Aortic Valve Stenosis

Common Name(s)

Aortic Valve Stenosis

Aortic valve stenosis, or aortic stenosis, is a relatively common heart condition. Generally, blood is pumped by the heart to the rest of the body, exiting the heart through the aortic valve. Aortic stenosis is characterized by a narrowing of this valve. This narrowed valve can hinder blood flow from the heart, also causing the heart to work harder. Over time, this may weaken the heart muscle and cause fatigue and dizziness. Other symptoms include: chest pain, coughing (sometimes bloody), and breathing problems. Symptoms experienced by infants include: failure to gain weight, difficulty feeding, and serious breathing problems. This condition can be present from birth, but most often develops later in life due to the buildup of calcium in the valve. Aortic stenosis can affect both men and women, but is more common in men. Treatment includes medication to control blood pressure and possibly surgery to replace the valve.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Aortic Valve Stenosis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Aortic Valve Stenosis" returned 359 free, full-text research articles on human participants. First 3 results:

Echocardiography underestimates stroke volume and aortic valve area: implications for patients with small-area low-gradient aortic stenosis.
 

Author(s): Calvin W L Chin, Hwan J Khaw, Elton Luo, Shuwei Tan, Audrey C White, David E Newby, Marc R Dweck

Journal: Can J Cardiol. 2014 Sep;30(9):1064-72.

 

Discordance between small aortic valve area (AVA; < 1.0 cm(2)) and low mean pressure gradient (MPG; < 40 mm Hg) affects a third of patients with moderate or severe aortic stenosis (AS). We hypothesized that this is largely due to inaccurate echocardiographic measurements of the left ...

Last Updated: 25 Aug 2014

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Low circulating monocyte count is associated with severe aortic valve stenosis.
 

Author(s): Shmuel Schwartzenberg, Valery Meledin, Liaz Zilberman, Sorel Goland, Jacob George, Sara Shimoni

Journal: Isr. Med. Assoc. J.. 2013 Sep;15(9):500-4.

 

The pathophysiology of aortic stenosis (AS) involves inflammatory features including infiltration of the aortic valve (AV) by activated macrophages and T cells, deposition of lipids, and heterotopic calcification.

Last Updated: 13 Dec 2013

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Mini-Konno procedure using a 10 mm handmade valve for pulmonary atresia with intact ventricular septum and severe aortic stenosis.
 

Author(s): Hironori Matsuhisa, Yoshihiro Oshima, Akiko Tanaka, Naoya Kamei

Journal: Interact Cardiovasc Thorac Surg. 2014 Mar;18(3):404-6.

 

We herein report the case of a neonate with pulmonary atresia with intact ventricular septum, right ventricular hypoplasia and severe aortic stenosis. Repetitive aortic valve surgeries in early infancy resulted in early relapse of the aortic stenosis due to the small aortic annulus, ...

Last Updated: 17 Feb 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Aortic Valve Stenosis" returned 27 free, full-text review articles on human participants. First 3 results:

Cost-effectiveness of transcatheter aortic valve implantation (TAVI) for aortic stenosis in patients who are high risk or contraindicated for surgery: a model-based economic evaluation.
 

Author(s): R Orlando, M Pennant, S Rooney, S Khogali, S Bayliss, A Hassan, D Moore, P Barton

Journal: Health Technol Assess. 2013 Aug;17(33):1-86.

 

Calcific aortic stenosis (AS) is a common valvular heart disease. Patients with severe symptomatic AS typically survive less than 3 years. In such patients, intervention with surgical aortic valve replacement (SAVR) may increase survival. However, in some patients SAVR is associated ...

Last Updated: 16 Aug 2013

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Transcatheter aortic valve implantation (TAVI) for treatment of aortic valve stenosis: an evidence update.
 

Author(s): S Sehatzadeh, B Doble, F Xie, G Blackhouse, K Campbell, K Kaulback, K Chandra, R Goeree

Journal:

 

One-year mortality outcomes in the PARTNER trial showed that transcatheter aortic valve implantation (TAVI) was noninferior to surgical aortic valve replacement (sAVR) in patients who were eligible for sAVR (cohort A), and superior to standard treatment in patients who were ineligible ...

Last Updated: 9 Jul 2013

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Comparison 30-day clinical complications between transfemoral versus transapical aortic valve replacement for aortic stenosis: a meta-analysis review.
 

Author(s): Xuebiao Li, Minjian Kong, Daming Jiang, Aiqiang Dong

Journal:

 

Since 2002, transapical aortic valve replacement has been developed as a clinical pathway for transcatheter aortic valve implantation (TAVI). However the appropriate role of TA in the AS population versus TF remains unclear. We performed a meta-analysis to assess if TF has any benefit ...

Last Updated: 25 Jul 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Genetic of Aortic Valve Stenosis - Clinical and Therapeutic Implications
 

Status: Recruiting

Condition Summary: Aortic Valve Stenosis

 

Last Updated: 3 Aug 2011

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Surgical Treatment of Aortic Stenosis With a Next Generation Surgical Aortic Valve
 

Status: Recruiting

Condition Summary: Aortic Valve Stenosis With Insufficiency; Aortic Valve Stenosis

 

Last Updated: 30 Sep 2011

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Preoperative Assessment of Aortic Valve Stenosis and Coronary Artery Disease
 

Status: Recruiting

Condition Summary: Aortic Valve Stenosis; Coronary Disease

 

Last Updated: 16 Apr 2013

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