Antithrombin III Deficiency

Common Name(s)

Antithrombin III Deficiency

Deficiency of antithrombin III is a major risk factor for venous thromboembolic disease. Two categories of AT-III deficiency have been defined on the basis of AT-III antigen levels in the plasma of affected individuals. The majority of AT-III deficiency families belong in the type I (classic) deficiency group and have a quantitatively abnormal phenotype in which antigen and heparin cofactor levels are both reduced to about 50% of normal. The second category of AT-III deficiency has been termed type II (functional) deficiency. Affected individuals from these kindreds produce dysfunctional AT-III molecules; they have reduced heparin cofactor activity levels (about 50% of normal) but levels of AT-III antigen are often normal or nearly normal (summary by {5:Bock and Prochownik, 1987}). The 2 categories of antithrombmin III deficiency have been classified further. Type I (low functional and immunologic antithrombin) has been subdivided into subtype Ia (reduced levels of normal antithrombin), and type Ib (reduced levels of antithrombin and the presence of low levels of a variant). Type II (low functional but normal immunologic antithrombin) has been subdivided into subtype IIa (functional abnormalities affecting both the reactive site and the heparin-binding site of AT3); subtype IIb (functional abnormalities limited to the reactive site); and subtype IIc (functional abnormalities limited to the heparin-binding site) (summary by {15:Lane et al., 1992}).
 

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Condition Specific Organizations

Following organizations serve the condition "Antithrombin III Deficiency" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Antithrombin III Deficiency" returned 39 free, full-text research articles on human participants. First 3 results:

Hereditary antithrombin III deficiency and neuraxial anaesthesia.
 

Author(s): B J Piper, P T Farrell

Journal: Anaesth Intensive Care. 2015 Nov;43(6):782-5.

 

Antithrombin III (ATIII) deficiency offers unique challenges to the anaesthetist in the perioperative setting due to the inherent thrombophilia, the anticoagulant therapies instituted and replacement of the deficient intrinsic natural anticoagulant. A particular challenge is the use ...

Last Updated: 25 Nov 2015

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Antithrombin III deficiency in Indian patients with deep vein thrombosis: identification of first India based AT variants including a novel point mutation (T280A) that leads to aggregation.
 

Author(s): Teena Bhakuni, Amit Sharma, Qudsia Rashid, Charu Kapil, Renu Saxena, Manoranjan Mahapatra, Mohamad Aman Jairajpuri

Journal:

 

Antithrombin III (AT) is the main inhibitor of blood coagulation proteases like thrombin and factor Xa. In this study we report the identification and characterization of several variants of AT for the first time in Indian population. We screened 1950 deep vein thrombosis (DVT) patients ...

Last Updated: 27 Mar 2015

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Portal vein thrombosis after aortic valve replacement surgery in a patient with antithrombin III deficiency--case presentation.
 

Author(s): Yu-qing Wang, Qiu-lin Chen, Da Zhu, Li Dong

Journal:

 

We presented an unique case of portal vein thrombosis (PVT) after aortic valve replacement due to antithrombin III (ATIII) deficiency. PVT after aortic valve replacement (AVR) is a serious complication, which has not previously been reported.

Last Updated: 3 Jun 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Antithrombin III Deficiency" returned 2 free, full-text review articles on human participants. First 3 results:

Plasma antithrombin III deficiency in ischaemic stroke in the young.
 

Author(s): D Nagaraja, R Christopher, M Tripathi

Journal: Neurol India. 1999 Jun;47(2):155-6.

 

A deficiency of plasma antithrombin III has been identified as a potential risk factor for thrombosis. In a pilot study of 56 patients aged less than 40 years who presented with ischaemic stroke of unknown etiology, we detected only one case of plasma antithrombin III deficiency. ...

Last Updated: 11 Aug 1999

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Catastrophic secondary antiphospholipid syndrome with concomitant antithrombin III deficiency.
 

Author(s): V R Peddi, K S Kant

Journal: J. Am. Soc. Nephrol.. 1995 May;5(11):1882-7.

 

The association between thrombotic events and primary or secondary antiphospholipid/anticardiolipin syndrome is now well recognized. A spectrum of renal involvement ranging from glomerular thrombosis to renal infarction has been described. A case of systemic lupus erythematosus with ...

Last Updated: 30 Aug 1995

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Safety, Pharmacokinetics and Efficacy of an AT-III Concentrate.
 

Status: Recruiting

Condition Summary: Antithrombin III Deficiency

 

Last Updated: 17 Feb 2014

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Atenativ Effect on Uterine Blood Flow and Preeclampsia
 

Status: Recruiting

Condition Summary: Antithrombin III Deficiency

 

Last Updated: 22 Mar 2016

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"Incidence and Consequences of Disorders of Glycosylation in Patients With Conotruncal and Septal Heart Defects"
 

Status: Recruiting

Condition Summary: Congenital Heart Diseases; Conotruncal Defects; Congenital Disorder of Glycosylation; Antithrombin III Deficiency

 

Last Updated: 21 Oct 2016

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