Nephrogenic diabetes insipidus

Common Name(s)

Nephrogenic diabetes insipidus, Nephrogenic diabetes insipidus, x-linked

Nephrogenic diabetes insipidus is a disorder in which a defect in the small tubes (tubules) in the kidneys causes a person to pass a large amount of urine. Nephrogenic diabetes insipidus occurs when the kidney tubules, which allow water to be removed from the body or reabsorbed, do not respond to a chemical in the body called antidiuretic hormone (ADH) or vasopressin. ADH normally tells the kidneys to make the urine more concentrated. As a result of the defect, the kidneys release an excessive amount of water into the urine, producing a large quantity of very dilute urine.

Nephrogenic diabetes insipidus can be either acquired or hereditary. The acquired form is brought on by certain drugs and chronic diseases and can occur at any time during life. The hereditary form is caused by genetic mutations, and its signs and symptoms usually become apparent within the first few months of life.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Nephrogenic diabetes insipidus" for support, advocacy or research.

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Nephrogenic Diabetes Insipidus Network

The NDI Foundation was formed to support education, research, treatment and cure for Nephrogenic Diabetes Insipidus. Our goal is to create a communication channel to serve the entire NDI community: patients and their families, researchers, physicians and other health care providers. The NDI foundation has helped to stimulate clinical trials and ongoing research to improve the therapy and treatment options for this kidney disorder. While we focus on research, we enthusisaticly provide information to help educate patients and famalies on treatment options, support groups and the lastest research news.

Last Updated: 9 Nov 2012

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Nephrogenic diabetes insipidus" for support, advocacy or research.

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Nephrogenic Diabetes Insipidus Network

The NDI Foundation was formed to support education, research, treatment and cure for Nephrogenic Diabetes Insipidus. Our goal is to create a communication channel to serve the entire NDI community: patients and their families, researchers, physicians and other health care providers. The NDI foundation has helped to stimulate clinical trials and ongoing research to improve the therapy and treatment options for this kidney disorder. While we focus on research, we enthusisaticly provide information to help educate patients and famalies on treatment options, support groups and the lastest research news.

http://www.ndif.org

Last Updated: 9 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Nephrogenic diabetes insipidus" returned 131 free, full-text research articles on human participants. First 3 results:

Evolutionary Influenced Interaction Pattern as Indicator for the Investigation of Natural Variants Causing Nephrogenic Diabetes Insipidus.
 

Author(s): Steffen Grunert, Dirk Labudde

Journal: Comput Math Methods Med. 2015 ;2015():641393.

 

The importance of short membrane sequence motifs has been shown in many works and emphasizes the related sequence motif analysis. Together with specific transmembrane helix-helix interactions, the analysis of interacting sequence parts is helpful for understanding the process during ...

Last Updated: 16 Jul 2015

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X-ray structure of human aquaporin 2 and its implications for nephrogenic diabetes insipidus and trafficking.
 

Author(s): Anna Frick, Urszula Kosinska Eriksson, Fabrizio de Mattia, Fredrik Oberg, Kristina Hedfalk, Richard Neutze, Willem J de Grip, Peter M T Deen, Susanna Törnroth-Horsefield

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2014 Apr;111(17):6305-10.

 

Human aquaporin 2 (AQP2) is a water channel found in the kidney collecting duct, where it plays a key role in concentrating urine. Water reabsorption is regulated by AQP2 trafficking between intracellular storage vesicles and the apical membrane. This process is tightly controlled ...

Last Updated: 30 Apr 2014

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Genetic analysis of a congenital nephrogenic diabetes insipidus pedigree.
 

Author(s): Yunfeng Shen, Xiaoyang Lai, Xinlan Xiao, Jing Li, Rong Yu, Hui Gao, Meiying Zhang

Journal: Chin. Med. J.. 2014 ;127(6):1089-92.

 

As an X-linked recessive way, arginine vasopressin receptor 2 (AVPR2) gene mutation resulted in a hereditary disease - congenital nephrogenic diabetes insipidus (CNDI). We found a suspect clinical CNDI pedigree. In order to identify the genetic etiology, we performed the genetic analysis.

Last Updated: 13 Mar 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Nephrogenic diabetes insipidus" returned 14 free, full-text review articles on human participants. First 3 results:

Congenital nephrogenic diabetes insipidus with end-stage renal disease.
 

Author(s): Hyun Ho Ryu, Jong Hoon Chung, Byung Chul Shin, Hyun Lee Kim

Journal: Korean J. Intern. Med.. 2015 Mar;30(2):259-61.

 

Last Updated: 9 Mar 2015

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A novel therapeutic effect of statins on nephrogenic diabetes insipidus.
 

Author(s): Leonilde Bonfrate, Giuseppe Procino, David Q-H Wang, Maria Svelto, Piero Portincasa

Journal: J. Cell. Mol. Med.. 2015 Feb;19(2):265-82.

 

Statins competitively inhibit hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase, resulting in reduced plasma total and low-density lipoprotein cholesterol levels. Recently, it has been shown that statins exert additional 'pleiotropic' effects by increasing expression levels ...

Last Updated: 29 Jan 2015

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Inherited secondary nephrogenic diabetes insipidus: concentrating on humans.
 

Author(s): D Bockenhauer, D G Bichet

Journal: Am. J. Physiol. Renal Physiol.. 2013 Apr;304(8):F1037-42.

 

The study of human physiology is paramount to understanding disease and developing rational and targeted treatments. Conversely, the study of human disease can teach us a lot about physiology. Investigations into primary inherited nephrogenic diabetes insipidus (NDI) have contributed ...

Last Updated: 16 Apr 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Metformin and Congenital Nephrogenic Diabetes Insipidus
 

Status: Recruiting

Condition Summary: Diabetes Insipidus

 

Last Updated: 20 Apr 2016

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