Multiple sclerosis

Common Name(s)

Multiple sclerosis, MS

Multiple sclerosis (MS) is an autoimmune disorder that causes damage to the body’s central nervous system (CNS). In a person with MS, the immune system attacks part of the body, specifically myelin, mistaking it for something foreign (from outside the body). Myelin is a fatty substance that covers and protects the nerves. When myelin is damaged, the brain cannot send signals and communicate with the rest of the body. The symptoms depend on the location of the nerves which have damaged myelin. Symptoms may include numbness or weakness in the limbs, partial or complete loss of vision, pain in the body, electric-shock sensations with certain neck movements, lack of coordination, slurred speech, fatigue, dizziness, and problems with the bowel and bladder.

Many people with MS have periods of new symptoms (relapse) that are then followed by periods of improvement in symptoms (remission). This form of MS, which is the most common form, is called relapsing-remitting course. The exact cause of MS is unknown. Researchers believe genetics and environmental factors, such as smoking, diet, or infections during childhood, may play a role.

In order to diagnose this condition, your doctor will take a detailed medical history and perform a physical examination. Your doctor may also perform various tests, such as blood tests, imaging tests, or collect fluid from your spine (spinal tap) to both rule out other conditions and find evidence of MS. Although there is no cure for MS, there are medications and therapies available to help control the symptoms and slow the progression. Talk with your doctor to decide which treatment plan is best for you. Support groups are also a good resource for support and additional information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple sclerosis" for support, advocacy or research.

Logo
Multiple Sclerosis Association of America

MSAA's mission is to enrich the quality of life for everyone affected by multiple sclerosis. MSAA also serves to promote greater understanding of multiple sclerosis and the diverse needs and challenges of people with MS.

Last Updated: 5 May 2015

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Multiple Sclerosis Foundation

The mission of the Multiple Sclerosis Foundation, Inc. is to provide programs and support services to those persons affected by MS that help them maintain their health, safety, self-sufficiency, and personal well-being; and to heighten public awareness of multiple sclerosis in order to elicit financial support for the MSF’s programs and services and promote understanding for those diagnosed with the illness.

Last Updated: 5 May 2015

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National Multiple Sclerosis Society

The mission of the National Multiple Sclerosis Society is to mobilize people and resources so everyone affected by MS can live their best lives as we stop MS in its tracks, restore what has been lost, and end MS forever. Our vision is a world free of MS.

Last Updated: 20 Jun 2016

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APS Foundation of America, Inc.

The APS Foundation of America, Inc. is dedicated to fostering and facilitating joint efforts in the areas of education, public awareness, research and patient services in an effective and ethical manner.

Last Updated: 12 Aug 2013

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Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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The Myelin Project

We are an international 501(c)(3) non-profit organization funding medical research and raising awareness for rare brain diseases.

Last Updated: 13 Nov 2012

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United Spinal Association

United Spinal Association’s mission is to improve the quality of life of all people living with spinal cord injuries and disorders (SCI/D). United Spinal never loses sight of our founders' grassroots efforts to provide a voice to the disability community and to transform the public’s perception of wheelchair users. Now the largest non-profit organization dedicated to helping people living with SCI/D, United Spinal is committed to providing active-lifestyle information, peer support and advocacy that empowers individuals to achieve their highest potential in all facets of life.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple sclerosis" for support, advocacy or research.

Logo
Multiple Sclerosis Association of America

MSAA's mission is to enrich the quality of life for everyone affected by multiple sclerosis. MSAA also serves to promote greater understanding of multiple sclerosis and the diverse needs and challenges of people with MS.

http://www.msassociation.org

Last Updated: 5 May 2015

View Details
Multiple Sclerosis Foundation

The mission of the Multiple Sclerosis Foundation, Inc. is to provide programs and support services to those persons affected by MS that help them maintain their health, safety, self-sufficiency, and personal well-being; and to heighten public awareness of multiple sclerosis in order to elicit financial support for the MSF’s programs and services and promote understanding for those diagnosed with the illness.

http://www.msfocus.org

Last Updated: 5 May 2015

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National Multiple Sclerosis Society

The mission of the National Multiple Sclerosis Society is to mobilize people and resources so everyone affected by MS can live their best lives as we stop MS in its tracks, restore what has been lost, and end MS forever. Our vision is a world free of MS.

https://www.nationalmssociety.org

Last Updated: 20 Jun 2016

View Details
APS Foundation of America, Inc.

The APS Foundation of America, Inc. is dedicated to fostering and facilitating joint efforts in the areas of education, public awareness, research and patient services in an effective and ethical manner.

http://www.apsfa.org

Last Updated: 12 Aug 2013

View Details
Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

View Details
HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

View Details
The Myelin Project

We are an international 501(c)(3) non-profit organization funding medical research and raising awareness for rare brain diseases.

http://www.myelin.org

Last Updated: 13 Nov 2012

View Details
United Spinal Association

United Spinal Association’s mission is to improve the quality of life of all people living with spinal cord injuries and disorders (SCI/D). United Spinal never loses sight of our founders' grassroots efforts to provide a voice to the disability community and to transform the public’s perception of wheelchair users. Now the largest non-profit organization dedicated to helping people living with SCI/D, United Spinal is committed to providing active-lifestyle information, peer support and advocacy that empowers individuals to achieve their highest potential in all facets of life.

