Narcolepsy

Common Name(s)

Narcolepsy

Narcolepsy is a long-term (chronic) sleep disorder that usually begins showing symptoms in individuals between the ages of 10-25 years old. People with narcolepsy experience sudden, uncontrollable periods of sleepiness that can strike at any time.

Symptoms of narcolepsy include excessive daytime sleepiness (EDS) and cataplexy, which is a sudden loss of muscle tone leading to an overwhelming feeling of weakness and loss of voluntary muscle control. Other possible symptoms may include sleep paralysis, which is the inability to move or speak while falling asleep or waking; hallucinations, which may occur when a person is falling asleep, waking or during sleep; and general disrupted nighttime sleep patterns. People with narcolepsy may have trouble staying asleep and may report sleep talking, vivid dreaming, or periodic leg movements. Affected individuals are also more likely to become obese, although lifestyle changes can help in the prevention of excessive weight gain.

Narcolepsy is commonly caused by an abnormally low level of a type of neurotransmitter, called hypocretin. Neurotransmitters are chemicals that brain cells produce to communicate with each other and to regulate other processes in the body. Hypocretin is responsible for helping the body to stay awake. Most cases of narcolepsy are “sporadic,” meaning there is not a family history of the disorder. However, about 10 percent of people with narcolepsy have a close relative who is also affected, meaning there may be a genetic cause that is not yet understood.

A doctor can diagnose the condition by using sleep studies and a medical history. Additionally, there are tests to detect low levels of hypocretin. There is currently no cure for narcolepsy, but there are medications available to help manage the condition. Ask your doctor or specialist about the most current treatment options available. Support groups are a good resource for information and support.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Narcolepsy" for support, advocacy or research.

Caring Voice Coalition,Inc,

Caring Voice Coalition empowers patients who live with a life threatening chronic disease through comprehensive outreach programs and services aimed at financial, emotional and educational support. With a steadfast dedication to the organization’s set of core values, our knowledgeable, caring staff maintains our solid reputation as a dependable, responsive organization with a unique, holistic approach to improving the lives of our patients.

Last Updated: 29 Apr 2014

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Narcolepsy Network, Inc.

Narcolepsy Network, Inc.'s mission is to: educate the public about narcolepsy and other related sleep disorders, support individuals with narcolepsy, their families and friends, promote the efficient diagnosis of narcolepsy, and encourage and promote research for narcolepsy.

Last Updated: 26 Mar 2013

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Wake Up Narcolepsy, Inc.

Wake Up Narcolepsy is a 501(c)(3) not-for-profit organization dedicated to supporting narcolepsy awareness and research to find a cure. WUN carries out its mission by: Providing funding to accelerate a cure for narcolepsy; increasing awareness of narcolepsy; decreasing time-lapse from symptom onset to proper diagnosis; and providing supportive resources for people with narcolepsy and their families.

Last Updated: 29 Apr 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Narcolepsy" for support, advocacy or research.

Caring Voice Coalition,Inc,

Caring Voice Coalition empowers patients who live with a life threatening chronic disease through comprehensive outreach programs and services aimed at financial, emotional and educational support. With a steadfast dedication to the organization’s set of core values, our knowledgeable, caring staff maintains our solid reputation as a dependable, responsive organization with a unique, holistic approach to improving the lives of our patients.

http://www.caringvoice.org

Last Updated: 29 Apr 2014

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Narcolepsy Network, Inc.

Narcolepsy Network, Inc.'s mission is to: educate the public about narcolepsy and other related sleep disorders, support individuals with narcolepsy, their families and friends, promote the efficient diagnosis of narcolepsy, and encourage and promote research for narcolepsy.

http://www.narcolepsynetwork.org

Last Updated: 26 Mar 2013

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Wake Up Narcolepsy, Inc.

Wake Up Narcolepsy is a 501(c)(3) not-for-profit organization dedicated to supporting narcolepsy awareness and research to find a cure. WUN carries out its mission by: Providing funding to accelerate a cure for narcolepsy; increasing awareness of narcolepsy; decreasing time-lapse from symptom onset to proper diagnosis; and providing supportive resources for people with narcolepsy and their families.

http://www.wakeupnarcolepsy.org/

Last Updated: 29 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Narcolepsy" returned 325 free, full-text research articles on human participants. First 3 results:

Comments on 'Sleep Disordered Breathing and Periodic Limb Movements in Patients with Narcolepsy with Cataplexy'.
 

Author(s): Nitin K Sethi

Journal: Eur. Neurol.. 2015 ;74(3-4):169.

 

Last Updated: 1 Dec 2015

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Reply to Comments on 'Sleep Disordered Breathing and Periodic Limb Movements in Patients with Narcolepsy with Cataplexy'.
 

Author(s): Fabio Pizza, Claudio L Bassetti

Journal: Eur. Neurol.. 2015 ;74(3-4):170.

 

Last Updated: 1 Dec 2015

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Last Updated: 27 Nov 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Narcolepsy" returned 41 free, full-text review articles on human participants. First 3 results:

The Safety of Adjuvanted Vaccines Revisited: Vaccine-Induced Narcolepsy.
 

Author(s): S Sohail Ahmed, Emanuele Montomoli, Franco Laghi Pasini, Lawrence Steinman

Journal: Isr. Med. Assoc. J.. ;18(3-4):216-20.

 

Despite the very high benefit-to-risk ratio of vaccines, the fear of negative side effects has discouraged many people from getting vaccinated, resulting in the reemergence of previously controlled diseases such as measles, pertussis and diphtheria. This fear has been amplified more ...

Last Updated: 27 May 2016

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Second Opinion: Does This Patient Really Have Narcolepsy?
 

Author(s): Scott Ryals, Richard B Berry, Ankur Girdhar, Mary Wagner

Journal:

 

Last Updated: 28 Aug 2015

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[Narcolepsy with cataplexy: an autoimmune disease?].
 

Author(s): Louis Jacob, Yves Dauvilliers

Journal: Med Sci (Paris). 2014 Dec;30(12):1136-43.

 

Narcolepsy type 1 (also named narcolepsy-cataplexy or hypocretin deficiency syndrome) is a rare sleep disorder characterized by excessive daytime sleepiness and cataplexy, plus frequently hypnagogic hallucinations, sleep paralysis and nocturnal sleep disturbances. Narcolepsy type ...

Last Updated: 24 Dec 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Xyrem and Brain Dopamine in Narcolepsy
 

Status: Recruiting

Condition Summary: Narcolepsy With Cataplexy

 

Last Updated: 15 Jan 2016

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Last Updated: 11 May 2016

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Study Assessing Effects of JZP-110 on Driving Performance in the Treatment of Excessive Sleepiness in Narcolepsy
 

Status: Recruiting

Condition Summary: Narcolepsy; Excessive Sleepiness

 

Last Updated: 21 Jun 2016

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