Oligodendroglioma

Common Name(s)

Oligodendroglioma

Oligodendroglioma is a rare tumor that begins in oligodendrocytes, one of the types of cells that make up the supportive, or glial, tissue of the brain. They can be classified as low grade (grade II) or high grade (grade III) which refers to the how abnormal the tumor cells appear and suggests how fast the tumor may grow or spread. Type III is more aggressive than type II. This type of tumor can be found anywhere in the brain but are most commonly found in the frontal or temporal lobes (front or side of the brain). Symptoms vary depending on the size and location of the tumor but may include headaches, seizures, personality changes, one-sided weakness, and difficulty with short-term memory. Vision problems have also been reported due to added pressure on the brain. Tumors located in the temporal lobes often do not show symptoms for a long time. In general, these types of tumors are considered slow-growing so symptoms may not arise long after it begins to grow.

The cause of oligodendroglioma is not fully known, but both genetics and exposure to radiation are potential links to the development of the tumor. The majority of these tumors do no develop until mid-life, around 40 to 50 years old. Diagnosis may be made through a CT or MRI scan, a biopsy, or a combination of these methods. Treatment varies depending on the type, size, and placement of the tumor, but may include surgery, chemotherapy, radiation, steroids, or other medications. Talk to your doctor if you think you or your child may have oligodendroglioma.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Oligodendroglioma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

Last Updated: 21 Nov 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Oligodendroglioma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

http://www.abc2.org

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

http://braintumor.org/

Last Updated: 21 Nov 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Oligodendroglioma" returned 101 free, full-text research articles on human participants. First 3 results:

Farewell to GBM-O: Genomic and transcriptomic profiling of glioblastoma with oligodendroglioma component reveals distinct molecular subgroups.
 

Author(s): Benjamin H Hinrichs, Scott Newman, Christina L Appin, William Dunn, Lee Cooper, Rini Pauly, Jeanne Kowalski, Michael R Rossi, Daniel J Brat

Journal:

 

Glioblastoma with oligodendroglioma component (GBM-O) was recognized as a histologic pattern of glioblastoma (GBM) by the World Health Organization (WHO) in 2007 and is distinguished by the presence of oligodendroglioma-like differentiation. To better understand the genetic underpinnings ...

Last Updated: 13 Jan 2016

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Quantitative proteomic analysis shows differentially expressed HSPB1 in glioblastoma as a discriminating short from long survival factor and NOVA1 as a differentiation factor between low-grade astrocytoma and oligodendroglioma.
 

Author(s): Marcela Gimenez, Suely Kazue Nagahashi Marie, Sueli Oba-Shinjo, Miyuki Uno, Clarice Izumi, João Bosco Oliveira, Jose Cesar Rosa

Journal:

 

Gliomas account for more than 60 % of all primary central nervous system neoplasms. Low-grade gliomas display a tendency to progress to more malignant phenotypes and the most frequent and malignant gliomas are glioblastomas (GBM). Another type of glioma, oligodendroglioma originates ...

Last Updated: 25 Jun 2015

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Recurrent Oligodendroglioma Treated with Acupuncture and Pharmacopuncture.
 

Author(s): Jae Soo Kim, Hyun Jong Lee, Sang Hoon Lee, Bong Hyo Lee

Journal: J Acupunct Meridian Stud. 2015 Jun;8(3):147-51.

 

Acupuncture and pharmacopuncture have been shown to be effective in tumor treatment. However, their effectiveness for treating oligodendroglioma has not been reported yet. The purpose of this study was to provide an initial report on the effectiveness of acupuncture and pharmacopuncture ...

Last Updated: 23 Jun 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Oligodendroglioma" returned 15 free, full-text review articles on human participants. First 3 results:

Imaging of oligodendroglioma.
 

Author(s): Marion Smits

Journal: Br J Radiol. 2016 ;89(1060):20150857.

 

Oligodendroglioma are glial tumours, predominantly occurring in adults. Their hallmark molecular feature is codeletion of the 1p and 19q chromosome arms, which is not only of diagnostic but also of prognostic and predictive relevance. On imaging, these tumours characteristically show ...

Last Updated: 19 Mar 2016

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Oligodendroglioma: pathology, molecular mechanisms and markers.
 

Author(s): Pieter Wesseling, Martin van den Bent, Arie Perry

Journal: Acta Neuropathol.. 2015 Jun;129(6):809-27.

 

For nearly a century, the diagnosis and grading of oligodendrogliomas and oligoastrocytomas has been based on histopathology alone. Roughly 20 years ago, the first glioma-associated molecular signature was found with complete chromosome 1p and 19q codeletion being particularly common ...

Last Updated: 19 May 2015

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Secondary oligodendroglioma after postoperative irradiation for medulloblastoma: a case report and review of the literature.
 

Author(s): Hong-Lin He, Ying-En Lee, Han-Jung Chen, Chao-Tien Hsu, Yu-Yi Huang, I-Wei Chang

Journal:

 

Medulloblastoma, a malignant, invasive embryonal tumor of the cerebellum, occurs most often in children. It has high metastatic potential and is usually treated by aggressive multimodal therapy, including surgery, chemotherapy and craniospinal irradiation. Multiple secondary tumors ...

Last Updated: 12 May 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Multicenter Safety Trial Assessing an Innovative Tumor Molecular and Cellular Print Medical Device in Glioma
 

Status: Recruiting

Condition Summary: Glioma : Oligodendroglioma or Astrocytoma

 

Last Updated: 30 Aug 2016

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Phase 1 Two Part Dose Escalation Trial of RRx-001 + Radiation + Temozolomide and RRx-001 + Temozolomide Post-RT In Newly Diagnosed Glioblastoma and Anaplastic Gliomas
 

Status: Not yet recruiting

Condition Summary: Glioblastoma; Oligodendroglioma; Anaplastic Oligodendroglioma

 

Last Updated: 15 Aug 2016

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