Aortic Valve Stenosis

Common Name(s)

Aortic Valve Stenosis

Aortic valve stenosis, or aortic stenosis, is a relatively common heart condition. Generally, blood is pumped by the heart to the rest of the body, exiting the heart through the aortic valve. Aortic stenosis is characterized by a narrowing of this valve. This narrowed valve can hinder blood flow from the heart, also causing the heart to work harder. Over time, this may weaken the heart muscle and cause fatigue and dizziness. Other symptoms include: chest pain, coughing (sometimes bloody), and breathing problems. Symptoms experienced by infants include: failure to gain weight, difficulty feeding, and serious breathing problems. This condition can be present from birth, but most often develops later in life due to the buildup of calcium in the valve. Aortic stenosis can affect both men and women, but is more common in men. Treatment includes medication to control blood pressure and possibly surgery to replace the valve.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Aortic Valve Stenosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Aortic Valve Stenosis" returned 391 free, full-text research articles on human participants. First 3 results:

Systemic vascular load in calcific degenerative aortic valve stenosis: insight from percutaneous valve replacement.
 

Author(s): Raquel Yotti, Javier Bermejo, Enrique Gutiérrez-Ibañes, Candelas Pérez del Villar, Teresa Mombiela, Jaime Elízaga, Yolanda Benito, Ana González-Mansilla, Alicia Barrio, Daniel Rodríguez-Pérez, Pablo Martínez-Legazpi, Francisco Fernández-Avilés

Journal: J. Am. Coll. Cardiol.. 2015 Feb;65(5):423-33.

 

Systemic arterial load impacts the symptomatic status and outcome of patients with calcific degenerative aortic stenosis (AS). However, assessing vascular properties is challenging because the arterial tree's behavior could be influenced by the valvular obstruction.

Last Updated: 9 Feb 2015

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Association of low-density lipoprotein cholesterol-related genetic variants with aortic valve calcium and incident aortic stenosis.
 

Author(s): J Gustav Smith, Kevin Luk, Christina-Alexandra Schulz, James C Engert, Ron Do, George Hindy, Gull Rukh, Line Dufresne, Peter Almgren, David S Owens, Tamara B Harris, Gina M Peloso, Kathleen F Kerr, Quenna Wong, Albert V Smith, Matthew J Budoff, Jerome I Rotter, L Adrienne Cupples, Stephen Rich, Sekar Kathiresan, Marju Orho-Melander, Vilmundur Gudnason, Christopher J O'Donnell, Wendy S Post, George Thanassoulis,

Journal: JAMA. 2014 Nov;312(17):1764-71.

 

Plasma low-density lipoprotein cholesterol (LDL-C) has been associated with aortic stenosis in observational studies; however, randomized trials with cholesterol-lowering therapies in individuals with established valve disease have failed to demonstrate reduced disease progression.

Last Updated: 5 Nov 2014

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Sex differences in cardiovascular outcome during progression of aortic valve stenosis.
 

Author(s): Dana Cramariuc, Barbara Patricia Rogge, Mai Tone Lønnebakken, Kurt Boman, Edda Bahlmann, Christa Gohlke-Bärwolf, John B Chambers, Terje R Pedersen, Eva Gerdts

Journal: Heart. 2015 Feb;101(3):209-14.

 

Women with severe aortic valve stenosis (AS) have better LV systolic function and more concentric LV geometry than their male counterparts. However, sex differences in cardiovascular (CV) outcome during progression of AS have not been reported from a longitudinal prospective study.

Last Updated: 16 Jan 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Aortic Valve Stenosis" returned 27 free, full-text review articles on human participants. First 3 results:

Beyond adding years to life: health-related quality-of-life and functional outcomes in patients with severe aortic valve stenosis at high surgical risk undergoing transcatheter aortic valve replacement.
 

Author(s): Marcus-Andre Deutsch, Sabine Bleiziffer, Yacine Elhmidi, Nicolo Piazza, Bernhard Voss, Ruediger Lange, Markus Krane

Journal: Curr Cardiol Rev. 2013 Nov;9(4):281-94.

 

Aortic valve stenosis (AVS) is the most frequent acquired valvular heart disease in western industrialized countries and its prevalence considerably increases with age. Once becoming symptomatic severe AVS has a very poor prognosis. Progressive and rapid symptom deterioration leads ...

Last Updated: 21 Feb 2014

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Cost-effectiveness of transcatheter aortic valve implantation (TAVI) for aortic stenosis in patients who are high risk or contraindicated for surgery: a model-based economic evaluation.
 

Author(s): R Orlando, M Pennant, S Rooney, S Khogali, S Bayliss, A Hassan, D Moore, P Barton

Journal: Health Technol Assess. 2013 Aug;17(33):1-86.

 

Calcific aortic stenosis (AS) is a common valvular heart disease. Patients with severe symptomatic AS typically survive less than 3 years. In such patients, intervention with surgical aortic valve replacement (SAVR) may increase survival. However, in some patients SAVR is associated ...

Last Updated: 16 Aug 2013

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Transcatheter aortic valve implantation (TAVI) for treatment of aortic valve stenosis: an evidence update.
 

Author(s): S Sehatzadeh, B Doble, F Xie, G Blackhouse, K Campbell, K Kaulback, K Chandra, R Goeree

Journal:

 

One-year mortality outcomes in the PARTNER trial showed that transcatheter aortic valve implantation (TAVI) was noninferior to surgical aortic valve replacement (sAVR) in patients who were eligible for sAVR (cohort A), and superior to standard treatment in patients who were ineligible ...

Last Updated: 9 Jul 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Genetic of Aortic Valve Stenosis - Clinical and Therapeutic Implications
 

Status: Recruiting

Condition Summary: Aortic Valve Stenosis

 

Last Updated: 10 Apr 2015

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Preoperative Assessment of Aortic Valve Stenosis and Coronary Artery Disease
 

Status: Recruiting

Condition Summary: Aortic Valve Stenosis; Coronary Disease

 

Last Updated: 16 Apr 2013

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Left Atrial Volume Index in Asymptomatic Aortic Stenosis
 

Status: Recruiting

Condition Summary: Aortic Valve Stenosis; Heart Failure

 

Last Updated: 20 Mar 2015

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