Neuroblastoma

Common Name(s)

Neuroblastoma

Neuroblastoma is a tumor that develops from a nerve in a child, usually before the age of 5.  It occurs in the abdomen near the adrenal glands, but it can also occur in other parts of the body.  It is considered an aggressive tumor because it often spreads to other parts of the body (metastasizes).   The symptoms of a neuroblastoma may include a lump in the abdomen, pain, diarrhea, or generally feeling unwell.  It affects one out of 100,000 children.   The exact cause of this tumor is not yet known.  Neuroblastoma may be diagnosed by physical examination; specific blood tests; imaging tests such as x-rays, magnetic resonance imaging (MRI), or computed tomography (CT) scans; and a biopsy.   Treatment depends on the size and location of the tumor within the body, as well as the childÕs age. Surgery is often the first step of treatment, and may be followed by chemotherapy, radiation therapy, or a stem cell transplant in more severe cases.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neuroblastoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neuroblastoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Neuroblastoma" returned 3179 free, full-text research articles on human participants. First 3 results:

Heterogeneous nuclear ribonucleoprotein A1 post-transcriptionally regulates Drp1 expression in neuroblastoma cells.
 

Author(s): So Jung Park, Heejin Lee, Doo Shin Jo, Yoon Kyung Jo, Ji Hyun Shin, Han Byeol Kim, Hae Mi Seo, David C Rubinsztein, Jae-Young Koh, Eun Kyung Lee, Dong-Hyung Cho

Journal: Biochim. Biophys. Acta. 2015 Dec;1849(12):1423-31.

 

Excessive mitochondrial fission is associated with the pathogenesis of neurodegenerative diseases. Dynamin-related protein 1 (Drp1) possesses specific fission activity in the mitochondria and peroxisomes. Various post-translational modifications of Drp1 are known to modulate complex ...

Last Updated: 23 Nov 2015

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Usefulness of 18F-Fluorodeoxyglucose Positron Emission Tomography for Follow-Up of 13-cis-Retinoic Acid Treatment for Residual Neuroblastoma After Myeloablative Chemotherapy.
 

Author(s): Yuya Sato, Hidemitsu Kurosawa, Setsu Sakamoto, Shigeko Kuwashima, Teisuke Hashimoto, Kentaro Okamoto, Takashi Tsuchioka, Keitaro Fukushima, Osamu Arisaka

Journal: Medicine (Baltimore). 2015 Aug;94(31):e1290.

 

13-cis-retinoic acid (13-cis-RA) treatment is used as a second-line treatment for residual or recurrent neuroblastoma. However, determining the duration of 13-cis-RA treatment for residual and recurrent neuroblastoma can be a problem because it is difficult to evaluate the effectiveness ...

Last Updated: 8 Aug 2015

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COX/mPGES-1/PGE2 pathway depicts an inflammatory-dependent high-risk neuroblastoma subset.
 

Author(s): Karin Larsson, Anna Kock, Helena Idborg, Marie Arsenian Henriksson, Tommy Martinsson, John I Johnsen, Marina Korotkova, Per Kogner, Per-Johan Jakobsson

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2015 Jun;112(26):8070-5.

 

The majority of solid tumors are presented with an inflammatory microenvironment. Proinflammatory lipid mediators including prostaglandin E2 (PGE2) contribute to the establishment of inflammation and have been linked to tumor growth and aggressiveness. Here we show that high-risk ...

Last Updated: 1 Jul 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Neuroblastoma" returned 97 free, full-text review articles on human participants. First 3 results:

Neuroblastoma: molecular pathogenesis and therapy.
 

Author(s): Chrystal U Louis, Jason M Shohet

Journal: Annu. Rev. Med.. 2015 ;66():49-63.

 

Neuroblastoma is a developmental tumor of young children arising from the embryonic sympathoadrenal lineage of the neural crest. Neuroblastoma is the primary cause of death from pediatric cancer for children between the ages of one and five years and accounts for ∼13% of all pediatric ...

Last Updated: 15 Jan 2015

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Mechanisms of neuroblastoma regression.
 

Author(s): Garrett M Brodeur, Rochelle Bagatell

Journal: Nat Rev Clin Oncol. 2014 Dec;11(12):704-13.

 

Recent genomic and biological studies of neuroblastoma have shed light on the dramatic heterogeneity in the clinical behaviour of this disease, which spans from spontaneous regression or differentiation in some patients, to relentless disease progression in others, despite intensive ...

Last Updated: 24 Nov 2014

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Recent insights into the biology of neuroblastoma.
 

Author(s): Gudrun Schleiermacher, Isabelle Janoueix-Lerosey, Olivier Delattre

Journal: Int. J. Cancer. 2014 Nov;135(10):2249-61.

 

Neuroblastoma (NB) is an embryonal tumor of the sympathetic nervous system which accounts for 8-10% of pediatric cancers. It is characterized by a broad spectrum of clinical behaviors from spontaneous regression to fatal outcome despite aggressive therapies. Considerable progress ...

Last Updated: 8 Sep 2014

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma
 

Status: Recruiting

Condition Summary: Disseminated Neuroblastoma; Ganglioneuroblastoma; Localized Resectable Neuroblastoma; Localized Unresectable Neuroblastoma; Regional Neuroblastoma; Stage 4S Neuroblastoma

 

Last Updated: 12 Nov 2015

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Study of DNA in Blood Samples From Patients With Neuroblastoma
 

Status: Recruiting

Condition Summary: Disseminated Neuroblastoma; Localized Resectable Neuroblastoma; Localized Unresectable Neuroblastoma; Recurrent Neuroblastoma; Regional Neuroblastoma; Stage 4S Neuroblastoma

 

Last Updated: 16 Nov 2015

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Expanded Access Study of Fenretinide Lym-X-Sorb Plus Ketoconazole in Neuroblastoma
 

Status: Available

Condition Summary: Recurrent Neuroblastoma; Neuroblastoma

 

Last Updated: 9 Dec 2014

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