Onchocerciasis

Common Name(s)

Onchocerciasis

Onchocerciasis, also known as river blindness, is a parasitic disease affecting the eyes and skin caused by the parasitic worm Onchocerca volvulus. Onchocerciasis is transmitted to humans through bites of infected blackflies. These blackflies are common in fast-flowing rivers and streams, typically in remote villages nearby fertile land used for agriculture. Symptoms of Onchocerciasis include severe itching, skin lesions, the development of nodules under the skin, and eye lesions that can lead to visual impairment and permanent blindness. This disease occurs primarily in tropical areas, with almost all of the infected people living in sub-Saharan Africa. Cases of this disease have also appeared in Yemen and Latin America. There is currently no vaccine or medication available to prevent infection.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Onchocerciasis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Onchocerciasis" returned 318 free, full-text research articles on human participants. First 3 results:

Modelling Anti-Ov16 IgG4 Antibody Prevalence as an Indicator for Evaluation and Decision Making in Onchocerciasis Elimination Programmes.
 

Author(s): Yvonne L Lont, Luc E Coffeng, Sake J de Vlas, Allison Golden, Tala de Los Santos, Gonzalo J Domingo, Wilma A Stolk

Journal:

 

Onchocerciasis is targeted for elimination in Africa through annual or biannual ivermectin mass drug administration (MDA). An immunodiagnostic test, based on the detection of human IgG4 antibodies in the blood to the Onchocerca volvulus-specific antigen Ov16, is one of the recommended ...

Last Updated: 23 Jan 2017

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Evaluation of Lymphatic Filariasis and Onchocerciasis in Three Senegalese Districts Treated for Onchocerciasis with Ivermectin.
 

Author(s): Nana O Wilson, Alioune Badara Ly, Vitaliano A Cama, Paul T Cantey, Daniel Cohn, Lamine Diawara, Abdel Direny, Mawo Fall, Karla R Feeser, LeAnne M Fox, Achille Kabore, Amadou F Seck, Ngayo Sy, Daouda Ndiaye, Christine Dubray

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In Africa, onchocerciasis and lymphatic filariasis (LF) are co-endemic in many areas. Current efforts to eliminate both diseases are through ivermectin-based mass drug administration (MDA). Years of ivermectin distribution for onchocerciasis may have interrupted LF transmission in ...

Last Updated: 7 Dec 2016

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Using Community-Level Prevalence of Loa loa Infection to Predict the Proportion of Highly-Infected Individuals: Statistical Modelling to Support Lymphatic Filariasis and Onchocerciasis Elimination Programs.
 

Author(s): Daniela K Schl├╝ter, Martial L Ndeffo-Mbah, Innocent Takougang, Tony Ukety, Samuel Wanji, Alison P Galvani, Peter J Diggle

Journal:

 

Lymphatic Filariasis and Onchocerciasis (river blindness) constitute pressing public health issues in tropical regions. Global elimination programs, involving mass drug administration (MDA), have been launched by the World Health Organisation. Although the drugs used are generally ...

Last Updated: 1 Dec 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Onchocerciasis" returned 21 free, full-text review articles on human participants. First 3 results:

Loa loa vectors Chrysops spp.: perspectives on research, distribution, bionomics, and implications for elimination of lymphatic filariasis and onchocerciasis.
 

Author(s): Louise Kelly-Hope, Rossely Paulo, Brent Thomas, Miguel Brito, Thomas R Unnasch, David Molyneux

Journal:

 

Loiasis is a filarial disease caused Loa loa. The main vectors are Chrysops silacea and C. dimidiata which are confined to the tropical rainforests of Central and West Africa. Loiasis is a mild disease, but individuals with high microfilaria loads may suffer from severe adverse events ...

Last Updated: 6 Apr 2017

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Doxycycline plus ivermectin versus ivermectin alone for treatment of patients with onchocerciasis.
 

Author(s): Ayokunle T Abegunde, Richard M Ahuja, Nkem J Okafor

Journal:

 

Onchocerciasis, also known as "river blindness," is a parasitic disease that is caused by infection from the filarial nematode (roundworm), Onchocerca volvulus. Nematodes are transmitted from person to person by blackflies of the Simulium genus, which usually breed in fast flowing ...

Last Updated: 1 Feb 2016

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Contribution and performance of female Community-Directed Distributors in the treatment of onchocerciasis with Ivermectin in Sub-Saharan Africa: a systematic review.
 

Author(s): Marius Zambou Vouking, Violette Claire Tamo, Carine Nouboudem Tadenfok

Journal:

 

The African Program for Onchocerciasis Control (APOC) was launched in 1995 with the main goal being to boost the fight against onchocerciasis in Africa. In 2011, over 80 million people benefited from this intervention thanks to the contribution of 268.718 Community-Directed Distributors ...

Last Updated: 2 Oct 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Efficacy of Ivermectin and Albendazole Against Onchocerciasis in the Volta Region, Ghana
 

Status: Not yet recruiting

Condition Summary: Onchocerciasis

 

Last Updated: 28 Feb 2014

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Ivermectin Treatment in Patients With Onchocerciasis-associated Epilepsy
 

Status: Not yet recruiting

Condition Summary: Ivermectin; Onchocerciasis; Epilepsy

 

Last Updated: 15 Feb 2017

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Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis for Ivory Coast (DOLF-Ivory Coast)
 

Status: Recruiting

Condition Summary: Lymphatic Filariasis; Onchocerciasis; Soil Transmitted Helminth (STH) Infections

 

Last Updated: 21 Nov 2016

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