Neuroblastoma

Common Name(s)

Neuroblastoma

Neuroblastoma is a tumor that develops from a nerve in a child, usually before the age of 5.  It occurs in the abdomen near the adrenal glands, but it can also occur in other parts of the body.  It is considered an aggressive tumor because it often spreads to other parts of the body (metastasizes).   The symptoms of a neuroblastoma may include a lump in the abdomen, pain, diarrhea, or generally feeling unwell.  It affects one out of 100,000 children.   The exact cause of this tumor is not yet known.  Neuroblastoma may be diagnosed by physical examination; specific blood tests; imaging tests such as x-rays, magnetic resonance imaging (MRI), or computed tomography (CT) scans; and a biopsy.   Treatment depends on the size and location of the tumor within the body, as well as the childÕs age. Surgery is often the first step of treatment, and may be followed by chemotherapy, radiation therapy, or a stem cell transplant in more severe cases.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neuroblastoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neuroblastoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Neuroblastoma" returned 3353 free, full-text research articles on human participants. First 3 results:

Neuroblastoma Mass Screening--What Can We Learn From It?
 

Author(s): Kota Katanoda

Journal: J Epidemiol. 2016 ;26(4):163-5.

 

Last Updated: 7 Apr 2016

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An Optimized GD2-Targeting Retroviral Cassette for More Potent and Safer Cellular Therapy of Neuroblastoma and Other Cancers.
 

Author(s): Simon Thomas, Karin Straathof, Nourredine Himoudi, John Anderson, Martin Pule

Journal:

 

Neuroblastoma is the commonest extra cranial solid cancer of childhood. Despite escalation of treatment regimens, a significant minority of patients die of their disease. Disialoganglioside (GD2) is consistently expressed at high-levels in neuroblastoma tumors, which have been targeted ...

Last Updated: 1 Apr 2016

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Role of Nrf2, HO-1 and GSH in Neuroblastoma Cell Resistance to Bortezomib.
 

Author(s): A L Furfaro, S Piras, C Domenicotti, D Fenoglio, A De Luigi, M Salmona, L Moretta, U M Marinari, M A Pronzato, N Traverso, M Nitti

Journal:

 

The activation of Nrf2 has been demonstrated to play a crucial role in cancer cell resistance to different anticancer therapies. The inhibition of proteasome activity has been proposed as a chemosensitizing therapy but the activation of Nrf2 could reduce its efficacy. Using the highly ...

Last Updated: 30 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Neuroblastoma" returned 103 free, full-text review articles on human participants. First 3 results:

Neuroblastoma: oncogenic mechanisms and therapeutic exploitation of necroptosis.
 

Author(s): S Nicolai, M Pieraccioli, A Peschiaroli, G Melino, G Raschellà

Journal:

 

Neuroblastoma (NB) is the most common extracranial childhood tumor classified in five stages (1, 2, 3, 4 and 4S), two of which (3 and 4) identify chemotherapy-resistant, highly aggressive disease. High-risk NB frequently displays MYCN amplification, mutations in ALK and ATRX, and ...

Last Updated: 4 Dec 2015

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123I-MIBG scintigraphy and 18F-FDG-PET imaging for diagnosing neuroblastoma.
 

Author(s): Gitta Bleeker, Godelieve A M Tytgat, Judit A Adam, Huib N Caron, Leontien C M Kremer, Lotty Hooft, Elvira C van Dalen

Journal:

 

Neuroblastoma is an embryonic tumour of childhood that originates in the neural crest. It is the second most common extracranial malignant solid tumour of childhood.Neuroblastoma cells have the unique capacity to accumulate Iodine-123-metaiodobenzylguanidine (¹²³I-MIBG), which ...

Last Updated: 1 Oct 2015

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Advances in Risk Classification and Treatment Strategies for Neuroblastoma.
 

Author(s): Navin R Pinto, Mark A Applebaum, Samuel L Volchenboum, Katherine K Matthay, Wendy B London, Peter F Ambros, Akira Nakagawara, Frank Berthold, Gudrun Schleiermacher, Julie R Park, Dominique Valteau-Couanet, Andrew D J Pearson, Susan L Cohn

Journal: J. Clin. Oncol.. 2015 Sep;33(27):3008-17.

 

Risk-based treatment approaches for neuroblastoma have been ongoing for decades. However, the criteria used to define risk in various institutional and cooperative groups were disparate, limiting the ability to compare clinical trial results. To mitigate this problem and enhance collaborative ...

Last Updated: 19 Sep 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma
 

Status: Recruiting

Condition Summary: Disseminated Neuroblastoma; Ganglioneuroblastoma; Localized Resectable Neuroblastoma; Localized Unresectable Neuroblastoma; Regional Neuroblastoma; Stage 4S Neuroblastoma

 

Last Updated: 16 May 2016

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Expanded Access Study of Fenretinide Lym-X-Sorb Plus Ketoconazole in Neuroblastoma
 

Status: Available

Condition Summary: Recurrent Neuroblastoma; Neuroblastoma

 

Last Updated: 12 Apr 2016

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Fenretinide Lym-X-Sorb + Ketoconazole + Vincristine for Recurrent or Resistant Neuroblastoma
 

Status: Recruiting

Condition Summary: Recurrent Neuroblastoma; Neuroblastoma

 

Last Updated: 12 Apr 2016

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