Neonatal hemochromatosis

Common Name(s)

Neonatal hemochromatosis

Neonatal hemochromatosis is a disorder caused by iron building up in the heart, pancreas, and liver in newborns. Liver disease is usually noticeable hours after birth. The iron build up most often leads to liver failure in newborns.

Hemochromatosis is typically a genetic disease in which the body absorbs too much iron from food, damaging many organs. Medical researchers and doctors are not certain of the cause, but neonatal hemochromatosis is most likely not genetic. Many researchers believe that the condition is caused by the mother’s immune system mistakenly attacking the fetus (maternal fetal alloimmunity) thinking that it is an outside invader. Mothers with one child with hemochromatosis are more likely to have another child with the disorder. If you already have a child with this condition, it may be helpful to speak with a genetic counselor who can help explain why this condition occurred and if there are any new testing and options available.

Doctors will likely make a diagnosis soon after your baby is born. Occasionally, the condition may be diagnosed prenatally (before birth). Treatment after birth requires supportive care with or without administration of an iron-chelating cocktail and several antioxidants. A liver transplant may also be a treatment option. Research is ongoing; therefore, talk with your baby’s doctor(s) about the most current treatment options. Support groups are also a good source of information and can connect you with other families who have had children born with neonatal hemochromatosis.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neonatal hemochromatosis" for support, advocacy or research.

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American Hemochromatosis Society, Inc.

The mission of the American Hemochromatosis Society (AHS) is to educate and support the victims of HFE-associated hereditary hemochromatosis (genetic iron overload) and their families as well as educate the medical community on the latest research on Hereditary Hemochromatosis (HH). AHS' aim is to identify through genetic testing, the 43 million+ Americans who unknowingly carry the single or double gene mutations for HH which puts them at risk for loading excess iron.

Last Updated: 13 Sep 2015

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Haemochromatosis Australia.

Our vision is that no Australian should suffer harm from haemochromatosis. As the primary support and advocacy group for Australians affected by haemochromatosis, we provide support and promote awareness, early diagnosis and research.

Last Updated: 13 Sep 2015

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Iron Disorders Institute

Reducing pain, suffering and unnecessary death due to disorders of iron through awareness, education and research.

Last Updated: 13 Sep 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neonatal hemochromatosis" for support, advocacy or research.

Logo
American Hemochromatosis Society, Inc.

The mission of the American Hemochromatosis Society (AHS) is to educate and support the victims of HFE-associated hereditary hemochromatosis (genetic iron overload) and their families as well as educate the medical community on the latest research on Hereditary Hemochromatosis (HH). AHS' aim is to identify through genetic testing, the 43 million+ Americans who unknowingly carry the single or double gene mutations for HH which puts them at risk for loading excess iron.

http://www.americanhs.org

Last Updated: 13 Sep 2015

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Haemochromatosis Australia.

Our vision is that no Australian should suffer harm from haemochromatosis. As the primary support and advocacy group for Australians affected by haemochromatosis, we provide support and promote awareness, early diagnosis and research.

http://www.haemochromatosis.org.au

Last Updated: 13 Sep 2015

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Iron Disorders Institute

Reducing pain, suffering and unnecessary death due to disorders of iron through awareness, education and research.

http://www.irondisorders.org

Last Updated: 13 Sep 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Neonatal hemochromatosis" returned 15 free, full-text research articles on human participants. First 3 results:

Quantification of prenatal liver and spleen iron in a sheep model and assessment of iron stores in a human neonate with neonatal hemochromatosis using R2* mapping.
 

Author(s): Bjoern P Schoennagel, Chressen C Remus, Ulrike Wedegaertner, Ina Salzmann, Enke Grabhorn, Gerhard Adam, Roland Fischer, Paul Harmatz, Hendrik Kooijman, Jin Yamamura

Journal: Magn Reson Med Sci. 2014 ;13(3):167-73.

 

We evaluated the feasibility of prenatal quantification of liver and spleen iron by magnetic resonance imaging (MRI) gradient recalled echo (GRE) measurements of transverse relaxation time (R2*) (MRI-GRE-R2*) in a fetal sheep model and applied the method to a human neonate with suspected ...

Last Updated: 29 Sep 2014

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Last Updated: 30 Dec 2013

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Control of iron metabolism--lessons from neonatal hemochromatosis.
 

Author(s): Heinz Zoller, A S Knisely

Journal: J. Hepatol.. 2012 Jun;56(6):1226-9.

 

Last Updated: 21 May 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Neonatal hemochromatosis" returned 2 free, full-text review articles on human participants. First 3 results:

[The new paradigm of neonatal hemochromatosis: fetal alloimmune hepatitis].
 

Author(s): Alejandro Costaguta, Fernando Alvarez

Journal: Arch Argent Pediatr. ;110(3):237-43.

 

The classical model of neonatal hemochromatosis was based on the analogy with hereditary hemochromatosis. Medical treatment consisted on the antioxidant-chelator cocktail. The new hypothesis of an alloimmune origin of the process by which the pregnant woman mounts an IgG-based destructive ...

Last Updated: 4 Jul 2012

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[Neonatal hemochromatosis. A cause of liver failure in utero. Report of two cases and review of the literature].
 

Author(s): Enrique Gebara, Mariel A Fernández, Enrique Rojas, Adriana Afazani, Mirta Ciocca, Andrea Bosaleh, Fabiana Lubieniecki, Guillermo Cervio, María T G de Dávila

Journal: Arch Argent Pediatr. 2008 Apr;106(2):155-61.

 

Neonatal hemochromatosis is a rare clinical pathologic entity, defined by severe neonatal liver failure of intrauterine onset associated with intra-and extra- hepatic siderosis that spares reticuloendothelial system. It is the most frequently recognized cause of liver failure in neonates. ...

Last Updated: 28 Jul 2008

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Research Network for Neonatal Diseases Induced by Tissular Fetomaternal Alloimmunization
 

Status: Recruiting

Condition Summary: Glomerulonephritis, Membranous; Neonatal Diseases and Abnormalities; Hemochromatosis

 

Last Updated: 10 Mar 2006

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