Osteomalacia

Common Name(s)

Osteomalacia

Osteomalacia is a disease that causes softening of the bones in adults. When this disease occurs in children, it is known as rickets. Soft bones are much more prone to breaking or bending than hardened bones. This leads to increased risk of broken bones (fractures) and increased risk of falls, especially in older adults. Vitamin D deficiency is usually the cause of osteomalacia. Our bodies need vitamin D to absorb calcium from the foods we eat. Without vitamin D, our bodies do not get enough calcium for our bones and this causes the bones to become softened.

There are usually no symptoms in the early stages of osteomalacia. However, changes in the bones can usually be seen on x-ray images. As the disease progresses, symptoms include dull, aching bone pain and muscle weakness. Osteomalacia occurs as a result of vitamin D deficiency. Vitamin D deficiency can develop as a result of surgery to the stomach or small intestine, disorders of the kidneys or liver, celiac disease, and some drugs used to treat seizures. People who have a lack of vitamin D in their diets or who have very little exposure to sunlight are also at risk for osteomalacia, as well as those of South Asian origin.

Osteomalacia is most often diagnosed through x-ray imaging, blood tests, or a bone biopsy. Treatment for osteomalacia involves increasing vitamin D and calcium intake, sometimes in the form of dietary supplements. Support groups are available as a resource for more information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteomalacia" for support, advocacy or research.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteomalacia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteomalacia" returned 296 free, full-text research articles on human participants. First 3 results:

Missed causative tumors in diagnosing tumor-induced osteomalacia with (18)F-FDG PET/CT: a potential pitfall of standard-field imaging.
 

Author(s): Yoichi Kaneuchi, Michiyuki Hakozaki, Hitoshi Yamada, Osamu Hasegawa, Takahiro Tajino, Shinichi Konno

Journal: Hell J Nucl Med. ;19(1):46-8.

 

We describe herein two tumor-induced osteomalacia (TIO) cases for whom the causative lesions, located in their popliteal fossa, that were not identified in the standard field of fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT), which ...

Last Updated: 2 Apr 2016

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A case of severe osteomalacia caused by Tubulointerstitial nephritis with Fanconi syndrome in asymptomotic primary biliary cirrhosis.
 

Author(s): Shintaro Yamaguchi, Tatsuya Maruyama, Shu Wakino, Hirobumi Tokuyama, Akinori Hashiguchi, Shinichiro Tada, Koichiro Homma, Toshiaki Monkawa, James Thomas, Kazutoshi Miyashita, Isao Kurihara, Tadashi Yoshida, Konosuke Konishi, Koichi Hayashi, Matsuhiko Hayashi, Hiroshi Itoh

Journal:

 

Primary biliary cirrhosis (PBC) is an immune-mediated chronic cholestatic liver disease, characterized by increased concentrations of serum IgM and the presence of circulating anti-mitochondrial antibodies. Although bone diseases such as osteoporosis or osteodystrophy are commonly ...

Last Updated: 11 Nov 2015

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Bilateral Femoral Neck Fatigue Fracture due to Osteomalacia Secondary to Celiac Disease: Report of Three Cases.
 

Author(s): Ozgur Selek, Kaya Memisoglu, Alev Selek

Journal: Arch Iran Med. 2015 Aug;18(8):542-4.

 

Bilateral non traumatic femoral neck fatigue fracture is a rare condition usually occurring secondary to medical conditions such as pregnancy, pelvic irradiation, corticosteroid exposure, chronic renal failure and osteomalacia. In this report, we present three young female patients ...

Last Updated: 12 Aug 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteomalacia" returned 18 free, full-text review articles on human participants. First 3 results:

En bloc resection for treatment of tumor-induced osteomalacia: a case presentation and a systematic review.
 

Author(s): Tong Meng, Wang Zhou, Bo Li, Huabin Yin, Zhenxi Li, Lei Zhou, Jinhai Kong, Wangjun Yan, Xinghai Yang, Tielong Liu, Dianwen Song, Jianru Xiao

Journal:

 

Tumor-induced osteomalacia (TIO) is a rare disorder, which is commonly found in craniofacial locations and in the extremities. To the best of our knowledge, only 16 cases have been described in the spine, and this is the first report to describe a case of patient with TIO in the thoracic ...

Last Updated: 18 May 2015

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Hypophosphatemic osteomalacia due to drug-induced Fanconi's syndrome associated with adefovir dipivoxil treatment for hepatitis B.
 

Author(s): Hiroyuki Eguchi, Munehisa Tsuruta, Junichi Tani, Reiichiro Kuwahara, Yuji Hiromatsu

Journal: Intern. Med.. 2014 ;53(3):233-7.

 

We herein present the case of a 58-year-old Japanese man with Fanconi's syndrome with a 13-month history of bone pain in his ribs, hips, knees and ankles. He had been receiving low-dose adefovir dipivoxil (ADV) for the treatment of lamivudine-resistant chronic hepatitis B virus infection ...

Last Updated: 4 Feb 2014

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Osteocyte regulation of phosphate homeostasis and bone mineralization underlies the pathophysiology of the heritable disorders of rickets and osteomalacia.
 

Author(s): Jian Q Feng, Erica L Clinkenbeard, Baozhi Yuan, Kenneth E White, Marc K Drezner

Journal: Bone. 2013 Jun;54(2):213-21.

 

Although recent studies have established that osteocytes function as secretory cells that regulate phosphate metabolism, the biomolecular mechanism(s) underlying these effects remain incompletely defined. However, investigations focusing on the pathogenesis of X-linked hypophosphatemia ...

Last Updated: 10 Apr 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

68Ga-DOTATATE PET/CT in Oncogenic Osteomalacia
 

Status: Recruiting

Condition Summary: Oncogenic Osteomalacia; Mesenchymal Tumor

 

Last Updated: 13 Jan 2015

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A Study of KRN23 in Subjects With Tumor-Induced Osteomalacia or Epidermal Nevus Syndrome
 

Status: Not yet recruiting

Condition Summary: Tumor-Induced Osteomalacia or Epidermal Nevus Syndrome

 

Last Updated: 23 Mar 2016

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Last Updated: 5 Jan 2015

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