Nephrogenic Systemic Fibrosis

Common Name(s)

Nephrogenic Systemic Fibrosis

Nephrogenic fibrosing dermopathy (NFD) is a condition of unknown cause that affects different parts of the body, particularly the skin. Symptoms of the condition may include progressive swelling and tightening of the skin, sometimes resulting in contractures, and pruritis (itching).  The skin findings are similar to those seen in patients with scleroderma.  NFD was first described in 1997.  To date, NFD has only been reported in patients with kidney disease. 
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Nephrogenic Systemic Fibrosis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Nephrogenic Systemic Fibrosis" returned 48 free, full-text research articles on human participants. First 3 results:

Gadolinium contrast agent-induced CD163+ ferroportin+ osteogenic cells in nephrogenic systemic fibrosis.
 

Author(s): Sundararaman Swaminathan, Chhanda Bose, Sudhir V Shah, Kimberly A Hall, Kim M Hiatt

Journal: Am. J. Pathol.. 2013 Sep;183(3):796-807.

 

Gadolinium-based contrast agents are linked to nephrogenic systemic fibrosis in patients with renal insufficiency. The pathology of nephrogenic systemic fibrosis is characterized by abnormal tissue repair: fibrosis and ectopic ossification. The mechanisms by which gadolinium could ...

Last Updated: 26 Aug 2013

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Nephrogenic systemic fibrosis: evidence for oxidative stress and bone marrow-derived fibrocytes in skin, liver, and heart lesions using a 5/6 nephrectomy rodent model.
 

Author(s): Brent Wagner, Chunyan Tan, Jeffrey L Barnes, Seema Ahuja, Thomas L Davis, Yves Gorin, Fabio Jimenez

Journal: Am. J. Pathol.. 2012 Dec;181(6):1941-52.

 

Nephrogenic systemic fibrosis (NSF) is associated with gadolinium-based magnetic resonance imaging (MRI) contrast exposure in the setting of acute or chronic renal compromise. It has been proposed that circulating fibrocytes mediate the disease. A study was conducted to determine ...

Last Updated: 19 Nov 2012

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Gadolinium compounds signaling through TLR4 and TLR7 in normal human macrophages: establishment of a proinflammatory phenotype and implications for the pathogenesis of nephrogenic systemic fibrosis.
 

Author(s): Peter J Wermuth, Sergio A Jimenez

Journal: J. Immunol.. 2012 Jul;189(1):318-27.

 

Nephrogenic systemic sibrosis is a progressive disorder occurring in some renal insufficiency patients exposed to gadolinium-based contrast agents (GdBCA). Previous studies demonstrated that the GdBCA Omniscan upregulated several innate immunity pathways in normal differentiated human ...

Last Updated: 22 Jun 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Nephrogenic Systemic Fibrosis" returned 24 free, full-text review articles on human participants. First 3 results:

Application of extracellular gadolinium-based MRI contrast agents and the risk of nephrogenic systemic fibrosis.
 

Author(s): J T Heverhagen, G A Krombach, E Gizewski

Journal: Rofo. 2014 Jul;186(7):661-9.

 

Nephrogenic systemic fibrosis (NSF) is a serious, sometimes fatal disease. Findings in recent years have shown that a causal association between gadolinium containing contrast media and NSF is most likely. Therefore, the regulatory authorities have issued guidelines on the use of ...

Last Updated: 19 Jun 2014

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Nephrogenic systemic fibrosis: concepts and perspectives.
 

Author(s): Ana Carolina de Souza Machado Igreja, Kleyton de Carvalho Mesquita, Shawn Edwin Cowper, Izelda Maria Carvalho Costa

Journal: An Bras Dermatol. ;87(4):597-607.

 

Nephrogenic systemic fibrosis is a chronic, progressive condition that develops in some patients with renal impairment after exposure to gadolinium-based contrast agents used in magnetic resonance imaging. Thickening of the skin is typical, usually affecting the extremities. Visceral ...

Last Updated: 15 Aug 2012

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Linking drugs to obscure illnesses: lessons from pure red cell aplasia, nephrogenic systemic fibrosis, and Reye's syndrome. a report from the Southern Network on Adverse Reactions (SONAR).
 

Author(s): Charles L Bennett, Karen M Starko, Henrik S Thomsen, Shawn Cowper, Oliver Sartor, Iain C Macdougall, Zaina P Qureshi, P Brandon Bookstaver, April D Miller, LeAnn B Norris, Sudha Xirasagar, Alyssa Trenery, Isaac Lopez, Adam Kahn, Alanna Murday, Stefano Luminari, Denis Cournoyer, Francesco Locatelli, Paul Ray, Donald R Mattison

Journal: J Gen Intern Med. 2012 Dec;27(12):1697-703.

 

Identification of serious adverse drug reactions (sADRS) associated with commonly used drugs can elude detection for years. Reye's syndrome (RS), nephrogenic systemic fibrosis (NSF), and pure red cell aplasia (PRCA) among chronic kidney disease (CKD) patients were recognized in 1951, ...

Last Updated: 29 Nov 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Use of Plasmapheresis for Nephrogenic Fibrosing Dermopathy (NFD)/Nephrogenic Systemic Fibrosis (NSF) and Understanding Its Etiology
 

Status: Recruiting

Condition Summary: Nephrogenic Fibrosing Dermopathy; Nephrogenic Systemic Fibrosis

 

Last Updated: 1 Jun 2011

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