Nephrogenic Systemic Fibrosis

Common Name(s)

Nephrogenic Systemic Fibrosis

Nephrogenic fibrosing dermopathy (NFD) is a condition of unknown cause that affects different parts of the body, particularly the skin. Symptoms of the condition may include progressive swelling and tightening of the skin, sometimes resulting in contractures, and pruritis (itching).  The skin findings are similar to those seen in patients with scleroderma.  NFD was first described in 1997.  To date, NFD has only been reported in patients with kidney disease. 
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Nephrogenic Systemic Fibrosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Nephrogenic Systemic Fibrosis" returned 59 free, full-text research articles on human participants. First 3 results:

Advancing pharmacovigilance through academic-legal collaboration: the case of gadolinium-based contrast agents and nephrogenic systemic fibrosis-a Research on Adverse Drug Events and Reports (RADAR) report.
 

Author(s): B J Edwards, A E Laumann, B Nardone, F H Miller, J Restaino, D W Raisch, J M McKoy, J A Hammel, K Bhatt, K Bauer, A T Samaras, M J Fisher, C Bull, E Saddleton, S M Belknap, H S Thomsen, E Kanal, S E Cowper, A K Abu Alfa, D P West

Journal: Br J Radiol. 2014 Oct;87(1042):20140307.

 

To compare and contrast three databases, that is, The International Centre for Nephrogenic Systemic Fibrosis Registry (ICNSFR), the Food and Drug Administration Adverse Event Reporting System (FAERS) and a legal data set, through pharmacovigilance and to evaluate international nephrogenic ...

Last Updated: 20 Sep 2014

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Nephrogenic systemic fibrosis is associated with hypophosphataemia: a case-control study.
 

Author(s): Elana J Bernstein, Tamara Isakova, Mary E Sullivan, Lori B Chibnik, Myles Wolf, Jonathan Kay

Journal: Rheumatology (Oxford). 2014 Sep;53(9):1613-7.

 

Nephrogenic systemic fibrosis (NSF) is an iatrogenic fibrosing disorder that primarily affects individuals with chronic kidney disease (CKD) following exposure to gadolinium-based contrast agents (GBCAs). Derangements of calcium and phosphorus have been reported in patients with NSF. ...

Last Updated: 19 Aug 2014

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Nephrogenic systemic fibrosis in Denmark--a nationwide investigation.
 

Author(s): Tina R Elmholdt, Anne B B Olesen, Bettina Jørgensen, Stinne Kvist, Lone Skov, Henrik S Thomsen, Peter Marckmann, Michael Pedersen

Journal:

 

Nephrogenic systemic fibrosis is a debilitating and painful disorder with an increased stimulation of the connective tissue in the skin and systemic tissues. The disease is associated with exposure to gadolinium-based contrast agent used in magnetic resonance imaging in patients with ...

Last Updated: 18 Dec 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Nephrogenic Systemic Fibrosis" returned 26 free, full-text review articles on human participants. First 3 results:

[Causal relationship between the use of gadolinium based contrast media and nephrogenic systemic fibrosis].
 

Author(s): Cristian U Varela, Juan Carlos Prieto-Rayo

Journal: Rev Med Chil. 2014 Dec;142(12):1565-74.

 

Nephrogenic systemic fibrosis (NSF) is a severe iatrogenic disease that affect patients with impaired renal function exposed to gadolinium-based contrast agents. Clinically, symptoms develop within days or weeks after the exposure and mimic a scleromyxedema. The causal relationship ...

Last Updated: 19 Feb 2015

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Application of extracellular gadolinium-based MRI contrast agents and the risk of nephrogenic systemic fibrosis.
 

Author(s): J T Heverhagen, G A Krombach, E Gizewski

Journal: Rofo. 2014 Jul;186(7):661-9.

 

Nephrogenic systemic fibrosis (NSF) is a serious, sometimes fatal disease. Findings in recent years have shown that a causal association between gadolinium containing contrast media and NSF is most likely. Therefore, the regulatory authorities have issued guidelines on the use of ...

Last Updated: 19 Jun 2014

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Nephrogenic systemic fibrosis: concepts and perspectives.
 

Author(s): Ana Carolina de Souza Machado Igreja, Kleyton de Carvalho Mesquita, Shawn Edwin Cowper, Izelda Maria Carvalho Costa

Journal: An Bras Dermatol. ;87(4):597-607.

 

Nephrogenic systemic fibrosis is a chronic, progressive condition that develops in some patients with renal impairment after exposure to gadolinium-based contrast agents used in magnetic resonance imaging. Thickening of the skin is typical, usually affecting the extremities. Visceral ...

Last Updated: 15 Aug 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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