Nasopharyngeal carcinoma

Common Name(s)

Nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC, NPCA) is a multifactorial malignancy associated with both genetic and environmental factors. The cancer arises from the epithelium of the nasopharynx. The Epstein-Barr virus has been implicated ({12:Tse et al., 2009}). A susceptibility locus for nasopharyngeal carcinoma (NPCA1) has been mapped to chromosome 4p. A second locus, NPCA2 ({161550}), has been mapped to chromosome 6p21.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Nasopharyngeal carcinoma" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Nasopharyngeal carcinoma" returned 1135 free, full-text research articles on human participants. First 3 results:

The inhibitory effects of extracellular ATP on the growth of nasopharyngeal carcinoma cells via P2Y2 receptor and osteopontin.
 

Author(s): Guang Yang, Shenghong Zhang, Yanling Zhang, Qiming Zhou, Sheng Peng, Tao Zhang, Changfu Yang, Zhenyu Zhu, Fujun Zhang

Journal:

 

Nasopharyngeal carcinoma (NPC) is a common malignant tumor observed in the populations of southern China and Southeast Asia. However, little is known about the effects of purinergic signal on the behavior of NPC cells. This study analyzed the effects of ATP on the growth and migration ...

Last Updated: 3 Jul 2014

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Local failure patterns for patients with nasopharyngeal carcinoma after intensity-modulated radiotherapy.
 

Author(s): Jia-Xin Li, Shao-min Huang, Xin-hua Jiang, Bin Ouyang, Fei Han, Shuai Liu, Bi-xiu Wen, Tai-xiang Lu

Journal:

 

To investigate the clinical feature and the local failure patterns after intensity-modulated radiotherapy for nasopharyngeal carcinoma.

Last Updated: 9 Apr 2014

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Targeting Epstein-Barr virus oncoprotein LMP1-mediated glycolysis sensitizes nasopharyngeal carcinoma to radiation therapy.
 

Author(s): L Xiao, Z-Y Hu, X Dong, Z Tan, W Li, M Tang, L Chen, L Yang, Y Tao, Y Jiang, J Li, B Yi, B Li, S Fan, S You, X Deng, F Hu, L Feng, A M Bode, Z Dong, L-Q Sun, Y Cao

Journal: Oncogene. 2014 Sep;33(37):4568-78.

 

Our goal in this work was to illustrate the Epstein-Barr virus (EBV)-modulated global biochemical profile and provide a novel metabolism-related target to improve the therapeutic regimen of nasopharyngeal carcinoma (NPC). We used a metabolomics approach to investigate EBV-modulated ...

Last Updated: 11 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Nasopharyngeal carcinoma" returned 53 free, full-text review articles on human participants. First 3 results:

The Interleukin-18 promoter -607C>A polymorphism contributes to nasopharyngeal carcinoma risk: evidence from a meta-analysis including 1,886 subjects.
 

Author(s): Xu-Guang Guo, Yong Xia

Journal: Asian Pac. J. Cancer Prev.. 2013 ;14(12):7577-81.

 

The interleukin-18 promoter -607C>A gene polymorphism may be related to nasopharyngeal carcinoma (NPC) risk but the results of individual studies remain conflicting. A meta-analysis including 1,886 subjects from five individual studies was therefore performed to provide a more accurate ...

Last Updated: 27 Jan 2014

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Current treatment options for local residual nasopharyngeal carcinoma.
 

Author(s): S D Stoker, J N A van Diessen, J P de Boer, B Karakullukcu, C R Leemans, I B Tan

Journal: Curr Treat Options Oncol. 2013 Dec;14(4):475-91.

 

Local residual disease occurs in 7-13 % after primary treatment for nasopharyngeal carcinoma (NPC). To prevent tumor progression and/or distant metastasis, treatment is indicated. Biopsy is the "gold standard" for diagnosing residual disease. Because late histological regression frequently ...

Last Updated: 27 Nov 2013

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Quantitative association of tobacco smoking with the risk of nasopharyngeal carcinoma: a comprehensive meta-analysis of studies conducted between 1979 and 2011.
 

Author(s): Wen-Qiong Xue, Hai-De Qin, Hong-Lian Ruan, Yin Yao Shugart, Wei-Hua Jia

Journal: Am. J. Epidemiol.. 2013 Aug;178(3):325-38.

 

Over the years, many studies have attempted to establish a link between tobacco smoking and an increased risk of nasopharyngeal carcinoma (NPC), but their results have been inconsistent. To clarify this link, we first conducted a comprehensive meta-analysis to integrate the findings ...

Last Updated: 31 Jul 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Famitinib in Treating Patients With Recurrent and/or Metastatic Nasopharyngeal Carcinoma (NPC)
 

Status: Recruiting

Condition Summary: Recurrent Nasopharyngeal Carcinoma; Metastatic Nasopharyngeal Carcinoma

 

Last Updated: 8 Feb 2012

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Retrospective Study About Nasopharyngeal Carcinoma at C. S. Parc Tauli
 

Status: Not yet recruiting

Condition Summary: Nasopharyngeal Carcinoma

 

Last Updated: 23 Jul 2014

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Atorvastatin in Preventing Nasopharyngeal Carcinoma Patients Receiving Radiotherapy From Carotid Stenosis
 

Status: Recruiting

Condition Summary: Nasopharyngeal Carcinoma; Radiation Therapy Complication

 

Last Updated: 7 Feb 2014

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