Mycosis fungoides

Common Name(s)

Mycosis fungoides

Mycosis fungoides is a disease in which T-cell lymphocytes (a type of white blood cell) become malignant (cancerous) and affect the skin. This condition is one of the most common types of T-cell lymphoma. Mycosis fungoides is characterized by a scaly, red rash that develops on the skin, particularly on areas that are not usually exposed to the sun. The rash may last for months or years without causing any symptoms. Over time, a thin, reddened, eczema-like rash may develop, followed by thickened, red patches of skin. Finally, tumors form which may develop into ulcers and become infected. Mycosis fungoides is difficult to cure. Treatment is usually palliative, with the intention of relieving symptoms and improving the quality of life.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mycosis fungoides" for support, advocacy or research.

Cutaneous Lymphoma Foundation

The Cutaneous Lymphoma Foundation is an independent, nonprofit patient advocacy organization whose mission is supporting every person with cutaneous lymphoma by promoting awareness and education, advancing patient care and facilitating research.

Last Updated: 6 Jan 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mycosis fungoides" for support, advocacy or research.

Cutaneous Lymphoma Foundation

The Cutaneous Lymphoma Foundation is an independent, nonprofit patient advocacy organization whose mission is supporting every person with cutaneous lymphoma by promoting awareness and education, advancing patient care and facilitating research.

http://www.clfoundation.org

Last Updated: 6 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Mycosis fungoides" returned 398 free, full-text research articles on human participants. First 3 results:

The Therapeutic Potential of AN-7, a Novel Histone Deacetylase Inhibitor, for Treatment of Mycosis Fungoides/Sezary Syndrome Alone or with Doxorubicin.
 

Author(s): Lilach Moyal, Nataly Feldbaum, Neta Goldfeiz, Ada Rephaeli, Abraham Nudelman, Michal Weitman, Nataly Tarasenko, Batia Gorovitz, Leah Maron, Shiran Yehezkel, Iris Amitay-Laish, Ido Lubin, Emmilia Hodak

Journal:

 

The 2 histone deacetylase inhibitors (HDACIs) approved for the treatment of cutaneous T-cell lymphoma (CTCL) including mycosis fungoides/sezary syndrome (MF/SS), suberoylanilide hydroxamic acid (SAHA) and romidepsin, are associated with low rates of overall response and high rates ...

Last Updated: 12 Jan 2016

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Granulomatous mycosis fungoides--a diagnostic challenge.
 

Author(s): Catharina Maria Freire de Lucena Pousa, Natália Solon Nery, Danielle Mann, Daniel Lago Obadia, Maria de Fátima Gonçalves Scotelaro Alves

Journal: An Bras Dermatol. ;90(4):554-6.

 

Granulomatous mycosis fungoides is a rare subtype of T-cell cutaneous lymphoma. Due to its clinical heterogenicity the diagnosis is delayed and based on histopathological and immuno-histochemical findings, sometimes requiring gene rearrangement studies for confirmation. We report ...

Last Updated: 17 Sep 2015

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Whole-genome sequencing reveals oncogenic mutations in mycosis fungoides.
 

Author(s): Laura Y McGirt, Peilin Jia, Devin A Baerenwald, Robert J Duszynski, Kimberly B Dahlman, John A Zic, Jeffrey P Zwerner, Donald Hucks, Utpal Dave, Zhongming Zhao, Christine M Eischen

Journal: Blood. 2015 Jul;126(4):508-19.

 

The pathogenesis of mycosis fungoides (MF), the most common cutaneous T-cell lymphoma (CTCL), is unknown. Although genetic alterations have been identified, none are considered consistently causative in MF. To identify potential drivers of MF, we performed whole-genome sequencing ...

Last Updated: 24 Jul 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Mycosis fungoides" returned 33 free, full-text review articles on human participants. First 3 results:

Poikilodermatous mycosis fungoides: clinical and histopathological analysis of a case and literature review.
 

Author(s): Oleg Pankratov, Svetlana Gradova, Svetlana Tarasevich, Valentin Pankratov

Journal: Acta Dermatovenerol Alp Pannonica Adriat. 2015 ;24(2):37-41.

 

Poikilodermatous mycosis fungoides is a rare distinct clinical variant of cutaneous T-cell lymphoma (CTCL), formerly referred to as poikiloderma vasculare atrophicans or parapsoriasis variegata. Mycosis fungoides (MF) is a malignant neoplasm of T-lymphocyte origin, most commonly memory ...

Last Updated: 19 Jun 2015

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Phototherapy for mycosis fungoides.
 

Author(s): Sunil Dogra, Rahul Mahajan

Journal: Indian J Dermatol Venereol Leprol. ;81(2):124-35.

 

Both phototherapy and photochemotherapy have been used in all stages of mycosis fungoides since they improve the symptoms and have a favourable adverse effect profile.

Last Updated: 10 Mar 2015

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New and established treatment options for mycosis fungoides and Sézary syndrome - an update.
 

Author(s): Susanne Dugas-Breit, Hans-Joachim Schulze, Christian Hallermann

Journal: J Dtsch Dermatol Ges. 2014 Jul;12(7):561-9.

 

At the time of diagnosis primary cutaneous lymphomas are limited to the skin. T-cell lymphomas represent at least two thirds of all primary cutaneous lymphomas with mycosis fungoides and Sézary syndrome being the most frequent entities. A precise staging based on clinical, histological, ...

Last Updated: 1 Jul 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Low-Dose Total Skin Electron Therapy in Treating Patients With Refractory or Relapsed Stage IB-IIIA Mycosis Fungoides
 

Status: Recruiting

Condition Summary: Recurrent Mycosis Fungoides; Refractory Mycosis Fungoides; Stage I Mycosis Fungoides; Stage II Mycosis Fungoides; Stage III Mycosis Fungoides

 

Last Updated: 27 Apr 2016

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Study of Alemtuzumab to Treat Advanced Mycosis Fungoides/Sezary Syndrome
 

Status: Recruiting

Condition Summary: Mycosis Fungoides; Sezary Syndrome

 

Last Updated: 2 Apr 2007

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