Multiple system atrophy

Common Name(s)

Multiple system atrophy

Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by symptoms of autonomic nervous system failure such as fainting spells and bladder control problems, combined with motor control symptoms such as tremor, rigidity, and loss of muscle coordination.  MSA affects both men and women primarily in their 50s.  The disease tends to advance rapidly over the course of 9 to 10 years, with progressive loss of motor skills, eventual confinement to bed, and death. The cause of multiple system atrophy is unknown, although environmental toxins, trauma, and genetic factors have been suggested.  There is no cure for this condition, and there is no known way to prevent the disease from getting worse. The goal of treatment is to control symptoms.  
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple system atrophy" for support, advocacy or research.

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National MSA Support Group

The MSA Support Group has a four pillar mission statement: 1) To support patients and caregivers 2) To educate patients, caregivers, healthcare providers, and others affected by MSA 3) To raise money for MSA research 4) to advocate and create awareness for MSA

Last Updated: 16 Nov 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple system atrophy" for support, advocacy or research.

Logo
National MSA Support Group

The MSA Support Group has a four pillar mission statement: 1) To support patients and caregivers 2) To educate patients, caregivers, healthcare providers, and others affected by MSA 3) To raise money for MSA research 4) to advocate and create awareness for MSA

http://www.shy-drager.org

Last Updated: 16 Nov 2012

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General Support Organizations

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General Resources

The MSA Research Fund

The MSA Research Fund is the National MSA Support Group's fund dedicated to supporting meaningful MSA research. The Support Group is a 501(c)3 so donations are tax deductible.

Updated 16 Nov 2012

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The MSA Forum

The MSA Forum is hosted by the National MSA Support Group. The forum offers an opportunity for patients and caregivers to communicate and share with others affected by MSA.

Updated 16 Nov 2012

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Blogs

The MSA Blog

The multiple system atrophy MSA) blog is dedicated to providing relevant information about support, education, research and advocacy to those affected by MSA

Updated 16 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Multiple system atrophy" returned 202 free, full-text research articles on human participants. First 3 results:

Multiple-system atrophy.
 

Author(s): Alessandra Fanciulli, Gregor K Wenning

Journal: N. Engl. J. Med.. 2015 Apr;372(14):1375-6.

 

Last Updated: 2 Apr 2015

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LRRK2 exonic variants and risk of multiple system atrophy.
 

Author(s): Michael G Heckman, Lucia Schottlaender, Alexandra I Soto-Ortolaza, Nancy N Diehl, Sruti Rayaprolu, Kotaro Ogaki, Shinsuke Fujioka, Melissa E Murray, William P Cheshire, Ryan J Uitti, Zbigniew K Wszolek, Matthew J Farrer, Anna Sailer, Andrew B Singleton, Patrick F Chinnery, Michael J Keogh, Steve M Gentleman, Janice L Holton, Kiely Aoife, David M A Mann, Safa Al-Sarraj, Claire Troakes, Dennis W Dickson, Henry Houlden, Owen A Ross

Journal: Neurology. 2014 Dec;83(24):2256-61.

 

The aim of this study was to evaluate the association between common exonic variants in the leucine-rich repeat kinase 2 (LRRK2) gene and risk of multiple system atrophy (MSA).

Last Updated: 9 Dec 2014

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Analysis of COQ2 gene in multiple system atrophy.
 

Author(s): Kotaro Ogaki, Shinsuke Fujioka, Michael G Heckman, Sruti Rayaprolu, Alexandra I Soto-Ortolaza, Catherine Labbé, Ronald L Walton, Oswaldo Lorenzo-Betancor, Xue Wang, Yan Asmann, Rosa Rademakers, Neill Graff-Radford, Ryan Uitti, William P Cheshire, Zbigniew K Wszolek, Dennis W Dickson, Owen A Ross

Journal:

 

Loss of function COQ2 mutations results in primary CoQ10 deficiency. Recently, recessive mutations of the COQ2 gene have been identified in two unrelated Japanese families with multiple system atrophy (MSA). It has also been proposed that specific heterozygous variants in the COQ2 ...

Last Updated: 14 Nov 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Multiple system atrophy" returned 13 free, full-text review articles on human participants. First 3 results:

Cognitive impairment in multiple system atrophy: a position statement by the Neuropsychology Task Force of the MDS Multiple System Atrophy (MODIMSA) study group.
 

Author(s): Iva Stankovic, Florian Krismer, Aleksandar Jesic, Angelo Antonini, Thomas Benke, Richard G Brown, David J Burn, Janice L Holton, Horacio Kaufmann, Vladimir S Kostic, Helen Ling, Wassilios G Meissner, Werner Poewe, Marija Semnic, Klaus Seppi, Atsushi Takeda, Daniel Weintraub, Gregor K Wenning,

Journal: Mov. Disord.. 2014 Jun;29(7):857-67.

 

Consensus diagnostic criteria for multiple system atrophy consider dementia as a nonsupporting feature, despite emerging evidence demonstrating that cognitive impairments are an integral part of the disease. Cognitive disturbances in multiple system atrophy occur across a wide spectrum ...

Last Updated: 13 Jun 2014

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Towards translational therapies for multiple system atrophy.
 

Author(s): Daniela Kuzdas-Wood, Nadia Stefanova, Kurt A Jellinger, Klaus Seppi, Michael G Schlossmacher, Werner Poewe, Gregor K Wenning

Journal: Prog. Neurobiol.. 2014 Jul;118():19-35.

 

Multiple system atrophy (MSA) is a fatal adult-onset neurodegenerative disorder of uncertain etiopathogenesis manifesting with autonomic failure, parkinsonism, and ataxia in any combination. The underlying neuropathology affects central autonomic, striatonigral and olivopontocerebellar ...

Last Updated: 9 Jun 2014

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Lipid dysfunction and pathogenesis of multiple system atrophy.
 

Author(s): Jonathan M Bleasel, Joanna H Wong, Glenda M Halliday, Woojin Scott Kim

Journal:

 

Multiple system atrophy (MSA) is a progressive neurodegenerative disease characterized by the accumulation of α-synuclein protein in the cytoplasm of oligodendrocytes, the myelin-producing support cells of the central nervous system (CNS). The brain is the most lipid-rich organ in ...

Last Updated: 13 Feb 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

PET Imaging Study of Neurochemical and Autonomic Disorders in Multiple System Atrophy (MSA)
 

Status: Recruiting

Condition Summary: Multiple System Atrophy - Parkinsonian Subtype (MSA-P); Multiple System Atrophy - Cerebellar Subtype (MSA-C)

 

Last Updated: 23 May 2014

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Oligomeric Alpha-synuclein in Multiple System Atrophy
 

Status: Recruiting

Condition Summary: Multiple System Atrophy (MSA)

 

Last Updated: 4 Mar 2015

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Cognitive and Behavioral Dysexecutive Syndrome in Multiple System Atrophy
 

Status: Recruiting

Condition Summary: Multiple System Atrophy

 

Last Updated: 8 Jan 2015

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