Necrotizing enterocolitis

Common Name(s)

Necrotizing enterocolitis

Necrotizing enterocolitis (NEC) is a condition characterized by variable injury or damage to the intestinal tract, causing death of intestinal tissue. The condition most often occurs in premature newborns, but it may also occur in term or near-term babies. Signs and symptoms may include abdominal distension, bloody stools, vomiting bile-stained fluid, and pneumatosis intestinalis (gas in the bowel wall) identified on abdominal x-ray. Affected infants occasionally have temperature instability, lethargy, or other findings of sepsis. The exact cause of NEC is unknown. Treatment involves stopping feedings, passing a small tube into the stomach to relieve gas, and giving intravenous fluids and antibiotics. Surgery may be needed if there is perforated or necrotic (dead) bowel tissue. About 60-80% of affected newborns survive the condition.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Necrotizing enterocolitis" for support, advocacy or research.

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Action Medical Research

For over 60 years we’ve been saving and changing lives through medical research and have spent over £100m, funding some amazing breakthroughs. Today in the UK, there are hundreds of thousands of sick and disabled children who need help. We find and fund the best research to help these children.

Last Updated: 26 Sep 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Necrotizing enterocolitis" for support, advocacy or research.

Logo
Action Medical Research

For over 60 years we’ve been saving and changing lives through medical research and have spent over £100m, funding some amazing breakthroughs. Today in the UK, there are hundreds of thousands of sick and disabled children who need help. We find and fund the best research to help these children.

http://www.action.org.uk/

Last Updated: 26 Sep 2013

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General Resources

Action Medical Research - Necrotising Enterocolitis Resources Page

Right now researchers are developing a new test to help identify and treat NEC as fast as possible. They hope this test will reduce the chances of the disease becoming life threatening.

Updated 26 Sep 2013

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Key research breakthrough on feeding of premature vulnerable babies

The way premature babies are fed in hospitals could be set to change following the results of a research programme – funded by children’s charity Action Medical Research* – which were published online in the journal Pediatrics, 9 April 2012.

Updated 26 Sep 2013

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Tackling a life-threatening disease that can strike newborn babies

Just the name itself sounds nasty and necrotising enterocolitis (NEC) is certainly that. It’s a serious bowel disease that typically strikes without warning, mainly affecting premature babies who are already very vulnerable.

Updated 26 Sep 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Necrotizing enterocolitis" returned 204 free, full-text research articles on human participants. First 3 results:

[Prophylactic probiotics for preventing necrotizing enterocolitis and reducing mortality in very low birth weight infants: a Meta analysis].
 

Author(s): Xiao-Ling Wang, Xiong Li, Lan Kang, Sheng-Hui Wang

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2015 Aug;17(8):852-8.

 

To systematically evaluate the efficacy and safety of probiotic supplementation for preventing necrotizing enterocolitis (NEC) and reducing mortality in preterm very low birth weight (VLBW) infants.

Last Updated: 20 Aug 2015

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Colonic stenosis post-necrotizing enterocolitis in term newborn with acquired cytomegalovirus infection.
 

Author(s): L Marseglia, S Manti, G D'Angelo, M Lima, P Impellizzeri, C Romeo, E Gitto,

Journal: Chirurgia (Bucur). ;110(2):175-8.

 

Necrotizing enterocolitis is a gastrointestinal emergency typical of premature infants. Intestinal strictures infrequently complicate medical or surgical treatment of necrotizing enterocolitis. Postnatal cytomegalovirus infection with gastrointestinal linvolvement has occasionally ...

Last Updated: 27 May 2015

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Association of neonatal necrotizing enterocolitis with myeloid differentiation-2 and GM2 activator protein genetic polymorphisms.
 

Author(s): Wei Zhou, Weiming Yuan, Longguang Huang, Ping Wang, Xiao Rong, Juan Tang

Journal: Mol Med Rep. 2015 Jul;12(1):974-80.

 

The aim of the present study was to investigate the association of neonatal necrotizing enterocolitis (NEC) with myeloid differentiation-(MD-2) and GM2 activator protein (GM2A) genetic polymorphisms. Gene resequencing of the MD-2 and GM2A gene exons was performed on 42 neonates, diagnosed ...

Last Updated: 15 Apr 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Necrotizing enterocolitis" returned 47 free, full-text review articles on human participants. First 3 results:

Probiotics and necrotizing enterocolitis.
 

Author(s): Josef Neu

Journal: Clin Perinatol. 2014 Dec;41(4):967-78.

 

One of the most controversial areas in neonatology is whether probiotics should be provided routinely to preterm infants to prevent necrotizing enterocolitis (NEC). This review provides the reader with a brief overview of NEC and current concepts of its pathophysiology, discusses ...

Last Updated: 3 Dec 2014

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Pathogenesis of necrotizing enterocolitis: modeling the innate immune response.
 

Author(s): Scott M Tanner, Taylor F Berryhill, James L Ellenburg, Tamas Jilling, Dava S Cleveland, Robin G Lorenz, Colin A Martin

Journal: Am. J. Pathol.. 2015 Jan;185(1):4-16.

 

Necrotizing enterocolitis (NEC) is a major cause of morbidity and mortality in premature infants. The pathophysiology is likely secondary to innate immune responses to intestinal microbiota by the premature infant's intestinal tract, leading to inflammation and injury. This review ...

Last Updated: 22 Dec 2014

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Arginine supplementation in prevention of necrotizing enterocolitis in the premature infant: an updated systematic review.
 

Author(s): Kevin Mitchell, Alexander Lyttle, Harish Amin, Huma Shaireen, Helen Lee Robertson, Abhay K Lodha

Journal:

 

Hypoxic-ischemic injury is thought to play a significant role in necrotizing enterocolitis (NEC). Nitric Oxide (NO) is the principal inhibitory neurotransmitter in the gut and is involved in regulation of mucosal blood flow and maintenance of mucosal integrity. NO is synthesized from ...

Last Updated: 15 Sep 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Clostridium and Neonatal Necrotizing Enterocolitis Pathophysiology : Clinical and Molecular Approaches
 

Status: Recruiting

Condition Summary: Necrotizing Enterocolitis

 

Last Updated: 16 Sep 2015

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Effect of Saccharomyces Boulardii on Necrotizing Enterocolitis in Very Low Birth Weight Infants
 

Status: Recruiting

Condition Summary: Necrotizing Enterocolitis; Very Low Birth Weight Infants

 

Last Updated: 4 Aug 2011

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Neutrophil Extracellular Trap Formation in Newborn Infants at Risk for Necrotizing Enterocolitis
 

Status: Recruiting

Condition Summary: Prematurity; Necrotizing Enterocolitis

 

Last Updated: 2 Dec 2015

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