Nasopharyngeal carcinoma

Common Name(s)

Nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC, NPCA) is a multifactorial malignancy associated with both genetic and environmental factors. The cancer arises from the epithelium of the nasopharynx. The Epstein-Barr virus has been implicated ({12:Tse et al., 2009}). A susceptibility locus for nasopharyngeal carcinoma (NPCA1) has been mapped to chromosome 4p. A second locus, NPCA2 ({161550}), has been mapped to chromosome 6p21.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Nasopharyngeal carcinoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Nasopharyngeal carcinoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Nasopharyngeal carcinoma" returned 1537 free, full-text research articles on human participants. First 3 results:

[Effect of HMGB1 on proliferation of human nasopharyngeal carcinoma cell line C666-1 in vitro].
 

Author(s): Shengni Hua, Lushan Xiao, Dehua Wu

Journal: Nan Fang Yi Ke Da Xue Xue Bao. 2015 Nov;35(11):1540-5.

 

To observe the effect of high-mobility group box-1 protein (HMGB1) on the proliferation of human nasopharyngeal carcinoma cell line C666-1 and explore the possible underlying mechanisms.

Last Updated: 26 Nov 2015

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Omission of Chemotherapy in Early Stage Nasopharyngeal Carcinoma Treated with IMRT: A Paired Cohort Study.
 

Author(s): Tingting Xu, Chunying Shen, Guopei Zhu, Chaosu Hu

Journal: Medicine (Baltimore). 2015 Sep;94(39):e1457.

 

The objective of this study was to evaluate the necessity of concurrent chemotherapy in T1-2N1 nasopharyngeal carcinoma (NPC) patients treated with intensity-modulated radiation therapy (IMRT). The retrospective analysis was conducted using the paired comparison method. We matched ...

Last Updated: 2 Oct 2015

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Pretreatment Serum Lactate Dehydrogenase and N Classification Predict Long-Term Survival and Distant Metastasis in Patients With Nasopharyngeal Carcinoma Who Have A Positive Family History of Cancer.
 

Author(s): Wenna Zhang, Yupei Chen, Guanqun Zhou, Xu Liu, Lei Chen, Linglong Tang, Yanping Mao, Ying Sun, Jun Ma

Journal: Medicine (Baltimore). 2015 Sep;94(37):e1505.

 

The purpose of the present study was to evaluate prognostic factors in patients with nasopharyngeal carcinoma (NPC) from the endemic area of southern China who have a positive family history (FH) of cancer. Retrospective analysis of 600 patients with nondisseminated NPC and a positive ...

Last Updated: 17 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Nasopharyngeal carcinoma" returned 74 free, full-text review articles on human participants. First 3 results:

The clinical utility of plasma Epstein-Barr virus DNA assays in nasopharyngeal carcinoma: the dawn of a new era?: a systematic review and meta-analysis of 7836 cases.
 

Author(s): Wenna Zhang, Yupei Chen, Lei Chen, Rui Guo, Guanqun Zhou, Linglong Tang, Yanping Mao, Wenfei Li, Xu Liu, Xiaojing Du, Ying Sun, Jun Ma

Journal: Medicine (Baltimore). 2015 May;94(20):e845.

 

In this study, we assessed the potential of plasma Epstein-Barr virus (EBV) DNA assays to predict clinical outcomes in a large sample of nasopharyngeal carcinoma (NPC) patients and proposed a risk stratification model based on standardized EBV DNA load monitoring.We conducted a meta-analysis ...

Last Updated: 22 May 2015

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Relationship Between Salted Fish Consumption and Nasopharyngeal Carcinoma: An Evidence-based Case Report.
 

Author(s): Ikhwanuliman Putera, M Gema Ramadhan, Shafira Anindya, Natalia R Sutanto, Arief Kurniawan, F Nikodemus Hosea, Eka D Safitri

Journal: Acta Med Indones. 2015 Jan;47(1):72-7.

 

to know the relationship between salted fish consumption and nasopharyngeal carcinoma (NPC).

Last Updated: 7 May 2015

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Advances and challenges in intensity-modulated radiotherapy for nasopharyngeal carcinoma.
 

Author(s): Song Qu, Zhong-Guo Liang, Xiao-Dong Zhu

Journal: Asian Pac. J. Cancer Prev.. 2015 ;16(5):1687-92.

 

Nasopharyngeal carcinoma is an endemic disease within specific regions in the world. Radiotherapy is the main treatment. In recent decades, intensity-modulated radiation therapy has undergone a rapid evolution. Compared with two-dimensional radiotherapy and/or three-dimensional conformal ...

Last Updated: 16 Mar 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Famitinib in Treating Patients With Recurrent and/or Metastatic Nasopharyngeal Carcinoma (NPC)
 

Status: Recruiting

Condition Summary: Recurrent Nasopharyngeal Carcinoma; Metastatic Nasopharyngeal Carcinoma

 

Last Updated: 8 Feb 2012

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Individualized Treatment in Treating Patients With Stage II-IVB Nasopharyngeal Cancer Based on EBV DNA
 

Status: Recruiting

Condition Summary: Epstein-Barr Virus Infection; Stage II Nasopharyngeal Carcinoma; Stage III Nasopharyngeal Carcinoma; Stage IVA Nasopharyngeal Carcinoma; Stage IVB Nasopharyngeal Carcinoma

 

Last Updated: 29 Jan 2016

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Nasopharyngeal Carcinoma Post IMRT
 

Status: Recruiting

Condition Summary: Nasopharyngeal Carcinoma

 

Last Updated: 3 Nov 2015

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