Oligodendroglioma

Common Name(s)

Oligodendroglioma

Oligodendroglioma is a rare tumor that begins in oligodendrocytes, one of the types of cells that make up the supportive, or glial, tissue of the brain. They can be classified as low grade (grade II) or high grade (grade III) which refers to the how abnormal the tumor cells appear and suggests how fast the tumor may grow or spread. Type III is more aggressive than type II. This type of tumor can be found anywhere in the brain but are most commonly found in the frontal or temporal lobes (front or side of the brain). Symptoms vary depending on the size and location of the tumor but may include headaches, seizures, personality changes, one-sided weakness, and difficulty with short-term memory. Vision problems have also been reported due to added pressure on the brain. Tumors located in the temporal lobes often do not show symptoms for a long time. In general, these types of tumors are considered slow-growing so symptoms may not arise long after it begins to grow.

The cause of oligodendroglioma is not fully known, but both genetics and exposure to radiation are potential links to the development of the tumor. The majority of these tumors do no develop until mid-life, around 40 to 50 years old. Diagnosis may be made through a CT or MRI scan, a biopsy, or a combination of these methods. Treatment varies depending on the type, size, and placement of the tumor, but may include surgery, chemotherapy, radiation, steroids, or other medications. Talk to your doctor if you think you or your child may have oligodendroglioma.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Oligodendroglioma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

Last Updated: 21 Nov 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Oligodendroglioma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

http://www.abc2.org

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

http://braintumor.org/

Last Updated: 21 Nov 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Oligodendroglioma" returned 103 free, full-text research articles on human participants. First 3 results:

Recurrent Oligodendroglioma Treated with Acupuncture and Pharmacopuncture.
 

Author(s): Jae Soo Kim, Hyun Jong Lee, Sang Hoon Lee, Bong Hyo Lee

Journal: J Acupunct Meridian Stud. 2015 Jun;8(3):147-51.

 

Acupuncture and pharmacopuncture have been shown to be effective in tumor treatment. However, their effectiveness for treating oligodendroglioma has not been reported yet. The purpose of this study was to provide an initial report on the effectiveness of acupuncture and pharmacopuncture ...

Last Updated: 23 Jun 2015

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High rate of concurrent BRAF-KIAA1549 gene fusion and 1p deletion in disseminated oligodendroglioma-like leptomeningeal neoplasms (DOLN).
 

Author(s): Fausto J Rodriguez, Matthew J Schniederjan, Theo Nicolaides, Tarik Tihan, Peter C Burger, Arie Perry

Journal: Acta Neuropathol.. 2015 Apr;129(4):609-10.

 

Last Updated: 20 Mar 2015

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Novel MSH6 mutations in treatment-naïve glioblastoma and anaplastic oligodendroglioma contribute to temozolomide resistance independently of MGMT promoter methylation.
 

Author(s): Stephanie A Nguyen, Owen D M Stechishin, H Artee Luchman, Xueqing Q Lun, Donna L Senger, Stephen M Robbins, J Gregory Cairncross, Samuel Weiss

Journal: Clin. Cancer Res.. 2014 Sep;20(18):4894-903.

 

The current standard of care for glioblastoma (GBM) involves a combination of surgery, radiotherapy, and temozolomide chemotherapy, but this regimen fails to achieve long-term tumor control. Resistance to temozolomide is largely mediated by expression of the DNA repair enzyme MGMT; ...

Last Updated: 16 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Oligodendroglioma" returned 13 free, full-text review articles on human participants. First 3 results:

Secondary oligodendroglioma after postoperative irradiation for medulloblastoma: a case report and review of the literature.
 

Author(s): Hong-Lin He, Ying-En Lee, Han-Jung Chen, Chao-Tien Hsu, Yu-Yi Huang, I-Wei Chang

Journal:

 

Medulloblastoma, a malignant, invasive embryonal tumor of the cerebellum, occurs most often in children. It has high metastatic potential and is usually treated by aggressive multimodal therapy, including surgery, chemotherapy and craniospinal irradiation. Multiple secondary tumors ...

Last Updated: 12 May 2014

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Occipital anaplastic oligodendroglioma with multiple organ metastases after a short clinical course: a case report and literature review.
 

Author(s): Gang Li, Zhiguo Zhang, Jianghong Zhang, Tianbo Jin, Hongjuan Liang, Li Gong, Guangbin Cui, Haixia Yang, Shiming He, Yongsheng Zhang, Guodong Gao

Journal:

 

It is generally believed that malignant gliomas never metastasize outside the central nervous system (CNS). However, the notion that oligodendrogliomas (OGDs) cells cannot spread outside CNS is being challenged.

Last Updated: 6 Mar 2014

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Multicentric oligodendroglioma: case report and review of the literature.
 

Author(s): Pamela Garcia Pulido, James Neal, Shawn Halpin, Khalid Hamandi

Journal: Seizure. 2013 Jul;22(6):480-2.

 

Last Updated: 12 Jun 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Temozolomide in Relapsed or Advanced Anaplastic Oligodendroglioma and Oligoastrocytoma: Single-arm, Phase II Trial
 

Status: Recruiting

Condition Summary: Anaplastic Oligodendroglioma; Anaplastic Oligoastrocytoma

 

Last Updated: 24 Jun 2015

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Carboplatin, Melphalan, Etoposide Phosphate, Mannitol, and Sodium Thiosulfate in Treating Patients With Previously Treated Brain Tumors
 

Status: Recruiting

Condition Summary: Adult Anaplastic Oligodendroglioma; Adult Mixed Glioma; Adult Oligodendroglioma; Recurrent Adult Brain Neoplasm

 

Last Updated: 7 Aug 2015

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