Myositis ossificans

Common Name(s)

Myositis ossificans

Myositis ossificans is the development of bone where other muscle or other soft tissue is normally present. This bone formation is often painful and limits the range of motion in the affected area. Myositis ossificans develops due to deep muscle bruises after traumatic injury or as a result of inherited conditions. The inherited form, fibrodysplasia ossificans progressiva (FOP), is extremely rare and is caused by a specific gene mutation.

Symptoms of myositis ossifications caused by trauma include a solid bump, pain, and limited range of motion. Most bone growths develop in the arms or legs within a few weeks of injury and tend to occur in young adults or paraplegics, although anyone who experiences a deep muscle bruise may be affected. Individuals with myositis ossificans from FOP generally show symptoms before the age of 10. The symptoms become worse with age and may cause severe pain. FOP eventually causes the skeleton of the affected individual to fuse into a single bone structure.

Myositis ossificans is diagnosed using medical imaging to reveal abnormal bone growth. Treatments for myositis ossifications depend on the subtype and severity of bone formation. Minor myositis ossificans from trauma will often resolve without treatment. Medications may be used to decrease inflammation and pain. Surgery may be used in severe cases following trauma, but often worsens symptoms for individuals with FOP. There is currently no cure for FOP. If you are suffering from myositis ossificans, talk to your doctor about the most current treatment options.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Myositis ossificans" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Myositis ossificans" returned 69 free, full-text research articles on human participants. First 3 results:

Myositis ossificans occupying the thenar region: a case report.
 

Author(s): Tsutomu Akahane, Naoya Mori, Yukio Nakatsuchi

Journal:

 

Myositis ossificans is a benign, self-limiting, tumor-like lesion that usually affects the elbow and thigh; occurrence in the hand is uncommon. We report a rare case of a patient with myositis ossificans in the thenar region.

Last Updated: 12 May 2015

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Myositis ossificans traumatica causing ankylosis of the elbow.
 

Author(s): B Kanthimathi, S Udhaya Shankar, K Arun Kumar, V L Narayanan

Journal: Clin Orthop Surg. 2014 Dec;6(4):480-3.

 

Myositis ossificans traumatica is an unusual complication following a muscle contusion injury. A significantly large myositic mass causing ankylosis of the elbow is even rarer. We report a 13-year-old boy who presented with a 14-month history of a fixed elbow with no movement and ...

Last Updated: 1 Dec 2014

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Non-traumatic myositis ossificans in the lumbar spine.
 

Author(s): Anas Abdallah, Akin Gokcedag, Ali Ender Ofluoglu, Erhan Emel

Journal:

 

Myositis ossificans is a non-neoplastic benign reactive bone and cartilage matrix-producing pseudotumor that develops in skeletal muscles adjacent to the joint. The clinical and pathologic appearance of myositis ossificans varies depending on the time elapsed after heterotopic bone ...

Last Updated: 2 Oct 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Myositis ossificans" returned 1 free, full-text review articles on human participants. First 3 results:

Bilateral myositis ossificans of the masseter muscle after chemoradiotherapy and critical illness neuropathy--report of a rare entity and review of literature.
 

Author(s): Astrid L Kruse, Christine Dannemann, Klaus W Gr├Ątz

Journal:

 

Myositis ossificans in the head and neck is a rare heterotropic bone formation within a muscle. Besides fibrodysplasia ossificans progressiva, traumatic and neurogenic forms are described in the literature. We are presenting the case of a 35-year-old female patient with a very rare ...

Last Updated: 21 Aug 2009

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

In-Home Evaluation of Episodic Administration of Palovarotene in Fibrodysplasia Ossificans Progressiva (FOP) Subjects
 

Status: Recruiting

Condition Summary: Fibrodysplasia Ossificans Progressiva

 

Last Updated: 7 Jan 2016

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A Natural History Study of Fibrodysplasia Ossificans Progressiva (FOP)
 

Status: Recruiting

Condition Summary: Fibrodysplasia Ossificans Progressiva

 

Last Updated: 17 Dec 2015

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An Open-Label Extension Study of Palovarotene to Treat Preosseous Flare-ups in FOP Subjects
 

Status: Recruiting

Condition Summary: Fibrodysplasia Ossificans Progressiva

 

Last Updated: 7 Jan 2016

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