Neuroblastoma

Common Name(s)

Neuroblastoma

Neuroblastoma is a tumor that develops from a nerve in a child, usually before the age of 5.  It occurs in the abdomen near the adrenal glands, but it can also occur in other parts of the body.  It is considered an aggressive tumor because it often spreads to other parts of the body (metastasizes).   The symptoms of a neuroblastoma may include a lump in the abdomen, pain, diarrhea, or generally feeling unwell.  It affects one out of 100,000 children.   The exact cause of this tumor is not yet known.  Neuroblastoma may be diagnosed by physical examination; specific blood tests; imaging tests such as x-rays, magnetic resonance imaging (MRI), or computed tomography (CT) scans; and a biopsy.   Treatment depends on the size and location of the tumor within the body, as well as the childÕs age. Surgery is often the first step of treatment, and may be followed by chemotherapy, radiation therapy, or a stem cell transplant in more severe cases.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neuroblastoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neuroblastoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Neuroblastoma" returned 3546 free, full-text research articles on human participants. First 3 results:

Analysis of the risk factor for the poor prognosis of localized neuroblastoma after the surgical.
 

Author(s): Kai Zhou, Xiao-Lu Li, Jian Pan, Jian-Zhong Xu, Jian Wang

Journal: Medicine (Baltimore). 2018 Oct;97(40):e12718.

 

Neuroblastoma is a unique malignancy in infants often presenting with either localized or metastatic disease. The study was carried out to explore the risk stratification of the poor prognosis for patients underwent surgical treatment.60 patients diagnosed with neuroblastoma were ...

Last Updated: 31 Dec 1969

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Innate immune sensor laboratory of genetics and physiology 2 suppresses tumor cell growth and functions as a prognostic marker in neuroblastoma.
 

Author(s): Li-Ling Lin, Chao-Cheng Huang, Min-Tsui Wu, Wen-Ming Hsu, Jiin-Haur Chuang

Journal: Cancer Sci.. 2018 Nov;109(11):3494-3502.

 

The innate immune receptors, such as toll-like receptor 3 (TLR3), melanoma differentiation-associated 5 (MDA5) and retinoic acid-inducible gene-I (RIG-I), have been shown to be differentially expressed in neuroblastoma (NB) and promote dsRNA poly (I:C)-induced NB suppression in vitro ...

Last Updated: 31 Dec 1969

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Micro-RNA-137 Inhibits Tau Hyperphosphorylation in Alzheimer's Disease and Targets the CACNA1C Gene in Transgenic Mice and Human Neuroblastoma SH-SY5Y Cells.
 

Author(s): Yang Jiang, Bing Xu, Jing Chen, Yi Sui, Li Ren, Jing Li, Huiyu Zhang, Liqing Guo, Xiaohong Sun

Journal:

 

BACKGROUND Alzheimer's disease (AD) results in cognitive impairment. The calcium voltage-gated channel subunit alpha-1 C CACNA1C gene encodes an alpha-1 C subunit of L-type calcium channel (LTCC). The aim of this study was to investigate the role of micro-RNA-137 (miR-137) and the ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Neuroblastoma" returned 123 free, full-text review articles on human participants. First 3 results:

Neuroblastoma Origin and Therapeutic Targets for Immunotherapy.
 

Author(s): Irina V Kholodenko, Daniel V Kalinovsky, Igor I Doronin, Sergey M Deyev, Roman V Kholodenko

Journal:

 

Neuroblastoma is a pediatric solid cancer of heterogeneous clinical behavior. The unique features of this type of cancer frequently hamper the process of determining clinical presentation and predicting therapy effectiveness. The tumor can spontaneously regress without treatment or ...

Last Updated: 31 Dec 1969

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Paraneoplastic limbic encephalitis associated with mixed olfactory neuroblastoma and craniopharyngioma: A case report and literature review.
 

Author(s): Hiroshi Nagafuji, Hidenori Yokoi, Masachika Fujiwara, Dai Sato, Koichiro Saito

Journal: Medicine (Baltimore). 2018 Jun;97(24):e10932.

 

Paraneoplastic limbic encephalitis (PLE) is a rare disorder of the nervous system associated with malignant disease. It has a subacute onset with the following symptoms: cognitive dysfunction, seizures, irritability, hallucinations, and short-term memory loss. Herein, we report the ...

Last Updated: 31 Dec 1969

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Immune Escape Mechanisms and Future Prospects for Immunotherapy in Neuroblastoma.
 

Author(s): Thitinee Vanichapol, Somchai Chutipongtanate, Usanarat Anurathapan, Suradej Hongeng

Journal:

 

Neuroblastoma (NB) is the most common extracranial solid tumor in childhood with 5-year survival rate of 40% in high-risk patients despite intensive therapies. Recently, adoptive cell therapy, particularly chimeric antigen receptor (CAR) T cell therapy, represents a revolutionary ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Neuroblastoma Precision Trial
 

Status: Recruiting

Condition Summary: Neuroblastoma

 

Last Updated: 16 Aug 2018

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Naxitamab for Neuroblastoma With Osteomedullary Disease
 

Status: Recruiting

Condition Summary: Neuroblastoma

 

Last Updated: 2 Oct 2018

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Immunotherapy of Relapsed Refractory Neuroblastoma With Expanded NK Cells
 

Status: Recruiting

Condition Summary: Neuroblastoma

 

Last Updated: 19 Nov 2018

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