Ocular toxoplasmosis

Common Name(s)

Ocular toxoplasmosis

Ocular toxoplasmosis is an infection in the eye caused by the parasite, Toxoplasm a gondii.  Toxoplasmosis is the most common cause of eye inflammation in the world.  Toxoplamosis can be acquired or present at birth (congenital), having crossed the placenta from a newly infected mother to her fetus.  Most humans acquire toxoplasmosis by eating raw or undercooked meat, vegetables or milk products, or by coming into contact with infected cat litterbox or sandboxes. In humans, the infection usually causes no symptoms, and resolves without treatment in a few months.  In individuals with compromised immune systems, Toxoplasm a gondii can reactivate to cause disease.   

Reactivation of a congenital infection was traditionally thought to be the most common cause of ocular toxoplasmosis, but an acquired infection is now considered to be more common.   A toxoplasmosis infection that affects the eye usually attacks the retina and initially resolves without symptoms.  However, the inactive parasite may later reactivate causing the ocular presentation of eye pain, blurred vision, and possibly permanent damage, including blindness.  Although most cases of toxoplasmosis resolve on their own, for some, inflammation can be treated with antibiotics and steroids.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ocular toxoplasmosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ocular toxoplasmosis" returned 92 free, full-text research articles on human participants. First 3 results:

Evaluation of cystoid change phenotypes in ocular toxoplasmosis using optical coherence tomography.
 

Author(s): Yanling Ouyang, Uwe Pleyer, Qing Shao, Pearse A Keane, Nicole Stübiger, Antonia M Joussen, Srinivas R Sadda, Florian M Heussen

Journal:

 

To present unique cystoid changes occurring in patients with ocular toxoplasmosis observed in spectral domain optical coherence tomography (OCT).

Last Updated: 7 Feb 2014

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Severe South American ocular toxoplasmosis is associated with decreased Ifn-γ/Il-17a and increased Il-6/Il-13 intraocular levels.
 

Author(s): Alejandra de-la-Torre, Arnaud Sauer, Alexander W Pfaff, Tristan Bourcier, Julie Brunet, Claude Speeg-Schatz, Laurent Ballonzoli, Odile Villard, Daniel Ajzenberg, Natarajan Sundar, Michael E Grigg, Jorge E Gomez-Marin, Ermanno Candolfi

Journal:

 

In a cross sectional study, 19 French and 23 Colombian cases of confirmed active ocular toxoplasmosis (OT) were evaluated. The objective was to compare clinical, parasitological and immunological responses and relate them to the infecting strains. A complete ocular examination was ...

Last Updated: 26 Nov 2013

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Toxoplasma serotype is associated with development of ocular toxoplasmosis.
 

Author(s): Leila Shobab, Uwe Pleyer, Joerdis Johnsen, Sylvia Metzner, Erick R James, N Torun, Michael P Fay, Oliver Liesenfeld, Michael E Grigg

Journal: J. Infect. Dis.. 2013 Nov;208(9):1520-8.

 

Worldwide, ocular toxoplasmosis (OT) is the principal cause of posterior uveitis, a severe, life-altering disease. A Toxoplasma gondii enzyme-linked immunoassay that detects strain-specific antibodies present in serum was used to correlate serotype with disease.

Last Updated: 4 Oct 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ocular toxoplasmosis" returned 11 free, full-text review articles on human participants. First 3 results:

Clinical features and treatment of ocular toxoplasmosis.
 

Author(s): Young-Hoon Park, Ho-Woo Nam

Journal: Korean J. Parasitol.. 2013 Aug;51(4):393-9.

 

Ocular toxoplasmosis is a disease caused by the infection with Toxoplasma gondii through congenital or acquired routes. Once the parasite reaches the retina, it proliferates within host cells followed by rupture of the host cells and invasion into neighboring cells to make primary ...

Last Updated: 16 Sep 2013

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[Ocular toxoplasmosis: from pathophysiology to microbiological diagnosis].
 

Author(s): A Sauer, O Villard, T Bourcier, C Speeg-Schatz, E Candolfi

Journal: J Fr Ophtalmol. 2013 Jan;36(1):76-81.

 

Toxoplasmosis is the most common cause of posterior uveitis in immunocompetent subjects: 30% of the world population may be affected, with wide variability. However, despite high seroprevalence, the incidence of ocular toxoplasmosis (OT) is limited to about 2% of infected patients; ...

Last Updated: 12 Feb 2013

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Ocular toxoplasmosis II: clinical features, pathology and management.
 

Author(s): Nicholas J Butler, João M Furtado, Kevin L Winthrop, Justine R Smith

Journal: Clin. Experiment. Ophthalmol.. ;41(1):95-108.

 

The term, ocular toxoplasmosis, refers to eye disease related to infection with the parasite, Toxoplasma gondii. Recurrent posterior uveitis is the typical form of this disease, characterized by unilateral, necrotizing retinitis with secondary choroiditis, occurring adjacent to a ...

Last Updated: 28 Jan 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Influence of Trimethoprim-Sulfamethoxazole for the Recurrence of Ocular Toxoplasmosis
 

Status: Recruiting

Condition Summary: Ocular Toxoplasmosis

 

Last Updated: 12 Jun 2012

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