Neuroblastoma

Common Name(s)

Neuroblastoma

Neuroblastoma is a tumor that develops from a nerve in a child, usually before the age of 5.  It occurs in the abdomen near the adrenal glands, but it can also occur in other parts of the body.  It is considered an aggressive tumor because it often spreads to other parts of the body (metastasizes).   The symptoms of a neuroblastoma may include a lump in the abdomen, pain, diarrhea, or generally feeling unwell.  It affects one out of 100,000 children.   The exact cause of this tumor is not yet known.  Neuroblastoma may be diagnosed by physical examination; specific blood tests; imaging tests such as x-rays, magnetic resonance imaging (MRI), or computed tomography (CT) scans; and a biopsy.   Treatment depends on the size and location of the tumor within the body, as well as the childÕs age. Surgery is often the first step of treatment, and may be followed by chemotherapy, radiation therapy, or a stem cell transplant in more severe cases.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neuroblastoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neuroblastoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Neuroblastoma" returned 3376 free, full-text research articles on human participants. First 3 results:

Neuroblastoma revealing cervical metastasis.
 

Author(s): Senda Turki, Maher Abouda, Amani Hachicha, Dorra Ben Ghachem

Journal: Tunis Med. 2016 Feb;94(2):164-5.

 

Last Updated: 18 Aug 2016

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Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma.
 

Author(s): John T Powers, Kaloyan M Tsanov, Daniel S Pearson, Frederik Roels, Catherine S Spina, Richard Ebright, Marc Seligson, Yvanka de Soysa, Patrick Cahan, Jessica Theißen, Ho-Chou Tu, Areum Han, Kyle C Kurek, Grace S LaPier, Jihan K Osborne, Samantha J Ross, Marcella Cesana, James J Collins, Frank Berthold, George Q Daley

Journal: Nature. 2016 07;535(7611):246-51.

 

Poor prognosis in neuroblastoma is associated with genetic amplification of MYCN. MYCN is itself a target of let-7, a tumour suppressor family of microRNAs implicated in numerous cancers. LIN28B, an inhibitor of let-7 biogenesis, is overexpressed in neuroblastoma and has been reported ...

Last Updated: 15 Jul 2016

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Bilateral Synchronous Ectopic Ethmoid Sinus Olfactory Neuroblastoma: A Case Report.
 

Author(s): Elena Leon-Soriano, Carolina Alfonso, Laura Yebenes, Julio Garcia-Polo, Luis Lassaletta, Javier Gavilan

Journal:

 

Olfactory neuroblastoma (ONB), also known as esthesioneuroblastoma, is a rare malignant head and neck cancer thought to originate from the olfactory epithelium. It typically invades contiguous structures at presentation. We report a very rare case of multifocal and ectopic ONB.

Last Updated: 21 Apr 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Neuroblastoma" returned 105 free, full-text review articles on human participants. First 3 results:

Neuroblastoma: A Tough Nut to Crack.
 

Author(s): Frank Speleman, Julie R Park, Tara O Henderson

Journal: Am Soc Clin Oncol Educ Book. 2016 ;35():e548-57.

 

Neuroblastoma, an embryonal tumor arising from neural crest-derived progenitor cells, is the most common solid tumor in childhood, with more than 700 cases diagnosed per year in the United States. In the past several decades, significant advances have been made in the treatment of ...

Last Updated: 2 Jun 2016

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Neuroblastoma: oncogenic mechanisms and therapeutic exploitation of necroptosis.
 

Author(s): S Nicolai, M Pieraccioli, A Peschiaroli, G Melino, G Raschellà

Journal:

 

Neuroblastoma (NB) is the most common extracranial childhood tumor classified in five stages (1, 2, 3, 4 and 4S), two of which (3 and 4) identify chemotherapy-resistant, highly aggressive disease. High-risk NB frequently displays MYCN amplification, mutations in ALK and ATRX, and ...

Last Updated: 4 Dec 2015

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Advances in the translational genomics of neuroblastoma: From improving risk stratification and revealing novel biology to identifying actionable genomic alterations.
 

Author(s): Kristopher R Bosse, John M Maris

Journal: Cancer. 2016 Jan;122(1):20-33.

 

Neuroblastoma is an embryonal malignancy that commonly affects young children and is remarkably heterogenous in its malignant potential. Recently, the genetic basis of neuroblastoma has come into focus and not only has catalyzed a more comprehensive understanding of neuroblastoma ...

Last Updated: 9 Jan 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Neuroblastoma Precision Trial
 

Status: Recruiting

Condition Summary: Neuroblastoma

 

Last Updated: 15 Nov 2016

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Immunotherapy of Relapsed Refractory Neuroblastoma With Expanded NK Cells
 

Status: Not yet recruiting

Condition Summary: Neuroblastoma

 

Last Updated: 11 Dec 2015

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