Nephrocalcinosis

Common Name(s)

Nephrocalcinosis

Nephrocalcinosis is a disorder in which there is excess calcium deposited in the kidneys. It is relatively common in premature infants. Individuals may be asymptomatic or have symptoms related to the condition causing nephrocalcinosis. If kidney stones are present, an individual may have blood in the urine; fever and chills; nausea and vomiting; or severe pain in the belly area, sides of the back (flank), groin, or testicles. Later symptoms related to nephrocalcinosis may be associated with chronic kidney failure. It may be caused by use of certain medications or supplements; infection; or any condition that leads to high levels of calcium in the blood or urine including hyperparathyroidism, renal tubular acidosis, Alport syndrome, Bartter syndrome, and a variety of other conditions. Some of the underlying disorders that can cause nephrocalcinosis are genetic, with the inheritance pattern depending on the specific disorder. The goal of treatment is to reduce symptoms and prevent more calcium from being deposited in the kidneys.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Nephrocalcinosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Nephrocalcinosis" returned 70 free, full-text research articles on human participants. First 3 results:

Nephrocalcinosis in pre-term neonates: a study of incidence and risk factors.
 

Author(s): Gamal B Mohamed, Mohamed A Ibrahiem, Waleed M Abdel Hameed

Journal: Saudi J Kidney Dis Transpl. 2014 Mar;25(2):326-32.

 

The objective of this study was to determine the incidence and risk factors of nephrocalcinosis (NC) in pre-term neonates in the neonatal intensive care unit (NICU) at the Al-Minya University, Egypt. The study included 97 pre-term neonates with a gestational age 34 weeks. Data on ...

Last Updated: 14 Mar 2014

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A novel CLDN16 mutation in a large family with familial hypomagnesaemia with hypercalciuria and nephrocalcinosis.
 

Author(s): Asma Deeb, Salima Atia Abood, Job Simon, Hormazdiar Dastoor, Simon Hs Pearce, John A Sayer

Journal:

 

Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis is a rare tubulopathy leading to renal calcification and progressive renal failure.

Last Updated: 19 Dec 2013

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Renal function and linear growth of children with nephrocalcinosis: a retrospective single-center study.
 

Author(s): Cağla Serpil Doğan, Arife Uslu-Gökçeoğlu, Elif Comak, Emel Alimoğlu, Mustafa Koyun, Sema Akman

Journal: Turk. J. Pediatr.. ;55(1):58-62.

 

The aim of this study was to analyze the etiology of nephrocalcinosis (NC) and whether it has any effect on growth and renal function in children. Forty-three children who were diagnosed with bilateral NC were studied retrospectively. Two neonates treated with furosemide and five ...

Last Updated: 22 May 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Nephrocalcinosis" returned 4 free, full-text review articles on human participants. First 3 results:

Nephrocalcinosis: new insights into mechanisms and consequences.
 

Author(s): Benjamin A Vervaet, Anja Verhulst, Patrick C D'Haese, Marc E De Broe

Journal: Nephrol. Dial. Transplant.. 2009 Jul;24(7):2030-5.

 

Last Updated: 22 Jun 2009

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Diagnostic examination of the child with urolithiasis or nephrocalcinosis.
 

Author(s): Bernd Hoppe, Markus J Kemper

Journal: Pediatr. Nephrol.. 2010 Mar;25(3):403-13.

 

Urolithiasis and nephrocalcinosis are more frequent in children then currently anticipated, but still remain under- or misdiagnosed in a significant proportion of patients, since symptoms and signs may be subtle or misleading. All children with colicky abdominal pain or macroscopic ...

Last Updated: 25 Jan 2010

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Nephrocalcinosis: molecular insights into calcium precipitation within the kidney.
 

Author(s): John A Sayer, Georgina Carr, Nicholas L Simmons

Journal: Clin. Sci.. 2004 Jun;106(6):549-61.

 

Nephrocalcinosis may be defined as a generalized increase in the calcium content of the kidneys. This renal calcification may occur at a molecular, microscopic or macroscopic level leading to progressive amounts of renal damage. The major causes include those associated with an increase ...

Last Updated: 25 May 2004

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 26 Dec 2012

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Randall's Plaque Study: Pathogenesis and Relationship to Nephrolithiasis
 

Status: Recruiting

Condition Summary: Nephrocalcinosis; Renal Calculi; Hypercalciuria; Hyperparathyroidism; Cystinuria

 

Last Updated: 23 Jun 2014

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ACTHAR GEL for Sarcoidosis-Associated Calcium Dysregulation: An Open-label Pilot Study
 

Status: Not yet recruiting

Condition Summary: Sarcoidosis-Associated Calcium Dysregulation; Sarcoidosis-Associated Hypercalciuria

 

Last Updated: 2 Jun 2014

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