Onchocerciasis

Common Name(s)

Onchocerciasis

Onchocerciasis, also known as river blindness, is a parasitic disease affecting the eyes and skin caused by the parasitic worm Onchocerca volvulus. Onchocerciasis is transmitted to humans through bites of infected blackflies. These blackflies are common in fast-flowing rivers and streams, typically in remote villages nearby fertile land used for agriculture. Symptoms of Onchocerciasis include severe itching, skin lesions, the development of nodules under the skin, and eye lesions that can lead to visual impairment and permanent blindness. This disease occurs primarily in tropical areas, with almost all of the infected people living in sub-Saharan Africa. Cases of this disease have also appeared in Yemen and Latin America. There is currently no vaccine or medication available to prevent infection.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Onchocerciasis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Onchocerciasis" returned 242 free, full-text research articles on human participants. First 3 results:

Last Updated: 12 Sep 2014

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Impact of repeated ivermectin treatments against onchocerciasis on the transmission of loiasis: an entomologic evaluation in central Cameroon.
 

Author(s): Marc K Kouam, Jules B Tchatchueng-Mbougua, Maurice Demanou, Michel Boussinesq, Sébastien D S Pion, Joseph Kamgno

Journal:

 

Annual community-directed treatment with ivermectin (CDTI) have been carried out since 1999 in the Lekie division (central region of Cameroon where most cases of Loa-related post ivermectin severe adverse events were reported) as part of the joined activities of the African Programme ...

Last Updated: 2 Dec 2013

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MRI findings in people with epilepsy and nodding syndrome in an area endemic for onchocerciasis: an observational study.
 

Author(s): A S Winkler, K Friedrich, S Velicheti, J Dharsee, R König, A Nassri, M Meindl, A Kidunda, T H Müller, L Jilek-Aall, W Matuja, T Gotwald, E Schmutzhard

Journal: Afr Health Sci. 2013 Jun;13(2):529-40.

 

Onchocerciasis has been implicated in the pathogenesis of epilepsy. The debate on a potential causal relationship between Onchocerca volvulus and epilepsy has taken a new direction in the light of the most recent epidemic of nodding syndrome.

Last Updated: 15 Nov 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Onchocerciasis" returned 15 free, full-text review articles on human participants. First 3 results:

Anti-Wolbachia drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis.
 

Author(s): Mark J Taylor, Achim Hoerauf, Simon Townson, Barton E Slatko, Stephen A Ward

Journal: Parasitology. 2014 Jan;141(1):119-27.

 

Anti-Wolbachia therapy delivers safe macrofilaricidal activity with superior therapeutic outcomes compared to all standard anti-filarial treatments, with the added benefit of substantial improvements in clinical pathology. These outcomes can be achieved, in principle, with existing ...

Last Updated: 9 Jan 2014

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Case-control studies on the relationship between onchocerciasis and epilepsy: systematic review and meta-analysis.
 

Author(s): Christoph Kaiser, Sébastien D S Pion, Michel Boussinesq

Journal: PLoS Negl Trop Dis. 2013 ;7(3):e2147.

 

A systematic review and meta-analysis of all available case-control studies on the relationship between onchocerciasis and epilepsy. Because age and level of onchocerciasis endemicity in the area of residence are major determinants for infection, an additional analysis was performed, ...

Last Updated: 4 Apr 2013

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Onchocerciasis in the Americas: from arrival to (near) elimination.
 

Author(s): Ken Gustavsen, Adrian Hopkins, Mauricio Sauerbrey

Journal:

 

Onchocerciasis (river blindness) is a blinding parasitic disease that threatens the health of approximately 120 million people worldwide. While 99% of the population at-risk for infection from onchocerciasis live in Africa, some 500,000 people in the Americas are also threatened by ...

Last Updated: 14 Nov 2011

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Mass Drug Administration for Lymphatic Filariasis and Onchocerciasis for Liberia
 

Status: Recruiting

Condition Summary: Lymphatic Filariasis; Onchocerciasis; Soil Transmitted Helminth (STH) Infections

 

Last Updated: 11 Aug 2014

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Efficacy of Ivermectin and Albendazole Against Onchocerciasis in the Volta Region, Ghana
 

Status: Not yet recruiting

Condition Summary: Onchocerciasis

 

Last Updated: 28 Feb 2014

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Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis for Ivory Coast (DOLF-Ivory Coast)
 

Status: Recruiting

Condition Summary: Lymphatic Filariasis; Onchocerciasis; Soil Transmitted Helminth (STH) Infections

 

Last Updated: 30 Apr 2014

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