Necrotizing enterocolitis

Common Name(s)

Necrotizing enterocolitis

Necrotizing enterocolitis (NEC) is a condition characterized by variable injury or damage to the intestinal tract, causing death of intestinal tissue. The condition most often occurs in premature newborns, but it may also occur in term or near-term babies. Signs and symptoms may include abdominal distension, bloody stools, vomiting bile-stained fluid, and pneumatosis intestinalis (gas in the bowel wall) identified on abdominal x-ray. Affected infants occasionally have temperature instability, lethargy, or other findings of sepsis. The exact cause of NEC is unknown. Treatment involves stopping feedings, passing a small tube into the stomach to relieve gas, and giving intravenous fluids and antibiotics. Surgery may be needed if there is perforated or necrotic (dead) bowel tissue. About 60-80% of affected newborns survive the condition.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Necrotizing enterocolitis" for support, advocacy or research.

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Action Medical Research

For over 60 years we’ve been saving and changing lives through medical research and have spent over £100m, funding some amazing breakthroughs. Today in the UK, there are hundreds of thousands of sick and disabled children who need help. We find and fund the best research to help these children.

Last Updated: 26 Sep 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Necrotizing enterocolitis" for support, advocacy or research.

Logo
Action Medical Research

For over 60 years we’ve been saving and changing lives through medical research and have spent over £100m, funding some amazing breakthroughs. Today in the UK, there are hundreds of thousands of sick and disabled children who need help. We find and fund the best research to help these children.

http://www.action.org.uk/

Last Updated: 26 Sep 2013

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General Resources

Action Medical Research - Necrotising Enterocolitis Resources Page

Right now researchers are developing a new test to help identify and treat NEC as fast as possible. They hope this test will reduce the chances of the disease becoming life threatening.

Updated 26 Sep 2013

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Key research breakthrough on feeding of premature vulnerable babies

The way premature babies are fed in hospitals could be set to change following the results of a research programme – funded by children’s charity Action Medical Research* – which were published online in the journal Pediatrics, 9 April 2012.

Updated 26 Sep 2013

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Tackling a life-threatening disease that can strike newborn babies

Just the name itself sounds nasty and necrotising enterocolitis (NEC) is certainly that. It’s a serious bowel disease that typically strikes without warning, mainly affecting premature babies who are already very vulnerable.

Updated 26 Sep 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Necrotizing enterocolitis" returned 234 free, full-text research articles on human participants. First 3 results:

[Appendicitis in neonatal (AN) patients with secondary necrotizing enterocolitis (ECN) due to sepsis in the uterus: a case report].
 

Author(s): Julio César López-Valdés, Rocío Escarcega-Servín

Journal: Gac Med Mex. ;152(3):419-23.

 

Nowadays appendicitis is the leading cause of acute surgical abdomen. It occurs mainly between the first and third decade of life and is very rare in the neonatal period. The pathophysiology and clinical manifestations differ from the typical signs and symptoms, making it difficult ...

Last Updated: 23 Jun 2016

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Urinary Intestinal Fatty Acid-Binding Protein Can Distinguish Necrotizing Enterocolitis from Sepsis in Early Stage of the Disease.
 

Author(s): Stepan Coufal, Alena Kokesova, Helena Tlaskalova-Hogenova, Jiri Snajdauf, Michal Rygl, Miloslav Kverka

Journal: J Immunol Res. 2016 ;2016():5727312.

 

Necrotizing enterocolitis (NEC) is severe disease of gastrointestinal tract, yet its early symptoms are nonspecific, easily interchangeable with sepsis. Therefore, reliable biomarkers for early diagnostics are needed in clinical practice. Here, we analyzed if markers of gut mucosa ...

Last Updated: 25 Apr 2016

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Association of Red Blood Cell Transfusion, Anemia, and Necrotizing Enterocolitis in Very Low-Birth-Weight Infants.
 

Author(s): Ravi M Patel, Andrea Knezevic, Neeta Shenvi, Michael Hinkes, Sarah Keene, John D Roback, Kirk A Easley, Cassandra D Josephson

Journal: JAMA. 2016 Mar;315(9):889-97.

 

Data regarding the contribution of red blood cell (RBC) transfusion and anemia to necrotizing enterocolitis (NEC) are conflicting. These associations have not been prospectively evaluated, accounting for repeated, time-varying exposures.

Last Updated: 3 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Necrotizing enterocolitis" returned 54 free, full-text review articles on human participants. First 3 results:

Serologic Intestinal-Fatty Acid Binding Protein in Necrotizing Enterocolitis Diagnosis: A Meta-Analysis.
 

Author(s): Shupeng Cheng, Jialin Yu, Min Zhou, Yan Tu, Qi Lu

Journal: Biomed Res Int. 2015 ;2015():156704.

 

Previous studies showed that intestinal-fatty acid binding protein (I-FABP) may be a valid and promising serologic biomarker for early diagnosis of necrotizing enterocolitis (NEC).

Last Updated: 22 Jan 2016

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Probiotics for prevention of necrotizing enterocolitis in preterm infants: systematic review and meta-analysis.
 

Author(s): Arianna Aceti, Davide Gori, Giovanni Barone, Maria Luisa Callegari, Antonio Di Mauro, Maria Pia Fantini, Flavia Indrio, Luca Maggio, Fabio Meneghin, Lorenzo Morelli, Gianvincenzo Zuccotti, Luigi Corvaglia,

Journal:

 

Necrotizing enterocolitis (NEC) affects predominantly preterm infants, who have specific risk factors leading to intestinal dysbiosis. Manipulations of gut microbiota through probiotics have the potential to prevent NEC.The aim of this systematic review and meta-analysis was to evaluate ...

Last Updated: 16 Nov 2015

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The Role of Immunonutrients in the Prevention of Necrotizing Enterocolitis in Preterm Very Low Birth Weight Infants.
 

Author(s): Ping Zhou, Yanqi Li, Li-Ya Ma, Hung-Chih Lin

Journal:

 

Necrotizing enterocolitis (NEC) is a critical intestinal emergency condition, which mainly occurs in preterm very low birth weight (PVLBW) infants. Despite remarkable advances in the care of PVLBW infants, with considerable improvement of the survival rate in recent decades, the incidence ...

Last Updated: 8 Sep 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Clostridium and Neonatal Necrotizing Enterocolitis Pathophysiology : Clinical and Molecular Approaches
 

Status: Recruiting

Condition Summary: Necrotizing Enterocolitis

 

Last Updated: 16 Sep 2015

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Simulated Amniotic Fluid In Preventing Feeding Intolerance and Necrotizing Enterocolitis VLBW Neonates
 

Status: Recruiting

Condition Summary: Necrotizing Enterocolitis

 

Last Updated: 28 Mar 2015

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Enteral Administration of Docosahexaenoic Acid to Prevent Necrotizing Enterocolitis in Preterm Neonates
 

Status: Recruiting

Condition Summary: Necrotizing Enterocolitis

 

Last Updated: 25 Aug 2016

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