal: J. Dent. Res.. 2015 Feb;94(2):252-60.

 

Medication-related osteonecrosis of the jaw (MRONJ) is a severe devastating complication for which the exact pathogenesis is not completely understood. Multiple systemic and local factors may contribute to the development of MRONJ. A growing body of evidence supports diabetes mellitus ...

Last Updated: 21 Jan 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Osteonecrosis of the Hip and Bisphosphonate Treatment
 

Status: Recruiting

Condition Summary: Osteonecrosis

 

Last Updated: 11 Jan 2013

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Osteonecrosis in Children With Acute Lymphoblastic Leukemia
 

Status: Recruiting

Condition Summary: Osteonecrosis; Acute Lymphoblastic Leukemia

 

Last Updated: 14 Apr 2010

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Osteonecroses in Pediatric Patients With ALL
 

Status: Recruiting

Condition Summary: Osteonecrosis; Acute Lymphoblastic Leukaemia; Lymphoblastic Lymphoma

 

Last Updated: 4 Mar 2014

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