Nasopharyngeal carcinoma

Common Name(s)

Nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC, NPCA) is a multifactorial malignancy associated with both genetic and environmental factors. The cancer arises from the epithelium of the nasopharynx. The Epstein-Barr virus has been implicated ({12:Tse et al., 2009}). Genetic Heterogeneity of Susceptibility to Nasopharyngeal Carcinoma NPCA1 maps to chromosome 4p. NPCA2 ({161550}) maps to chromosome 6p21. NPCA3 ({617075}) is associated with variation in the MST1R gene ({600168}) on chromosome 3p21.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Nasopharyngeal carcinoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Nasopharyngeal carcinoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Nasopharyngeal carcinoma" returned 1750 free, full-text research articles on human participants. First 3 results:

Development and validation of quality of life scale of nasopharyngeal carcinoma patients: the QOL-NPC (version 2).
 

Author(s): Yong Su, Chuan-Wei Mo, Wan-Qin Cheng, Lei Wang, Qian Xu, Zu-Chun Wu, Zhe-Li Wu, Li-Zhi Liu, Xin-Lin Chen

Journal:

 

The aim was to develop and validate the quality of life scale for nasopharyngeal carcinoma (NPC) patients, the QOL-NPC (version 2), a specific instrument to measure quality of life for NPC patients.

Last Updated: 11 May 2016

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Using a nasoseptal flap for the reconstruction of osteoradionecrosis in nasopharyngeal carcinoma: a case report.
 

Author(s): Mohamad Adel, Kai-Ping Chang

Journal:

 

Osteoradionecrosis (ORN) is a challenging complication in patients with postirradiated nasopharyngeal carcinoma (NPC). The aim of this study was to evaluate the usage of a nasoseptal flap (NSF) after endoscopic sequestrectomy to reconstruct resultant skull base defects for the treatment of ORN.

Last Updated: 28 Apr 2016

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miR-3188 regulates nasopharyngeal carcinoma proliferation and chemosensitivity through a FOXO1-modulated positive feedback loop with mTOR-p-PI3K/AKT-c-JUN.
 

Author(s): Mengyang Zhao, Rongcheng Luo, Yiyi Liu, Linyuan Gao, Zhaojian Fu, Qiaofen Fu, Xiaojun Luo, Yiyu Chen, Xiaojie Deng, Zixi Liang, Xin Li, Chao Cheng, Zhen Liu, Weiyi Fang

Journal:

 

The biological role of miR-3188 has not yet been reported in the context of cancer. In this study, we observe that miR-3188 not only reduces cell-cycle transition and proliferation, but also significantly prolongs the survival time of tumour-bearing mice as well as sensitizes cells ...

Last Updated: 20 Apr 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Nasopharyngeal carcinoma" returned 82 free, full-text review articles on human participants. First 3 results:

Diagnostic Value of Magnetic Resonance Spectroscopy in Radiation Encephalopathy Induced by Radiotherapy for Patients with Nasopharyngeal Carcinoma: A Meta-Analysis.
 

Author(s): Wang-Sheng Chen, Jian-Jun Li, Lan Hong, Zeng-Bao Xing, Fen Wang, Chang-Qing Li

Journal: Biomed Res Int. 2016 ;2016():5126074.

 

In this study, articles in English and Chinese were selected from available electronic databases prior to September 2014. The metabolic concentrations and patterns of N-acetylaspartic acid (NAA), Choline (Cho), Creatine (Cr), NAA/Cr, NAA/Cho, and Cho/Cr ratios in radiotherapy-induced ...

Last Updated: 8 Mar 2016

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Extramedullary hematopoiesis on 18F-FDG PET/CT in a patient with thalassemia and nasopharyngeal carcinoma: A case report and literature review.
 

Author(s): Dasheng Qiu, Xiaoyan Hu, Liying Xu, Xiaofang Guo

Journal: J Cancer Res Ther. ;11(4):1034.

 

Extramedullary hematopoiesis (EMH) occurs in various bone marrow disorders and is most commonly seen in thalassemia and myelofibrosis. Here, we report a patient with beta-thalassemia and nasopharyngeal carcinoma having intrathoracic EMH. Our patient is a 42-year-old man who complained ...

Last Updated: 17 Feb 2016

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DNA Methylation Biomarkers for Nasopharyngeal Carcinoma: Diagnostic and Prognostic Tools.
 

Author(s): Wei Jiang, Rui Cai, Qiu-Qiu Chen

Journal: Asian Pac. J. Cancer Prev.. 2015 ;16(18):8059-65.

 

Nasopharyngeal carcinoma (NPC) is a common tumor in southern China and south-eastern Asia. Effective strategies for the prevention or screening of NPC are limited. Exploring effective biomarkers for the early diagnosis and prognosis of NPC continues to be a rigorous challenge. Evidence ...

Last Updated: 9 Jan 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Donafenib Monotherapy for Previously Treated Metastatic Nasopharyngeal Carcinoma
 

Status: Not yet recruiting

Condition Summary: Nasopharyngeal Carcinoma

 

Last Updated: 12 Oct 2016

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TPC vs PF as Induction Chemotherapy Combined With CCRT for Stage IVa-b Nasopharyngeal Carcinoma
 

Status: Recruiting

Condition Summary: Nasopharyngeal Carcinoma

 

Last Updated: 20 Oct 2016

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Last Updated: 15 Apr 2016

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