Nasopharyngeal carcinoma

Common Name(s)

Nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC, NPCA) is a multifactorial malignancy associated with both genetic and environmental factors. The cancer arises from the epithelium of the nasopharynx. The Epstein-Barr virus has been implicated ({12:Tse et al., 2009}). A susceptibility locus for nasopharyngeal carcinoma (NPCA1) has been mapped to chromosome 4p. A second locus, NPCA2 ({161550}), has been mapped to chromosome 6p21.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Nasopharyngeal carcinoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Nasopharyngeal carcinoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Nasopharyngeal carcinoma" returned 1604 free, full-text research articles on human participants. First 3 results:

Plasma Epstein-Barr Viral Deoxyribonucleic Acid Predicts Worse Outcomes in Pediatric Nonmetastatic Nasopharyngeal Carcinoma Patients: An Observational Study of 89 Cases in an Endemic Area.
 

Author(s): Ting Shen, Lin-Quan Tang, Wei-Guang Gu, Dong-Hua Luo, Qiu-Yan Chen, Pei-Jing Li, Dong-Mei Mai, Hai-Qiang Mai, Hao-Yuan Mo

Journal: Medicine (Baltimore). 2015 Dec;94(50):e1945.

 

To evaluate the clinical significance of pretreatment levels of plasma Epstein-Barr virus DNA (pEBV DNA) on prognoses in pediatric nasopharyngeal carcinoma (NPC) patients. Eighty-nine patients aged 21 years old or younger with nonmetastatic NPC were evaluated to determine the effect ...

Last Updated: 19 Dec 2015

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Characterization and Prognostic Significance of Methylthioadenosine Phosphorylase Deficiency in Nasopharyngeal Carcinoma.
 

Author(s): Hong-Lin He, Ying-En Lee, Yow-Ling Shiue, Sung-Wei Lee, Tzu-Ju Chen, Chien-Feng Li

Journal: Medicine (Baltimore). 2015 Dec;94(49):e2271.

 

Identification of cancer-associated genes by genomic profiling contributes to the elucidation of tumor development and progression. The methylthioadenosine phosphorylase (MTAP) gene, located at chromosome 9p21, plays a critical role in tumorigenicity and disease progression in a wide ...

Last Updated: 15 Dec 2015

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Prognostic Value and Grading of MRI-Based T Category in Patients With Nasopharyngeal Carcinoma Without Lymph Node Metastasis Undergoing Intensity-Modulated Radiation Therapy.
 

Author(s): Yu-Pei Chen, Ling-Long Tang, Wen-Na Zhang, Yan-Ping Mao, Lei Chen, Ying Sun, Li-Zhi Liu, Wen-Fei Li, Xu Liu, Guan-Qun Zhou, Rui Guo, Hai-Qiang Mai, Jian-Yong Shao, Ai-Hua Lin, Li Li, Jun Ma

Journal: Medicine (Baltimore). 2015 Oct;94(43):e1624.

 

We investigated the prognostic value and gradation of the T category in N0 nasopharyngeal carcinoma (NPC) patients undergoing magnetic resonance imaging (MRI) and intensity-modulated radiotherapy (IMRT).A total of 749 patients were retrospectively reviewed, and a total of 181 N0 NPC ...

Last Updated: 30 Oct 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Nasopharyngeal carcinoma" returned 77 free, full-text review articles on human participants. First 3 results:

A Review: Proteomics in Nasopharyngeal Carcinoma.
 

Author(s): Ze-Tan Chen, Zhong-Guo Liang, Xiao-Dong Zhu

Journal:

 

Although radiotherapy is generally effective in the treatment of major nasopharyngeal carcinoma (NPC), this treatment still makes approximately 20% of patients radioresistant. Therefore, the identification of blood or biopsy biomarkers that can predict the treatment response to radioresistance ...

Last Updated: 18 Jul 2015

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Progresses and Challenges in Chemotherapy for Loco- Regionally Advanced Nasopharyngeal Carcinoma.
 

Author(s): Zhong-Guo Liang, Ze-Tan Chen, Ling Li, Song Qu, Xiao-Dong Zhu

Journal: Asian Pac. J. Cancer Prev.. 2015 ;16(12):4825-32.

 

Incidence rates of nasopharyngeal carcinoma are high in Indonesia, Singapore and South-Eastern China. Chemoradiotherapy has been the standard regimen for locally advanced nasopharyngeal carcinoma according to guidelines from the National Comprehensive Cancer Network. Recently, advances ...

Last Updated: 12 Jul 2015

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Omics-based identification of biomarkers for nasopharyngeal carcinoma.
 

Author(s): Tavan Janvilisri

Journal: Dis. Markers. 2015 ;2015():762128.

 

Nasopharyngeal carcinoma (NPC) is a head and neck cancer that is highly found in distinct geographic areas, such as Southeast Asia. The management of NPC remains burdensome as the prognosis is poor due to the late presentation of the disease and the complex nature of NPC pathogenesis. ...

Last Updated: 22 May 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Famitinib in Treating Patients With Recurrent and/or Metastatic Nasopharyngeal Carcinoma (NPC)
 

Status: Recruiting

Condition Summary: Recurrent Nasopharyngeal Carcinoma; Metastatic Nasopharyngeal Carcinoma

 

Last Updated: 8 Feb 2012

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Individualized Treatment in Treating Patients With Stage II-IVB Nasopharyngeal Cancer Based on EBV DNA
 

Status: Recruiting

Condition Summary: Epstein-Barr Virus Infection; Stage II Nasopharyngeal Carcinoma; Stage III Nasopharyngeal Carcinoma; Stage IVA Nasopharyngeal Carcinoma; Stage IVB Nasopharyngeal Carcinoma

 

Last Updated: 29 Jan 2016

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Nasopharyngeal Carcinoma Post IMRT
 

Status: Recruiting

Condition Summary: Nasopharyngeal Carcinoma

 

Last Updated: 3 Nov 2015

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