Nephrogenic diabetes insipidus

Common Name(s)

Nephrogenic diabetes insipidus, Nephrogenic diabetes insipidus, x-linked

Nephrogenic diabetes insipidus is a disorder in which a defect in the small tubes (tubules) in the kidneys causes a person to pass a large amount of urine. Nephrogenic diabetes insipidus occurs when the kidney tubules, which allow water to be removed from the body or reabsorbed, do not respond to a chemical in the body called antidiuretic hormone (ADH) or vasopressin. ADH normally tells the kidneys to make the urine more concentrated. As a result of the defect, the kidneys release an excessive amount of water into the urine, producing a large quantity of very dilute urine.

Nephrogenic diabetes insipidus can be either acquired or hereditary. The acquired form is brought on by certain drugs and chronic diseases and can occur at any time during life. The hereditary form is caused by genetic mutations, and its signs and symptoms usually become apparent within the first few months of life.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Nephrogenic diabetes insipidus" for support, advocacy or research.

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Nephrogenic Diabetes Insipidus Network

The NDI Foundation was formed to support education, research, treatment and cure for Nephrogenic Diabetes Insipidus. Our goal is to create a communication channel to serve the entire NDI community: patients and their families, researchers, physicians and other health care providers. The NDI foundation has helped to stimulate clinical trials and ongoing research to improve the therapy and treatment options for this kidney disorder. While we focus on research, we enthusisaticly provide information to help educate patients and famalies on treatment options, support groups and the lastest research news.

Last Updated: 9 Nov 2012

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Nephrogenic diabetes insipidus" for support, advocacy or research.

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Nephrogenic Diabetes Insipidus Network

The NDI Foundation was formed to support education, research, treatment and cure for Nephrogenic Diabetes Insipidus. Our goal is to create a communication channel to serve the entire NDI community: patients and their families, researchers, physicians and other health care providers. The NDI foundation has helped to stimulate clinical trials and ongoing research to improve the therapy and treatment options for this kidney disorder. While we focus on research, we enthusisaticly provide information to help educate patients and famalies on treatment options, support groups and the lastest research news.

http://www.ndif.org

Last Updated: 9 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Nephrogenic diabetes insipidus" returned 123 free, full-text research articles on human participants. First 3 results:

X-ray structure of human aquaporin 2 and its implications for nephrogenic diabetes insipidus and trafficking.
 

Author(s): Anna Frick, Urszula Kosinska Eriksson, Fabrizio de Mattia, Fredrik Oberg, Kristina Hedfalk, Richard Neutze, Willem J de Grip, Peter M T Deen, Susanna Törnroth-Horsefield

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2014 Apr;111(17):6305-10.

 

Human aquaporin 2 (AQP2) is a water channel found in the kidney collecting duct, where it plays a key role in concentrating urine. Water reabsorption is regulated by AQP2 trafficking between intracellular storage vesicles and the apical membrane. This process is tightly controlled ...

Last Updated: 30 Apr 2014

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Nephrogenic diabetes insipidus with intracranial calcification in a child with thalassemia minor.
 

Author(s): Jain Dimple, Jadhav Alka, Gajre Mona, Deshmukh Atul

Journal: Arab J Nephrol Transplant. 2013 Sep;6(3):185-7.

 

There are numerous causes for intracranial calcification in children. We describe an unusual cause of intracranial calcification in a child, namely, nephrogenic diabetes insipidus (NDI).

Last Updated: 23 Sep 2013

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Paradoxical hyponatremia and polyurodipsia in a patient with lithium-induced nephrogenic diabetes insipidus.
 

Author(s): Richard A Fasanello, Tam M Vu

Journal: J Am Osteopath Assoc. 2012 Sep;112(9):588.

 

Last Updated: 17 Sep 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Nephrogenic diabetes insipidus" returned 11 free, full-text review articles on human participants. First 3 results:

Inherited secondary nephrogenic diabetes insipidus: concentrating on humans.
 

Author(s): D Bockenhauer, D G Bichet

Journal: Am. J. Physiol. Renal Physiol.. 2013 Apr;304(8):F1037-42.

 

The study of human physiology is paramount to understanding disease and developing rational and targeted treatments. Conversely, the study of human disease can teach us a lot about physiology. Investigations into primary inherited nephrogenic diabetes insipidus (NDI) have contributed ...

Last Updated: 16 Apr 2013

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Nephrogenic diabetes insipidus: essential insights into the molecular background and potential therapies for treatment.
 

Author(s): Hanne B Moeller, Søren Rittig, Robert A Fenton

Journal: Endocr. Rev.. 2013 Apr;34(2):278-301.

 

The water channel aquaporin-2 (AQP2), expressed in the kidney collecting ducts, plays a pivotal role in maintaining body water balance. The channel is regulated by the peptide hormone arginine vasopressin (AVP), which exerts its effects through the type 2 vasopressin receptor (AVPR2). ...

Last Updated: 8 Apr 2013

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Two new large deletions of the AVPR2 gene causing nephrogenic diabetes insipidus and a review of previously published deletions.
 

Author(s): Laura Anesi, Paola de Gemmis, Daniela Galla, Uros Hladnik

Journal: Nephrol. Dial. Transplant.. 2012 Oct;27(10):3705-12.

 

In this paper, we report two new original deletions and present an extended review of the previously characterized AVPR2 gene deletions to better understand the underlying deletion mechanisms.

Last Updated: 1 Nov 2012

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.