Osteonecrosis

Common Name(s)

Osteonecrosis

Osteonecrosis is when there is a lack of blood flow to bones in the joints. Osteonecrosis is most common in people ages 30-50. In healthy people, new bone is always replacing old bone. However those with osteonecrosis, have a breakdown of old bone faster than formation of new bone because of reduced blood flow. Osteonecrosis is most common in the upper leg, but also occurs in the upper arm, knees, shoulders, and ankles. The cause of osteonecrosis is unknown but risk factors include long-term steroid treatment, alcohol abuse, joint injuries, arthritis, and some cancers.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteonecrosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteonecrosis" returned 464 free, full-text research articles on human participants. First 3 results:

Rehabilitation program after mesenchymal stromal cell transplantation augmented by vascularized bone grafts for idiopathic osteonecrosis of the femoral head: a preliminary study.
 

Author(s): Tomoki Aoyama, Yasuko Fujita, Katsuyuki Madoba, Manabu Nankaku, Minoru Yamada, Motoko Tomita, Koji Goto, Ryosuke Ikeguchi, Ryosuke Kakinoki, Shuichi Matsuda, Takashi Nakamura, Junya Toguchida

Journal: Arch Phys Med Rehabil. 2015 Mar;96(3):532-9.

 

To determine the feasibility and safety of implementing a 12-week rehabilitation program after mesenchymal stromal cell (MSC) transplantation augmented by vascularized bone grafting for idiopathic osteonecrosis (ION) of the femoral head.

Last Updated: 23 Feb 2015

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Relationship between the Apolipoprotein AI, B gene polymorphism and the risk of non-traumatic osteonecrosis.
 

Author(s): Ji-Min Yin, Zhao Liu, Shi-Chang Zhao, Yan-Jie Guo, Zhong-Tang Liu

Journal:

 

Previous studies suggested that Apolipoprotein AI (ApoAI) and apolipoprotein B (ApoB) gene polymorphisms may result in lipid metabolism disorders. Genetic polymorphisms in these genes may be associated with the occurrence of osteonecrosis.

Last Updated: 22 Oct 2014

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iNOS expression and osteocyte apoptosis in idiopathic, non-traumatic osteonecrosis.
 

Author(s): Jun Wang, Ali Kalhor, Shifeier Lu, Ross Crawford, Jiang-Dong Ni, Yin Xiao

Journal: Acta Orthop. 2015 Feb;86(1):134-41.

 

Non-traumatic osteonecrosis is a progressive disease with multiple etiologies. It affects younger individuals more and more, often leading to total hip arthroplasty. We investigated whether there is a correlation between inducible nitric oxide synthase (iNOS) expression and osteocyte ...

Last Updated: 23 Jan 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteonecrosis" returned 59 free, full-text review articles on human participants. First 3 results:

Management and treatment of osteonecrosis in children and adolescents with acute lymphoblastic leukemia.
 

Author(s): Mariël L Te Winkel, Rob Pieters, Ernst-Jan D Wind, J H J M Gert Bessems, Marry M van den Heuvel-Eibrink

Journal: Haematologica. 2014 Mar;99(3):430-6.

 

There is no consensus regarding how to manage osteonecrosis in pediatric acute lymphoblastic leukemia patients. Therefore, we performed a quality assessment of the literature with the result of a search strategy using the MESH terms osteonecrosis, children, childhood cancer, surgery, ...

Last Updated: 6 Mar 2014

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Epidemiology, clinical manifestations, risk reduction and treatment strategies of jaw osteonecrosis in cancer patients exposed to antiresorptive agents.
 

Author(s): Giuseppina Campisi, Stefano Fedele, Vittorio Fusco, Giuseppe Pizzo, Olga Di Fede, Alberto Bedogni

Journal: Future Oncol. 2014 Feb;10(2):257-75.

 

 Osteonecrosis of the jaws (ONJ) is an adverse side event of bisphosphonates and denosumab, antiresorptive agents that effectively reduce the incidence of skeletal-related events in patients with metastatic bone cancer and multiple myeloma. Available data suggest that 0-27.5% of ...

Last Updated: 4 Feb 2014

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Alendronate-associated osteonecrosis of the jaws: a review of the main topics.
 

Author(s): F Paiva-Fonseca, A-R Santos-Silva, R Della-Coletta, P-A Vargas, M-A Lopes

Journal:

 

Bisphosphonates is a group of inorganic pyrophosphates analogues that suppress bone resorption by inducing osteoclast inactivation, being frequently used for management of diseases affecting bone metabolism, bone metastases and bone tumors. However, since 2003 many cases describing ...

Last Updated: 3 Mar 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Osteonecrosis of the Hip and Bisphosphonate Treatment
 

Status: Recruiting

Condition Summary: Osteonecrosis

 

Last Updated: 11 Jan 2013

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Osteonecrosis in Children With Acute Lymphoblastic Leukemia
 

Status: Recruiting

Condition Summary: Osteonecrosis; Acute Lymphoblastic Leukemia

 

Last Updated: 14 Apr 2010

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Osteonecroses in Pediatric Patients With ALL
 

Status: Recruiting

Condition Summary: Osteonecrosis; Acute Lymphoblastic Leukaemia; Lymphoblastic Lymphoma

 

Last Updated: 4 Mar 2014

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