Myositis ossificans

Common Name(s)

Myositis ossificans

Myositis ossificans is the development of bone where other muscle or other soft tissue is normally present. This bone formation is often painful and limits the range of motion in the affected area. Myositis ossificans develops due to deep muscle bruises after traumatic injury or as a result of inherited conditions. The inherited form, fibrodysplasia ossificans progressiva (FOP), is extremely rare and is caused by a specific gene mutation.

Symptoms of myositis ossifications caused by trauma include a solid bump, pain, and limited range of motion. Most bone growths develop in the arms or legs within a few weeks of injury and tend to occur in young adults or paraplegics, although anyone who experiences a deep muscle bruise may be affected. Individuals with myositis ossificans from FOP generally show symptoms before the age of 10. The symptoms become worse with age and may cause severe pain. FOP eventually causes the skeleton of the affected individual to fuse into a single bone structure.

Myositis ossificans is diagnosed using medical imaging to reveal abnormal bone growth. Treatments for myositis ossifications depend on the subtype and severity of bone formation. Minor myositis ossificans from trauma will often resolve without treatment. Medications may be used to decrease inflammation and pain. Surgery may be used in severe cases following trauma, but often worsens symptoms for individuals with FOP. There is currently no cure for FOP. If you are suffering from myositis ossificans, talk to your doctor about the most current treatment options.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Myositis ossificans" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Myositis ossificans" returned 71 free, full-text research articles on human participants. First 3 results:

[About a rare form of myositis ossificans progressiva of Münchmeyer].
 

Author(s): Hicham Sator, Rachida Dafiri, Latifa Chat

Journal:

 

Last Updated: 24 Aug 2015

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Myositis ossificans of the serratus anterior as a rare complication of massage: a case report.
 

Author(s): Jian Wei, Yingwei Jia, Bingsheng Liang

Journal:

 

Myositis ossificans usually occurs in the vicinity of the elbow, knee joints, or hip joints, following obvious trauma or surgery. This is the first report on myositis ossificans of the serratus anterior.

Last Updated: 18 Jun 2015

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Myositis ossificans occupying the thenar region: a case report.
 

Author(s): Tsutomu Akahane, Naoya Mori, Yukio Nakatsuchi

Journal:

 

Myositis ossificans is a benign, self-limiting, tumor-like lesion that usually affects the elbow and thigh; occurrence in the hand is uncommon. We report a rare case of a patient with myositis ossificans in the thenar region.

Last Updated: 12 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Myositis ossificans" returned 1 free, full-text review articles on human participants. First 3 results:

Bilateral myositis ossificans of the masseter muscle after chemoradiotherapy and critical illness neuropathy--report of a rare entity and review of literature.
 

Author(s): Astrid L Kruse, Christine Dannemann, Klaus W Grätz

Journal:

 

Myositis ossificans in the head and neck is a rare heterotropic bone formation within a muscle. Besides fibrodysplasia ossificans progressiva, traumatic and neurogenic forms are described in the literature. We are presenting the case of a 35-year-old female patient with a very rare ...

Last Updated: 21 Aug 2009

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

In-Home Evaluation of Episodic Administration of Palovarotene in Fibrodysplasia Ossificans Progressiva (FOP) Subjects
 

Status: Recruiting

Condition Summary: Fibrodysplasia Ossificans Progressiva

 

Last Updated: 7 Jan 2016

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The Fibrodysplasia Ossificans Progressiva (FOP) Connection Registry
 

Status: Recruiting

Condition Summary: Fibrodysplasia Ossificans Progressiva (FOP)

 

Last Updated: 15 Apr 2016

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A Natural History Study of Fibrodysplasia Ossificans Progressiva (FOP)
 

Status: Recruiting

Condition Summary: Fibrodysplasia Ossificans Progressiva

 

Last Updated: 27 Apr 2016

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