Ocular melanoma

Common Name(s)

Ocular melanoma

Ocular melanoma (OM) is a cancer in pigment-producing cells of the eye called melanocytes.   Melanocytes are cells that produce the pigment melanin that colors the skin, hair, and eyes, as well as forms moles.  There are four tissues in the eye in which melanoma can develop: the uveal tract (uvea); conjunctiva; eyelid; and orbit.  The uvea - the middle layer within the eye  - is divided into three main parts: the iris, ciliary body, and choroid.  Uveal melanoma, also called intraocular melanoma, is the most common ocular melanoma. Conjunctival melanoma manifests on the surface of the eye and has been increasing in incidence. Eyelid and primary orbiatl melanoma are the least common variants.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ocular melanoma" for support, advocacy or research.

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Ocular Melanoma Foundation

OMF’s mission is to accelerate and enhance scientific research, advocacy, and awareness of ocular melanoma and to provide education and support to patients, their families, and healthcare professionals.

Last Updated: 20 Feb 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ocular melanoma" for support, advocacy or research.

Logo
Ocular Melanoma Foundation

OMF’s mission is to accelerate and enhance scientific research, advocacy, and awareness of ocular melanoma and to provide education and support to patients, their families, and healthcare professionals.

http://www.ocularmelanoma.org/

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ocular melanoma" returned 75 free, full-text research articles on human participants. First 3 results:

TERT promoter mutations in ocular melanoma distinguish between conjunctival and uveal tumours.
 

Author(s): K G Griewank, R Murali, B Schilling, S Scholz, A Sucker, M Song, D Süsskind, F Grabellus, L Zimmer, U Hillen, K-P Steuhl, D Schadendorf, H Westekemper, M Zeschnigk

Journal: Br. J. Cancer. 2013 Jul;109(2):497-501.

 

Recently, activating mutations in the TERT promoter were identified in cutaneous melanoma. We tested a cohort of ocular melanoma samples for similar mutations.

Last Updated: 24 Jul 2013

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Protein kinase C inhibitor AEB071 targets ocular melanoma harboring GNAQ mutations via effects on the PKC/Erk1/2 and PKC/NF-κB pathways.
 

Author(s): Xinqi Wu, Jingjing Li, Meijun Zhu, Jonathan A Fletcher, F Stephen Hodi

Journal: Mol. Cancer Ther.. 2012 Sep;11(9):1905-14.

 

Somatic GNAQ mutations at codon 209 have been identified in approximately 50% of uveal melanomas and have been reported to be oncogenic through activating PLCβ/PKC/Erk1/2 pathways. We hypothesized that protein kinase C (PKC) may provide new opportunities for therapeutic targeting ...

Last Updated: 10 Sep 2012

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Ocular melanoma in a patient successfully treated for diffuse malignant peritoneal mesothelioma: a case report.
 

Author(s): Sara Langlais, Juan Pablo Velazquez-Martin, Pierre Dubé, Ernest Rand Simpson, Guy Leblanc, Lucas Sideris

Journal:

 

Diffuse malignant peritoneal mesothelioma and ocular melanoma are both rare tumors. To the best of our knowledge there is only one previous report of three cases in a family with known susceptibility to malignancies associating diffuse malignant peritoneal mesothelioma and ocular ...

Last Updated: 6 Aug 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ocular melanoma" returned 4 free, full-text review articles on human participants. First 3 results:

Ocular melanoma: an overview of the current status.
 

Author(s): Predrag Jovanovic, Marija Mihajlovic, Jasmina Djordjevic-Jocic, Slobodan Vlajkovic, Sonja Cekic, Vladisav Stefanovic

Journal:

 

Ocular melanoma is the second most common type of melanoma after cutaneous and the most common primary intraocular malignant tumor in adults. Large majority of ocular melanomas originate from uvea, while conjunctival melanomas are far less frequent. Incidence of uveal melanoma has ...

Last Updated: 4 Jul 2013

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Does ocular treatment of uveal melanoma influence survival?
 

Author(s): B Damato

Journal: Br. J. Cancer. 2010 Jul;103(3):285-90.

 

Treatment of uveal (intraocular) melanoma is aimed at prolonging life, if possible conserving the eye and useful vision. About 50% of patients develop fatal metastatic disease despite successful eradication of the primary intraocular tumour. The effect of ocular treatment on survival ...

Last Updated: 27 Jul 2010

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The Collaborative Ocular Melanoma Study: an overview.
 

Author(s): Curtis E Margo

Journal: Cancer Control. ;11(5):304-9.

 

The Collaborative Ocular Melanoma Study (COMS) is a 3-arm study that includes two multicenter randomized clinical trials designed to compare the effectiveness of brachytherapy to enucleation for treatment of medium-size choroidal melanomas, and the effectiveness of enucleation with ...

Last Updated: 20 Sep 2004

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Metastatic Ocular Melanoma
 

Status: Recruiting

Condition Summary: Ocular Melanoma

 

Last Updated: 30 Aug 2007

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STA-9090(Ganetespib) in Metastatic Ocular Melanoma
 

Status: Recruiting

Condition Summary: Ocular Melanoma

 

Last Updated: 26 Feb 2014

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Last Updated: 2 Jul 2013

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