Obsessive Compulsive Disorder

Common Name(s)

Obsessive Compulsive Disorder, OCD

Obsessive-compulsive disorder (OCD) is a lifelong condition where unreasonable thoughts and fears, or obsessions, lead a person to do repetitive behaviors, or compulsions. A person with OCD may or may not realize that their obsessions are unreasonable. A primary symptom of OCD is the presence of obsessions, which are repeated, persistent and unwanted urges that cause distress or anxiety. OCD obsessions often center on themes, such as fear of contamination, having things orderly/symmetric, or thoughts regarding harming oneself or others. Another symptom is the presence of compulsions, which are repetitive behavior that a person with OCD feels like they have to perform. Completing these repetitive behaviors are meant to prevent or reduce anxiety and prevent something bad from happening. Compulsions also follow themes like washing and cleaning, counting, checking, demanding reassurances and following a routine. Usually OCD is made up of both obsessions and compulsions, but it’s possible to only experience one. The general criteria to diagnose OCD is the person has obsessions and/or compulsions and these obsessions/compulsions are time-consuming and interfere with daily life. OCD has no cure, but symptoms can be controlled using exposure therapy and medication.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Obsessive Compulsive Disorder" for support, advocacy or research.

International OCD Foundation

Founded by a group of people with OCD in 1986, the International OCD Foundation (IOCDF) is an international not-for-profit organization made up of people with Obsessive Compulsive Disorder (OCD) and related disorders, as well as their families, friends, professionals and others. The mission and goals of the IOCDF are to: Educate the public and professionals about OCD in order to raise awareness and improve the quality of treatment provided; Support research into the cause of, and effective treatments for, OCD and related disorders; Improve access to resources for those with OCD and their fam

Last Updated: 19 Feb 2013

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National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

Last Updated: 6 Apr 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Obsessive Compulsive Disorder" for support, advocacy or research.

International OCD Foundation

Founded by a group of people with OCD in 1986, the International OCD Foundation (IOCDF) is an international not-for-profit organization made up of people with Obsessive Compulsive Disorder (OCD) and related disorders, as well as their families, friends, professionals and others. The mission and goals of the IOCDF are to: Educate the public and professionals about OCD in order to raise awareness and improve the quality of treatment provided; Support research into the cause of, and effective treatments for, OCD and related disorders; Improve access to resources for those with OCD and their fam

http://www.ocfoundation.org

Last Updated: 19 Feb 2013

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National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

http://www.nami.org

Last Updated: 6 Apr 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Obsessive Compulsive Disorder" returned 644 free, full-text research articles on human participants. First 3 results:

Pathophysiology of refractory obsessive-compulsive disorder: A study of visual search combined with overactive performance monitoring.
 

Author(s): Qingxiao Liu, Bo Tan, Jing Zhou, Zhong Zheng, Ling Li, Yanchun Yang

Journal: Medicine (Baltimore). 2017 Jan;96(1):e5655.

 

Based on both functional and structural studies of excessive activity, fronto-striatal-thalamic-cortical and cortico-striatal circuits have been hypothesized to underlie the pathophysiology of obsessive-compulsive disorder (OCD). However, the neurobiological underpinnings of OCD refractory ...

Last Updated: 10 Jan 2017

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Decisional impulsivity and the associative-limbic subthalamic nucleus in obsessive-compulsive disorder: stimulation and connectivity.
 

Author(s): Valerie Voon, Fabien Droux, Laurel Morris, Stephan Chabardes, Thierry Bougerol, Olivier David, Paul Krack, Mircea Polosan

Journal: Brain. 2017 Feb;140(Pt 2):442-456.

 

Why do we make hasty decisions for short-term gain? Rapid decision-making with limited accumulation of evidence and delay discounting are forms of decisional impulsivity. The subthalamic nucleus is implicated in inhibitory function but its role in decisional impulsivity is less well-understood. ...

Last Updated: 1 Jan 2017

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A Case of Obsessive-Compulsive Disorder With Fear of Contamination of Percutaneous Endoscopic Gastrostomy Tube.
 

Author(s): Ali Najafian Jazi, Shady S Shebak, Bush Kavuru

Journal:

 

Last Updated: 13 Dec 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Obsessive Compulsive Disorder" returned 121 free, full-text review articles on human participants. First 3 results:

Deep brain stimulation for aggressive behavior and obsessive-compulsive disorder.
 

Author(s): Giuseppe Messina, Lucrezia Islam, Roberto Cordella, Orsola Gambini, Angelo Franzini

Journal: J Neurosurg Sci. 2016 Jun;60(2):211-7.

 

Drug-resistant obsessive-compulsive disorder and aggressive behavior are two severely disabling psychiatric conditions which may carry a certain burden on the patients themselves and on their families. In the last decade, the fields of interests of deep brain stimulation (DBS) also ...

Last Updated: 6 May 2016

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Pharmacotherapy of obsessive-compulsive disorder during pregnancy: a clinical approach.
 

Author(s): Faruk Uguz

Journal: Rev Bras Psiquiatr. ;37(4):334-42.

 

Obsessive-compulsive disorder (OCD) is a relatively common psychiatric disorder in the perinatal period. However, specific pharmacological treatment approaches for patients with OCD during pregnancy have not been satisfactorily discussed in the literature. In addition, there are no ...

Last Updated: 22 Dec 2015

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Using mice to model Obsessive Compulsive Disorder: From genes to circuits.
 

Author(s): Susanne E Ahmari

Journal: Neuroscience. 2016 May;321():121-37.

 

Obsessive Compulsive Disorder (OCD) is a severe, chronic, and highly prevalent psychiatric disorder that affects between 1.5% and 3% of people worldwide. Despite its severity, high prevalence, and clear societal cost, current OCD therapies are only partially effective. In order to ...

Last Updated: 22 Mar 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pharmacogenetic Study of Obsessive-Compulsive Disorder
 

Status: Recruiting

Condition Summary: Obsessive-Compulsive Disorder

 

Last Updated: 24 Apr 2017

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Efficacy of Adding Topiramate to Current Treatment in Refractory Obsessive Compulsive Disorder (OCD)
 

Status: Recruiting

Condition Summary: Obsessive Compulsive Disorder

 

Last Updated: 21 Mar 2017

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Deep Brain Stimulation of NAc/ALIC to Prevent Treatment-Refractory Obsessive Compulsive Disorder
 

Status: Not yet recruiting

Condition Summary: Obsessive Compulsive Disorder

 

Last Updated: 9 Nov 2015

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