Nephrocalcinosis

Common Name(s)

Nephrocalcinosis

Nephrocalcinosis is a disorder in which there is excess calcium deposited in the kidneys. It is relatively common in premature infants. Individuals may be asymptomatic or have symptoms related to the condition causing nephrocalcinosis. If kidney stones are present, an individual may have blood in the urine; fever and chills; nausea and vomiting; or severe pain in the belly area, sides of the back (flank), groin, or testicles. Later symptoms related to nephrocalcinosis may be associated with chronic kidney failure. It may be caused by use of certain medications or supplements; infection; or any condition that leads to high levels of calcium in the blood or urine including hyperparathyroidism, renal tubular acidosis, Alport syndrome, Bartter syndrome, and a variety of other conditions. Some of the underlying disorders that can cause nephrocalcinosis are genetic, with the inheritance pattern depending on the specific disorder. The goal of treatment is to reduce symptoms and prevent more calcium from being deposited in the kidneys.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Nephrocalcinosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Nephrocalcinosis" returned 74 free, full-text research articles on human participants. First 3 results:

Hypercalcemia, hypercalciuria and nephrocalcinosis in a breast-fed term newborn: a rare presentation.
 

Author(s): Issa A Hazza, Manahil S Ghandour, Reham I Almardini, Rana E Haddad, Ghazi M Salaita

Journal: Saudi J Kidney Dis Transpl. 2014 Jul;25(4):849-53.

 

Although hypercalcemia and hypercalciuria are known to occur in breast-fed pre-term infants, to the best of our knowledge, it has never been reported in a term baby previously. We report a term male baby who was followed-up during pregnancy for having bright kidneys, but a follow-up ...

Last Updated: 27 Jun 2014

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Nephrocalcinosis as adult presentation of Bartter syndrome type II.
 

Author(s): L Huang, G P M Luiken, I C van Riemsdijk, F Petrij, A A M Zandbergen, A Dees

Journal: Neth J Med. 2014 Feb;72(2):91-3.

 

Bartter syndrome consists a group of rare autosomal-recessive renal tubulopathies characterised by renal salt wasting, hypokalaemic metabolic alkalosis, hypercalciuria and hyperreninaemic hyperaldosteronism. It is classified into five types. Mutations in the KCNJ1 gene (classified ...

Last Updated: 24 Mar 2014

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Nephrocalcinosis in pre-term neonates: a study of incidence and risk factors.
 

Author(s): Gamal B Mohamed, Mohamed A Ibrahiem, Waleed M Abdel Hameed

Journal: Saudi J Kidney Dis Transpl. 2014 Mar;25(2):326-32.

 

The objective of this study was to determine the incidence and risk factors of nephrocalcinosis (NC) in pre-term neonates in the neonatal intensive care unit (NICU) at the Al-Minya University, Egypt. The study included 97 pre-term neonates with a gestational age 34 weeks. Data on ...

Last Updated: 14 Mar 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Nephrocalcinosis" returned 3 free, full-text review articles on human participants. First 3 results:

Nephrocalcinosis: new insights into mechanisms and consequences.
 

Author(s): Benjamin A Vervaet, Anja Verhulst, Patrick C D'Haese, Marc E De Broe

Journal: Nephrol. Dial. Transplant.. 2009 Jul;24(7):2030-5.

 

Last Updated: 22 Jun 2009

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Diagnostic examination of the child with urolithiasis or nephrocalcinosis.
 

Author(s): Bernd Hoppe, Markus J Kemper

Journal: Pediatr. Nephrol.. 2010 Mar;25(3):403-13.

 

Urolithiasis and nephrocalcinosis are more frequent in children then currently anticipated, but still remain under- or misdiagnosed in a significant proportion of patients, since symptoms and signs may be subtle or misleading. All children with colicky abdominal pain or macroscopic ...

Last Updated: 25 Jan 2010

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Hypomagnesaemia-hypercalciuria-nephrocalcinosis: a report of nine cases and a review.
 

Author(s): V Benigno, C S Canonica, A Bettinelli, R O von Vigier, A C Truttmann, M G Bianchetti

Journal: Nephrol. Dial. Transplant.. 2000 May;15(5):605-10.

 

The cardinal characteristics of primary hypomagnesaemia-hypercalciuria-nephrocalcinosis include renal magnesium wasting, marked hypercalciuria, renal stones, nephrocalcinosis, a tendency towards chronic renal insufficiency and sometimes even ocular abnormalities or hearing impairment.

Last Updated: 14 Jun 2000

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 26 Dec 2012

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Preterm Infants and Nephrocalcinosis
 

Status: Recruiting

Condition Summary: Prematurity; Nephrocalcinosis; Hypercalciuria

 

Last Updated: 5 May 2015

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Randall's Plaque Study: Pathogenesis and Relationship to Nephrolithiasis
 

Status: Recruiting

Condition Summary: Nephrocalcinosis; Renal Calculi; Hypercalciuria; Hyperparathyroidism; Cystinuria

 

Last Updated: 31 Dec 2014

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