Nasopharyngeal carcinoma

Common Name(s)

Nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC, NPCA) is a multifactorial malignancy associated with both genetic and environmental factors. The cancer arises from the epithelium of the nasopharynx. The Epstein-Barr virus has been implicated ({12:Tse et al., 2009}). Genetic Heterogeneity of Susceptibility to Nasopharyngeal Carcinoma NPCA1 maps to chromosome 4p. NPCA2 ({161550}) maps to chromosome 6p21. NPCA3 ({617075}) is associated with variation in the MST1R gene ({600168}) on chromosome 3p21.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Nasopharyngeal carcinoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Nasopharyngeal carcinoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Nasopharyngeal carcinoma" returned 1740 free, full-text research articles on human participants. First 3 results:

Increased expression of Cks1 protein is associated with lymph node metastasis and poor prognosis in nasopharyngeal carcinoma.
 

Author(s): Lina Xu, Songqing Fan, Jin Zhao, Peng Zhou, Shuzhou Chu, Jiadi Luo, Qiuyuan Wen, Lingjiao Chen, Sailan Wen, Li Wang, Lei Shi

Journal:

 

The Cks1 protein is an essential factor in regulating cell cycle by mediating the ubiquitination of CDK inhibitor p27(kip1). It has been reported that aberrant expression of Cks1 and p27(kip1) proteins was found in various tumors and related to initiation and progression of carcinomas. ...

Last Updated: 7 Jan 2017

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Human Ribosomal Proteins RPeL27, RPeL43, and RPeL41 Are Upregulated in Nasopharyngeal Carcinoma Cell Lines.
 

Author(s): Edmund Ui-Hang Sim, Stella Li-Li Chan, Kher-Lee Ng, Choon-Weng Lee, Kumaran Narayanan

Journal: Dis. Markers. 2016 ;2016():5179594.

 

Apart from their canonical role in ribosome biogenesis, there is increasing evidence of ribosomal protein genes' involvement in various cancers. A previous study by us revealed significant differential expression of three ribosomal protein genes (RPeL27, RPeL41, and RPeL43) between ...

Last Updated: 26 Dec 2016

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Noninvasive monitoring of early antiangiogenic therapy response in human nasopharyngeal carcinoma xenograft model using MRI with RGD-conjugated ultrasmall superparamagnetic iron oxide nanoparticles.
 

Author(s): Yanfen Cui, Caiyuan Zhang, Ran Luo, Huanhuan Liu, Zhongyang Zhang, Tianyong Xu, Yong Zhang, Dengbin Wang

Journal:

 

Arginine-glycine-aspartic acid (RGD)-based nanoprobes allow specific imaging of integrin αvβ3, a protein overexpressed during angiogenesis. Therefore, this study applied a novel RGD-coupled, polyacrylic acid (PAA)-coated ultrasmall superparamagnetic iron oxide (USPIO) (referred ...

Last Updated: 29 Nov 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Nasopharyngeal carcinoma" returned 86 free, full-text review articles on human participants. First 3 results:

Epstein-Barr virus DNA level as a novel prognostic factor in nasopharyngeal carcinoma: A meta-analysis.
 

Author(s): Jing Zhang, Chi Shu, Yanlin Song, Qingfang Li, Jingwen Huang, Xuelei Ma

Journal: Medicine (Baltimore). 2016 Oct;95(40):e5130.

 

The plasma Epstein-Barr virus (EBV) DNA level in patients with nasopharyngeal carcinoma (NPC) performs as an appealing prognostic factor, but conclusions of its prognostic values from previous studies are inconsistent. In this study, we performed a comprehensive meta-analysis to evaluate ...

Last Updated: 17 Oct 2016

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Prognostic significance of pretreated serum lactate dehydrogenase level in nasopharyngeal carcinoma among Chinese population: A meta-analysis.
 

Author(s): Mingwei Zhang, Shushan Wei, Li Su, Wenlong Lv, Jinsheng Hong

Journal: Medicine (Baltimore). 2016 Aug;95(35):e4494.

 

A large number of studies have investigated the prognostic value of pretreated lactate dehydrogenase (LDH) level in nasopharyngeal carcinoma (NPC) patients while the role of it was inconsistent and inconclusive. Hence, the aim of the current study was to conduct a meta-analysis of ...

Last Updated: 2 Sep 2016

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Proton therapy for nasopharyngeal carcinoma.
 

Author(s): Emma B Holliday, Steven J Frank

Journal: Chin Clin Oncol. 2016 Apr;5(2):25.

 

The treatment of nasopharyngeal carcinoma (NPC) has traditionally included a multimodality approach including radiotherapy (RT) and systemic chemotherapy. RT has long been favored as the mainstay of local treatment for disease in this challenging anatomic location owing to the morbidity ...

Last Updated: 28 Apr 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Donafenib Monotherapy for Previously Treated Metastatic Nasopharyngeal Carcinoma
 

Status: Not yet recruiting

Condition Summary: Nasopharyngeal Carcinoma

 

Last Updated: 12 Oct 2016

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TPC vs PF as Induction Chemotherapy Combined With CCRT for Stage IVa-b Nasopharyngeal Carcinoma
 

Status: Recruiting

Condition Summary: Nasopharyngeal Carcinoma

 

Last Updated: 20 Oct 2016

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Last Updated: 15 Apr 2016

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