Oral cancer

Common Name(s)

Oral cancer

Oral cancer includes cancers of the mouth, lips, and oropharynx (the part of the throat at the back of the mouth).  Most cases are designated as squamous cell carcinomas because they begin in the flat cells (squamous cells) that cover the surfaces of the mouth, tongue, and lips. About 35,000 individuals in the United Stated are diagnosed with oral cancer each year. The use of alcohol and/or tobacco is associated with approximately 75 percent of oral cancers. Treatment for oral cancer may include surgery, radiation therapy, chemotherapy, or targeted therapy.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Oral cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

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The Oral Cancer Foundation

Through increased public and professional awareness, prevention through lifestyle changes, early detection initiatives, education, improved treatment modalities, and sponsorship of research, the Oral Cancer Foundation's mission is to contribute to the reduction of suffering, permanent physical damage and disfigurement, and death caused by this disease.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Oral cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

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The Oral Cancer Foundation

Through increased public and professional awareness, prevention through lifestyle changes, early detection initiatives, education, improved treatment modalities, and sponsorship of research, the Oral Cancer Foundation's mission is to contribute to the reduction of suffering, permanent physical damage and disfigurement, and death caused by this disease.

http://oralcancer.org/

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Oral cancer" returned 1330 free, full-text research articles on human participants. First 3 results:

Oral epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of non-small cell lung cancer: comparative pharmacokinetics and drug-drug interactions.
 

Author(s): Solange Peters, Stefan Zimmermann, Alex A Adjei

Journal: Cancer Treat. Rev.. 2014 Sep;40(8):917-26.

 

The development of orally active small molecule inhibitors of the epidermal growth factor receptor (EGFR) has led to new treatment options for non-small cell lung cancer (NSCLC). Patients with activating mutations of the EGFR gene show sensitivity to, and clinical benefit from, treatment ...

Last Updated: 28 Jul 2014

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Oral manifestations of hereditary nonpolyposis colorectal cancer syndrome: a family case series.
 

Author(s): Fabiana Tolentino Almeida, Raquel Ribeiro Gomes, André Ferreira Leite, João Batista Sousa, Ana Carolina Acevedo, Eliete Neves Silva Guerra

Journal:

 

Hereditary nonpolyposis colorectal cancer is a colorectal cancer syndrome characterized by the development of colorectal cancer and extracolonic tumors, and this syndrome has an autosomal dominant mode of inheritance. To our knowledge, our study was the first to find dento-osseous ...

Last Updated: 23 Jul 2014

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Selective apoptotic cell death effects of oral cancer cells treated with destruxin B.
 

Author(s): Rosa Huang Liu, Shih-Pin Chen, Tsong-Ming Lu, Wei-Yu Tsai, Chung-Hung Tsai, Chi-Chiang Yang, Yew-Min Tzeng

Journal:

 

Recent studies have revealed that destruxins (Dtx) have potent cytotoxic activities on individual cancer cells, however, data on oral cancer cells especial human are absent.

Last Updated: 16 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Oral cancer" returned 128 free, full-text review articles on human participants. First 3 results:

Oral epithelial stem cells - implications in normal development and cancer metastasis.
 

Author(s): Silvana Papagerakis, Giuseppe Pannone, Li Zheng, Imad About, Nawar Taqi, Nghia P T Nguyen, Margarite Matossian, Blake McAlpin, Angela Santoro, Jonathan McHugh, Mark E Prince, Petros Papagerakis

Journal: Exp. Cell Res.. 2014 Jul;325(2):111-29.

 

Oral mucosa is continuously exposed to environmental forces and has to be constantly renewed. Accordingly, the oral mucosa epithelium contains a large reservoir of epithelial stem cells necessary for tissue homeostasis. Despite considerable scientific advances in stem cell behavior ...

Last Updated: 25 Jun 2014

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Oral and dental late effects in survivors of childhood cancer: a Children's Oncology Group report.
 

Author(s): Karen E Effinger, Cesar A Migliorati, Melissa M Hudson, Kevin P McMullen, Sue C Kaste, Kathy Ruble, Gregory M T Guilcher, Ami J Shah, Sharon M Castellino

Journal: Support Care Cancer. 2014 Jul;22(7):2009-19.

 

Multi-modality therapy has resulted in improved survival for childhood malignancies. The Children's Oncology Group Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancers provide practitioners with exposure- and risk-based recommendations for ...

Last Updated: 2 Jun 2014

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Oral bacteria and cancer.
 

Author(s): Sarah E Whitmore, Richard J Lamont

Journal:

 

Last Updated: 28 Mar 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Expression of VEGF-C and VEGF-CR in Oral Cancers and Premalignant Lesions
 

Status: Recruiting

Condition Summary: Oral Cancer

 

Last Updated: 12 Sep 2005

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Validation of DNA Methylation Biomarkers for Oral Cancer Detection
 

Status: Recruiting

Condition Summary: Oral Cancer

 

Last Updated: 14 Apr 2014

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Study on the Carcinogenesis of Gα12 in Oral Cancer, and the Treatment of Oral Cancer Using Ga12 Inhibitor.
 

Status: Recruiting

Condition Summary: Carcinogenesis; Oral Cancer

 

Last Updated: 14 Apr 2014

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