Optic neuritis

Common Name(s)

Optic neuritis

Optic neuritis is inflammation of the optic nerve, the nerve that carries the visual signal from the eye to the brain.  The condition may cause sudden, reduced vision in the affected eye(s). While the cause of optic neuritis is unknown, it has been associated with autoimmune diseases, infections, multiple sclerosis, drug toxicity and deficiency of vitamin B-12. Vision often returns to normal within 2-3 weeks without treatment. In some cases, corticosteroids are given to speed recovery. If known, the underlying cause should be treated.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Optic neuritis" for support, advocacy or research.

The Transverse Myelitis Association

Our Mission is- -To support and advocate for individuals and their families diagnosed with rare neuro-immunologic disorders of the central nervous system -To promote awareness and to empower patients, families, clinicians and scientists through education programs and publications -To advance the scientific understanding of and therapy development for these rare disorders by supporting the training of clinicians-scientists dedicated to these rare diseases and by supporting basic and clinical research. OUR GOAL IS TO IMPROVE THE QUALITY OF LIFE OF INDIVIDUALS WITH THESE RARE NEURO-IMMUNOLOGIC DISORDERS

Last Updated: 29 Apr 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Optic neuritis" for support, advocacy or research.

The Transverse Myelitis Association

Our Mission is- -To support and advocate for individuals and their families diagnosed with rare neuro-immunologic disorders of the central nervous system -To promote awareness and to empower patients, families, clinicians and scientists through education programs and publications -To advance the scientific understanding of and therapy development for these rare disorders by supporting the training of clinicians-scientists dedicated to these rare diseases and by supporting basic and clinical research. OUR GOAL IS TO IMPROVE THE QUALITY OF LIFE OF INDIVIDUALS WITH THESE RARE NEURO-IMMUNOLOGIC DISORDERS

http://www.myelitis.org/

Last Updated: 29 Apr 2014

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General Resources

Newsletters and publications

Quarterly newsletters and journals to update the community on current research and various community outreach events and opportunities.

Updated 5 Mar 2013

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Ask the Expert Podcast

Ask the Expert Podcast Series are held about once a month and the recordings are made available on the TMA website. The podcast is offered at no cost to TMA members and members share their questions in advance of the podcast for the experts.

Updated 29 Apr 2014

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Research and Educational Symposia

Recordings of all our national and international symposia are made available for our community to learn more about rare neuro-immune diseases

Updated 29 Apr 2014

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Physician Network

Physician network of specialists focused on rare neuro-immune diseases which is community sourced.

Updated 29 Apr 2014

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Blogs

The TMA Blog

Articles, news and reflections from our TMA members and medical professionals

Updated 5 Mar 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Optic neuritis" returned 278 free, full-text research articles on human participants. First 3 results:

Permeability of the blood-brain barrier predicts conversion from optic neuritis to multiple sclerosis.
 

Author(s): Stig P Cramer, Signe Modvig, Helle J Simonsen, Jette L Frederiksen, Henrik B W Larsson

Journal: Brain. 2015 Sep;138(Pt 9):2571-83.

 

Optic neuritis is an acute inflammatory condition that is highly associated with multiple sclerosis. Currently, the best predictor of future development of multiple sclerosis is the number of T2 lesions visualized by magnetic resonance imaging. Previous research has found abnormalities ...

Last Updated: 25 Aug 2015

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Antibodies to myelin oligodendrocyte glycoprotein in idiopathic optic neuritis.
 

Author(s): Hideki Nakajima, Masakatsu Motomura, Keiko Tanaka, Azusa Fujikawa, Ruka Nakata, Yasuhiro Maeda, Tomoaki Shima, Akihiro Mukaino, Shunsuke Yoshimura, Teiichiro Miyazaki, Hirokazu Shiraishi, Atsushi Kawakami, Akira Tsujino

Journal:

 

To investigate the differences of clinical features, cerebrospinal fluid (CSF), MRI findings and response to steroid therapies between patients with optic neuritis (ON) who have myelin oligodendrocyte glycoprotein (MOG) antibodies and those who have seronegative ON.

Last Updated: 3 Apr 2015

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An Eye on Brain Integrity: Acute Optic Neuritis Affects Resting State Functional Connectivity.
 

Author(s): Gregory F Wu, Matthew R Brier, Cassie A-L Parks, Beau M Ances, Gregory P Van Stavern

Journal: Invest. Ophthalmol. Vis. Sci.. 2015 Apr;56(4):2541-6.

 

Currently, the ability for imaging to capture brain adaptations to injury that occurs in multiple sclerosis (MS) is limited. In particular, how the brain initially contends with the earliest clinical manifestations of white matter injury has yet to be defined. The purpose of this ...

Last Updated: 17 Jun 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Optic neuritis" returned 20 free, full-text review articles on human participants. First 3 results:

Re-evaluating the treatment of acute optic neuritis.
 

Author(s): Jeffrey L Bennett, Molly Nickerson, Fiona Costello, Robert C Sergott, Jonathan C Calkwood, Steven L Galetta, Laura J Balcer, Clyde E Markowitz, Timothy Vartanian, Mark Morrow, Mark L Moster, Andrew W Taylor, Thaddeus W W Pace, Teresa Frohman, Elliot M Frohman

Journal: J. Neurol. Neurosurg. Psychiatr.. 2015 Jul;86(7):799-808.

 

Clinical case reports and prospective trials have demonstrated a reproducible benefit of hypothalamic-pituitary-adrenal (HPA) axis modulation on the rate of recovery from acute inflammatory central nervous system (CNS) demyelination. As a result, corticosteroid preparations and adrenocorticotrophic ...

Last Updated: 13 Jun 2015

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[Optic neuritis].
 

Author(s): H Wilhelm, C Heine, F Tonagel

Journal: Klin Monbl Augenheilkd. 2014 Nov;231(11):1073-83.

 

Optic neuritis is a frequent neuro-ophthalmological disease in which the diagnosis can be based on just a few symptoms and findings. It is not only important to differentiate from other optic nerve disorders but also to recognise special types of optic neuritis, which is mostly only ...

Last Updated: 25 Nov 2014

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Bilateral monosymptomatic optic neuritis following Mycoplasma pneumoniae infection: a case report and literature review.
 

Author(s): Wei-Yu Chiang, Hsiu-Mei Huang

Journal: Indian J Ophthalmol. 2014 Jun;62(6):724-7.

 

Herein, we report the clinical findings, treatment choice, and clinical course of a rare case of Mycoplasma pneumoniae (M. pneumoniae) infection with the sole manifestation of optic neuritis (ON). To the best of our knowledge, this is the first case presenting monosymptomatic visual ...

Last Updated: 9 Jul 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 9 Jun 2015

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Lipoic Acid as a Treatment for Acute Optic Neuritis
 

Status: Recruiting

Condition Summary: Optic Neuritis

 

Last Updated: 2 Feb 2015

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Defining the Functional and Neuro-Protective Potential of ACTHAR in Acute Optic Neuritis
 

Status: Recruiting

Condition Summary: Optic Neuritis

 

Last Updated: 22 Jan 2016

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