Nasopharyngeal carcinoma

Common Name(s)

Nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC, NPCA) is a multifactorial malignancy associated with both genetic and environmental factors. The cancer arises from the epithelium of the nasopharynx. The Epstein-Barr virus has been implicated ({11:Tse et al., 2009}). A susceptibility locus for nasopharyngeal carcinoma (NPCA1) has been mapped to chromosome 4p. A second locus, NPCA2 ({161550}), has been mapped to chromosome 6p21.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Nasopharyngeal carcinoma" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Nasopharyngeal carcinoma" returned 1039 free, full-text research articles on human participants. First 3 results:

Nuclear p27 expression confers a favorable outcome for nasopharyngeal carcinoma patients.
 

Author(s): Zhen Liu, Yufei Long, Yajie Zhang, Wei Huang, Xiaobin Long, Huiling Yang, Jie Long, Chao Cheng, Weiyi Fang

Journal: Dis. Markers. 2013 ;35(6):925-32.

 

The purpose of the present study is to explore the correlation between nuclear expression of cyclin-dependent kinase inhibitor 1B (p27) and clinicopathologic features in nasopharyngeal carcinoma (NPC), including patient survival.

Last Updated: 14 Jan 2014

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T4-locally advanced nasopharyngeal carcinoma: prognostic influence of cranial nerve involvement in different radiotherapy techniques.
 

Author(s): Hsin-I Huang, Kee-Tak Chan, Chih-Hung Shu, Ching-Yin Ho

Journal:

 

Cranial nerve involvement at disease presentation of nasopharyngeal carcinoma was not uncommon. We investigated the prognosis of patients with T4-locally advanced NPC, with or without cranial nerve involvement, and compared the outcome of patients treated using different radiotherapy techniques.

Last Updated: 3 Jan 2014

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Concurrent chemoradiotherapy comparison of taxanes and platinum versus 5-fluorouracil and platinum in nasopharyngeal carcinoma treatment.
 

Author(s): Xichuang Chen, Yuan Hong, Jinhua Feng, Jianlin Ye, Panpan Zheng, Xiyin Guan, Xiaohong You, Huizhu Song

Journal: Chin. Med. J.. 2014 ;127(1):142-9.

 

Nasopharyngeal carcinoma (NPC) is a squamous-cell carcinoma especially prevailing among the natives of southern China. The regimen of concurrent chemoradiotherapy (CCRT) that include platinum and 5-fluorouracil (5-FU) is considered to be the standard treatment for NPC. However, its ...

Last Updated: 3 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Nasopharyngeal carcinoma" returned 52 free, full-text review articles on human participants. First 3 results:

Emerging treatment options for nasopharyngeal carcinoma.
 

Author(s): Lu Zhang, Qiu-Yan Chen, Huai Liu, Lin-Quan Tang, Hai-Qiang Mai

Journal: Drug Des Devel Ther. 2013 ;7():37-52.

 

Nasopharyngeal carcinoma is endemic in Asia and is etiologically associated with Epstein-Barr virus. Radiotherapy is the primary treatment modality. The role of systemic therapy has become more prominent. Based on multiple phase III studies and meta-analyses, concurrent cisplatin-based ...

Last Updated: 13 Feb 2013

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Biomarkers for use in monitoring responses of nasopharyngeal carcinoma cells to ionizing radiation.
 

Author(s): Wei Gao, John Zenghong Li, Wai Kuen Ho, Jimmy Yuwai Chan, Thian Sze Wong

Journal: Sensors (Basel). 2012 ;12(7):8832-46.

 

Nasopharyngeal carcinoma (NPC) is a common head and neck cancer. The incidence rate is higher in southern China and Southeast Asia in comparison with the Western countries. Radiotherapy is the standard treatment of NPC as the cancer cells are sensitive to ionizing radiation. Radiation ...

Last Updated: 26 Sep 2012

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Systematic review on Epstein-Barr virus (EBV) DNA in diagnosis of nasopharyngeal carcinoma in Asian populations.
 

Author(s): Bao-Lin Han, Xiang-Ying Xu, Chun-Zhi Zhang, Jian-Juan Wu, Chun-Feng Han, Hui Wang, Xuan Wang, Guang-Shun Wang, Shu-Juan Yang, Yao Xie

Journal: Asian Pac. J. Cancer Prev.. 2012 ;13(6):2577-81.

 

To conduct a meta-analysis to investigate the value of EBV DNA in diagnosis of nasopharyngeal cancer (NPC) in Asian populations, and provide important evidence for screening.

Last Updated: 3 Sep 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Famitinib in Treating Patients With Recurrent and/or Metastatic Nasopharyngeal Carcinoma (NPC)
 

Status: Recruiting

Condition Summary: Recurrent Nasopharyngeal Carcinoma; Metastatic Nasopharyngeal Carcinoma

 

Last Updated: 8 Feb 2012

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Phase II Sequential and Concurrent Chemoradiation for Advanced Nasopharyngeal Carcinoma (NPC)
 

Status: Recruiting

Condition Summary: Stage II Lymphoepithelioma of the Nasopharynx; Stage II Squamous Cell Carcinoma of the Nasopharynx; Stage III Lymphoepithelioma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Nasopharynx

 

Last Updated: 19 May 2014

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Individualized Treatment in Treating Patients With Stage II-IVB Nasopharyngeal Cancer Based on EBV DNA
 

Status: Recruiting

Condition Summary: Epstein-Barr Virus Infection; Stage II Lymphoepithelioma of the Nasopharynx; Stage II Squamous Cell Carcinoma of the Nasopharynx; Stage III Lymphoepithelioma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Nasopharynx

 

Last Updated: 10 Jul 2014

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