Onchocerciasis

Common Name(s)

Onchocerciasis

Onchocerciasis, also known as river blindness, is a parasitic disease affecting the eyes and skin caused by the parasitic worm Onchocerca volvulus. Onchocerciasis is transmitted to humans through bites of infected blackflies. These blackflies are common in fast-flowing rivers and streams, typically in remote villages nearby fertile land used for agriculture. Symptoms of Onchocerciasis include severe itching, skin lesions, the development of nodules under the skin, and eye lesions that can lead to visual impairment and permanent blindness. This disease occurs primarily in tropical areas, with almost all of the infected people living in sub-Saharan Africa. Cases of this disease have also appeared in Yemen and Latin America. There is currently no vaccine or medication available to prevent infection.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Onchocerciasis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Onchocerciasis" returned 336 free, full-text research articles on human participants. First 3 results:

Programmatic factors associated with the limited impact of Community-Directed Treatment with Ivermectin to control Onchocerciasis in three drainage basins of South West Cameroon.
 

Author(s): Christian Tetteh Duamor, Fabrice Roberto Datchoua-Poutcheu, Winston Patrick Chounna Ndongmo, Aldof Tah Yoah, Ernest Njukang, Emmanuel Kah, Mary Sheena Maingeh, Jonas Arnaud Kengne-Ouaffo, Dizzle Bita Tayong, Peter A Enyong, Samuel Wanji

Journal:

 

The CDTI model is known to have enhanced community participation in planning and resource mobilization toward the control of onchocerciasis. These effects were expected to translate into better individual acceptance of the intervention and hence high Treatment Coverage, leading to ...

Last Updated: 31 Dec 1969

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A Test-and-Not-Treat Strategy for Onchocerciasis in Loa loa-Endemic Areas.
 

Author(s): Joseph Kamgno, Sébastien D Pion, Cédric B Chesnais, Matthew H Bakalar, Michael V D'Ambrosio, Charles D Mackenzie, Hugues C Nana-Djeunga, Raceline Gounoue-Kamkumo, Guy-Roger Njitchouang, Philippe Nwane, Jules B Tchatchueng-Mbouga, Samuel Wanji, Wilma A Stolk, Daniel A Fletcher, Amy D Klion, Thomas B Nutman, Michel Boussinesq

Journal: N. Engl. J. Med.. 2017 11;377(21):2044-2052.

 

Implementation of an ivermectin-based community treatment strategy for the elimination of onchocerciasis or lymphatic filariasis has been delayed in Central Africa because of the occurrence of serious adverse events, including death, in persons with high levels of circulating Loa ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Onchocerciasis" returned 22 free, full-text review articles on human participants. First 3 results:

Loa loa vectors Chrysops spp.: perspectives on research, distribution, bionomics, and implications for elimination of lymphatic filariasis and onchocerciasis.
 

Author(s): Louise Kelly-Hope, Rossely Paulo, Brent Thomas, Miguel Brito, Thomas R Unnasch, David Molyneux

Journal:

 

Loiasis is a filarial disease caused Loa loa. The main vectors are Chrysops silacea and C. dimidiata which are confined to the tropical rainforests of Central and West Africa. Loiasis is a mild disease, but individuals with high microfilaria loads may suffer from severe adverse events ...

Last Updated: 31 Dec 1969

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An appraisal of the neglected tropical diseases control program in Cameroon: the case of the national program against onchocerciasis.
 

Author(s): Tsi Njim, Leopold Ndemnge Aminde

Journal:

 

Onchocerciasis is a severe parasitic infestation which causes disabling skin and subcutaneous tissue changes. Current global estimates suggest that it accounts for 1135.7 disability adjusted life years (DALYs) per 100,000 population. The disease is endemic in many African countries ...

Last Updated: 31 Dec 1969

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Doxycycline plus ivermectin versus ivermectin alone for treatment of patients with onchocerciasis.
 

Author(s): Ayokunle T Abegunde, Richard M Ahuja, Nkem J Okafor

Journal:

 

Onchocerciasis, also known as "river blindness," is a parasitic disease that is caused by infection from the filarial nematode (roundworm), Onchocerca volvulus. Nematodes are transmitted from person to person by blackflies of the Simulium genus, which usually breed in fast flowing ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Ivermectin Treatment in Patients With Onchocerciasis-associated Epilepsy
 

Status: Not yet recruiting

Condition Summary: Ivermectin; Onchocerciasis; Epilepsy

 

Last Updated: 15 Feb 2017

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Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis for Ivory Coast (DOLF-Ivory Coast)
 

Status: Recruiting

Condition Summary: Lymphatic Filariasis; Onchocerciasis; Soil Transmitted Helminth (STH) Infections

 

Last Updated: 21 Nov 2016

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Prevalence of LF Infection in Districts Not Included in LF Control Activities
 

Status: Not yet recruiting

Condition Summary: Lymphatic Filariases; Onchocerciasis

 

Last Updated: 12 Sep 2017

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