Multiple system atrophy

Common Name(s)

Multiple system atrophy

Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by symptoms of autonomic nervous system failure such as fainting spells and bladder control problems, combined with motor control symptoms such as tremor, rigidity, and loss of muscle coordination.  MSA affects both men and women primarily in their 50s.  The disease tends to advance rapidly over the course of 9 to 10 years, with progressive loss of motor skills, eventual confinement to bed, and death. The cause of multiple system atrophy is unknown, although environmental toxins, trauma, and genetic factors have been suggested.  There is no cure for this condition, and there is no known way to prevent the disease from getting worse. The goal of treatment is to control symptoms.  
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple system atrophy" for support, advocacy or research.

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National MSA Support Group

The MSA Support Group has a four pillar mission statement: 1) To support patients and caregivers 2) To educate patients, caregivers, healthcare providers, and others affected by MSA 3) To raise money for MSA research 4) to advocate and create awareness for MSA

Last Updated: 16 Nov 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple system atrophy" for support, advocacy or research.

Logo
National MSA Support Group

The MSA Support Group has a four pillar mission statement: 1) To support patients and caregivers 2) To educate patients, caregivers, healthcare providers, and others affected by MSA 3) To raise money for MSA research 4) to advocate and create awareness for MSA

http://www.shy-drager.org

Last Updated: 16 Nov 2012

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General Support Organizations

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General Resources

The MSA Research Fund

The MSA Research Fund is the National MSA Support Group's fund dedicated to supporting meaningful MSA research. The Support Group is a 501(c)3 so donations are tax deductible.

Updated 16 Nov 2012

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The MSA Forum

The MSA Forum is hosted by the National MSA Support Group. The forum offers an opportunity for patients and caregivers to communicate and share with others affected by MSA.

Updated 16 Nov 2012

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Blogs

The MSA Blog

The multiple system atrophy MSA) blog is dedicated to providing relevant information about support, education, research and advocacy to those affected by MSA

Updated 16 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Multiple system atrophy" returned 230 free, full-text research articles on human participants. First 3 results:

[1H-proton magnetic resonance spectroscopy in patients with multiple system atrophy and 
cognitive dysfunction].
 

Author(s): Xiaoshuang Xiang, Xuan Hou, Zhanfang Sun, Gaofeng Zhou, Beisha Tang, Hong Jiang

Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2015 Jun;40(6):639-45.

 

To detect metabolic changes of bilateral frontal lobe in patients with multiple system atrophy (MSA) and cognitive dysfunction by 1H-proton magnetic resonance spectroscopy (1H-MRS).


Last Updated: 13 Jul 2015

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Filamentous aggregations of phosphorylated α-synuclein in Schwann cells (Schwann cell cytoplasmic inclusions) in multiple system atrophy.
 

Author(s): Keiko Nakamura, Fumiaki Mori, Tomoya Kon, Kunikazu Tanji, Yasuo Miki, Masahiko Tomiyama, Hidekachi Kurotaki, Yasuko Toyoshima, Akiyoshi Kakita, Hitoshi Takahashi, Masahito Yamada, Koichi Wakabayashi

Journal:

 

The histological hallmark of multiple system atrophy (MSA) is the presence of filamentous aggregations of phosphorylated α-synuclein in oligodendrocytes, referred to as glial cytoplasmic inclusions (GCIs). Although GCIs can occur widely in the central nervous system, accumulation ...

Last Updated: 20 May 2015

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Pain in multiple system atrophy and progressive supranuclear palsy compared to Parkinson's disease.
 

Author(s): Lewis Kass-Iliyya, Christopher Kobylecki, Kathryn R McDonald, Alexander Gerhard, Monty A Silverdale

Journal: Brain Behav. 2015 May;5(5):e00320.

 

Pain is a common nonmotor symptom in Parkinson's disease (PD). The pathophysiology of pain in PD is not well understood. Pain characteristics have rarely been studied in atypical parkinsonian disorders such as Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP).

Last Updated: 19 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Multiple system atrophy" returned 17 free, full-text review articles on human participants. First 3 results:

Cognitive and sleep features of multiple system atrophy: review and prospective study.
 

Author(s): Michelangelo Stanzani-Maserati, Roberto Gallassi, Giovanna Calandra-Buonaura, Maria Alessandria, Federico Oppi, Roberto Poda, Luisa Sambati, Federica Provini, Pietro Cortelli

Journal: Eur. Neurol.. 2014 ;72(5-6):349-59.

 

The profile and degree of cognitive impairment in Multiple System Atrophy (MSA) and the impact of sleep disorders, REM sleep behavior disorder (RBD) in particular, in parkinsonism-related cognitive deficits are currently being debated.

Last Updated: 27 Nov 2014

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Multiple system atrophy as emerging template for accelerated drug discovery in α-synucleinopathies.
 

Author(s): Florian Krismer, Kurt A Jellinger, Sonja W Scholz, Klaus Seppi, Nadia Stefanova, Angelo Antonini, Werner Poewe, Gregor K Wenning

Journal: Parkinsonism Relat. Disord.. 2014 Aug;20(8):793-9.

 

There is evidence that the α-synucleinopathies Parkinson's disease (PD) and the Parkinson variant of multiple system atrophy (MSA-P) overlap at multiple levels. Both disorders are characterized by deposition of abnormally phosphorylated fibrillar α-synuclein within the central nervous ...

Last Updated: 6 Aug 2014

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Cognitive impairment in multiple system atrophy: a position statement by the Neuropsychology Task Force of the MDS Multiple System Atrophy (MODIMSA) study group.
 

Author(s): Iva Stankovic, Florian Krismer, Aleksandar Jesic, Angelo Antonini, Thomas Benke, Richard G Brown, David J Burn, Janice L Holton, Horacio Kaufmann, Vladimir S Kostic, Helen Ling, Wassilios G Meissner, Werner Poewe, Marija Semnic, Klaus Seppi, Atsushi Takeda, Daniel Weintraub, Gregor K Wenning,

Journal: Mov. Disord.. 2014 Jun;29(7):857-67.

 

Consensus diagnostic criteria for multiple system atrophy consider dementia as a nonsupporting feature, despite emerging evidence demonstrating that cognitive impairments are an integral part of the disease. Cognitive disturbances in multiple system atrophy occur across a wide spectrum ...

Last Updated: 13 Jun 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

PET Imaging Study of Neurochemical and Autonomic Disorders in Multiple System Atrophy (MSA)
 

Status: Recruiting

Condition Summary: Multiple System Atrophy - Parkinsonian Subtype (MSA-P); Multiple System Atrophy - Cerebellar Subtype (MSA-C)

 

Last Updated: 15 Jul 2015

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Oligomeric Alpha-synuclein in Multiple System Atrophy
 

Status: Recruiting

Condition Summary: Multiple System Atrophy (MSA)

 

Last Updated: 4 Mar 2015

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Cognitive and Behavioral Dysexecutive Syndrome in Multiple System Atrophy
 

Status: Recruiting

Condition Summary: Multiple System Atrophy

 

Last Updated: 8 Jan 2015

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