Nephrogenic Systemic Fibrosis

Common Name(s)

Nephrogenic Systemic Fibrosis

Nephrogenic fibrosing dermopathy (NFD) is a condition of unknown cause that affects different parts of the body, particularly the skin. Symptoms of the condition may include progressive swelling and tightening of the skin, sometimes resulting in contractures, and pruritis (itching).  The skin findings are similar to those seen in patients with scleroderma.  NFD was first described in 1997.  To date, NFD has only been reported in patients with kidney disease. 
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Nephrogenic Systemic Fibrosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Nephrogenic Systemic Fibrosis" returned 45 free, full-text research articles on human participants. First 3 results:

Nephrogenic systemic fibrosis in Denmark--a nationwide investigation.
 

Author(s): Tina R Elmholdt, Anne B B Olesen, Bettina Jørgensen, Stinne Kvist, Lone Skov, Henrik S Thomsen, Peter Marckmann, Michael Pedersen

Journal:

 

Nephrogenic systemic fibrosis is a debilitating and painful disorder with an increased stimulation of the connective tissue in the skin and systemic tissues. The disease is associated with exposure to gadolinium-based contrast agent used in magnetic resonance imaging in patients with ...

Last Updated: 18 Dec 2013

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Pediatric nephrogenic systemic fibrosis is rarely reported: a RADAR report.
 

Author(s): Beatrice Nardone, Elise Saddleton, Anne E Laumann, Beatrice J Edwards, Dennis W Raisch, June M McKoy, Steven M Belknap, Christian Bull, Anand Haryani, Shawn E Cowper, Ali K Abu-Alfa, Frank H Miller, Victoria Godinez-Puig, Vikas R Dharnidharka, Dennis P West

Journal: Pediatr Radiol. 2014 Feb;44(2):173-80.

 

Nephrogenic systemic fibrosis is a fibrosing disorder associated with exposure to gadolinium-based contrast agents in people with severely compromised renal function.

Last Updated: 31 Jan 2014

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Gadolinium contrast agent-induced CD163+ ferroportin+ osteogenic cells in nephrogenic systemic fibrosis.
 

Author(s): Sundararaman Swaminathan, Chhanda Bose, Sudhir V Shah, Kimberly A Hall, Kim M Hiatt

Journal: Am. J. Pathol.. 2013 Sep;183(3):796-807.

 

Gadolinium-based contrast agents are linked to nephrogenic systemic fibrosis in patients with renal insufficiency. The pathology of nephrogenic systemic fibrosis is characterized by abnormal tissue repair: fibrosis and ectopic ossification. The mechanisms by which gadolinium could ...

Last Updated: 26 Aug 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Nephrogenic Systemic Fibrosis" returned 25 free, full-text review articles on human participants. First 3 results:

[Causal relationship between the use of gadolinium based contrast media and nephrogenic systemic fibrosis].
 

Author(s): Cristian U Varela, Juan Carlos Prieto-Rayo

Journal: Rev Med Chil. 2014 Dec;142(12):1565-74.

 

Nephrogenic systemic fibrosis (NSF) is a severe iatrogenic disease that affect patients with impaired renal function exposed to gadolinium-based contrast agents. Clinically, symptoms develop within days or weeks after the exposure and mimic a scleromyxedema. The causal relationship ...

Last Updated: 19 Feb 2015

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Application of extracellular gadolinium-based MRI contrast agents and the risk of nephrogenic systemic fibrosis.
 

Author(s): J T Heverhagen, G A Krombach, E Gizewski

Journal: Rofo. 2014 Jul;186(7):661-9.

 

Nephrogenic systemic fibrosis (NSF) is a serious, sometimes fatal disease. Findings in recent years have shown that a causal association between gadolinium containing contrast media and NSF is most likely. Therefore, the regulatory authorities have issued guidelines on the use of ...

Last Updated: 19 Jun 2014

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Nephrogenic systemic fibrosis: concepts and perspectives.
 

Author(s): Ana Carolina de Souza Machado Igreja, Kleyton de Carvalho Mesquita, Shawn Edwin Cowper, Izelda Maria Carvalho Costa

Journal: An Bras Dermatol. ;87(4):597-607.

 

Nephrogenic systemic fibrosis is a chronic, progressive condition that develops in some patients with renal impairment after exposure to gadolinium-based contrast agents used in magnetic resonance imaging. Thickening of the skin is typical, usually affecting the extremities. Visceral ...

Last Updated: 15 Aug 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.