Optic neuritis

Common Name(s)

Optic neuritis

Optic neuritis is inflammation of the optic nerve, the nerve that carries the visual signal from the eye to the brain.  The condition may cause sudden, reduced vision in the affected eye(s). While the cause of optic neuritis is unknown, it has been associated with autoimmune diseases, infections, multiple sclerosis, drug toxicity and deficiency of vitamin B-12. Vision often returns to normal within 2-3 weeks without treatment. In some cases, corticosteroids are given to speed recovery. If known, the underlying cause should be treated.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Optic neuritis" for support, advocacy or research.

The Transverse Myelitis Association

Our Mission is- -To support and advocate for individuals and their families diagnosed with rare neuro-immunologic disorders of the central nervous system -To promote awareness and to empower patients, families, clinicians and scientists through education programs and publications -To advance the scientific understanding of and therapy development for these rare disorders by supporting the training of clinicians-scientists dedicated to these rare diseases and by supporting basic and clinical research. OUR GOAL IS TO IMPROVE THE QUALITY OF LIFE OF INDIVIDUALS WITH THESE RARE NEURO-IMMUNOLOGIC DISORDERS

Last Updated: 29 Apr 2014

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General Support Organizations

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How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Optic neuritis" for support, advocacy or research.

The Transverse Myelitis Association

Our Mission is- -To support and advocate for individuals and their families diagnosed with rare neuro-immunologic disorders of the central nervous system -To promote awareness and to empower patients, families, clinicians and scientists through education programs and publications -To advance the scientific understanding of and therapy development for these rare disorders by supporting the training of clinicians-scientists dedicated to these rare diseases and by supporting basic and clinical research. OUR GOAL IS TO IMPROVE THE QUALITY OF LIFE OF INDIVIDUALS WITH THESE RARE NEURO-IMMUNOLOGIC DISORDERS

http://www.myelitis.org/

Last Updated: 29 Apr 2014

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General Resources

Newsletters and publications

Quarterly newsletters and journals to update the community on current research and various community outreach events and opportunities.

Updated 5 Mar 2013

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Ask the Expert Podcast

Ask the Expert Podcast Series are held about once a month and the recordings are made available on the TMA website. The podcast is offered at no cost to TMA members and members share their questions in advance of the podcast for the experts.

Updated 29 Apr 2014

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Research and Educational Symposia

Recordings of all our national and international symposia are made available for our community to learn more about rare neuro-immune diseases

Updated 29 Apr 2014

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Physician Network

Physician network of specialists focused on rare neuro-immune diseases which is community sourced.

Updated 29 Apr 2014

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Blogs

The TMA Blog

Articles, news and reflections from our TMA members and medical professionals

Updated 5 Mar 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Optic neuritis" returned 240 free, full-text research articles on human participants. First 3 results:

Imidazol-1-ylethylindazole voltage-gated sodium channel ligands are neuroprotective during optic neuritis in a mouse model of multiple sclerosis.
 

Author(s): Lorcan Browne, Katie Lidster, Sarah Al-Izki, Lisa Clutterbuck, Cristina Posada, A W Edith Chan, Dieter Riddall, John Garthwaite, David Baker, David L Selwood

Journal: J. Med. Chem.. 2014 Apr;57(7):2942-52.

 

A series of imidazol-1-ylethylindazole sodium channel ligands were developed and optimized for sodium channel inhibition and in vitro neuroprotective activity. The molecules exhibited displacement of a radiolabeled sodium channel ligand and selectivity for blockade of the inactivated ...

Last Updated: 6 May 2014

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Prospective study on retinal nerve fibre layer thickness changes in isolated unilateral retrobulbar optic neuritis.
 

Author(s): Gordon S K Yau, Jacky W Y Lee, Patrick P K Lau, Victor T Y Tam, Winnie W Y Wong, Can Y F Yuen

Journal:

 

To investigate the retinal nerve fibre layer (RNFL) thickness after unilateral acute optic neuritis using optical coherence tomography (OCT).

Last Updated: 24 Jan 2014

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Optic neuritis due to immunobiologics: first Brazilian case report.
 

Author(s): Luiz Gustavo Martins da Silva, Letícia Soares Sasso, Carlos José Nelli, Fred Bernardes Filho, Marilda Aparecida Milanez Morgado de Abreu

Journal: An Bras Dermatol. ;88(6 Suppl 1):162-5.

 

The change in immunological response obtained by immunobiologics has brought a new paradigm to the treatment of immune-mediated disorders. As a result of their efficacy, there is a positive impact on the quality of life of patients. However, severe side effects, such as demyelination ...

Last Updated: 18 Dec 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Optic neuritis" returned 10 free, full-text review articles on human participants. First 3 results:

New-onset type 1 diabetes mellitus and anti-aquaporin-4 antibody positive optic neuritis associated with type 1 interferon therapy for chronic hepatitis C.
 

Author(s): Tomoya Kawazoe, Manabu Araki, Youwei Lin, Masafumi Ogawa, Tomoko Okamoto, Takashi Yamamura, Masato Wakakura, Miho Murata

Journal: Intern. Med.. 2012 ;51(18):2625-9.

 

A 60-year-old woman developed type 1 diabetes mellitus and anti-aquaporin-4 antibody positive optic neuritis during type 1 interferon therapies for chronic hepatitis C. The diabetes mellitus was elicited by interferon-α plus ribavirin therapy, while the optic neuritis was induced ...

Last Updated: 19 Sep 2012

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Optic neuritis.
 

Author(s): D Pau, N Al Zubidi, S Yalamanchili, G T Plant, A G Lee

Journal: Eye (Lond). 2011 Jul;25(7):833-42.

 

The aim of this study is to provide a clinical update on optic neuritis (ON), its association with multiple sclerosis (MS), and neuromyelitis optica (NMO).

Last Updated: 14 Jul 2011

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Optical coherence tomography (OCT) in optic neuritis and multiple sclerosis.
 

Author(s): C Lamirel, N J Newman, V Biousse

Journal: Rev. Neurol. (Paris). 2010 Dec;166(12):978-86.

 

Optical coherence tomography (OCT) is a non-invasive imaging technique routinely used in ophthalmology to visualize and quantify the layers of the retina. It also provides information on optic nerve head topography, peripapillary retinal nerve fiber layer thickness, and macular volume, ...

Last Updated: 14 Dec 2010

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Amiloride Clinical Trial In Optic Neuritis
 

Status: Recruiting

Condition Summary: Optic Neuritis; Multiple Sclerosis

 

Last Updated: 26 Mar 2013

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Neuroprotection With Phenytoin in Optic Neuritis
 

Status: Recruiting

Condition Summary: Optic Neuritis; Multiple Sclerosis

 

Last Updated: 20 Dec 2013

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Defining the Functional and Neuro-Protective Potential of ACTHAR in Acute Optic Neuritis
 

Status: Recruiting

Condition Summary: Optic Neuritis

 

Last Updated: 12 Nov 2013

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