Oligodendroglioma

Common Name(s)

Oligodendroglioma

Oligodendroglioma is a rare tumor that begins in oligodendrocytes, one of the types of cells that make up the supportive, or glial, tissue of the brain. They can be classified as low grade (grade II) or high grade (grade III) which refers to the how abnormal the tumor cells appear and suggests how fast the tumor may grow or spread. Type III is more aggressive than type II. This type of tumor can be found anywhere in the brain but are most commonly found in the frontal or temporal lobes (front or side of the brain). Symptoms vary depending on the size and location of the tumor but may include headaches, seizures, personality changes, one-sided weakness, and difficulty with short-term memory. Vision problems have also been reported due to added pressure on the brain. Tumors located in the temporal lobes often do not show symptoms for a long time. In general, these types of tumors are considered slow-growing so symptoms may not arise long after it begins to grow.

The cause of oligodendroglioma is not fully known, but both genetics and exposure to radiation are potential links to the development of the tumor. The majority of these tumors do no develop until mid-life, around 40 to 50 years old. Diagnosis may be made through a CT or MRI scan, a biopsy, or a combination of these methods. Treatment varies depending on the type, size, and placement of the tumor, but may include surgery, chemotherapy, radiation, steroids, or other medications. Talk to your doctor if you think you or your child may have oligodendroglioma.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Oligodendroglioma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

Last Updated: 21 Nov 2014

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Oligodendroglioma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

http://www.abc2.org

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

http://braintumor.org/

Last Updated: 21 Nov 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Oligodendroglioma" returned 79 free, full-text research articles on human participants. First 3 results:

Well-differentiated pediatric glial neoplasms with features of oligodendroglioma, angiocentric glioma and dysembryoplastic neuroepithelial tumors: a morphological diagnostic challenge.
 

Author(s): Hande Keser, Michael Barnes, Gregory Moes, Han Sung Lee, Tarık Tıhan

Journal: Turk Patoloji Derg. 2014 ;30(1):23-9.

 

Oligodendrogliomas are rare in the pediatric population, and most oligodendroglioma-like tumors in this age group may belong to other entities. In addition, accurate diagnosis and grading of such lesions using criteria developed for adult oligodendrogliomas prove difficult, and often controversial.

Last Updated: 22 Jan 2014

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Acetate supplementation induces growth arrest of NG2/PDGFRα-positive oligodendroglioma-derived tumor-initiating cells.
 

Author(s): Patrick M Long, Scott W Tighe, Heather E Driscoll, John R Moffett, Aryan M A Namboodiri, Mariano S Viapiano, Sean E Lawler, Diane M Jaworski

Journal:

 

Cancer is associated with globally hypoacetylated chromatin and considerable attention has recently been focused on epigenetic therapies. N-acetyl-L-aspartate (NAA), the primary storage form of acetate in the brain, and aspartoacylase (ASPA), the enzyme responsible for NAA catalysis ...

Last Updated: 26 Nov 2013

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Short-term survivors in glioblastomas with oligodendroglioma component: a clinical study of 186 Chinese patients from a single institution.
 

Author(s): Haihui Jiang, Xiaohui Ren, Junmei Wang, Zhe Zhang, Wenqing Jia, Song Lin

Journal: J. Neurooncol.. 2014 Jan;116(2):395-404.

 

This study was designed to display the molecular genetic features of short-term survivors in glioblastomas with oligodendroglioma component (GBMO). A total of 186 patients with histological diagnosis of primary gliomas, including 11 GBMO-STS (short-term survivors, survival ≤12 months), ...

Last Updated: 9 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Oligodendroglioma" returned 11 free, full-text review articles on human participants. First 3 results:

Occipital anaplastic oligodendroglioma with multiple organ metastases after a short clinical course: a case report and literature review.
 

Author(s): Gang Li, Zhiguo Zhang, Jianghong Zhang, Tianbo Jin, Hongjuan Liang, Li Gong, Guangbin Cui, Haixia Yang, Shiming He, Yongsheng Zhang, Guodong Gao

Journal:

 

It is generally believed that malignant gliomas never metastasize outside the central nervous system (CNS). However, the notion that oligodendrogliomas (OGDs) cells cannot spread outside CNS is being challenged.

Last Updated: 6 Mar 2014

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Multicentric oligodendroglioma: case report and review of the literature.
 

