Myxoid liposarcoma

Common Name(s)

Myxoid liposarcoma

Myxoid liposarcoma is a soft tissue tumor that tends to occur in the limbs (especially the thigh) of patients ranging in age from 35 to 55 years. It is defined by the presence of a hypocellular spindle cell proliferation set in a myxoid background, often with mucin pooling. Lipoblasts tend to be small and often monovacuolated and to cluster around vessels or at the periphery of the lesion (review by {4:Dei Tos, 2000}).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Myxoid liposarcoma" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Myxoid liposarcoma" returned 81 free, full-text research articles on human participants. First 3 results:

Mixed type retroperitoneal liposarcoma-combination of myxoid and well-differentiated type.
 

Author(s): Subrata Pal, Sanjay Sengupta, Kingshuk Bose, Sritanu Jana

Journal: J Cancer Res Ther. ;12(1):424-6.

 

Last Updated: 13 Apr 2016

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HSP90 inhibition blocks ERBB3 and RET phosphorylation in myxoid/round cell liposarcoma and causes massive cell death in vitro and in vivo.
 

Author(s): Setareh Safavi, Sofia Järnum, Christoffer Vannas, Sameer Udhane, Emma Jonasson, Tajana Tesan Tomic, Pernilla Grundevik, Henrik Fagman, Magnus Hansson, Zeynep Kalender, Alexandra Jauhiainen, Soheila Dolatabadi, Eva Wessel Stratford, Ola Myklebost, Mikael Eriksson, Göran Stenman, Regine Schneider Stock, Anders Ståhlberg, Pierre Åman

Journal: Oncotarget. 2016 Jan;7(1):433-45.

 

Myxoid sarcoma (MLS) is one of the most common types of malignant soft tissue tumors. MLS is characterized by the FUS-DDIT3 or EWSR1-DDIT3 fusion oncogenes that encode abnormal transcription factors. The receptor tyrosine kinase (RTK) encoding RET was previously identified as a putative ...

Last Updated: 5 Feb 2016

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FGFR2 is overexpressed in myxoid liposarcoma and inhibition of FGFR signaling impairs tumor growth in vitro.
 

Author(s): Helen Künstlinger, Jana Fassunke, Hans-Ulrich Schildhaus, Benedikt Brors, Carina Heydt, Michaela Angelika Ihle, Gunhild Mechtersheimer, Eva Wardelmann, Reinhard Büttner, Sabine Merkelbach-Bruse

Journal: Oncotarget. 2015 Aug;6(24):20215-30.

 

Myxoid liposarcomas account for more than one third of liposarcomas and about 10% of all adult soft tissue sarcomas. The tumors are characterized by specific chromosomal translocations leading to the chimeric oncogenes FUS-DDIT3 or EWS1R-DDIT3. The encoded fusion proteins act as aberrant ...

Last Updated: 8 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Myxoid liposarcoma" returned 3 free, full-text review articles on human participants. First 3 results:

[Myxoid primitive liposarcoma of the middle mediastinum].
 

Author(s): Rachid Marouf, Ihssan Alloubi

Journal:

 

Last Updated: 24 Feb 2015

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Lipoblastoma mimicking myxoid liposarcoma: a clinical report and literature review.
 

Author(s): Akihito Nagano, Takatoshi Ohno, Yutaka Nishimoto, Yoshinobu Hirose, Satoru Miyake, Katsuji Shimizu

Journal: Tohoku J. Exp. Med.. 2011 ;223(1):75-8.

 

Lipoblastoma is an uncommon benign lipomatous tumor, occurring typically in children less than 3 years of age. The magnetic resonance image (MRI) is a useful tool for diagnosis of lipoblastoma; its imaging typically shows high-intensity signals on both T1-weighted (T1-W) and T2 weighted ...

Last Updated: 7 Jan 2011

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Pleural myxoid liposarcoma: features of 2 cases and associated literature review.
 

Author(s): Paul Goldsmith, Kostas Papagiannopoulos

Journal:

 

Primary pleural myxoid liposarcoma is a rare entity and no agreed treatment options have been formulated once diagnosis has been made. We report two cases with subsequent management and make recommendations for treatment pathways in these rare cases.

Last Updated: 15 Jan 2008

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Dose Reduction of Preoperative Radiotherapy in Myxoid Liposarcomas
 

Status: Recruiting

Condition Summary: Myxoid Liposarcoma of Soft Tissue

 

Last Updated: 19 Sep 2016

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A Pilot Study of NY-ESO-1ᶜ²⁵⁹T Cells in Subjects With Advanced Myxoid/ Round Cell Liposarcoma
 

Status: Recruiting

Condition Summary: Myxoid Round Cell Liposarcoma; High Grade Myxoid Liposarcoma

 

Last Updated: 25 Jan 2017

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Sirolimus and Cyclophosphamide in Metastatic or Unresectable Myxoid Liposarcoma and Chondrosarcoma
 

Status: Recruiting

Condition Summary: Conventional Chondrosarcoma; Myxoid Liposarcoma; Mesenchymal Chondrosarcoma; Dedifferentiated Chondrosarcoma

 

Last Updated: 11 Jul 2016

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