Necrotizing enterocolitis

Common Name(s)

Necrotizing enterocolitis

Necrotizing enterocolitis (NEC) is a condition characterized by variable injury or damage to the intestinal tract, causing death of intestinal tissue. The condition most often occurs in premature newborns, but it may also occur in term or near-term babies. Signs and symptoms may include abdominal distension, bloody stools, vomiting bile-stained fluid, and pneumatosis intestinalis (gas in the bowel wall) identified on abdominal x-ray. Affected infants occasionally have temperature instability, lethargy, or other findings of sepsis. The exact cause of NEC is unknown. Treatment involves stopping feedings, passing a small tube into the stomach to relieve gas, and giving intravenous fluids and antibiotics. Surgery may be needed if there is perforated or necrotic (dead) bowel tissue. About 60-80% of affected newborns survive the condition.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Necrotizing enterocolitis" for support, advocacy or research.

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Action Medical Research

For over 60 years we’ve been saving and changing lives through medical research and have spent over £100m, funding some amazing breakthroughs. Today in the UK, there are hundreds of thousands of sick and disabled children who need help. We find and fund the best research to help these children.

Last Updated: 26 Sep 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Necrotizing enterocolitis" for support, advocacy or research.

Logo
Action Medical Research

For over 60 years we’ve been saving and changing lives through medical research and have spent over £100m, funding some amazing breakthroughs. Today in the UK, there are hundreds of thousands of sick and disabled children who need help. We find and fund the best research to help these children.

http://www.action.org.uk/

Last Updated: 26 Sep 2013

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General Resources

Action Medical Research - Necrotising Enterocolitis Resources Page

Right now researchers are developing a new test to help identify and treat NEC as fast as possible. They hope this test will reduce the chances of the disease becoming life threatening.

Updated 26 Sep 2013

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Key research breakthrough on feeding of premature vulnerable babies

The way premature babies are fed in hospitals could be set to change following the results of a research programme – funded by children’s charity Action Medical Research* – which were published online in the journal Pediatrics, 9 April 2012.

Updated 26 Sep 2013

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Tackling a life-threatening disease that can strike newborn babies

Just the name itself sounds nasty and necrotising enterocolitis (NEC) is certainly that. It’s a serious bowel disease that typically strikes without warning, mainly affecting premature babies who are already very vulnerable.

Updated 26 Sep 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Necrotizing enterocolitis" returned 193 free, full-text research articles on human participants. First 3 results:

[Clinical significance of serum intestinal fatty acid-binding protein in full-term infants with necrotizing enterocolitis].
 

Author(s): Chun-Rong Huang-Fu, Ping Li, Yun-Fen Tian

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2014 Nov;16(11):1125-8.

 

To evaluate the clinical value of intestinal fatty acid-binding protein (I-FABP) in full-term newborn infants with necrotizing enterocolitis (NEC).

Last Updated: 21 Nov 2014

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Mucosa-associated bacterial diversity in necrotizing enterocolitis.
 

Author(s): Rachel Brower-Sinning, Diana Zhong, Misty Good, Brian Firek, Robyn Baker, Chhinder P Sodhi, David J Hackam, Michael J Morowitz

Journal:

 

Previous studies of infant fecal samples have failed to clarify the role of gut bacteria in the pathogenesis of NEC. We sought to characterize bacterial communities within intestinal tissue resected from infants with and without NEC.

Last Updated: 10 Sep 2014

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Late onset of necrotizing enterocolitis in the full-term infant is associated with increased mortality: results from a two-center analysis.
 

Author(s): Scott S Short, Stephanie Papillon, Dror Berel, Henri R Ford, Philip K Frykman, Akemi Kawaguchi

Journal: J. Pediatr. Surg.. 2014 Jun;49(6):950-3.

 

The effect of timing of onset of necrotizing enterocolitis (NEC) on outcomes has not been determined for the full-term infant. In this study we aimed to characterize the full-term NEC population and to evaluate onset of NEC.

Last Updated: 3 Jun 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Necrotizing enterocolitis" returned 39 free, full-text review articles on human participants. First 3 results:

Arginine supplementation in prevention of necrotizing enterocolitis in the premature infant: an updated systematic review.
 

Author(s): Kevin Mitchell, Alexander Lyttle, Harish Amin, Huma Shaireen, Helen Lee Robertson, Abhay K Lodha

Journal:

 

Hypoxic-ischemic injury is thought to play a significant role in necrotizing enterocolitis (NEC). Nitric Oxide (NO) is the principal inhibitory neurotransmitter in the gut and is involved in regulation of mucosal blood flow and maintenance of mucosal integrity. NO is synthesized from ...

Last Updated: 15 Sep 2014

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Evidence-based feeding strategies before and after the development of necrotizing enterocolitis.
 

Author(s): Misty Good, Chhinder P Sodhi, David J Hackam

Journal: Expert Rev Clin Immunol. 2014 Jul;10(7):875-84.

 

Necrotizing enterocolitis (NEC) is a devastating disease of premature infants and is associated with significant morbidity and mortality. While the pathogenesis of NEC remains incompletely understood, it is well established that the risk of disease is increased by the administration ...

Last Updated: 17 Jun 2014

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[Probiotics and necrotizing enterocolitis in preterm infants: to NEC or not to NEC?, this is the question].
 

Author(s): Javier González de Dios, María González Muñoz

Journal:

 

Necrotizing enterocolitis (NEC) is the most commonly acquired neonatal intraabdominal emergency and causes significant morbidity and mortality. A proposed strategy for the prevention of NEC in preterm infants is the administration of oral probiotics. The objective of the study is ...

Last Updated: 10 Feb 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Clostridium and Neonatal Necrotizing Enterocolitis Pathophysiology : Clinical and Molecular Approaches
 

Status: Not yet recruiting

Condition Summary: Necrotizing Enterocolitis

 

Last Updated: 13 May 2015

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Effect of Saccharomyces Boulardii on Necrotizing Enterocolitis in Very Low Birth Weight Infants
 

Status: Recruiting

Condition Summary: Necrotizing Enterocolitis; Very Low Birth Weight Infants

 

Last Updated: 4 Aug 2011

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Neutrophil Extracellular Trap Formation in Newborn Infants at Risk for Necrotizing Enterocolitis
 

Status: Recruiting

Condition Summary: Prematurity; Necrotizing Enterocolitis

 

Last Updated: 1 May 2015

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