Author(s): Pamela Garcia Pulido, James Neal, Shawn Halpin, Khalid Hamandi

Journal: Seizure. 2013 Jul;22(6):480-2.

 

Last Updated: 12 Jun 2013

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Oligodendroglioma of the ciliary body: a unique case report and the review of literature.
 

Author(s): Qing Guo, Jie Hao, Shou bin Sun, Shou ping Xu, Qian Yang, Qi liang Guo, Guo dong Cui

Journal:

 

To date, there is no report in the international literature of an oligodendroglioma of the ciliary body, nor is there an analysis of the possible origins of this lesion.

Last Updated: 4 Nov 2010

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Combination Chemotherapy With BBBD Followed By Sodium Thiosulfate in Treating Patients With Anaplastic Oligodendroglioma or Oligoastrocytoma
 

Status: Recruiting

Condition Summary: Anaplastic Oligodendroglioma; Mixed Oligoastrocytoma; Brain and Central Nervous System Tumors

 

Last Updated: 2 May 2014

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Temozolomide in Relapsed or Advanced Anaplastic Oligodendroglioma and Oligoastrocytoma: Single-arm, Phase II Trial
 

Status: Recruiting

Condition Summary: Anaplastic Oligodendroglioma; Anaplastic Oligoastrocytoma

 

Last Updated: 23 May 2014

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18F FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly Diagnosed or Recurrent Gliomas
 

Status: Recruiting

Condition Summary: Adult Anaplastic Ependymoma; Adult Anaplastic Oligodendroglioma; Adult Brain Stem Glioma; Adult Diffuse Astrocytoma; Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Adult Mixed Glioma; Adult Oligodendroglioma; Adult Pilocytic Astrocytoma; Adult Pineal Gland Astrocytoma; Adult Subependymal Giant Cell Astrocytoma; Childhood High-grade Cerebellar Astrocytoma; Childhood High-grade Cerebral Astrocytoma; Childhood Low-grade Cerebellar Astrocytoma; Childhood Low-grade Cerebral Astrocytoma; Recurrent Adult Brain Tumor; Recurrent Childhood Anaplastic Astrocytoma; Recurrent Childhood Anaplastic Oligoastrocytoma; Recurrent Childhood Anaplastic Oligodendroglioma; Recurrent Childhood Brain Stem Glioma; Recurrent Childhood Cerebellar Astrocytoma; Recurrent Childhood Cerebral Astrocytoma; Recurrent Childhood Diffuse Astrocytoma; Recurrent Childhood Fibrillary Astrocytoma; Recurrent Childhood Gemistocytic Astrocytoma; Recurrent Childhood Giant Cell Glioblastoma; Recurrent Childhood Glioblastoma; Recurrent Childhood Gliomatosis Cerebri; Recurrent Childhood Gliosarcoma; Recurrent Childhood Oligoastrocytoma; Recurrent Childhood Oligodendroglioma; Recurrent Childhood Pilomyxoid Astrocytoma; Recurrent Childhood Protoplasmic Astrocytoma; Recurrent Childhood Subependymal Giant Cell Astrocytoma; Recurrent Childhood Visual Pathway and Hypothalamic Glioma; Recurrent Childhood Visual Pathway Glioma; Untreated Childhood Anaplastic Astrocytoma; Untreated Childhood Anaplastic Oligoastrocytoma; Untreated Childhood Anaplastic Oligodendroglioma; Untreated Childhood Brain Stem Glioma; Untreated Childhood Cerebellar Astrocytoma; Untreated Childhood Cerebral Astrocytoma; Untreated Childhood Diffuse Astrocytoma; Untreated Childhood Fibrillary Astrocytoma; Untreated Childhood Gemistocytic Astrocytoma; Untreated Childhood Giant Cell Glioblastoma; Untreated Childhood Glioblastoma; Untreated Childhood Gliomatosis Cerebri; Untreated Childhood Gliosarcoma; Untreated Childhood Oligoastrocytoma; Untreated Childhood Oligodendroglioma; Untreated Childhood Pilomyxoid Astrocytoma; Untreated Childhood Protoplasmic Astrocytoma; Untreated Childhood Subependymal Giant Cell Astrocytoma; Untreated Childhood Visual Pathway and Hypothalamic Glioma; Untreated Childhood Visual Pathway Glioma

 

Last Updated: 12 Dec 2014

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