Myasthenia gravis

Common Name(s)

Myasthenia gravis

Myasthenia gravis (MG) is an autoimmune disease that impacts an affected individual’s control of the skeletal muscles. The condition is typically seen in women below the age of 40, and in men above the age of 60. However, there are cases where MG has developed in individuals of all ages.

Symptoms of this condition may include muscle weakness, drooping eyelids, double vision, difficulty swallowing or eating, trouble talking, being unable to fully control facial expressions, fatigue, and difficulty breathing. The muscle weakness appears to increase after the individual is active, but then improves after rest.

Acetylcholine is a chemical that is normally present in the nervous system and is important for passing messages from the brain to the skeletal muscles. In individuals with MG, the body produces antibodies (proteins that are used to detect harmful agents in the body) which mistakenly attack certain sites that are responsible for receiving the acetylcholine messages. As a result, the symptoms of MG occur since the nervous system cannot communicate properly with the muscles. This response is an example of an autoimmune disease, where the body mistakenly begins attacking itself.

Removal of the thymus gland (an organ that is part of the immune system), blood plasma exchanges (where harmful antibodies are removed), and the use of certain types of medications are all current forms of treatment for MG. Other ways to manage the symptoms may include avoiding stressful situations and getting plenty of rest.

Although there is no cure for MG at this time, there are many treatment options available. Doctors seek help from various therapists and community services to provide support and care for families. Talk with a doctor or specialist if you or someone in your family has been diagnosed with Myasthenia gravis to discuss the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Myasthenia gravis" for support, advocacy or research.

Logo
Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

Last Updated: 15 Jul 2015

View Details
Myasthenia Gravis Foundation of America, Inc.

MGFA is committed to finding a cure for myasthenia gravis and closely related disorders, improving treatment options, and providing information and support to people with myasthenia gravis through research, education, community programs, and advocacy.

Last Updated: 29 Apr 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Myasthenia gravis" for support, advocacy or research.

Logo
Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

http://www.mdausa.org

Last Updated: 15 Jul 2015

View Details
Myasthenia Gravis Foundation of America, Inc.

MGFA is committed to finding a cure for myasthenia gravis and closely related disorders, improving treatment options, and providing information and support to people with myasthenia gravis through research, education, community programs, and advocacy.

http://www.myasthenia.org

Last Updated: 29 Apr 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Myasthenia gravis" returned 1014 free, full-text research articles on human participants. First 3 results:

[Juvenile myasthenia gravis in sub-Saharan Africa: a case study of two consanguine sisters born from consanguinity in Togo].
 

Author(s): Nidain Maneh, Kossivi Apetse, Bénédicte Marèbe Diatewa, Sidik Abou-Bakr Domingo, Aidé Isabelle Agba, Koffi Didier Ayena, Koffi Agnon Balogou, Komi Patrice Balo

Journal:

 

Myasthenia gravis is a rare acquired autoimmune pathology causing neuromuscular transmission impairment. Juvenile onset of myasthenia gravis is often characterized by ocular involvement. We report two cases of ocular juvenile myasthenia gravis (JMG) in two siblings. They were two ...

Last Updated: 31 Dec 1969

Go To URL
Myasthenia Gravis Impairment Index: Responsiveness, meaningful change, and relative efficiency.
 

Author(s): Carolina Barnett, Vera Bril, Moira Kapral, Abhaya V Kulkarni, Aileen M Davis

Journal: Neurology. 2017 Dec;89(23):2357-2364.

 

To study responsiveness and meaningful change of the Myasthenia Gravis Impairment Index (MGII) and its relative efficiency compared to other measures.

Last Updated: 31 Dec 1969

Go To URL
Analysis of peripheral B cells and autoantibodies against the anti-nicotinic acetylcholine receptor derived from patients with myasthenia gravis using single-cell manipulation tools.
 

Author(s): Tomohiro Makino, Ryuichi Nakamura, Maki Terakawa, Satoshi Muneoka, Kazuhiro Nagahira, Yuriko Nagane, Jyoji Yamate, Masakatsu Motomura, Kimiaki Utsugisawa

Journal:

 

The majority of patients with myasthenia gravis (MG), an organ-specific autoimmune disease, harbor autoantibodies that attack the nicotinic acetylcholine receptor (nAChR-Abs) at the neuromuscular junction of skeletal muscles, resulting in muscle weakness. Single cell manipulation ...

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Myasthenia gravis" returned 74 free, full-text review articles on human participants. First 3 results:

New onset of myasthenia gravis after intravesical Bacillus Calmette-Guerin: A case report and literature review.
 

Author(s): Tsubasa Takizawa, Marenori Kojima, Shigeaki Suzuki, Takashi Osada, Satoshi Kitagawa, Jin Nakahara, Shinichi Takahashi, Norihiro Suzuki

Journal: Medicine (Baltimore). 2017 Nov;96(46):e8757.

 

Recently, drug-related myasthenia gravis (MG) has received attention, because the number of reported cases involving MG associated with immune checkpoint inhibitors, a new immunotherapy, is increasing. We present a case involving the new onset of MG, in which the symptoms started ...

Last Updated: 31 Dec 1969

Go To URL
Comorbid Human Immunodeficiency Virus (HIV) and Muscle-Specific Kinase (MuSK) Myasthenia Gravis: A Case Report and Literature Review.
 

Author(s): Michael Sherpa, Ravi K Metai, Viki Kumar, Tinu Hirachan, Kawser U Ahmed, Sharon J Atkinson

Journal:

 

BACKGROUND HIV infections with concomitant immunologically-mediated disorders have been frequently described but there has been little research on the association between HIV and myasthenia gravis. MuSK myasthenia gravis coexisting with HIV is an even a rarer entity and can occur ...

Last Updated: 31 Dec 1969

Go To URL
Minimal change disease in a patient with myasthenia gravis: A case report.
 

Author(s): Jun-Li Tsai, Shang-Feng Tsai

Journal: Medicine (Baltimore). 2016 Sep;95(39):e5008.

 

Myasthenia gravis superimposed with proteinuria is a very rare disorder with only 39 cases reported so far. Of these cases, the most commonly associated disorder is minimal change disease. Myasthenia gravis and minimal change disease are both related to the dysfunction of T lymphocytes ...

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Myasthenia Gravis and Psyche
 

Status: Recruiting

Condition Summary: Myasthenia Gravis

 

Last Updated: 29 Jun 2017

Go to URL

Last Updated: 29 Nov 2017

Go to URL
Safety,Tolerability,Pharmacokinetics and Efficacy of CFZ533 in Moderate to Severe Myasthenia Gravis
 

Status: Recruiting

Condition Summary: Myasthenia Gravis, Generalized

 

Last Updated: 10 Apr 2017

Go to URL