Nephrocalcinosis

Common Name(s)

Nephrocalcinosis

Nephrocalcinosis is a disorder in which there is excess calcium deposited in the kidneys. It is relatively common in premature infants. Individuals may be asymptomatic or have symptoms related to the condition causing nephrocalcinosis. If kidney stones are present, an individual may have blood in the urine; fever and chills; nausea and vomiting; or severe pain in the belly area, sides of the back (flank), groin, or testicles. Later symptoms related to nephrocalcinosis may be associated with chronic kidney failure. It may be caused by use of certain medications or supplements; infection; or any condition that leads to high levels of calcium in the blood or urine including hyperparathyroidism, renal tubular acidosis, Alport syndrome, Bartter syndrome, and a variety of other conditions. Some of the underlying disorders that can cause nephrocalcinosis are genetic, with the inheritance pattern depending on the specific disorder. The goal of treatment is to reduce symptoms and prevent more calcium from being deposited in the kidneys.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Nephrocalcinosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Nephrocalcinosis" returned 87 free, full-text research articles on human participants. First 3 results:

Familial mixed nephrocalcinosis as a cause of chronic kidney failure: two case reports.
 

Author(s): Pedro Francisco Ferraz de Arruda, Márcio Gatti, José Germano Ferraz de Arruda, Fernando Nestor Fácio, Luis Cesar Fava Spessoto, Laísa Ferraz de Arruda, José Maria Pereira de Godoy, Moacir Fernandes Godoy

Journal:

 

Nephrocalcinosis consists of the deposition of calcium salts in the renal parenchyma and is considered the mixed form when it involves the renal cortex and medulla. The main etiological agents of this condition are primary hyperparathyroidism, renal tubular acidosis, medullary sponge ...

Last Updated: 4 Nov 2014

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Nephrocalcinosis is a risk factor for kidney failure in primary hyperoxaluria.
 

Author(s): Xiaojing Tang, Eric J Bergstralh, Ramila A Mehta, Terri J Vrtiska, Dawn S Milliner, John C Lieske

Journal: Kidney Int.. 2015 Mar;87(3):623-31.

 

Stone formation and nephrocalcinosis are both very common features of primary hyperoxaluria, yet the extent of each disease varies markedly between patients. Here we studied whether kidney damage from nephrocalcinosis and/or stone related events contributed to end-stage kidney disease ...

Last Updated: 28 Feb 2015

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Exome sequencing identifies a novel homozygous mutation in the phosphate transporter SLC34A1 in hypophosphatemia and nephrocalcinosis.
 

Author(s): Abbhirami Rajagopal, Débora Braslavsky, James T Lu, Soledad Kleppe, Florencia Clément, Hamilton Cassinelli, David S Liu, Jose Miguel Liern, Graciela Vallejo, Ignacio Bergadá, Richard A Gibbs, Phillipe M Campeau, Brendan H Lee

Journal: J. Clin. Endocrinol. Metab.. 2014 Nov;99(11):E2451-6.

 

Two Argentinean siblings (a boy and a girl) from a nonconsanguineous family presented with hypercalcemia, hypercalciuria, hypophosphatemia, low parathyroid hormone (PTH), and nephrocalcinosis.

Last Updated: 6 Nov 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Nephrocalcinosis" returned 3 free, full-text review articles on human participants. First 3 results:

Nephrocalcinosis: new insights into mechanisms and consequences.
 

Author(s): Benjamin A Vervaet, Anja Verhulst, Patrick C D'Haese, Marc E De Broe

Journal: Nephrol. Dial. Transplant.. 2009 Jul;24(7):2030-5.

 

Last Updated: 22 Jun 2009

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Diagnostic examination of the child with urolithiasis or nephrocalcinosis.
 

Author(s): Bernd Hoppe, Markus J Kemper

Journal: Pediatr. Nephrol.. 2010 Mar;25(3):403-13.

 

Urolithiasis and nephrocalcinosis are more frequent in children then currently anticipated, but still remain under- or misdiagnosed in a significant proportion of patients, since symptoms and signs may be subtle or misleading. All children with colicky abdominal pain or macroscopic ...

Last Updated: 25 Jan 2010

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Hypomagnesaemia-hypercalciuria-nephrocalcinosis: a report of nine cases and a review.
 

Author(s): V Benigno, C S Canonica, A Bettinelli, R O von Vigier, A C Truttmann, M G Bianchetti

Journal: Nephrol. Dial. Transplant.. 2000 May;15(5):605-10.

 

The cardinal characteristics of primary hypomagnesaemia-hypercalciuria-nephrocalcinosis include renal magnesium wasting, marked hypercalciuria, renal stones, nephrocalcinosis, a tendency towards chronic renal insufficiency and sometimes even ocular abnormalities or hearing impairment.

Last Updated: 14 Jun 2000

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 26 Dec 2012

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Preterm Infants and Nephrocalcinosis
 

Status: Recruiting

Condition Summary: Prematurity; Nephrocalcinosis; Hypercalciuria

 

Last Updated: 2 Dec 2015

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Randall's Plaque Study: Pathogenesis and Relationship to Nephrolithiasis
 

Status: Recruiting

Condition Summary: Nephrocalcinosis; Renal Calculi; Hypercalciuria; Hyperparathyroidism; Cystinuria

 

Last Updated: 2 Jul 2015

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