Neurofibromatosis type 2

Common Name(s)

Neurofibromatosis type 2, Neurofibromatosis 2 (NF2), Bilateral Acoustic Neurofibromatosis, BANF Acoustic Neurinoma

Neurofibromatosis type 2 is a disorder characterized by the growth of noncancerous tumors in the nervous system. The most common tumors associated with neurofibromatosis type 2 are called vestibular schwannomas or acoustic neuromas. These growths develop along the nerve that carries information from the inner ear to the brain (the auditory nerve). Tumors that occur on nerves in other areas of the brain or spinal cord are also commonly seen with this condition. Mutations in the NF2 gene cause neurofibromatosis type 2. Neurofibromatosis type 2 is considered to have an autosomal dominant pattern of inheritance.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neurofibromatosis type 2" for support, advocacy or research.

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Children's Tumor Foundation, Inc.

Funds research, patient support and public awareness of the neurofibromatoses (NF1, NF2, and Schwannomatosis) - genetic disorders that cause random tumor growth throughout the body.

Last Updated: 14 Jan 2013

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Littlest Tumor Foundation

The Littlest Tumor Foundation is a nonprofit organization dedicated to finding preventative therapies and threatment for tumor growth in children and providing wellness scholarships to families dealing with Neurofibromatosis (NF). Our mission is to increase understanding of NF, to empower families dealing with the disorder, and to continue research of preventative therapies.

Last Updated: 4 Feb 2013

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Neurofibromatosis Mid-Atlantic

Neurofibromatosis Mid-Atlantic is a non profit organization dedicated to helping people with Neurofibromatosis and their loved ones make sense of the complex medical disorder. We provide reliable, complete, and up to date information about Neurofibromatosis. We provide education, support, and community. There is no charge for our services.

Last Updated: 22 Dec 2012

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Neurofibromatosis, Inc., Northeast

Our mission is to find treatments and the cure for neurofibromatosis by promoting scientific research, creating awareness, and providing hope and support to those who are affected by NF.

Last Updated: 5 May 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neurofibromatosis type 2" for support, advocacy or research.

Logo
Children's Tumor Foundation, Inc.

Funds research, patient support and public awareness of the neurofibromatoses (NF1, NF2, and Schwannomatosis) - genetic disorders that cause random tumor growth throughout the body.

https://www.ctf.org

Last Updated: 14 Jan 2013

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Littlest Tumor Foundation

The Littlest Tumor Foundation is a nonprofit organization dedicated to finding preventative therapies and threatment for tumor growth in children and providing wellness scholarships to families dealing with Neurofibromatosis (NF). Our mission is to increase understanding of NF, to empower families dealing with the disorder, and to continue research of preventative therapies.

http://www.littlesttumor.org

Last Updated: 4 Feb 2013

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Neurofibromatosis Mid-Atlantic

Neurofibromatosis Mid-Atlantic is a non profit organization dedicated to helping people with Neurofibromatosis and their loved ones make sense of the complex medical disorder. We provide reliable, complete, and up to date information about Neurofibromatosis. We provide education, support, and community. There is no charge for our services.

http://www.nfmidatlantic.org

Last Updated: 22 Dec 2012

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Neurofibromatosis, Inc., Northeast

Our mission is to find treatments and the cure for neurofibromatosis by promoting scientific research, creating awareness, and providing hope and support to those who are affected by NF.

http://www.nfincne.org

Last Updated: 5 May 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Neurofibromatosis type 2" returned 101 free, full-text research articles on human participants. First 3 results:

Primary meningeal melanoma with cerebrospinal fluid dissemination mimicking neurofibromatosis type 2.
 

Author(s): Marcos Rosa Júnior, Luciene Lage da Motta, Fabrizio Scardino

Journal: Arq Neuropsiquiatr. 2015 Jul;73(7):636-7.

 

Last Updated: 23 Jul 2015

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Intractable yawning caused by foramen magnum meningioma in a patient with neurofibromatosis type 2.
 

Author(s): Yasar Bayri, Bahattin Tanrikulu, Fatih Bayrakli, Demet Yalçinkaya Koç, Adnan Dağçinar

Journal: Neurol India. ;63(1):107-9.

 

Last Updated: 10 Mar 2015

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Segmental neurofibromatosis type 2: discriminating two hit from four hit in a patient presenting multiple schwannomas confined to one limb.
 

Author(s): Elisabeth Castellanos, Isabel Bielsa, Cristina Carrato, Imma Rosas, Ares Solanes, Cristina Hostalot, Emilio Amilibia, José Prades, Francesc Roca-Ribas, Conxi Lázaro, Ignacio Blanco, Eduard Serra,

Journal:

 

A clinical overlap exists between mosaic Neurofibromatosis Type 2 and sporadic Schwannomatosis conditions. In these cases a molecular analysis of tumors is recommended for a proper genetic diagnostics. This analysis is challenged by the fact that schwannomas in both conditions bear ...

Last Updated: 16 Jul 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Neurofibromatosis type 2" returned 13 free, full-text review articles on human participants. First 3 results:

Targeted therapy for hereditary cancer syndromes: neurofibromatosis type 1, neurofibromatosis type 2, and Gorlin syndrome.
 

Author(s): Rishi Agarwal, Sarah Liebe, Michelle L Turski, Smruti J Vidwans, Filip Janku, Ignacio Garrido-Laguna, Javier Munoz, Richard Schwab, Jordi Rodon, Razelle Kurzrock, Vivek Subbiah,

Journal: Discov Med. 2014 Dec;18(101):323-30.

 

Hereditary cancer syndromes are well known in the oncology community, typically affecting children, adolescents, and young adults and thereby resulting in great cumulative morbidity and mortality. These syndromes often lag behind their de novo counterparts in the development of approved ...

Last Updated: 31 Dec 2014

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Gastrinoma and neurofibromatosis type 2: the first case report and review of the literature.
 

Author(s): Sara Massironi, Alessandra Zilli, Roberta Elisa Rossi, Federica Cavalcoli, Dario Conte, Maddalena Peracchi

Journal:

 

Gastroenteropancreatic neuroendocrine tumors have occasionally been described in association with neurofibromatosis type 1, whereas an association with neurofibromatosis type 2 has never been reported.

Last Updated: 5 Jul 2014

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[Neurofibromatosis type 2 and its head and neck manifestations: literature review and population study in the Community of Cantabria and the province of Las Palmas].
 

Author(s): Gloria Guerra-Jiménez, Pilar Camargo Camacho, Ángel Ramos-Macías, Carmelo Morales Angulo

Journal: Acta Otorrinolaringol Esp. ;65(3):148-56.

 

Neurofibromatosis type 2 (NF2) is an infrequent autosomal dominant disease characterised by the appearance of viii nerve schwannomas, meningiomas and ocular abnormalities. Incidence of 1:25,000 and prevalence above 1:80,000 are estimated in general. The objectives of our study were ...

Last Updated: 9 May 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Axitinib in Patients With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas
 

Status: Recruiting

Condition Summary: Neurofibromatosis Type 2; Vestibular Schwannomas

 

Last Updated: 13 Apr 2016

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Study of RAD001 for Treatment of NF2-related Vestibular Schwannoma
 

Status: Recruiting

Condition Summary: Neurofibromatosis Type 2; Neuroma, Acoustic

 

Last Updated: 22 Feb 2016

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Phase 2 Study of Bevacizumab in Children and Young Adults With NF 2 and Progressive Vestibular Schwannomas
 

Status: Recruiting

Condition Summary: Neurofibromatosis Type 2; Progressive Vestibular Schwannomas

 

Last Updated: 24 Feb 2016

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