Onchocerciasis

Common Name(s)

Onchocerciasis

Onchocerciasis, also known as river blindness, is a parasitic disease affecting the eyes and skin caused by the parasitic worm Onchocerca volvulus. Onchocerciasis is transmitted to humans through bites of infected blackflies. These blackflies are common in fast-flowing rivers and streams, typically in remote villages nearby fertile land used for agriculture. Symptoms of Onchocerciasis include severe itching, skin lesions, the development of nodules under the skin, and eye lesions that can lead to visual impairment and permanent blindness. This disease occurs primarily in tropical areas, with almost all of the infected people living in sub-Saharan Africa. Cases of this disease have also appeared in Yemen and Latin America. There is currently no vaccine or medication available to prevent infection.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Onchocerciasis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Onchocerciasis" returned 246 free, full-text research articles on human participants. First 3 results:

Last Updated: 12 Sep 2014

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The impact of Merowe Dam on Simulium hamedense vector of onchocerciasis in Abu Hamed focus - Northern Sudan.
 

Author(s): Isam M A Zarroug, Arwa H Elaagip, Sara A Abuelmaali, Hanan A Mohamed, Wigdan A ElMubarak, Kamal Hashim, Tong Chor M Deran, Nabil Aziz, Tarig B Higazi

Journal:

 

Abu Hamed, the northernmost onchocerciasis focus in the world, is located along the River Nile banks in the Nubian Desert. Hydroelectric dams can alter activity of black flies and may provide breeding sites for black fly. Merowe Dam, the largest hydropower project in Africa, was built ...

Last Updated: 8 Apr 2014

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Immunoepidemiological profiling of onchocerciasis patients reveals associations with microfilaria loads and ivermectin intake on both individual and community levels.
 

Author(s): Kathrin Arndts, Sabine Specht, Alexander Y Debrah, Francesca Tamarozzi, Ute Klarmann Schulz, Sabine Mand, Linda Batsa, Alexander Kwarteng, Mark Taylor, Ohene Adjei, Coralie Martin, Laura E Layland, Achim Hoerauf

Journal:

 

Mass drug administration (MDA) programmes against Onchocerca volvulus use ivermectin (IVM) which targets microfilariae (MF), the worm's offspring. Most infected individuals are hyporesponsive and present regulated immune responses despite high parasite burden. Recently, with MDA programmes, ...

Last Updated: 3 Mar 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Onchocerciasis" returned 15 free, full-text review articles on human participants. First 3 results:

Anti-Wolbachia drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis.
 

Author(s): Mark J Taylor, Achim Hoerauf, Simon Townson, Barton E Slatko, Stephen A Ward

Journal: Parasitology. 2014 Jan;141(1):119-27.

 

Anti-Wolbachia therapy delivers safe macrofilaricidal activity with superior therapeutic outcomes compared to all standard anti-filarial treatments, with the added benefit of substantial improvements in clinical pathology. These outcomes can be achieved, in principle, with existing ...

Last Updated: 9 Jan 2014

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Case-control studies on the relationship between onchocerciasis and epilepsy: systematic review and meta-analysis.
 

Author(s): Christoph Kaiser, Sébastien D S Pion, Michel Boussinesq

Journal: PLoS Negl Trop Dis. 2013 ;7(3):e2147.

 

A systematic review and meta-analysis of all available case-control studies on the relationship between onchocerciasis and epilepsy. Because age and level of onchocerciasis endemicity in the area of residence are major determinants for infection, an additional analysis was performed, ...

Last Updated: 4 Apr 2013

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Onchocerciasis in the Americas: from arrival to (near) elimination.
 

Author(s): Ken Gustavsen, Adrian Hopkins, Mauricio Sauerbrey

Journal:

 

Onchocerciasis (river blindness) is a blinding parasitic disease that threatens the health of approximately 120 million people worldwide. While 99% of the population at-risk for infection from onchocerciasis live in Africa, some 500,000 people in the Americas are also threatened by ...

Last Updated: 14 Nov 2011

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Mass Drug Administration for Lymphatic Filariasis and Onchocerciasis for Liberia
 

Status: Recruiting

Condition Summary: Lymphatic Filariasis; Onchocerciasis; Soil Transmitted Helminth (STH) Infections

 

Last Updated: 11 Aug 2014

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Efficacy of Ivermectin and Albendazole Against Onchocerciasis in the Volta Region, Ghana
 

Status: Not yet recruiting

Condition Summary: Onchocerciasis

 

Last Updated: 28 Feb 2014

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Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis for Ivory Coast (DOLF-Ivory Coast)
 

Status: Recruiting

Condition Summary: Lymphatic Filariasis; Onchocerciasis; Soil Transmitted Helminth (STH) Infections

 

Last Updated: 8 Dec 2014

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