Onchocerciasis

Common Name(s)

Onchocerciasis

Onchocerciasis, also known as river blindness, is a parasitic disease affecting the eyes and skin caused by the parasitic worm Onchocerca volvulus. Onchocerciasis is transmitted to humans through bites of infected blackflies. These blackflies are common in fast-flowing rivers and streams, typically in remote villages nearby fertile land used for agriculture. Symptoms of Onchocerciasis include severe itching, skin lesions, the development of nodules under the skin, and eye lesions that can lead to visual impairment and permanent blindness. This disease occurs primarily in tropical areas, with almost all of the infected people living in sub-Saharan Africa. Cases of this disease have also appeared in Yemen and Latin America. There is currently no vaccine or medication available to prevent infection.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Onchocerciasis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Onchocerciasis" returned 327 free, full-text research articles on human participants. First 3 results:

Adherence to ivermectin is more associated with perceptions of community directed treatment with ivermectin organization than with onchocerciasis beliefs.
 

Author(s): Fanny Nadia Dissak-Delon, Guy-Roger Kamga, Perrine Claire Humblet, Annie Robert, Jacob Souopgui, Joseph Kamgno, Marie José Essi, Stephen Mbigha Ghogomu, Isabelle Godin

Journal:

 

The fight against onchocerciasis in Africa has boomed thanks to the Community Directed Treatment with Ivermectin (CDTI) program. However, in Cameroon, after more than 15 years of mass treatment, onchocerciasis prevalence is still above the non-transmission threshold. This study aimed ...

Last Updated: 14 Aug 2017

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River-specific macrogenomic diversity in Simulium guianense s. l. (Diptera: Simuliidae), a complex of tropical American vectors associated with human onchocerciasis.
 

Author(s): Peter H Adler, Neusa Hamada, Jeane Marcelle Cavalcante do Nascimento, Maria Eugenia Grillet

Journal:

 

Simulium guianense Wise is a Latin American vector complex of black flies associated with transmission of the causal agent of human onchocerciasis (river blindness). An analysis of the chromosomal banding patterns of 607 larvae of S. guianense s. l. revealed a high level of variation ...

Last Updated: 20 Jul 2017

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High prevalence of epilepsy in onchocerciasis endemic regions in the Democratic Republic of the Congo.
 

Author(s): Bethany Levick, Anne Laudisoit, Floribert Tepage, Chellafe Ensoy-Musoro, Michel Mandro, Caroline Bonareri Osoro, Patrick Suykerbuyk, Jean Marie Kashama, Michel Komba, Alliance Tagoto, Dadi Falay, Michael Begon, Robert Colebunders

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An increased prevalence of epilepsy has been reported in many onchocerciasis endemic areas. The objective of this study was to determine the prevalence of epilepsy in onchocerciasis endemic areas in the Democratic Republic of the Congo (DRC) and investigate whether a higher annual ...

Last Updated: 14 Jul 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Onchocerciasis" returned 22 free, full-text review articles on human participants. First 3 results:

Loa loa vectors Chrysops spp.: perspectives on research, distribution, bionomics, and implications for elimination of lymphatic filariasis and onchocerciasis.
 

Author(s): Louise Kelly-Hope, Rossely Paulo, Brent Thomas, Miguel Brito, Thomas R Unnasch, David Molyneux

Journal:

 

Loiasis is a filarial disease caused Loa loa. The main vectors are Chrysops silacea and C. dimidiata which are confined to the tropical rainforests of Central and West Africa. Loiasis is a mild disease, but individuals with high microfilaria loads may suffer from severe adverse events ...

Last Updated: 6 Apr 2017

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An appraisal of the neglected tropical diseases control program in Cameroon: the case of the national program against onchocerciasis.
 

Author(s): Tsi Njim, Leopold Ndemnge Aminde

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Onchocerciasis is a severe parasitic infestation which causes disabling skin and subcutaneous tissue changes. Current global estimates suggest that it accounts for 1135.7 disability adjusted life years (DALYs) per 100,000 population. The disease is endemic in many African countries ...

Last Updated: 22 Jan 2017

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Doxycycline plus ivermectin versus ivermectin alone for treatment of patients with onchocerciasis.
 

Author(s): Ayokunle T Abegunde, Richard M Ahuja, Nkem J Okafor

Journal:

 

Onchocerciasis, also known as "river blindness," is a parasitic disease that is caused by infection from the filarial nematode (roundworm), Onchocerca volvulus. Nematodes are transmitted from person to person by blackflies of the Simulium genus, which usually breed in fast flowing ...

Last Updated: 1 Feb 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Ivermectin Treatment in Patients With Onchocerciasis-associated Epilepsy
 

Status: Not yet recruiting

Condition Summary: Ivermectin; Onchocerciasis; Epilepsy

 

Last Updated: 15 Feb 2017

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Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis for Ivory Coast (DOLF-Ivory Coast)
 

Status: Recruiting

Condition Summary: Lymphatic Filariasis; Onchocerciasis; Soil Transmitted Helminth (STH) Infections

 

Last Updated: 21 Nov 2016

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Prevalence of LF Infection in Districts Not Included in LF Control Activities
 

Status: Not yet recruiting

Condition Summary: Lymphatic Filariases; Onchocerciasis

 

Last Updated: 12 Sep 2017

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