Osteonecrosis

Common Name(s)

Osteonecrosis

Osteonecrosis is when there is a lack of blood flow to bones in the joints. Osteonecrosis is most common in people ages 30-50. In healthy people, new bone is always replacing old bone. However those with osteonecrosis, have a breakdown of old bone faster than formation of new bone because of reduced blood flow. Osteonecrosis is most common in the upper leg, but also occurs in the upper arm, knees, shoulders, and ankles. The cause of osteonecrosis is unknown but risk factors include long-term steroid treatment, alcohol abuse, joint injuries, arthritis, and some cancers.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteonecrosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteonecrosis" returned 448 free, full-text research articles on human participants. First 3 results:

Huogu I formula prevents steroid-induced osteonecrosis in rats by down-regulating PPARgamma expression and activating wnt/LRP5/ beta-catenin signaling.
 

Author(s): Yini Jiang, Daobing Liu, Xiangying Kong, Ying Xu, Weiheng Chen, Na Lin

Journal: J Tradit Chin Med. 2014 Jun;34(3):342-50.

 

To investigate the effects of Huogu I formula on regulation of lipid metabolism in steroid-induced osteonecrosis of the femoral head (SONFH) rats and verify our hypothesis that Huogu I formula regulates lipid metabolism by down-regulating peroxisome proliferator-activated receptor ...

Last Updated: 4 Jul 2014

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Corticosteroid administration within 2 weeks after renal transplantation affects the incidence of femoral head osteonecrosis.
 

Author(s): Masazumi Saito, Keiichiro Ueshima, Mikihiro Fujioka, Masashi Ishida, Tsuyoshi Goto, Yuji Arai, Kazuya Ikoma, Hiroyoshi Fujiwara, Wakaba Fukushima, Toshikazu Kubo

Journal: Acta Orthop. 2014 Jun;85(3):266-70.

 

It has been suggested that avascular osteonecrosis (AVN) of the femoral head occurs early after systemic steroid administration. The purpose of this study was to investigate the risks regarding development of AVN at a very early stage after renal transplantation.

Last Updated: 16 Jun 2014

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Osteo-radio-necrosis (ORN) and bisphosphonate-related osteonecrosis of the jaws (BRONJ): the histopathological differences under the clinical similarities.
 

Author(s): Konstantinos T Mitsimponas, Patrick Moebius, Kerstin Amann, Philipp Stockmann, Karl-Andreas Schlegel, Friedrich-Wilhelm Neukam, Falk Wehrhan

Journal:

 

Both osteoradionecrosis (ORN) and bisphosphonate associated osteonecrosis of the jaws (BRONJ) present clinically as regions of exposed necrotic bone. The study aimed to demonstrate the histopathological differences behind the observed clinical similarities.

Last Updated: 19 Feb 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteonecrosis" returned 55 free, full-text review articles on human participants. First 3 results:

Epidemiology, clinical manifestations, risk reduction and treatment strategies of jaw osteonecrosis in cancer patients exposed to antiresorptive agents.
 

Author(s): Giuseppina Campisi, Stefano Fedele, Vittorio Fusco, Giuseppe Pizzo, Olga Di Fede, Alberto Bedogni

Journal: Future Oncol. 2014 Feb;10(2):257-75.

 

 Osteonecrosis of the jaws (ONJ) is an adverse side event of bisphosphonates and denosumab, antiresorptive agents that effectively reduce the incidence of skeletal-related events in patients with metastatic bone cancer and multiple myeloma. Available data suggest that 0-27.5% of ...

Last Updated: 4 Feb 2014

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Bisphosphonate related osteonecrosis of the jaws: spontaneous or dental origin?
 

Author(s): Sarina E C Pichardo, J P Richard van Merkesteyn

Journal: Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Sep;116(3):287-92.

 

Bisphosphonates are frequently used worldwide mostly in osteoporosis and skeletal bone metastases. However, a serious side-effect is bisphosphonate related osteonecrosis of the jaws (BRONJ). The mechanism behind BRONJ remains unclear. In literature several origins are suggested. Presence ...

Last Updated: 19 Aug 2013

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C-terminal cross-linking telopeptide as a serologic marker for bisphosphonate-related osteonecrosis of the jaw: review of 2 cases.
 

Author(s): Michael Pasoff

Journal: J Can Dent Assoc. 2013 ;79():d51.

 

With the increasing use of the bisphosphonate class of drugs, dental professionals are encountering more cases of bisphosphonate-related osteonecrosis of the jaw (BRONJ). The C-terminal cross-linking telopeptide (CTX) assay is a serologic test to predict the risk of BRONJ. This paper ...

Last Updated: 7 Aug 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Osteonecrosis of the Hip and Bisphosphonate Treatment
 

Status: Recruiting

Condition Summary: Osteonecrosis

 

Last Updated: 11 Jan 2013

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Osteonecrosis in Children With Acute Lymphoblastic Leukemia
 

Status: Recruiting

Condition Summary: Osteonecrosis; Acute Lymphoblastic Leukemia

 

Last Updated: 14 Apr 2010

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Osteonecroses in Pediatric Patients With ALL
 

Status: Recruiting

Condition Summary: Osteonecrosis; Acute Lymphoblastic Leukaemia; Lymphoblastic Lymphoma

 

Last Updated: 4 Mar 2014

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