Multiple system atrophy

Common Name(s)

Multiple system atrophy

Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by symptoms of autonomic nervous system failure such as fainting spells and bladder control problems, combined with motor control symptoms such as tremor, rigidity, and loss of muscle coordination.  MSA affects both men and women primarily in their 50s.  The disease tends to advance rapidly over the course of 9 to 10 years, with progressive loss of motor skills, eventual confinement to bed, and death. The cause of multiple system atrophy is unknown, although environmental toxins, trauma, and genetic factors have been suggested.  There is no cure for this condition, and there is no known way to prevent the disease from getting worse. The goal of treatment is to control symptoms.  
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple system atrophy" for support, advocacy or research.

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National MSA Support Group

The MSA Support Group has a four pillar mission statement: 1) To support patients and caregivers 2) To educate patients, caregivers, healthcare providers, and others affected by MSA 3) To raise money for MSA research 4) to advocate and create awareness for MSA

Last Updated: 16 Nov 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple system atrophy" for support, advocacy or research.

Logo
National MSA Support Group

The MSA Support Group has a four pillar mission statement: 1) To support patients and caregivers 2) To educate patients, caregivers, healthcare providers, and others affected by MSA 3) To raise money for MSA research 4) to advocate and create awareness for MSA

http://www.shy-drager.org

Last Updated: 16 Nov 2012

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General Support Organizations

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General Resources

The MSA Research Fund

The MSA Research Fund is the National MSA Support Group's fund dedicated to supporting meaningful MSA research. The Support Group is a 501(c)3 so donations are tax deductible.

Updated 16 Nov 2012

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The MSA Forum

The MSA Forum is hosted by the National MSA Support Group. The forum offers an opportunity for patients and caregivers to communicate and share with others affected by MSA.

Updated 16 Nov 2012

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Blogs

The MSA Blog

The multiple system atrophy MSA) blog is dedicated to providing relevant information about support, education, research and advocacy to those affected by MSA

Updated 16 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Multiple system atrophy" returned 237 free, full-text research articles on human participants. First 3 results:

Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism.
 

Author(s): Stanley B Prusiner, Amanda L Woerman, Daniel A Mordes, Joel C Watts, Ryan Rampersaud, David B Berry, Smita Patel, Abby Oehler, Jennifer K Lowe, Stephanie N Kravitz, Daniel H Geschwind, David V Glidden, Glenda M Halliday, Lefkos T Middleton, Steve M Gentleman, Lea T Grinberg, Kurt Giles

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2015 Sep;112(38):E5308-17.

 

Prions are proteins that adopt alternative conformations that become self-propagating; the PrP(Sc) prion causes the rare human disorder Creutzfeldt-Jakob disease (CJD). We report here that multiple system atrophy (MSA) is caused by a different human prion composed of the α-synuclein ...

Last Updated: 23 Sep 2015

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Dynamic Cerebrospinal Fluid Flow on MRI in Cortical Cerebellar Atrophy and Multiple System Atrophy-cerebellar Type.
 

Author(s): Yusuke Fukui, Nozomi Hishikawa, Kota Sato, Syoichiro Kono, Kosuke Matsuzono, Yumiko Nakano, Yasuyuki Ohta, Toru Yamashita, Kentaro Deguchi, Koji Abe

Journal: Intern. Med.. 2015 ;54(14):1717-23.

 

The purpose of this study was to examine a new MRI technology, dynamic cerebrospinal fluid (CSF) flow, to examine sporadic cerebellar ataxia patients with cortical cerebellar atrophy (CCA) and multiple system atrophy-cerebellar type (MSA-C).

Last Updated: 16 Jul 2015

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[1H-proton magnetic resonance spectroscopy in patients with multiple system atrophy and 
cognitive dysfunction].
 

Author(s): Xiaoshuang Xiang, Xuan Hou, Zhanfang Sun, Gaofeng Zhou, Beisha Tang, Hong Jiang

Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2015 Jun;40(6):639-45.

 

To detect metabolic changes of bilateral frontal lobe in patients with multiple system atrophy (MSA) and cognitive dysfunction by 1H-proton magnetic resonance spectroscopy (1H-MRS).


Last Updated: 13 Jul 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Multiple system atrophy" returned 21 free, full-text review articles on human participants. First 3 results:

Optimizing clinical trial design for multiple system atrophy: lessons from the rifampicin study.
 

Author(s): Wolfgang Singer, Phillip A Low

Journal: Clin. Auton. Res.. 2015 Feb;25(1):47-52.

 

Multiple system atrophy (MSA) is a fatal neurodegenerative disorder characterized by autonomic failure and parkinsonism/ataxia; no treatment exists to slow disease progression. A number of factors have prevented or compromised trials targeting disease modification. A major hurdle ...

Last Updated: 21 Apr 2015

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Prevalence of REM sleep behavior disorder in multiple system atrophy: a multicenter study and meta-analysis.
 

Author(s): Jose-Alberto Palma, Clara Fernandez-Cordon, Elizabeth A Coon, Phillip A Low, Mitchell G Miglis, Safwan Jaradeh, Arijit K Bhaumik, Praveen Dayalu, Elena Urrestarazu, Jorge Iriarte, Italo Biaggioni, Horacio Kaufmann

Journal: Clin. Auton. Res.. 2015 Feb;25(1):69-75.

 

Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia frequently affecting patients with synucleinopathies, but its exact prevalence in multiple system atrophy (MSA) is unclear. Whether questionnaires alone are sufficient to diagnose RBD is also unknown.

Last Updated: 21 Apr 2015

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Cognitive and sleep features of multiple system atrophy: review and prospective study.
 

Author(s): Michelangelo Stanzani-Maserati, Roberto Gallassi, Giovanna Calandra-Buonaura, Maria Alessandria, Federico Oppi, Roberto Poda, Luisa Sambati, Federica Provini, Pietro Cortelli

Journal: Eur. Neurol.. 2014 ;72(5-6):349-59.

 

The profile and degree of cognitive impairment in Multiple System Atrophy (MSA) and the impact of sleep disorders, REM sleep behavior disorder (RBD) in particular, in parkinsonism-related cognitive deficits are currently being debated.

Last Updated: 27 Nov 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

PET Imaging Study of Neurochemical and Autonomic Disorders in Multiple System Atrophy (MSA)
 

Status: Recruiting

Condition Summary: Multiple System Atrophy - Parkinsonian Subtype (MSA-P); Multiple System Atrophy - Cerebellar Subtype (MSA-C)

 

Last Updated: 15 Jul 2015

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Oligomeric Alpha-synuclein in Multiple System Atrophy
 

Status: Recruiting

Condition Summary: Multiple System Atrophy (MSA)

 

Last Updated: 4 Mar 2015

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Cognitive and Behavioral Dysexecutive Syndrome in Multiple System Atrophy
 

Status: Recruiting

Condition Summary: Multiple System Atrophy

 

Last Updated: 8 Jan 2015

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