Neuroblastoma

Common Name(s)

Neuroblastoma

Neuroblastoma is a tumor that develops from a nerve in a child, usually before the age of 5.  It occurs in the abdomen near the adrenal glands, but it can also occur in other parts of the body.  It is considered an aggressive tumor because it often spreads to other parts of the body (metastasizes).   The symptoms of a neuroblastoma may include a lump in the abdomen, pain, diarrhea, or generally feeling unwell.  It affects one out of 100,000 children.   The exact cause of this tumor is not yet known.  Neuroblastoma may be diagnosed by physical examination; specific blood tests; imaging tests such as x-rays, magnetic resonance imaging (MRI), or computed tomography (CT) scans; and a biopsy.   Treatment depends on the size and location of the tumor within the body, as well as the childÕs age. Surgery is often the first step of treatment, and may be followed by chemotherapy, radiation therapy, or a stem cell transplant in more severe cases.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neuroblastoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neuroblastoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Neuroblastoma" returned 2413 free, full-text research articles on human participants. First 3 results:

Anti-tumor effect of rutin on human neuroblastoma cell lines through inducing G2/M cell cycle arrest and promoting apoptosis.
 

Author(s): Hongyan Chen, Qing Miao, Miao Geng, Jing Liu, Yazhuo Hu, Lei Tian, Jingkun Pan, Yi Yang

Journal:

 

To further investigate the antineuroblastoma effect of rutin which is a type of flavonoid.

Last Updated: 24 Jan 2014

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HO-1 up-regulation: a key point in high-risk neuroblastoma resistance to bortezomib.
 

Author(s): Anna Lisa Furfaro, Sabrina Piras, Mario Passalacqua, Cinzia Domenicotti, Alessia Parodi, Daniela Fenoglio, Maria Adelaide Pronzato, Umberto Maria Marinari, Lorenzo Moretta, Nicola Traverso, Mariapaola Nitti

Journal: Biochim. Biophys. Acta. 2014 Apr;1842(4):613-22.

 

High-risk neuroblastoma (NB) is characterized by the development of chemoresistance, and bortezomib (BTZ), a selective inhibitor of proteasome, has been proposed in order to overcome drug resistance. Considering the involvement of the nuclear factor-erythroid-derived 2-like 2 (Nrf2) ...

Last Updated: 24 Feb 2014

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Polymeric nanoparticles enhance the sonodynamic activity of meso-tetrakis (4-sulfonatophenyl) porphyrin in an in vitro neuroblastoma model.
 

Author(s): Roberto Canaparo, Greta Varchi, Marco Ballestri, Federica Foglietta, Giovanna Sotgiu, Andrea Guerrini, Andrea Francovich, Pierluigi Civera, Roberto Frairia, Loredana Serpe

Journal: Int J Nanomedicine. 2013 ;8():4247-63.

 

Sonodynamic therapy is a developing noninvasive modality for cancer treatment, based on the selective activation of a sonosensitizer agent by acoustic cavitation. The activated sonosensitizer agent might generate reactive oxygen species leading to cancer cell death. We investigated ...

Last Updated: 15 Nov 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Neuroblastoma" returned 75 free, full-text review articles on human participants. First 3 results:

Multidrug resistance and cancer stem cells in neuroblastoma and hepatoblastoma.
 

Author(s): Anna Alisi, William C Cho, Franco Locatelli, Doriana Fruci

Journal:

 

Chemotherapy is one of the major modalities in treating cancers. However, its effectiveness is limited by the acquisition of multidrug resistance (MDR). Several mechanisms could explain the up-regulation of MDR genes/proteins in cancer after chemotherapy. It is known that cancer stem ...

Last Updated: 19 Dec 2013

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New strategies in neuroblastoma: Therapeutic targeting of MYCN and ALK.
 

Author(s): Giuseppe Barone, John Anderson, Andrew D J Pearson, Kevin Petrie, Louis Chesler

Journal: Clin. Cancer Res.. 2013 Nov;19(21):5814-21.

 

Clinical outcome remains poor in patients with high-risk neuroblastoma, in which chemoresistant relapse is common following high-intensity conventional multimodal therapy. Novel treatment approaches are required. Although recent genomic profiling initiatives have not revealed a high ...

Last Updated: 4 Nov 2013

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The role of genetic and epigenetic alterations in neuroblastoma disease pathogenesis.
 

Author(s): Raquel Domingo-Fernandez, Karen Watters, Olga Piskareva, Raymond L Stallings, Isabella Bray

Journal: Pediatr. Surg. Int.. 2013 Feb;29(2):101-19.

 

Neuroblastoma is a highly heterogeneous tumor accounting for 15 % of all pediatric cancer deaths. Clinical behavior ranges from the spontaneous regression of localized, asymptomatic tumors, as well as metastasized tumors in infants, to rapid progression and resistance to therapy. ...

Last Updated: 28 Jan 2013

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of DNA in Blood Samples From Patients With Neuroblastoma
 

Status: Recruiting

Condition Summary: Disseminated Neuroblastoma; Localized Resectable Neuroblastoma; Localized Unresectable Neuroblastoma; Recurrent Neuroblastoma; Regional Neuroblastoma; Stage 4S Neuroblastoma

 

Last Updated: 18 Feb 2014

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Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma
 

Status: Recruiting

Condition Summary: Disseminated Neuroblastoma; Ganglioneuroblastoma; Localized Resectable Neuroblastoma; Localized Unresectable Neuroblastoma; Regional Neuroblastoma; Stage 4S Neuroblastoma

 

Last Updated: 23 Jul 2014

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Lenalidomide and Monoclonal Antibody With or Without Isotretinoin in Treating Younger Patients With Refractory or Recurrent Neuroblastoma
 

Status: Recruiting

Condition Summary: Disseminated Neuroblastoma; Localized Unresectable Neuroblastoma; Recurrent Neuroblastoma; Regional Neuroblastoma; Stage 4S Neuroblastoma

 

Last Updated: 18 Jul 2014

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