Nephrogenic diabetes insipidus

Common Name(s)

Nephrogenic diabetes insipidus, Nephrogenic diabetes insipidus, x-linked

Nephrogenic diabetes insipidus is a disorder in which a defect in the small tubes (tubules) in the kidneys causes a person to pass a large amount of urine. Nephrogenic diabetes insipidus occurs when the kidney tubules, which allow water to be removed from the body or reabsorbed, do not respond to a chemical in the body called antidiuretic hormone (ADH) or vasopressin. ADH normally tells the kidneys to make the urine more concentrated. As a result of the defect, the kidneys release an excessive amount of water into the urine, producing a large quantity of very dilute urine.

Nephrogenic diabetes insipidus can be either acquired or hereditary. The acquired form is brought on by certain drugs and chronic diseases and can occur at any time during life. The hereditary form is caused by genetic mutations, and its signs and symptoms usually become apparent within the first few months of life.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Nephrogenic diabetes insipidus" for support, advocacy or research.

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Nephrogenic Diabetes Insipidus Network

The NDI Foundation was formed to support education, research, treatment and cure for Nephrogenic Diabetes Insipidus. Our goal is to create a communication channel to serve the entire NDI community: patients and their families, researchers, physicians and other health care providers. The NDI foundation has helped to stimulate clinical trials and ongoing research to improve the therapy and treatment options for this kidney disorder. While we focus on research, we enthusisaticly provide information to help educate patients and famalies on treatment options, support groups and the lastest research news.

Last Updated: 9 Nov 2012

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Nephrogenic diabetes insipidus" for support, advocacy or research.

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Nephrogenic Diabetes Insipidus Network

The NDI Foundation was formed to support education, research, treatment and cure for Nephrogenic Diabetes Insipidus. Our goal is to create a communication channel to serve the entire NDI community: patients and their families, researchers, physicians and other health care providers. The NDI foundation has helped to stimulate clinical trials and ongoing research to improve the therapy and treatment options for this kidney disorder. While we focus on research, we enthusisaticly provide information to help educate patients and famalies on treatment options, support groups and the lastest research news.

http://www.ndif.org

Last Updated: 9 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Nephrogenic diabetes insipidus" returned 121 free, full-text research articles on human participants. First 3 results:

Paradoxical hyponatremia and polyurodipsia in a patient with lithium-induced nephrogenic diabetes insipidus.
 

Author(s): Richard A Fasanello, Tam M Vu

Journal: J Am Osteopath Assoc. 2012 Sep;112(9):588.

 

Last Updated: 17 Sep 2012

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ARC syndrome with complex renal problems: nephrocalcinosis, proximal and hyperkalemic distal RTA and nephrogenic diabetes insipidus.
 

Author(s): Majid Malaki, Rafeei Mandana, Shamsi Ghaffari

Journal: Saudi J Kidney Dis Transpl. 2012 Jul;23(4):804-9.

 

We present a female neonate with arthrogryposis, renal tubular abnormalities and cholestasis syndrome and complex renal structural and functional abnormalities that include medullary nephrocalcinosis, hydronephrosis, nephrogenic diabetes insipidus, Fanconi syndrome, proximal and distal ...

Last Updated: 18 Jul 2012

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Membrane protein stability analyses by means of protein energy profiles in case of nephrogenic diabetes insipidus.
 

Author(s): Florian Heinke, Dirk Labudde

Journal: Comput Math Methods Med. 2012 ;2012():790281.

 

Diabetes insipidus (DI) is a rare endocrine, inheritable disorder with low incidences in an estimated one per 25,000-30,000 live births. This disease is characterized by polyuria and compensatory polydypsia. The diverse underlying causes of DI can be central defects, in which no functional ...

Last Updated: 4 Apr 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Nephrogenic diabetes insipidus" returned 10 free, full-text review articles on human participants. First 3 results:

Inherited secondary nephrogenic diabetes insipidus: concentrating on humans.
 

Author(s): D Bockenhauer, D G Bichet

Journal: Am. J. Physiol. Renal Physiol.. 2013 Apr;304(8):F1037-42.

 

The study of human physiology is paramount to understanding disease and developing rational and targeted treatments. Conversely, the study of human disease can teach us a lot about physiology. Investigations into primary inherited nephrogenic diabetes insipidus (NDI) have contributed ...

Last Updated: 16 Apr 2013

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Nephrogenic diabetes insipidus: essential insights into the molecular background and potential therapies for treatment.
 

Author(s): Hanne B Moeller, Søren Rittig, Robert A Fenton

Journal: Endocr. Rev.. 2013 Apr;34(2):278-301.

 

The water channel aquaporin-2 (AQP2), expressed in the kidney collecting ducts, plays a pivotal role in maintaining body water balance. The channel is regulated by the peptide hormone arginine vasopressin (AVP), which exerts its effects through the type 2 vasopressin receptor (AVPR2). ...

Last Updated: 8 Apr 2013

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Bypassing vasopressin receptor signaling pathways in nephrogenic diabetes insipidus.
 

Author(s): Richard Bouley, Udo Hasler, Hua A J Lu, Paula Nunes, Dennis Brown

Journal: Semin. Nephrol.. 2008 May;28(3):266-78.

 

Water reabsorption in the kidney represents a critical physiological event in the maintenance of body water homeostasis. This highly regulated process relies largely on vasopressin (VP) action and on the VP-sensitive water channel (AQP2) that is expressed in principal cells of the ...

Last Updated: 3 Jun 2008

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.