Osteomalacia

Common Name(s)

Osteomalacia

Osteomalacia is a disease that causes softening of the bones in adults. When this disease occurs in children, it is known as rickets. Soft bones are much more prone to breaking or bending than hardened bones. This leads to increased risk of broken bones (fractures) and increased risk of falls, especially in older adults. Vitamin D deficiency is usually the cause of osteomalacia. Our bodies need vitamin D to absorb calcium from the foods we eat. Without vitamin D, our bodies do not get enough calcium for our bones and this causes the bones to become softened.

There are usually no symptoms in the early stages of osteomalacia. However, changes in the bones can usually be seen on x-ray images. As the disease progresses, symptoms include dull, aching bone pain and muscle weakness. Osteomalacia occurs as a result of vitamin D deficiency. Vitamin D deficiency can develop as a result of surgery to the stomach or small intestine, disorders of the kidneys or liver, celiac disease, and some drugs used to treat seizures. People who have a lack of vitamin D in their diets or who have very little exposure to sunlight are also at risk for osteomalacia, as well as those of South Asian origin.

Osteomalacia is most often diagnosed through x-ray imaging, blood tests, or a bone biopsy. Treatment for osteomalacia involves increasing vitamin D and calcium intake, sometimes in the form of dietary supplements. Support groups are available as a resource for more information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteomalacia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteomalacia" returned 299 free, full-text research articles on human participants. First 3 results:

A case of osteomalacia due to deranged mineral balance caused by saccharated ferric oxide and short-bowel syndrome: A case report.
 

Author(s): Hiroshi Nomoto, Hideaki Miyoshi, Akinobu Nakamura, So Nagai, Naoyuki Kitao, Chikara Shimizu, Tatsuya Atsumi

Journal: Medicine (Baltimore). 2017 Sep;96(39):e8147.

 

Saccharated ferric oxide has been shown to lead to elevation of fibroblast growth factor 23, hypophosphatemia, and, consequently, osteomalacia. Moreover, mineral imbalance is often observed in patients with short-bowel syndrome to some degree.

Last Updated: 31 Dec 1969

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Localization of Oncogenic Osteomalacia by Systemic Venous Sampling of Fibroblast Growth Factor 23.
 

Author(s): Ji Yeon Lee, Hye Sun Park, Seunghee Han, Jiyu Kelly Lim, Namki Hong, Sung Il Park, Yumie Rhee

Journal: Yonsei Med. J.. 2017 Sep;58(5):981-987.

 

Tumor-induced osteomalacia (TIO) is characterized by hypophosphatemia caused by a phosphaturic mesenchymal tumor. While surgical resection of the tumor leads to a cure, identification of the responsible tumor is challenging. Recently, several studies showed that systemic sampling ...

Last Updated: 31 Dec 1969

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Total hip/knee arthroplasty in the treatment of tumor-induced osteomalacia patients: More than 1 year follow-up.
 

Author(s): Wei Zhu, Qi Ma, Yanyan Bian, Qianyu Zhuang, Zenan Xia, Jin Jin, Xisheng Weng

Journal:

 

Tumor-induced osteomalacia (TIO) may result in a better prognosis after complete resection of the causative neoplasm. However, tumors located proximal to the articular surface of the metaphysis remain largely uninvestigated.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteomalacia" returned 21 free, full-text review articles on human participants. First 3 results:

177Lu-DOTATATE PRRT in Recurrent Skull-Base Phosphaturic Mesenchymal Tumor Causing Osteomalacia: A Potential Application of PRRT Beyond Neuroendocrine Tumors.
 

Author(s): Sandip Basu, Preeti Fargose

Journal: J Nucl Med Technol. 2016 Dec;44(4):248-250.

 

The potential of peptide receptor radionuclide therapy (PRRT) is described in a case of recurrent inoperable phosphaturic mesenchymal tumor causing osteomalacia in the left basiocciput, for which the patient had undergone surgery twice previously. After one cycle of PRRT, there was ...

Last Updated: 31 Dec 1969

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Tumour-induced osteomalacia: a literature review and a case report.
 

Author(s): Jolanta Dadoniene, Marius Miglinas, Dalia Miltiniene, Donatas Vajauskas, Dmitrij Seinin, Petras Butenas, Tomas Kacergius

Journal:

 

Tumour-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterised by severe hypophosphataemia and osteomalacia, with renal phosphate wasting that occurs in association with tumour. The epidemiology likewise aetiology is not known. The clinical presentation of TIO includes ...

Last Updated: 31 Dec 1969

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En bloc resection for treatment of tumor-induced osteomalacia: a case presentation and a systematic review.
 

Author(s): Tong Meng, Wang Zhou, Bo Li, Huabin Yin, Zhenxi Li, Lei Zhou, Jinhai Kong, Wangjun Yan, Xinghai Yang, Tielong Liu, Dianwen Song, Jianru Xiao

Journal:

 

Tumor-induced osteomalacia (TIO) is a rare disorder, which is commonly found in craniofacial locations and in the extremities. To the best of our knowledge, only 16 cases have been described in the spine, and this is the first report to describe a case of patient with TIO in the thoracic ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Observing the Changes of Fibroblast Growth Factor 23 in Patients of Tumor Induced Osteomalacia
 

Status: Recruiting

Condition Summary: Hypophosphatemia

 

Last Updated: 4 Jul 2016

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Evaluation and Treatment of Skeletal Diseases
 

Status: Recruiting

Condition Summary: Tumor Induced Osteomalcia; Osteomalacia; Familial Tumoral Calcinosis

 

Last Updated: 18 Oct 2017

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Study of the Diagnostic Value of Stable Calcium Isotope Profiling in Bone and Calcium Disorders
 

Status: Recruiting

Condition Summary: Bone Diseases; Osteomalacia; Osteoporosis

 

Last Updated: 23 Nov 2016

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