Nephrocalcinosis

Common Name(s)

Nephrocalcinosis

Nephrocalcinosis is a disorder in which there is excess calcium deposited in the kidneys. It is relatively common in premature infants. Individuals may be asymptomatic or have symptoms related to the condition causing nephrocalcinosis. If kidney stones are present, an individual may have blood in the urine; fever and chills; nausea and vomiting; or severe pain in the belly area, sides of the back (flank), groin, or testicles. Later symptoms related to nephrocalcinosis may be associated with chronic kidney failure. It may be caused by use of certain medications or supplements; infection; or any condition that leads to high levels of calcium in the blood or urine including hyperparathyroidism, renal tubular acidosis, Alport syndrome, Bartter syndrome, and a variety of other conditions. Some of the underlying disorders that can cause nephrocalcinosis are genetic, with the inheritance pattern depending on the specific disorder. The goal of treatment is to reduce symptoms and prevent more calcium from being deposited in the kidneys.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Nephrocalcinosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Nephrocalcinosis" returned 101 free, full-text research articles on human participants. First 3 results:

[Nephrocalcinosis complicating miliary tuberculosis in an infant].
 

Author(s): Jaouad El Maghraoui, Fatima Zahrae Souilmi, Mohamed Hbibi, Tarik Sqalli Houssaini, Mustapha Hida

Journal:

 

Last Updated: 28 Aug 2015

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Familial mixed nephrocalcinosis as a cause of chronic kidney failure: two case reports.
 

Author(s): Pedro Francisco Ferraz de Arruda, Márcio Gatti, José Germano Ferraz de Arruda, Fernando Nestor Fácio, Luis Cesar Fava Spessoto, Laísa Ferraz de Arruda, José Maria Pereira de Godoy, Moacir Fernandes Godoy

Journal:

 

Nephrocalcinosis consists of the deposition of calcium salts in the renal parenchyma and is considered the mixed form when it involves the renal cortex and medulla. The main etiological agents of this condition are primary hyperparathyroidism, renal tubular acidosis, medullary sponge ...

Last Updated: 4 Nov 2014

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Fourteen monogenic genes account for 15% of nephrolithiasis/nephrocalcinosis.
 

Author(s): Jan Halbritter, Michelle Baum, Ann Marie Hynes, Sarah J Rice, David T Thwaites, Zoran S Gucev, Brittany Fisher, Leslie Spaneas, Jonathan D Porath, Daniela A Braun, Ari J Wassner, Caleb P Nelson, Velibor Tasic, John A Sayer, Friedhelm Hildebrandt

Journal: J. Am. Soc. Nephrol.. 2015 Mar;26(3):543-51.

 

Nephrolithiasis is a prevalent condition with a high morbidity. Although dozens of monogenic causes have been identified, the fraction of single-gene disease has not been well studied. To determine the percentage of cases that can be molecularly explained by mutations in 1 of 30 known ...

Last Updated: 28 Feb 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Nephrocalcinosis" returned 3 free, full-text review articles on human participants. First 3 results:

Nephrocalcinosis: new insights into mechanisms and consequences.
 

Author(s): Benjamin A Vervaet, Anja Verhulst, Patrick C D'Haese, Marc E De Broe

Journal: Nephrol. Dial. Transplant.. 2009 Jul;24(7):2030-5.

 

Last Updated: 22 Jun 2009

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Diagnostic examination of the child with urolithiasis or nephrocalcinosis.
 

Author(s): Bernd Hoppe, Markus J Kemper

Journal: Pediatr. Nephrol.. 2010 Mar;25(3):403-13.

 

Urolithiasis and nephrocalcinosis are more frequent in children then currently anticipated, but still remain under- or misdiagnosed in a significant proportion of patients, since symptoms and signs may be subtle or misleading. All children with colicky abdominal pain or macroscopic ...

Last Updated: 25 Jan 2010

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Hypomagnesaemia-hypercalciuria-nephrocalcinosis: a report of nine cases and a review.
 

Author(s): V Benigno, C S Canonica, A Bettinelli, R O von Vigier, A C Truttmann, M G Bianchetti

Journal: Nephrol. Dial. Transplant.. 2000 May;15(5):605-10.

 

The cardinal characteristics of primary hypomagnesaemia-hypercalciuria-nephrocalcinosis include renal magnesium wasting, marked hypercalciuria, renal stones, nephrocalcinosis, a tendency towards chronic renal insufficiency and sometimes even ocular abnormalities or hearing impairment.

Last Updated: 14 Jun 2000

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 26 Dec 2012

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Preterm Infants and Nephrocalcinosis
 

Status: Recruiting

Condition Summary: Prematurity; Nephrocalcinosis; Hypercalciuria

 

Last Updated: 2 Dec 2015

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Randall's Plaque Study: Pathogenesis and Relationship to Nephrolithiasis
 

Status: Recruiting

Condition Summary: Nephrocalcinosis; Renal Calculi; Hypercalciuria; Hyperparathyroidism; Cystinuria

 

Last Updated: 22 Feb 2016

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