Nasopharyngeal carcinoma

Common Name(s)

Nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC, NPCA) is a multifactorial malignancy associated with both genetic and environmental factors. The cancer arises from the epithelium of the nasopharynx. The Epstein-Barr virus has been implicated ({11:Tse et al., 2009}). A susceptibility locus for nasopharyngeal carcinoma (NPCA1) has been mapped to chromosome 4p. A second locus, NPCA2 ({161550}), has been mapped to chromosome 6p21.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Nasopharyngeal carcinoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Nasopharyngeal carcinoma" returned 1100 free, full-text research articles on human participants. First 3 results:

The inhibitory effects of extracellular ATP on the growth of nasopharyngeal carcinoma cells via P2Y2 receptor and osteopontin.
 

Author(s): Guang Yang, Shenghong Zhang, Yanling Zhang, Qiming Zhou, Sheng Peng, Tao Zhang, Changfu Yang, Zhenyu Zhu, Fujun Zhang

Journal:

 

Nasopharyngeal carcinoma (NPC) is a common malignant tumor observed in the populations of southern China and Southeast Asia. However, little is known about the effects of purinergic signal on the behavior of NPC cells. This study analyzed the effects of ATP on the growth and migration ...

Last Updated: 3 Jul 2014

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Sixteen years post radiotherapy of nasopharyngeal carcinoma elicited multi-dysfunction along PTX and chronic kidney disease with microcytic anemia.
 

Author(s): Yi-Ting Lin, Chia-Chun Huang, Charng-Cherng Chyau, Kuan-Chou Chen, Robert Y Peng

Journal:

 

The hypothalamic-pituitary (h-p) unit is a particularly radiosensitive region in the central nervous system. As a consequence, radiation-induced irreversible, progressively chronic onset hypopituitarism (RIH) commonly develops after radiation treatments and can result in variably ...

Last Updated: 24 Feb 2014

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A case of oropharyngeal squamous cell carcinoma with nasopharyngeal extension via the levator veli palatini muscle.
 

Author(s): Hirofumi Kuno, Hiroaki Onaya

Journal: Jpn. J. Clin. Oncol.. 2014 Feb;44(2):195.

 

Last Updated: 5 Feb 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Nasopharyngeal carcinoma" returned 54 free, full-text review articles on human participants. First 3 results:

Current treatment options for local residual nasopharyngeal carcinoma.
 

Author(s): S D Stoker, J N A van Diessen, J P de Boer, B Karakullukcu, C R Leemans, I B Tan

Journal: Curr Treat Options Oncol. 2013 Dec;14(4):475-91.

 

Local residual disease occurs in 7-13 % after primary treatment for nasopharyngeal carcinoma (NPC). To prevent tumor progression and/or distant metastasis, treatment is indicated. Biopsy is the "gold standard" for diagnosing residual disease. Because late histological regression frequently ...

Last Updated: 27 Nov 2013

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Quantitative association of tobacco smoking with the risk of nasopharyngeal carcinoma: a comprehensive meta-analysis of studies conducted between 1979 and 2011.
 

Author(s): Wen-Qiong Xue, Hai-De Qin, Hong-Lian Ruan, Yin Yao Shugart, Wei-Hua Jia

Journal: Am. J. Epidemiol.. 2013 Aug;178(3):325-38.

 

Over the years, many studies have attempted to establish a link between tobacco smoking and an increased risk of nasopharyngeal carcinoma (NPC), but their results have been inconsistent. To clarify this link, we first conducted a comprehensive meta-analysis to integrate the findings ...

Last Updated: 31 Jul 2013

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Emerging treatment options for nasopharyngeal carcinoma.
 

Author(s): Lu Zhang, Qiu-Yan Chen, Huai Liu, Lin-Quan Tang, Hai-Qiang Mai

Journal: Drug Des Devel Ther. 2013 ;7():37-52.

 

Nasopharyngeal carcinoma is endemic in Asia and is etiologically associated with Epstein-Barr virus. Radiotherapy is the primary treatment modality. The role of systemic therapy has become more prominent. Based on multiple phase III studies and meta-analyses, concurrent cisplatin-based ...

Last Updated: 13 Feb 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Famitinib in Treating Patients With Recurrent and/or Metastatic Nasopharyngeal Carcinoma (NPC)
 

Status: Recruiting

Condition Summary: Recurrent Nasopharyngeal Carcinoma; Metastatic Nasopharyngeal Carcinoma

 

Last Updated: 8 Feb 2012

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Phase II Sequential and Concurrent Chemoradiation for Advanced Nasopharyngeal Carcinoma (NPC)
 

Status: Recruiting

Condition Summary: Stage II Lymphoepithelioma of the Nasopharynx; Stage II Squamous Cell Carcinoma of the Nasopharynx; Stage III Lymphoepithelioma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Nasopharynx

 

Last Updated: 19 May 2014

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Individualized Treatment in Treating Patients With Stage II-IVB Nasopharyngeal Cancer Based on EBV DNA
 

Status: Recruiting

Condition Summary: Epstein-Barr Virus Infection; Stage II Lymphoepithelioma of the Nasopharynx; Stage II Squamous Cell Carcinoma of the Nasopharynx; Stage III Lymphoepithelioma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Nasopharynx

 

Last Updated: 10 Jul 2014

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