Multiple system atrophy

Common Name(s)

Multiple system atrophy

Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by symptoms of autonomic nervous system failure such as fainting spells and bladder control problems, combined with motor control symptoms such as tremor, rigidity, and loss of muscle coordination.  MSA affects both men and women primarily in their 50s.  The disease tends to advance rapidly over the course of 9 to 10 years, with progressive loss of motor skills, eventual confinement to bed, and death. The cause of multiple system atrophy is unknown, although environmental toxins, trauma, and genetic factors have been suggested.  There is no cure for this condition, and there is no known way to prevent the disease from getting worse. The goal of treatment is to control symptoms.  
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple system atrophy" for support, advocacy or research.

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National MSA Support Group

The MSA Support Group has a four pillar mission statement: 1) To support patients and caregivers 2) To educate patients, caregivers, healthcare providers, and others affected by MSA 3) To raise money for MSA research 4) to advocate and create awareness for MSA

Last Updated: 16 Nov 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple system atrophy" for support, advocacy or research.

Logo
National MSA Support Group

The MSA Support Group has a four pillar mission statement: 1) To support patients and caregivers 2) To educate patients, caregivers, healthcare providers, and others affected by MSA 3) To raise money for MSA research 4) to advocate and create awareness for MSA

http://www.shy-drager.org

Last Updated: 16 Nov 2012

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General Support Organizations

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General Resources

The MSA Research Fund

The MSA Research Fund is the National MSA Support Group's fund dedicated to supporting meaningful MSA research. The Support Group is a 501(c)3 so donations are tax deductible.

Updated 16 Nov 2012

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The MSA Forum

The MSA Forum is hosted by the National MSA Support Group. The forum offers an opportunity for patients and caregivers to communicate and share with others affected by MSA.

Updated 16 Nov 2012

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Blogs

The MSA Blog

The multiple system atrophy MSA) blog is dedicated to providing relevant information about support, education, research and advocacy to those affected by MSA

Updated 16 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Multiple system atrophy" returned 250 free, full-text research articles on human participants. First 3 results:

Coenzyme Q10 Levels Are Decreased in the Cerebellum of Multiple-System Atrophy Patients.
 

Author(s): Lucia V Schottlaender, Conceição Bettencourt, Aoife P Kiely, Annapurna Chalasani, Viruna Neergheen, Janice L Holton, Iain Hargreaves, Henry Houlden

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The objective of this study was to evaluate whether the levels of coenzyme Q10 (CoQ10) in brain tissue of multiple system atrophy (MSA) patients differ from those in elderly controls and in patients with other neurodegenerative diseases.

Last Updated: 20 Feb 2016

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Serum Levels of Coenzyme Q10 in Patients with Multiple System Atrophy.
 

Author(s): Takashi Kasai, Takahiko Tokuda, Takuma Ohmichi, Ryotaro Ishii, Harutsugu Tatebe, Masanori Nakagawa, Toshiki Mizuno

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The COQ2 gene encodes an essential enzyme for biogenesis, coenzyme Q10 (CoQ10). Recessive mutations in this gene have recently been identified in families with multiple system atrophy (MSA). Moreover, specific heterozygous variants in the COQ2 gene have also been reported to confer ...

Last Updated: 27 Jan 2016

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Involvement of Peripheral Nerves in the Transgenic PLP-α-Syn Model of Multiple System Atrophy: Extending the Phenotype.
 

Author(s): Daniela Kuzdas-Wood, Regina Irschick, Markus Theurl, Philipp Malsch, Norbert Mair, Christine Mantinger, Julia Wanschitz, Lars Klimaschewski, Werner Poewe, Nadia Stefanova, Gregor K Wenning

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Multiple system atrophy (MSA) is a fatal, rapidly progressive neurodegenerative disease with (oligodendro-)glial cytoplasmic α-synuclein (α-syn) inclusions (GCIs). Peripheral neuropathies have been reported in up to 40% of MSA patients, the cause remaining unclear. In a transgenic ...

Last Updated: 27 Oct 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Multiple system atrophy" returned 21 free, full-text review articles on human participants. First 3 results:

Optimizing clinical trial design for multiple system atrophy: lessons from the rifampicin study.
 

Author(s): Wolfgang Singer, Phillip A Low

Journal: Clin. Auton. Res.. 2015 Feb;25(1):47-52.

 

Multiple system atrophy (MSA) is a fatal neurodegenerative disorder characterized by autonomic failure and parkinsonism/ataxia; no treatment exists to slow disease progression. A number of factors have prevented or compromised trials targeting disease modification. A major hurdle ...

Last Updated: 21 Apr 2015

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Prevalence of REM sleep behavior disorder in multiple system atrophy: a multicenter study and meta-analysis.
 

Author(s): Jose-Alberto Palma, Clara Fernandez-Cordon, Elizabeth A Coon, Phillip A Low, Mitchell G Miglis, Safwan Jaradeh, Arijit K Bhaumik, Praveen Dayalu, Elena Urrestarazu, Jorge Iriarte, Italo Biaggioni, Horacio Kaufmann

Journal: Clin. Auton. Res.. 2015 Feb;25(1):69-75.

 

Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia frequently affecting patients with synucleinopathies, but its exact prevalence in multiple system atrophy (MSA) is unclear. Whether questionnaires alone are sufficient to diagnose RBD is also unknown.

Last Updated: 21 Apr 2015

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Cognitive and sleep features of multiple system atrophy: review and prospective study.
 

Author(s): Michelangelo Stanzani-Maserati, Roberto Gallassi, Giovanna Calandra-Buonaura, Maria Alessandria, Federico Oppi, Roberto Poda, Luisa Sambati, Federica Provini, Pietro Cortelli

Journal: Eur. Neurol.. 2014 ;72(5-6):349-59.

 

The profile and degree of cognitive impairment in Multiple System Atrophy (MSA) and the impact of sleep disorders, REM sleep behavior disorder (RBD) in particular, in parkinsonism-related cognitive deficits are currently being debated.

Last Updated: 27 Nov 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Oligomeric Alpha-synuclein in Multiple System Atrophy
 

Status: Recruiting

Condition Summary: Multiple System Atrophy (MSA)

 

Last Updated: 4 Mar 2015

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Cognitive and Behavioral Dysexecutive Syndrome in Multiple System Atrophy
 

Status: Recruiting

Condition Summary: Multiple System Atrophy

 

Last Updated: 8 Jan 2015

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Last Updated: 13 Jan 2015

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