Mycosis fungoides

Common Name(s)

Mycosis fungoides

Mycosis fungoides is a disease in which T-cell lymphocytes (a type of white blood cell) become malignant (cancerous) and affect the skin. This condition is one of the most common types of T-cell lymphoma. Mycosis fungoides is characterized by a scaly, red rash that develops on the skin, particularly on areas that are not usually exposed to the sun. The rash may last for months or years without causing any symptoms. Over time, a thin, reddened, eczema-like rash may develop, followed by thickened, red patches of skin. Finally, tumors form which may develop into ulcers and become infected. Mycosis fungoides is difficult to cure. Treatment is usually palliative, with the intention of relieving symptoms and improving the quality of life.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mycosis fungoides" for support, advocacy or research.

Cutaneous Lymphoma Foundation

The Cutaneous Lymphoma Foundation is an independent, nonprofit patient advocacy organization whose mission is supporting every person with cutaneous lymphoma by promoting awareness and education, advancing patient care and facilitating research.

Last Updated: 6 Jan 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mycosis fungoides" for support, advocacy or research.

Cutaneous Lymphoma Foundation

The Cutaneous Lymphoma Foundation is an independent, nonprofit patient advocacy organization whose mission is supporting every person with cutaneous lymphoma by promoting awareness and education, advancing patient care and facilitating research.

http://www.clfoundation.org

Last Updated: 6 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Mycosis fungoides" returned 245 free, full-text research articles on human participants. First 3 results:

Evaluation of cardiovascular disease risk factors in patients with mycosis fungoides.
 

Author(s): Fatma Pelin Cengiz, Nazan Emiroglu

Journal: An Bras Dermatol. ;90(1):36-40.

 

Mycosis fungoides, the most common subtype of cutaneous T-cell lymphoma, is more common in patients aged 45-55.

Last Updated: 12 Feb 2015

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Allogeneic hematopoietic cell transplantation for mycosis fungoides and Sezary syndrome.
 

Author(s): M J Lechowicz, H M Lazarus, J Carreras, G G Laport, C S Cutler, P H Wiernik, G A Hale, D Maharaj, R P Gale, P A Rowlings, C O Freytes, A M Miller, J M Vose, R T Maziarz, S Montoto, D G Maloney, P N Hari

Journal: Bone Marrow Transplant.. 2014 Nov;49(11):1360-5.

 

We describe outcomes after allogeneic hematopoietic cell transplantation (HCT) for mycosis fungoides and Sezary syndrome (MF/SS). Outcomes of 129 subjects with MF/SS reported to the Center for the International Blood and Marrow Transplant from 2000-2009. Median time from diagnosis ...

Last Updated: 5 Nov 2014

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Thymocyte selection-associated high mobility group box gene (TOX) is aberrantly over-expressed in mycosis fungoides and correlates with poor prognosis.
 

Author(s): Yuanshen Huang, Ivan V Litvinov, Yang Wang, Ming-Wan Su, Ping Tu, Xiaoyan Jiang, Thomas S Kupper, Jan P Dutz, Denis Sasseville, Youwen Zhou

Journal: Oncotarget. 2014 Jun;5(12):4418-25.

 

Mycosis fungoides (MF) often mimics the common chronic inflammatory skin diseases and is difficult to be diagnosed with certainty, partly because of the lack of well-characterized molecular markers. Previously, we discovered that TOX, a key T cell development regulator,was aberrantly ...

Last Updated: 21 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Mycosis fungoides" returned 27 free, full-text review articles on human participants. First 3 results:

New and established treatment options for mycosis fungoides and Sézary syndrome - an update.
 

Author(s): Susanne Dugas-Breit, Hans-Joachim Schulze, Christian Hallermann

Journal: J Dtsch Dermatol Ges. 2014 Jul;12(7):561-9.

 

At the time of diagnosis primary cutaneous lymphomas are limited to the skin. T-cell lymphomas represent at least two thirds of all primary cutaneous lymphomas with mycosis fungoides and Sézary syndrome being the most frequent entities. A precise staging based on clinical, histological, ...

Last Updated: 1 Jul 2014

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A review of survival in mycosis fungoides.
 

Author(s): Robin T Vollmer

Journal: Am. J. Clin. Pathol.. 2014 May;141(5):706-11.

 

The objectives of this study are to review prior publications of survival for patients with mycosis fungoides (MF), to perform some analyses on the consolidated data, and then to consider the implications of the results.

Last Updated: 9 Apr 2014

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Hypopigmented mycosis fungoides: a review of its clinical features and pathophysiology.
 

Author(s): Fabricio Cecanho Furlan, José Antonio Sanches

Journal: An Bras Dermatol. ;88(6):954-60.

 

Several distinct clinical forms of mycosis fungoides have been described. Hypopigmented mycosis fungoides should be regarded as a subtype of mycosis fungoides, insofar as it presents some peculiar characteristics that contrast with the clinical features of the classical form. Most ...

Last Updated: 29 Jan 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pembrolizumab in Treating Patients With Relapsed or Refractory Stage IB-IVB Mycosis Fungoides or Sezary Syndrome
 

Status: Recruiting

Condition Summary: Recurrent Mycosis Fungoides and Sezary Syndrome; Stage IB Mycosis Fungoides and Sezary Syndrome; Stage IIA Mycosis Fungoides and Sezary Syndrome; Stage IIB Mycosis Fungoides and Sezary Syndrome; Stage IIIA Mycosis Fungoides and Sezary Syndrome; Stage IIIB Mycosis Fungoides and Sezary Syndrome; Stage IVA Mycosis Fungoides and Sezary Syndrome; Stage IVB Mycosis Fungoides and Sezary Syndrome

 

Last Updated: 22 Jul 2015

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Study of Alemtuzumab to Treat Advanced Mycosis Fungoides/Sezary Syndrome
 

Status: Recruiting

Condition Summary: Mycosis Fungoides; Sezary Syndrome

 

Last Updated: 2 Apr 2007

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Stem Cell Transplant Therapy With Campath-1H for Treating Advanced Mycosis Fungoides and Sezary Syndrome
 

Status: Recruiting

Condition Summary: Mycosis Fungoides; Sezary Syndrome

 

Last Updated: 6 May 2015

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