Nasopharyngeal carcinoma

Common Name(s)

Nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC, NPCA) is a multifactorial malignancy associated with both genetic and environmental factors. The cancer arises from the epithelium of the nasopharynx. The Epstein-Barr virus has been implicated ({12:Tse et al., 2009}). A susceptibility locus for nasopharyngeal carcinoma (NPCA1) has been mapped to chromosome 4p. A second locus, NPCA2 ({161550}), has been mapped to chromosome 6p21.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Nasopharyngeal carcinoma" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Nasopharyngeal carcinoma" returned 1138 free, full-text research articles on human participants. First 3 results:

The inhibitory effects of extracellular ATP on the growth of nasopharyngeal carcinoma cells via P2Y2 receptor and osteopontin.
 

Author(s): Guang Yang, Shenghong Zhang, Yanling Zhang, Qiming Zhou, Sheng Peng, Tao Zhang, Changfu Yang, Zhenyu Zhu, Fujun Zhang

Journal:

 

Nasopharyngeal carcinoma (NPC) is a common malignant tumor observed in the populations of southern China and Southeast Asia. However, little is known about the effects of purinergic signal on the behavior of NPC cells. This study analyzed the effects of ATP on the growth and migration ...

Last Updated: 3 Jul 2014

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Weighted risk score-based multifactor dimensionality reduction to detect gene-gene interactions in nasopharyngeal carcinoma.
 

Author(s): Chao-Feng Li, Fu-Tian Luo, Yi-Xin Zeng, Wei-Hua Jia

Journal:

 

Determining the complex relationships between diseases, polymorphisms in human genes and environmental factors is challenging. Multifactor dimensionality reduction (MDR) has been proven to be capable of effectively detecting the statistical patterns of epistasis, although classification ...

Last Updated: 17 Jun 2014

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Radiosensitization effect of nedaplatin on nasopharyngeal carcinoma cells in different status of Epstein-Barr virus infection.
 

Author(s): Li Yin, Jing Wu, Jianfeng Wu, Jinjun Ye, Xuesong Jiang, Meng Chen, Dejun Wang, Xue Wang, Dan Zong, Jiajia Gu, Junying Zhang, Jianzhong Wu, Lin Xu, Xia He, Wenjie Guo

Journal: Biomed Res Int. 2014 ;2014():713674.

 

This study aims to evaluate the radiosensitization effect of nedaplatin on nasopharyngeal carcinoma (NPC) cell lines with different Epstein-Barr virus (EBV) status. Human NPC cell lines CNE-2 (EBV-negative) and C666 (EBV-positive) were treated with 0-100 μg/mL nedaplatin, and inhibitory ...

Last Updated: 6 Jun 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Nasopharyngeal carcinoma" returned 50 free, full-text review articles on human participants. First 3 results:

The Interleukin-18 promoter -607C>A polymorphism contributes to nasopharyngeal carcinoma risk: evidence from a meta-analysis including 1,886 subjects.
 

Author(s): Xu-Guang Guo, Yong Xia

Journal: Asian Pac. J. Cancer Prev.. 2013 ;14(12):7577-81.

 

The interleukin-18 promoter -607C>A gene polymorphism may be related to nasopharyngeal carcinoma (NPC) risk but the results of individual studies remain conflicting. A meta-analysis including 1,886 subjects from five individual studies was therefore performed to provide a more accurate ...

Last Updated: 27 Jan 2014

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Involvement of EBV-encoded BART-miRNAs and dysregulated cellular miRNAs in nasopharyngeal carcinoma genesis.
 

Author(s): Yuan-Jie Xie, Zhi-Feng Long, Xiu-Sheng He

Journal: Asian Pac. J. Cancer Prev.. 2013 ;14(10):5637-44.

 

The definite molecular mechanisms underlying the genesis of nasopharyngeal carcinomas (NPCs) remain to be completely elucidated. miRNAs are small non-coding RNAs which are implicated in cell proliferation, apoptosis, and even carcinogenesis through negatively regulating gene expression ...

Last Updated: 2 Dec 2013

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Current treatment options for local residual nasopharyngeal carcinoma.
 

Author(s): S D Stoker, J N A van Diessen, J P de Boer, B Karakullukcu, C R Leemans, I B Tan

Journal: Curr Treat Options Oncol. 2013 Dec;14(4):475-91.

 

Local residual disease occurs in 7-13 % after primary treatment for nasopharyngeal carcinoma (NPC). To prevent tumor progression and/or distant metastasis, treatment is indicated. Biopsy is the "gold standard" for diagnosing residual disease. Because late histological regression frequently ...

Last Updated: 27 Nov 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Famitinib in Treating Patients With Recurrent and/or Metastatic Nasopharyngeal Carcinoma (NPC)
 

Status: Recruiting

Condition Summary: Recurrent Nasopharyngeal Carcinoma; Metastatic Nasopharyngeal Carcinoma

 

Last Updated: 8 Feb 2012

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Retrospective Study About Nasopharyngeal Carcinoma at C. S. Parc Tauli
 

Status: Not yet recruiting

Condition Summary: Nasopharyngeal Carcinoma

 

Last Updated: 23 Jul 2014

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Atorvastatin in Preventing Nasopharyngeal Carcinoma Patients Receiving Radiotherapy From Carotid Stenosis
 

Status: Recruiting

Condition Summary: Nasopharyngeal Carcinoma; Radiation Therapy Complication

 

Last Updated: 7 Feb 2014

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