Ocular toxoplasmosis

Common Name(s)

Ocular toxoplasmosis

Ocular toxoplasmosis is an infection in the eye caused by the parasite, Toxoplasm a gondii.  Toxoplasmosis is the most common cause of eye inflammation in the world.  Toxoplamosis can be acquired or present at birth (congenital), having crossed the placenta from a newly infected mother to her fetus.  Most humans acquire toxoplasmosis by eating raw or undercooked meat, vegetables or milk products, or by coming into contact with infected cat litterbox or sandboxes. In humans, the infection usually causes no symptoms, and resolves without treatment in a few months.  In individuals with compromised immune systems, Toxoplasm a gondii can reactivate to cause disease.   

Reactivation of a congenital infection was traditionally thought to be the most common cause of ocular toxoplasmosis, but an acquired infection is now considered to be more common.   A toxoplasmosis infection that affects the eye usually attacks the retina and initially resolves without symptoms.  However, the inactive parasite may later reactivate causing the ocular presentation of eye pain, blurred vision, and possibly permanent damage, including blindness.  Although most cases of toxoplasmosis resolve on their own, for some, inflammation can be treated with antibiotics and steroids.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ocular toxoplasmosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ocular toxoplasmosis" returned 108 free, full-text research articles on human participants. First 3 results:

Atypical Presentation of Ocular Toxoplasmosis: A Case Report of Exudative Retinal Detachment and Choroidal Ischemia.
 

Author(s): Yahya A Al-Zahrani, Hassan A Al-Dhibi, Abdulelah A Al-Abdullah

Journal: Middle East Afr J Ophthalmol. ;23(1):150-2.

 

A 24-year-old healthy male presented with a chief complaint of blurred vision in the right eye for 1-week. Fundus examination indicated right exudative retinal detachment and choroidal ischemia. The patient responded well to anti-toxoplasmosis medications and steroids. Exudative retinal ...

Last Updated: 9 Mar 2016

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MHC Class I Chain-Related Gene A Polymorphisms and Linkage Disequilibrium with HLA-B and HLA-C Alleles in Ocular Toxoplasmosis.
 

Author(s): Christiane Maria Ayo, Ana Vitória da Silveira Camargo, Fábio Batista Frederico, Rubens Camargo Siqueira, Mariana Previato, Fernando Henrique Antunes Murata, Aparecida Perpétuo Silveira-Carvalho, Amanda Pires Barbosa, Cinara de Cássia Brandão de Mattos, Luiz Carlos de Mattos

Journal:

 

This study investigated whether polymorphisms of the MICA (major histocompatibility complex class I chain-related gene A) gene are associated with eye lesions due to Toxoplasma gondii infection in a group of immunocompetent patients from southeastern Brazil. The study enrolled 297 ...

Last Updated: 17 Dec 2015

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A Brazilian report using serological and molecular diagnosis to monitoring acute ocular toxoplasmosis.
 

Author(s): Mariana Previato, Fábio Batista Frederico, Fernando Henrique Antunes Murata, Rubens Camargo Siqueira, Amanda Pires Barbosa, Aparecida Perpétuo Silveira-Carvalho, Cristina da Silva Meira, Vera Lúcia Pereira-Chioccola, Ricardo Gava, Plínio Pereira Martins Neto, Luiz Carlos de Mattos, Cinara Cássia Brandão de Mattos

Journal:

 

Toxoplasmosis was recently included as a neglected disease by the Center for Disease Control. Ocular toxoplasmosis is one clinical presentation of congenital or acquired infection. The laboratory diagnosis is being used worldwide to support the clinical diagnosis and imaging. The ...

Last Updated: 8 Dec 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ocular toxoplasmosis" returned 15 free, full-text review articles on human participants. First 3 results:

Ocular toxoplasmosis: recent aspects of pathophysiology and clinical implications.
 

Author(s): Uwe Pleyer, Dirk Schlüter, Martin Mänz

Journal: Ophthalmic Res.. 2014 ;52(3):116-23.

 

Toxoplasma gondii is an extremely successful opportunistic parasite which infects approximately one third of the human population worldwide. The impact of this parasite on human health becomes particularly manifest in congenital damage with infection and subsequent inflammation of ...

Last Updated: 7 Nov 2014

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Clinical features and treatment of ocular toxoplasmosis.
 

Author(s): Young-Hoon Park, Ho-Woo Nam

Journal: Korean J. Parasitol.. 2013 Aug;51(4):393-9.

 

Ocular toxoplasmosis is a disease caused by the infection with Toxoplasma gondii through congenital or acquired routes. Once the parasite reaches the retina, it proliferates within host cells followed by rupture of the host cells and invasion into neighboring cells to make primary ...

Last Updated: 16 Sep 2013

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Corticosteroids as adjuvant therapy for ocular toxoplasmosis.
 

Author(s): Smitha Jasper, Satyanarayana S Vedula, Sheeja S John, Saban Horo, Yasir J Sepah, Quan Dong Nguyen

Journal:

 

Ocular infestation with Toxoplasma gondii, a parasite, may result in inflammation in the retina, choroid, and uvea and consequently lead to complications such as glaucoma, cataract, and posterior synechiae.

Last Updated: 1 May 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Determination of Genetic Susceptibility in Severe Recurrences of Ocular Toxoplasmosis
 

Status: Not yet recruiting

Condition Summary: Toxoplasmosis Infection; Genotype II; Ocular Toxoplasmosis With Recurrences

 

Last Updated: 8 Aug 2016

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