Osteomalacia

Common Name(s)

Osteomalacia

Osteomalacia is a disease that causes softening of the bones in adults. When this disease occurs in children, it is known as rickets. Soft bones are much more prone to breaking or bending than hardened bones. This leads to increased risk of broken bones (fractures) and increased risk of falls, especially in older adults. Vitamin D deficiency is usually the cause of osteomalacia. Our bodies need vitamin D to absorb calcium from the foods we eat. Without vitamin D, our bodies do not get enough calcium for our bones and this causes the bones to become softened.

There are usually no symptoms in the early stages of osteomalacia. However, changes in the bones can usually be seen on x-ray images. As the disease progresses, symptoms include dull, aching bone pain and muscle weakness. Osteomalacia occurs as a result of vitamin D deficiency. Vitamin D deficiency can develop as a result of surgery to the stomach or small intestine, disorders of the kidneys or liver, celiac disease, and some drugs used to treat seizures. People who have a lack of vitamin D in their diets or who have very little exposure to sunlight are also at risk for osteomalacia, as well as those of South Asian origin.

Osteomalacia is most often diagnosed through x-ray imaging, blood tests, or a bone biopsy. Treatment for osteomalacia involves increasing vitamin D and calcium intake, sometimes in the form of dietary supplements. Support groups are available as a resource for more information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteomalacia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteomalacia" returned 298 free, full-text research articles on human participants. First 3 results:

A case of osteomalacia due to deranged mineral balance caused by saccharated ferric oxide and short-bowel syndrome: A case report.
 

Author(s): Hiroshi Nomoto, Hideaki Miyoshi, Akinobu Nakamura, So Nagai, Naoyuki Kitao, Chikara Shimizu, Tatsuya Atsumi

Journal: Medicine (Baltimore). 2017 Sep;96(39):e8147.

 

Saccharated ferric oxide has been shown to lead to elevation of fibroblast growth factor 23, hypophosphatemia, and, consequently, osteomalacia. Moreover, mineral imbalance is often observed in patients with short-bowel syndrome to some degree.

Last Updated: 27 Sep 2017

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Total hip/knee arthroplasty in the treatment of tumor-induced osteomalacia patients: More than 1 year follow-up.
 

Author(s): Wei Zhu, Qi Ma, Yanyan Bian, Qianyu Zhuang, Zenan Xia, Jin Jin, Xisheng Weng

Journal:

 

Tumor-induced osteomalacia (TIO) may result in a better prognosis after complete resection of the causative neoplasm. However, tumors located proximal to the articular surface of the metaphysis remain largely uninvestigated.

Last Updated: 25 May 2017

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Adult-onset hypophosphatemic osteomalacia associated with Sjogren syndrome: Clinical case report.
 

Author(s): Guohua Shen, Yuwei Zhang, Shuang Hu, Bin Liu, Anren Kuang

Journal: Medicine (Baltimore). 2017 Mar;96(13):e6493.

 

Hypophosphatemic osteomalacia (HO) is a metabolic bone disease, exhibiting different etiologies such as genetic mutation, tumor induction, dysimmunity, or renal disease. Sjogren's syndrome (SS) is a connective tissue disorder commonly involving exocrine glands; however kidney involvement ...

Last Updated: 29 Mar 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteomalacia" returned 20 free, full-text review articles on human participants. First 3 results:

Tumour-induced osteomalacia: a literature review and a case report.
 

Author(s): Jolanta Dadoniene, Marius Miglinas, Dalia Miltiniene, Donatas Vajauskas, Dmitrij Seinin, Petras Butenas, Tomas Kacergius

Journal:

 

Tumour-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterised by severe hypophosphataemia and osteomalacia, with renal phosphate wasting that occurs in association with tumour. The epidemiology likewise aetiology is not known. The clinical presentation of TIO includes ...

Last Updated: 8 Jan 2016

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En bloc resection for treatment of tumor-induced osteomalacia: a case presentation and a systematic review.
 

Author(s): Tong Meng, Wang Zhou, Bo Li, Huabin Yin, Zhenxi Li, Lei Zhou, Jinhai Kong, Wangjun Yan, Xinghai Yang, Tielong Liu, Dianwen Song, Jianru Xiao

Journal:

 

Tumor-induced osteomalacia (TIO) is a rare disorder, which is commonly found in craniofacial locations and in the extremities. To the best of our knowledge, only 16 cases have been described in the spine, and this is the first report to describe a case of patient with TIO in the thoracic ...

Last Updated: 18 May 2015

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Hypophosphatemic osteomalacia due to drug-induced Fanconi's syndrome associated with adefovir dipivoxil treatment for hepatitis B.
 

Author(s): Hiroyuki Eguchi, Munehisa Tsuruta, Junichi Tani, Reiichiro Kuwahara, Yuji Hiromatsu

Journal: Intern. Med.. 2014 ;53(3):233-7.

 

We herein present the case of a 58-year-old Japanese man with Fanconi's syndrome with a 13-month history of bone pain in his ribs, hips, knees and ankles. He had been receiving low-dose adefovir dipivoxil (ADV) for the treatment of lamivudine-resistant chronic hepatitis B virus infection ...

Last Updated: 4 Feb 2014

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Clinical Trial Information This information is provided by ClinicalTrials.gov

68Ga-DOTATATE PET/CT in Oncogenic Osteomalacia
 

Status: Recruiting

Condition Summary: Oncogenic Osteomalacia; Mesenchymal Tumor

 

Last Updated: 5 Apr 2017

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Observing the Changes of Fibroblast Growth Factor 23 in Patients of Tumor Induced Osteomalacia
 

Status: Recruiting

Condition Summary: Hypophosphatemia

 

Last Updated: 4 Jul 2016

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Evaluation and Treatment of Skeletal Diseases
 

Status: Recruiting

Condition Summary: Tumor Induced Osteomalcia; Osteomalacia; Familial Tumoral Calcinosis

 

Last Updated: 18 Oct 2017

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