http://www.unitedspinal.org

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

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General Resources

Resources for People Living with MS & Their Families

Family Matters, Library & Educational Programs, Find Support, Insurance & Financial Information, Living with Advanced MS, Employment, Resources for Specific Populations, Find Programs & Services in Your Area

Updated 20 Jun 2016

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Resources for People Living with MS & Their Families

Family Matters, Library & Educational Programs, Find Support, Insurance & Financial Information, Living with Advanced MS, Employment, Resources for Specific Populations, Find Programs & Services in Your Area

Updated 20 Jun 2016

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Multiple sclerosis" returned 5095 free, full-text research articles on human participants. First 3 results:

Patient-reported outcomes and survival in multiple sclerosis: A 10-year retrospective cohort study using the Multiple Sclerosis Impact Scale-29.
 

Author(s): Joel Raffel, Alison Wallace, Djordje Gveric, Richard Reynolds, Tim Friede, Richard Nicholas

Journal:

 

There is increasing emphasis on using patient-reported outcomes (PROs) to complement traditional clinical outcomes in medical research, including in multiple sclerosis (MS). Research, particularly in oncology and heart failure, has shown that PROs can be prognostic of hard clinical ...

Last Updated: 10 Jul 2017

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Is there a relationship between narcolepsy, multiple sclerosis and HLA-DQB1*06:02?
 

Author(s): Paulo José Lorenzoni, Lineu Cesar Werneck, Ana Christina de Souza Crippa, Alessandra Zanatta, Cláudia S Kamoi Kay, Carlos Eduardo S Silvado, Rosana Herminia Scola

Journal: Arq Neuropsiquiatr. 2017 Jun;75(6):345-348.

 

We studied multiple sclerosis (MS) patients with the HLA-DQB1*06:02 allele and compared them with MS patients who did not carry the HLA-DQB1*06:02 allele. We analyzed clinical and neurophysiological criteria for narcolepsy in six MS patients with HLA-DQB1*06:02, compared with 12 MS ...

Last Updated: 28 Jun 2017

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Effect of high-dose simvastatin on cognitive, neuropsychiatric, and health-related quality-of-life measures in secondary progressive multiple sclerosis: secondary analyses from the MS-STAT randomised, placebo-controlled trial.
 

Author(s): Dennis Chan, Sophie Binks, Jennifer M Nicholas, Chris Frost, M Jorge Cardoso, Sebastien Ourselin, David Wilkie, Richard Nicholas, Jeremy Chataway

Journal: Lancet Neurol. 2017 Aug;16(8):591-600.

 

In the 24-month MS-STAT phase 2 trial, we showed that high-dose simvastatin significantly reduced the annualised rate of whole brain atrophy in patients with secondary progressive multiple sclerosis (SPMS). We now describe the results of the MS-STAT cognitive substudy, in which we ...

Last Updated: 10 Jun 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Multiple sclerosis" returned 789 free, full-text review articles on human participants. First 3 results:

Benign multiple sclerosis: aspects of cognition and neuroimaging.
 

Author(s): Alyne Mendonça Marques Ton, Claudia Cristina Ferreira Vasconcelos, Regina Maria Papais Alvarenga

Journal: Arq Neuropsiquiatr. 2017 Jun;75(6):394-401.

 

The existence of a benign multiple sclerosis (BMS) form is a controversial subject. Recent studies of these patients reveal different levels of cognitive impairment, despite the apparent preservation of motor function. The objective of this study was to review and analyze a number ...

Last Updated: 28 Jun 2017

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Does the Gut Microbiota Influence Immunity and Inflammation in Multiple Sclerosis Pathophysiology?
 

Author(s): Monika Adamczyk-Sowa, Aldona Medrek, Paulina Madej, Wirginia Michlicka, Pawel Dobrakowski

Journal: J Immunol Res. 2017 ;2017():7904821.

 

Aim. Evaluation of the impact of gut microflora on the pathophysiology of MS. Results. The etiopathogenesis of MS is not fully known. Gut microbiota may be of a great importance in the pathogenesis of MS, since recent findings suggest that substitutions of certain microbial population ...

Last Updated: 20 Mar 2017

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Effect of rhythmic auditory stimulation on gait kinematic parameters of patients with multiple sclerosis.
 

Author(s): M Shahraki, M Sohrabi, H R Taheri Torbati, K Nikkhah, M NaeimiKia

Journal: J Med Life. ;10(1):33-37.

 

Purpose: This study aimed to examine the effect of rhythmic auditory stimulation on gait kinematic parameters of patients with multiple sclerosis. Subjects and Methods: In this study, 18 subjects, comprising 4 males and 14 females with Multiple Sclerosis with expanded disability status ...

Last Updated: 3 Mar 2017

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase 2 Study of Ublituximab in Patients With Relapsing Forms of Multiple Sclerosis
 

Status: Recruiting

Condition Summary: Multiple Sclerosis

 

Last Updated: 9 Jan 2017

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A Study of NeuroVax™, a Novel Therapeutic TCR Peptide Vaccine for Pediatric Multiple Sclerosis
 

Status: Not yet recruiting

Condition Summary: Multiple Sclerosis

 

Last Updated: 22 Feb 2016

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