Onchocerciasis

Common Name(s)

Onchocerciasis

Onchocerciasis, also known as river blindness, is a parasitic disease affecting the eyes and skin caused by the parasitic worm Onchocerca volvulus. Onchocerciasis is transmitted to humans through bites of infected blackflies. These blackflies are common in fast-flowing rivers and streams, typically in remote villages nearby fertile land used for agriculture. Symptoms of Onchocerciasis include severe itching, skin lesions, the development of nodules under the skin, and eye lesions that can lead to visual impairment and permanent blindness. This disease occurs primarily in tropical areas, with almost all of the infected people living in sub-Saharan Africa. Cases of this disease have also appeared in Yemen and Latin America. There is currently no vaccine or medication available to prevent infection.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Onchocerciasis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Onchocerciasis" returned 238 free, full-text research articles on human participants. First 3 results:

The cost of annual versus biannual community-directed treatment of onchocerciasis with ivermectin: Ghana as a case study.
 

Author(s): Hugo C Turner, Mike Y Osei-Atweneboana, Martin Walker, Edward J Tettevi, Thomas S Churcher, Odame Asiedu, Nana-Kwadwo Biritwum, María-Gloria Basáñez

Journal:

 

It has been proposed that switching from annual to biannual (twice yearly) mass community-directed treatment with ivermectin (CDTI) might improve the chances of onchocerciasis elimination in some African foci. However, historically, relatively few communities have received biannual ...

Last Updated: 26 Sep 2013

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Last Updated: 16 Sep 2013

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[The effect of ivermectin on geohelminth frequency (i.e. as used in the onchocerciasis control program in Colombia)].
 

Author(s): Angélica Knudson, Yoseth Ariza, Myriam C López, Oscar S Fajardo, Patricia Reyes, Ligia I Moncada, Sofía Duque, Carlos A Álvarez, Rubén S Nicholls

Journal: Rev Salud Publica (Bogota). 2012 Aug;14(4):681-94.

 

Evaluating the effect of ivermectin on soil-transmitted helminthes (STH) infection frequency in a Colombian population included in the Onchocerciasis Elimination Program for the Americas (OEPA).

Last Updated: 5 Aug 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Onchocerciasis" returned 14 free, full-text review articles on human participants. First 3 results:

Case-control studies on the relationship between onchocerciasis and epilepsy: systematic review and meta-analysis.
 

Author(s): Christoph Kaiser, Sébastien D S Pion, Michel Boussinesq

Journal: PLoS Negl Trop Dis. 2013 ;7(3):e2147.

 

A systematic review and meta-analysis of all available case-control studies on the relationship between onchocerciasis and epilepsy. Because age and level of onchocerciasis endemicity in the area of residence are major determinants for infection, an additional analysis was performed, ...

Last Updated: 4 Apr 2013

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Onchocerciasis in the Americas: from arrival to (near) elimination.
 

Author(s): Ken Gustavsen, Adrian Hopkins, Mauricio Sauerbrey

Journal:

 

Onchocerciasis (river blindness) is a blinding parasitic disease that threatens the health of approximately 120 million people worldwide. While 99% of the population at-risk for infection from onchocerciasis live in Africa, some 500,000 people in the Americas are also threatened by ...

Last Updated: 14 Nov 2011

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Onchocerciasis: the role of Wolbachia bacterial endosymbionts in parasite biology, disease pathogenesis, and treatment.
 

Author(s): Francesca Tamarozzi, Alice Halliday, Katrin Gentil, Achim Hoerauf, Eric Pearlman, Mark J Taylor

Journal: Clin. Microbiol. Rev.. 2011 Jul;24(3):459-68.

 

The discovery of Wolbachia intracellular bacteria within filarial nematodes, including Onchocerca volvulus, the causative agent of onchocerciasis or "river blindness," has delivered a paradigm shift in our understanding of the parasite's biology, to where we now know that the bacterial ...

Last Updated: 7 Jul 2011

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis for Liberia
 

Status: Recruiting

Condition Summary: Lymphatic Filariasis; Onchocerciasis; Soil Transmitted Helminth (STH) Infections

 

Last Updated: 18 Jul 2013

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Efficacy of Ivermectin and Albendazole Against Onchocerciasis in the Volta Region, Ghana
 

Status: Not yet recruiting

Condition Summary: Onchocerciasis

 

Last Updated: 28 Feb 2014

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Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis for Ivory Coast (DOLF-Ivory Coast)
 

Status: Recruiting

Condition Summary: Lymphatic Filariasis; Onchocerciasis; Soil Transmitted Helminth (STH) Infections

 

Last Updated: 30 Apr 2014

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