Necrotizing enterocolitis

Common Name(s)

Necrotizing enterocolitis

Necrotizing enterocolitis (NEC) is a condition characterized by variable injury or damage to the intestinal tract, causing death of intestinal tissue. The condition most often occurs in premature newborns, but it may also occur in term or near-term babies. Signs and symptoms may include abdominal distension, bloody stools, vomiting bile-stained fluid, and pneumatosis intestinalis (gas in the bowel wall) identified on abdominal x-ray. Affected infants occasionally have temperature instability, lethargy, or other findings of sepsis. The exact cause of NEC is unknown. Treatment involves stopping feedings, passing a small tube into the stomach to relieve gas, and giving intravenous fluids and antibiotics. Surgery may be needed if there is perforated or necrotic (dead) bowel tissue. About 60-80% of affected newborns survive the condition.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Necrotizing enterocolitis" for support, advocacy or research.

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Action Medical Research

For over 60 years we’ve been saving and changing lives through medical research and have spent over £100m, funding some amazing breakthroughs. Today in the UK, there are hundreds of thousands of sick and disabled children who need help. We find and fund the best research to help these children.

Last Updated: 26 Sep 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Necrotizing enterocolitis" for support, advocacy or research.

Logo
Action Medical Research

For over 60 years we’ve been saving and changing lives through medical research and have spent over £100m, funding some amazing breakthroughs. Today in the UK, there are hundreds of thousands of sick and disabled children who need help. We find and fund the best research to help these children.

http://www.action.org.uk/

Last Updated: 26 Sep 2013

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General Resources

Action Medical Research - Necrotising Enterocolitis Resources Page

Right now researchers are developing a new test to help identify and treat NEC as fast as possible. They hope this test will reduce the chances of the disease becoming life threatening.

Updated 26 Sep 2013

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Key research breakthrough on feeding of premature vulnerable babies

The way premature babies are fed in hospitals could be set to change following the results of a research programme – funded by children’s charity Action Medical Research* – which were published online in the journal Pediatrics, 9 April 2012.

Updated 26 Sep 2013

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Tackling a life-threatening disease that can strike newborn babies

Just the name itself sounds nasty and necrotising enterocolitis (NEC) is certainly that. It’s a serious bowel disease that typically strikes without warning, mainly affecting premature babies who are already very vulnerable.

Updated 26 Sep 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Necrotizing enterocolitis" returned 174 free, full-text research articles on human participants. First 3 results:

[Perinatal high-risk factors for necrotizing enterocolitis in preterm infants: a case-control study].
 

Author(s): Rui-Juan Wang, Xiang-Yong Kong, Na Cai, Ying Chen, Zhi-Chun Feng

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2014 Apr;16(4):414-7.

 

To study the timing of presentation and perinatal high-risk factors for necrotizing enterocolitis (NEC) in preterm infants with a gestational age of <33 weeks.

Last Updated: 22 Apr 2014

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Urine protein biomarkers for the diagnosis and prognosis of necrotizing enterocolitis in infants.
 

Author(s): Karl G Sylvester, Xuefeng B Ling, Gigi Yuen-Gee Liu, Zachary J Kastenberg, Jun Ji, Zhongkai Hu, Shuaibin Wu, Sihua Peng, Fizan Abdullah, Mary L Brandt, Richard A Ehrenkranz, Mary Catherine Harris, Timothy C Lee, B Joyce Simpson, Corinna Bowers, R Lawrence Moss

Journal: J. Pediatr.. 2014 Mar;164(3):607-12.e1-7.

 

To test the hypothesis that an exploratory proteomics analysis of urine proteins with subsequent development of validated urine biomarker panels would produce molecular classifiers for both the diagnosis and prognosis of infants with necrotizing enterocolitis (NEC).

Last Updated: 24 Feb 2014

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Intestinal microbial ecology and environmental factors affecting necrotizing enterocolitis.
 

Author(s): Roberto Murgas Torrazza, Maria Ukhanova, Xiaoyu Wang, Renu Sharma, Mark Lawrence Hudak, Josef Neu, Volker Mai

Journal:

 

Necrotizing enterocolitis (NEC) is the most devastating intestinal disease affecting preterm infants. In addition to being associated with short term mortality and morbidity, survivors are left with significant long term sequelae. The cost of caring for these infants is high. Epidemiologic ...

Last Updated: 3 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Necrotizing enterocolitis" returned 35 free, full-text review articles on human participants. First 3 results:

Innate immune signaling in the pathogenesis of necrotizing enterocolitis.
 

Author(s): David J Hackam, Amin Afrazi, Misty Good, Chhinder P Sodhi

Journal: Clin. Dev. Immunol.. 2013 ;2013():475415.

 

Necrotizing enterocolitis (NEC) is a challenging disease to treat, and caring for patients afflicted by it remains both frustrating and difficult. While NEC may develop quickly and without warning, it may also develop slowly, insidiously, and appear to take the caregiver by surprise. ...

Last Updated: 13 Jun 2013

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Intestinal microcirculatory dysfunction and neonatal necrotizing enterocolitis.
 

Author(s): Hong-yi Zhang, Fang Wang, Jie-xiong Feng

Journal: Chin. Med. J.. 2013 ;126(9):1771-8.

 

Based on the observation that coagulation necrosis occurs in the majority of neonatal necrotizing enterocolitis (NEC) patients, it is clear that intestinal ischemia is a contributing factor to the pathogenesis of NEC. However, the published studies regarding the role of intestinal ...

Last Updated: 8 May 2013

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The role of growth factors in intestinal regeneration and repair in necrotizing enterocolitis.
 

Author(s): Kathryn J Rowland, Pamela M Choi, Brad W Warner

Journal: Semin. Pediatr. Surg.. 2013 May;22(2):101-11.

 

Necrotizing enterocolitis (NEC) is a devastating intestinal disease resulting in major neonatal morbidity and mortality. The pathology is poorly understood, and the means of preventing and treating NEC are limited. Several endogenous growth factors have been identified as having important ...

Last Updated: 24 Apr 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Effect of Saccharomyces Boulardii on Necrotizing Enterocolitis in Very Low Birth Weight Infants
 

Status: Recruiting

Condition Summary: Necrotizing Enterocolitis; Very Low Birth Weight Infants

 

Last Updated: 4 Aug 2011

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Neutrophil Extracellular Trap Formation in Newborn Infants at Risk for Necrotizing Enterocolitis
 

Status: Recruiting

Condition Summary: Prematurity; Necrotizing Enterocolitis

 

Last Updated: 30 Jul 2014

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Therapeutic Controlled Hypothermia in the Treatment of Neonates With Severe Necrotizing Enterocolitis
 

Status: Recruiting

Condition Summary: Necrotizing Enterocolitis

 

Last Updated: 1 Mar 2012

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