Necrotizing enterocolitis

Common Name(s)

Necrotizing enterocolitis

Necrotizing enterocolitis (NEC) is a condition characterized by variable injury or damage to the intestinal tract, causing death of intestinal tissue. The condition most often occurs in premature newborns, but it may also occur in term or near-term babies. Signs and symptoms may include abdominal distension, bloody stools, vomiting bile-stained fluid, and pneumatosis intestinalis (gas in the bowel wall) identified on abdominal x-ray. Affected infants occasionally have temperature instability, lethargy, or other findings of sepsis. The exact cause of NEC is unknown. Treatment involves stopping feedings, passing a small tube into the stomach to relieve gas, and giving intravenous fluids and antibiotics. Surgery may be needed if there is perforated or necrotic (dead) bowel tissue. About 60-80% of affected newborns survive the condition.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Necrotizing enterocolitis" for support, advocacy or research.

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Action Medical Research

For over 60 years we’ve been saving and changing lives through medical research and have spent over £100m, funding some amazing breakthroughs. Today in the UK, there are hundreds of thousands of sick and disabled children who need help. We find and fund the best research to help these children.

Last Updated: 26 Sep 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Necrotizing enterocolitis" for support, advocacy or research.

Logo
Action Medical Research

For over 60 years we’ve been saving and changing lives through medical research and have spent over £100m, funding some amazing breakthroughs. Today in the UK, there are hundreds of thousands of sick and disabled children who need help. We find and fund the best research to help these children.

http://www.action.org.uk/

Last Updated: 26 Sep 2013

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General Resources

Action Medical Research - Necrotising Enterocolitis Resources Page

Right now researchers are developing a new test to help identify and treat NEC as fast as possible. They hope this test will reduce the chances of the disease becoming life threatening.

Updated 26 Sep 2013

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Key research breakthrough on feeding of premature vulnerable babies

The way premature babies are fed in hospitals could be set to change following the results of a research programme – funded by children’s charity Action Medical Research* – which were published online in the journal Pediatrics, 9 April 2012.

Updated 26 Sep 2013

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Tackling a life-threatening disease that can strike newborn babies

Just the name itself sounds nasty and necrotising enterocolitis (NEC) is certainly that. It’s a serious bowel disease that typically strikes without warning, mainly affecting premature babies who are already very vulnerable.

Updated 26 Sep 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Necrotizing enterocolitis" returned 234 free, full-text research articles on human participants. First 3 results:

Intestinal barrier dysfunction in human necrotizing enterocolitis.
 

Author(s): Sarah A Moore, Prashant Nighot, Cynthia Reyes, Manmeet Rawat, Jason McKee, David Lemon, Joshua Hanson, Thomas Y Ma

Journal: J. Pediatr. Surg.. 2016 Dec;51(12):1907-1913.

 

Intestinal barrier dysfunction has been implicated in necrotizing enterocolitis (NEC), but has not been directly measured in human NEC.

Last Updated: 10 Oct 2016

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[Risk factors for concurrent sepsis in neonates with necrotizing enterocolitis].
 

Author(s): Yao An, Li Liu, Qiu-Yu Li, Ya-Lin Ran, Lu-Quan Li

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2016 Aug;18(8):677-82.

 

To investigate the risk factors for concurrent sepsis in neonates with necrotizing enterocolitis (NEC).

Last Updated: 17 Aug 2016

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Short-term surgical outcomes of preterm infants with necrotizing enterocolitis: A single-center experience.
 

Author(s): Qingfeng Sheng, Zhibao Lv, Weijue Xu, Jiangbin Liu, Yibo Wu, Jingyi Shi, Zhengjun Xi

Journal: Medicine (Baltimore). 2016 Jul;95(30):e4379.

 

The purpose of this study was to analyze the nature of the disease, the surgical procedures, complications, and survival of preterm infants with necrotizing enterocolitis (NEC) at our institution.Medical records of 34 preterm (gestational age <37 weeks) infants with surgical NEC were ...

Last Updated: 30 Jul 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Necrotizing enterocolitis" returned 56 free, full-text review articles on human participants. First 3 results:

Serologic Intestinal-Fatty Acid Binding Protein in Necrotizing Enterocolitis Diagnosis: A Meta-Analysis.
 

Author(s): Shupeng Cheng, Jialin Yu, Min Zhou, Yan Tu, Qi Lu

Journal: Biomed Res Int. 2015 ;2015():156704.

 

Previous studies showed that intestinal-fatty acid binding protein (I-FABP) may be a valid and promising serologic biomarker for early diagnosis of necrotizing enterocolitis (NEC).

Last Updated: 22 Jan 2016

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Roles of nitric oxide and intestinal microbiota in the pathogenesis of necrotizing enterocolitis.
 

Author(s): Anatoly Grishin, Jordan Bowling, Brandon Bell, Jin Wang, Henri R Ford

Journal: J. Pediatr. Surg.. 2016 Jan;51(1):13-7.

 

Necrotizing enterocolitis remains one of the most vexing problems in the neonatal intensive care unit. Risk factors for NEC include prematurity, formula feeding, and inappropriate microbial colonization of the GI tract. The pathogenesis of NEC is believed to involve weakening of the ...

Last Updated: 15 Jan 2016

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Probiotics for prevention of necrotizing enterocolitis in preterm infants: systematic review and meta-analysis.
 

Author(s): Arianna Aceti, Davide Gori, Giovanni Barone, Maria Luisa Callegari, Antonio Di Mauro, Maria Pia Fantini, Flavia Indrio, Luca Maggio, Fabio Meneghin, Lorenzo Morelli, Gianvincenzo Zuccotti, Luigi Corvaglia,

Journal:

 

Necrotizing enterocolitis (NEC) affects predominantly preterm infants, who have specific risk factors leading to intestinal dysbiosis. Manipulations of gut microbiota through probiotics have the potential to prevent NEC.The aim of this systematic review and meta-analysis was to evaluate ...

Last Updated: 16 Nov 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Clostridium and Neonatal Necrotizing Enterocolitis Pathophysiology : Clinical and Molecular Approaches
 

Status: Recruiting

Condition Summary: Necrotizing Enterocolitis

 

Last Updated: 16 Sep 2015

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Simulated Amniotic Fluid In Preventing Feeding Intolerance and Necrotizing Enterocolitis VLBW Neonates
 

Status: Recruiting

Condition Summary: Necrotizing Enterocolitis

 

Last Updated: 28 Mar 2015

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Last Updated: 21 Jun 2016

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