Ocular toxoplasmosis

Common Name(s)

Ocular toxoplasmosis

Ocular toxoplasmosis is an infection in the eye caused by the parasite, Toxoplasm a gondii.  Toxoplasmosis is the most common cause of eye inflammation in the world.  Toxoplamosis can be acquired or present at birth (congenital), having crossed the placenta from a newly infected mother to her fetus.  Most humans acquire toxoplasmosis by eating raw or undercooked meat, vegetables or milk products, or by coming into contact with infected cat litterbox or sandboxes. In humans, the infection usually causes no symptoms, and resolves without treatment in a few months.  In individuals with compromised immune systems, Toxoplasm a gondii can reactivate to cause disease.   

Reactivation of a congenital infection was traditionally thought to be the most common cause of ocular toxoplasmosis, but an acquired infection is now considered to be more common.   A toxoplasmosis infection that affects the eye usually attacks the retina and initially resolves without symptoms.  However, the inactive parasite may later reactivate causing the ocular presentation of eye pain, blurred vision, and possibly permanent damage, including blindness.  Although most cases of toxoplasmosis resolve on their own, for some, inflammation can be treated with antibiotics and steroids.
 

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Condition Specific Organizations

Following organizations serve the condition "Ocular toxoplasmosis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ocular toxoplasmosis" returned 110 free, full-text research articles on human participants. First 3 results:

Ocular sarcoidosis masked by positive IgM for toxoplasmosis.
 

Author(s): Murilo Bertazzo Peres, Jacqueline Martins de Sousa, Heloisa Nascimento

Journal: Arq Bras Oftalmol. ;80(2):125-127.

 

We report a case of ocular sarcoidosis with positive immunoglobulin (Ig) M and IgG serology for toxoplasmosis. The patient was a young female with red painful eyes, bilateral eyelid edema, and panuveitis with periphlebitis. In laboratory testing, she was IgM and IgG positive for toxoplasmosis ...

Last Updated: 31 Dec 1969

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Causes of visual impairment in patients with ocular toxoplasmosis.
 

Author(s): Nedime Şahinoğlu Keşkek, Fikret Ünal, Selim Cevher, Şakir Özgür Keşkek

Journal:

 

The aim of this study was to report the causes of visual impairment in patients with the classic clinical presentation of ocular toxoplasmosis (OT).

Last Updated: 31 Dec 1969

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Late isolated ocular toxoplasmosis in a belatacept-treated kidney transplant patient.
 

Author(s): Luca Lanfranco, Priscille Olle Delahaye, Gaelle Dorr, Arnaud Del Bello, Nassim Kamar

Journal: Transpl. Int.. 2016 Dec;29(12):1352-1353.

 

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ocular toxoplasmosis" returned 17 free, full-text review articles on human participants. First 3 results:

Recent Developments in the Diagnosis and Treatment of Ocular Toxoplasmosis.
 

Author(s): Cem Ozgonul, Cagri Giray Besirli

Journal: Ophthalmic Res.. 2017 ;57(1):1-12.

 

Ocular toxoplasmosis, a chorioretinal infection with Toxoplasma gondii, is the most common etiology of posterior uveitis in many countries. Accurate diagnosis depends heavily on the characteristic clinical features of this disease, but atypical presentations, especially in immunocompromised ...

Last Updated: 31 Dec 1969

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Ocular toxoplasmosis: recent aspects of pathophysiology and clinical implications.
 

Author(s): Uwe Pleyer, Dirk Schlüter, Martin Mänz

Journal: Ophthalmic Res.. 2014 ;52(3):116-23.

 

Toxoplasma gondii is an extremely successful opportunistic parasite which infects approximately one third of the human population worldwide. The impact of this parasite on human health becomes particularly manifest in congenital damage with infection and subsequent inflammation of ...

Last Updated: 31 Dec 1969

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Clinical features and treatment of ocular toxoplasmosis.
 

Author(s): Young-Hoon Park, Ho-Woo Nam

Journal: Korean J. Parasitol.. 2013 Aug;51(4):393-9.

 

Ocular toxoplasmosis is a disease caused by the infection with Toxoplasma gondii through congenital or acquired routes. Once the parasite reaches the retina, it proliferates within host cells followed by rupture of the host cells and invasion into neighboring cells to make primary ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Determination of Genetic Susceptibility in Severe Recurrences of Ocular Toxoplasmosis
 

Status: Recruiting

Condition Summary: Toxoplasmosis Infection; Genotype II; Ocular Toxoplasmosis With Recurrences

 

Last Updated: 7 Sep 2017

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