Olivopontocerebellar atrophy

Common Name(s)

Olivopontocerebellar atrophy, Olivopontocerebellar Atrophy (OPCA)

Olivopontocerebellar atrophy is a progressive disease that causes areas deep in the brain, just above the spinal cord, to shrink. The main symptom is clumsiness (ataxia) that slowly gets worse. There may also be problems with balance, slurring of speech, and difficulty walking. Olivopontocerebellar atrophy can be passed down through families (inherited form), or it may affect people without a known family history (sporadic form). Symptoms tend to start at a younger age in people with the inherited form of the condition. There is no specific treatment or cure for this disease. Therapy is aimed at treating symptoms and preventing complications.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Olivopontocerebellar atrophy" for support, advocacy or research.

Logo
National Ataxia Foundation

The National Ataxia Foundation is dedicated to improving the lives of persons affected by ataxia through support, education, and research.

Last Updated: 12 Dec 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Olivopontocerebellar atrophy" for support, advocacy or research.

Logo
National Ataxia Foundation

The National Ataxia Foundation is dedicated to improving the lives of persons affected by ataxia through support, education, and research.

http://www.ataxia.org

Last Updated: 12 Dec 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Olivopontocerebellar atrophy" returned 14 free, full-text research articles on human participants. First 3 results:

Corticobasal degeneration with olivopontocerebellar atrophy and TDP-43 pathology: an unusual clinicopathologic variant of CBD.
 

Author(s): Naomi Kouri, Kenichi Oshima, Makio Takahashi, Melissa E Murray, Zeshan Ahmed, Joseph E Parisi, Shu-Hui C Yen, Dennis W Dickson

Journal: Acta Neuropathol.. 2013 May;125(5):741-52.

 

Corticobasal degeneration (CBD) is a disorder affecting cognition and movement due to a progressive neurodegeneration associated with distinctive neuropathologic features, including abnormal phosphorylated tau protein in neurons and glia in cortex, basal ganglia, diencephalon, and ...

Last Updated: 22 Apr 2013

Go To URL
Generation of induced pluripotent stem cells from skin fibroblasts of a patient with olivopontocerebellar atrophy.
 

Author(s): Yumei Luo, Yong Fan, Borong Zhou, Zhiqiang Xu, Yaoyong Chen, Xiaofang Sun

Journal: Tohoku J. Exp. Med.. 2012 ;226(2):151-9.

 

Generation of induced pluripotent stem (iPS) cells from somatic cells of patients represents a powerful tool for disease modeling, and they may have a wide range of applications in cell therapies. Olivopontocerebellar atrophy (OPCA) is a rare and debilitating neurologic disease of ...

Last Updated: 3 Feb 2012

Go To URL
[Improvements in the symptoms of olivopontocerebellar atrophy with gabapentin].
 

Author(s): J Gazulla, M I Benavente

Journal: Rev Neurol. ;40(5):285-8.

 

Olivopontocerebellar atrophy (OPCA) is a degenerative disease of the nervous system (NS) which currently has no known cure. The neuronal depopulation it brings about produces a number of neurochemical alterations, including a reduction in levels of gamma-aminobutyric acid (GABA) in ...

Last Updated: 22 Mar 2005

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Olivopontocerebellar atrophy" returned 0 free, full-text review articles on human participants.

 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Fipamezole in Neurogenic Orthostatic Hypotension
 

Status: Not yet recruiting

Condition Summary: Symptomatic Neurogenic Orthostatic Hypotension (NOH); Parkinson's Disease; Multiple System Atrophy

 

Last Updated: 30 Sep 2008

Go to URL