Nephrogenic Systemic Fibrosis

Common Name(s)

Nephrogenic Systemic Fibrosis

Nephrogenic fibrosing dermopathy (NFD) is a condition of unknown cause that affects different parts of the body, particularly the skin. Symptoms of the condition may include progressive swelling and tightening of the skin, sometimes resulting in contractures, and pruritis (itching).  The skin findings are similar to those seen in patients with scleroderma.  NFD was first described in 1997.  To date, NFD has only been reported in patients with kidney disease. 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Nephrogenic Systemic Fibrosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Nephrogenic Systemic Fibrosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Nephrogenic Systemic Fibrosis" returned 62 free, full-text research articles on human participants. First 3 results:

An Updated Study to Determine Association between Gadolinium-Based Contrast Agents and Nephrogenic Systemic Fibrosis.
 

Author(s): Bin Zhang, Long Liang, Wenbo Chen, Changhong Liang, Shuixing Zhang

Journal:

 

Nephrogenic systemic fibrosis (NSF) is a rare but serious disorder disease affecting patients with advanced renal disease. Although multiple studies have indicated an association between gadolinium-based contrast agents (GBCAs) and NSF, some studies published after 2007 found no association. ...

Last Updated: 16 Jun 2015

Go To URL
Nephrogenic systemic fibrosis risk after liver magnetic resonance imaging with gadoxetate disodium in patients with moderate to severe renal impairment: results of a prospective, open-label, multicenter study.
 

Author(s): Thomas Lauenstein, Francisco Ramirez-Garrido, Young Hoon Kim, Sung Eun Rha, Jens Ricke, Sith Phongkitkarun, Joachim Boettcher, Rajan T Gupta, Pornpim Korpraphong, Wiwatana Tanomkiat, Julia Furtner, Peter S Liu, Maren Henry, Jan Endrikat

Journal: Invest Radiol. 2015 Jun;50(6):416-22.

 

The objective of this study was to assess the risk of gadoxetate disodium in liver imaging for the development of nephrogenic systemic fibrosis (NSF) in patients with moderate to severe renal impairment.

Last Updated: 6 May 2015

Go To URL
Advancing pharmacovigilance through academic-legal collaboration: the case of gadolinium-based contrast agents and nephrogenic systemic fibrosis-a Research on Adverse Drug Events and Reports (RADAR) report.
 

Author(s): B J Edwards, A E Laumann, B Nardone, F H Miller, J Restaino, D W Raisch, J M McKoy, J A Hammel, K Bhatt, K Bauer, A T Samaras, M J Fisher, C Bull, E Saddleton, S M Belknap, H S Thomsen, E Kanal, S E Cowper, A K Abu Alfa, D P West

Journal: Br J Radiol. 2014 Oct;87(1042):20140307.

 

To compare and contrast three databases, that is, The International Centre for Nephrogenic Systemic Fibrosis Registry (ICNSFR), the Food and Drug Administration Adverse Event Reporting System (FAERS) and a legal data set, through pharmacovigilance and to evaluate international nephrogenic ...

Last Updated: 20 Sep 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Nephrogenic Systemic Fibrosis" returned 28 free, full-text review articles on human participants. First 3 results:

[Causal relationship between the use of gadolinium based contrast media and nephrogenic systemic fibrosis].
 

Author(s): Cristian U Varela, Juan Carlos Prieto-Rayo

Journal: Rev Med Chil. 2014 Dec;142(12):1565-74.

 

Nephrogenic systemic fibrosis (NSF) is a severe iatrogenic disease that affect patients with impaired renal function exposed to gadolinium-based contrast agents. Clinically, symptoms develop within days or weeks after the exposure and mimic a scleromyxedema. The causal relationship ...

Last Updated: 19 Feb 2015

Go To URL
Renal function, nephrogenic systemic fibrosis and other adverse reactions associated with gadolinium-based contrast media.
 

Author(s): Ana Canga, Maria Kislikova, María Martínez-Gálvez, Mercedes Arias, Patricia Fraga-Rivas, Cecilio Poyatos, Angel L M de Francisco

Journal: Nefrologia. 2014 ;34(4):428-38.

 

Nephrogenic systemic fibrosis is a fibrosing disorder that affects patients with impaired renal function and is associated with the administration of gadolinium-based contrast media used in MRI. Despite being in a group of drugs that were considered safe, report about this potentially ...

Last Updated: 19 Jul 2014

Go To URL
Application of extracellular gadolinium-based MRI contrast agents and the risk of nephrogenic systemic fibrosis.
 

Author(s): J T Heverhagen, G A Krombach, E Gizewski

Journal: Rofo. 2014 Jul;186(7):661-9.

 

Nephrogenic systemic fibrosis (NSF) is a serious, sometimes fatal disease. Findings in recent years have shown that a causal association between gadolinium containing contrast media and NSF is most likely. Therefore, the regulatory authorities have issued guidelines on the use of ...

Last Updated: 19 Jun 2014

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.