Neurofibroma

Common Name(s)

Neurofibroma

A neurofibroma is a non-cancerous (benign) tumor that develops from the cells and tissues that cover nerves. Some people who develop neurofibromas have a genetic condition known as neurofibromatosis (NF). There are different types of NF, but type 1 is the most common.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neurofibroma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neurofibroma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Neurofibroma" returned 107 free, full-text research articles on human participants. First 3 results:

Solitary neurofibroma of the palate.
 

Author(s): Fábio Wildson Gurgel Costa, Francisco Samuel Rodrigues Carvalho, Cássia Farias de Sousa, Roberta Barroso Cavalcante, Karuza Maria Alves Pereira

Journal: Braz J Otorhinolaryngol. 2014 Apr;80(2):184-5.

 

Last Updated: 16 May 2014

Go To URL
Diffuse neurofibroma--an uncommon cause of alopecia.
 

Author(s): Vasco Coelho Macias, Margarida Rafael, Cândida Fernandes, Joaninha Costa Rosa

Journal: An Bras Dermatol. ;88(6 Suppl 1):166-9.

 

Although infrequent, alopecia can be caused by benign cutaneous tumours. Neurofibromas are common benign tumors that originate in the peripheral nerve sheath. Diffuse neurofibroma is a rare variant of neurofibroma that is thought to occur mainly in the head and neck of children and ...

Last Updated: 18 Dec 2013

Go To URL
Expression profiling of 519 kinase genes in matched malignant peripheral nerve sheath tumor/plexiform neurofibroma samples is discriminatory and identifies mitotic regulators BUB1B, PBK and NEK2 as overexpressed with transformation.
 

Author(s): Thomas P Stricker, Kammi J Henriksen, James H Tonsgard, Anthony G Montag, Thomas N Krausz, Peter Pytel

Journal: Mod. Pathol.. 2013 Jul;26(7):930-43.

 

About 50% of all malignant peripheral nerve sheath tumors (MPNSTs) arise as neurofibromatosis type 1 associated lesions. In those patients malignant peripheral nerve sheath tumors are thought to arise through malignant transformation of a preexisting plexiform neurofibroma. The molecular ...

Last Updated: 1 Jul 2013

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Neurofibroma" returned 15 free, full-text review articles on human participants. First 3 results:

Neurofibroma of the bile duct: a rare cause of obstructive jaundice.
 

Author(s): A De Rosa, D Gomez, A M Zaitoun, I C Cameron

Journal: Ann R Coll Surg Engl. 2013 Mar;95(2):e38-40.

 

Neurofibromas of the common bile duct are extremely rare. The lack of specific clinical or radiological features makes preoperative diagnosis in the absence of histology difficult. We report the case of a female patient who presented with obstructive jaundice and evidence of a common ...

Last Updated: 14 Mar 2013

Go To URL
Pathogenesis of plexiform neurofibroma: tumor-stromal/hematopoietic interactions in tumor progression.
 

Author(s): Karl Staser, Feng-Chun Yang, D Wade Clapp

Journal: Annu Rev Pathol. 2012 ;7():469-95.

 

Neurofibromatosis type 1 (NF1) is a genetic disease that results from either heritable or spontaneous autosomal dominant mutations in the NF1 gene. A second-hit mutation precedes the predominant NF1 neoplasms, which include myeloid leukemia, optic glioma, and plexiform neurofibroma. ...

Last Updated: 8 Feb 2012

Go To URL
Plexiform neurofibroma genesis: questions of Nf1 gene dose and hyperactive mast cells.
 

Author(s): Karl Staser, Feng-Chun Yang, David W Clapp

Journal: Curr. Opin. Hematol.. 2010 Jul;17(4):287-93.

 

Tumorigenic cells can co-opt normal functions of nonmalignant hematopoietic cells, promoting tumor progression. Recent mouse and human studies indicate that mast cells underpin inflammation in the plexiform neurofibroma microenvironment of neurofibromatosis type 1. In this model, ...

Last Updated: 23 Jun 2010

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Natural History Study of Patients With Neurofibromatosis Type I
 

Status: Recruiting

Condition Summary: Neurofibromatosis Type 1; Malignant Peripheral Nerve Sheath Tumor; Plexiform Neurofibroma; Optic Glioma; Neurofibroma

 

Last Updated: 21 May 2014

Go to URL
Pegintron to Treat Plexiform Neurofibromas in Children and Young Adults
 

Status: Recruiting

Condition Summary: Neurofibromatosis Type 1; Plexiform Neurofibroma

 

Last Updated: 1 Aug 2014

Go to URL
Efficacy and Safety of RAD001 in Treating Plexiform Neurofibromas (PN) Associated With Neurofibromatosis (NF1)
 

Status: Recruiting

Condition Summary: Plexiform Neurofibroma Associated With Neurofibromatosis Type 1

 

Last Updated: 6 Jan 2014

Go to URL