Multiple Sclerosis

Common Name(s)

Multiple Sclerosis

Multiple sclerosis (MS) is a disorder that affects the central nervous system (CNS), specifically the brain and spinal cord.  A fatty tissue called myelin surrounds and protects the nerve fibers of the CNS.  Myelin insulates the nerves and allows them to transmit electrical impulses from the brain to other parts of the body.  In MS, myelin is lost in multiple areas, and sometimes the nerve fiber itself is damaged or broken.  When myelin or the nerve fiber is destroyed or damaged, the nerveÕs ability to conduct electrical impulses to and from the brain is disrupted; therefore, nerve signals cannot be transmitted.  The disruption of the electrical impulses causes the symptoms associated with MS.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple Sclerosis" for support, advocacy or research.

APS Foundation of America, Inc.

The APS Foundation of America, Inc. is dedicated to fostering and facilitating joint efforts in the areas of education, public awareness, research and patient services in an effective and ethical manner.

Last Updated: 12 Aug 2013

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Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2013

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 3 Oct 2013

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Multiple Sclerosis Association of America

MSAA's mission is to enrich the quality of life for everyone affected by multiple sclerosis. MSAA also serves to promote greater understanding of multiple sclerosis and the diverse needs and challenges of people with MS.

Last Updated: 13 Feb 2013

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Multiple Sclerosis Foundation

The mission of the Multiple Sclerosis Foundation, Inc. is to provide programs and support services to those persons affected by MS that help them maintain their health, safety, self-sufficiency, and personal well-being; and to heighten public awareness of multiple sclerosis in order to elicit financial support for the MSF’s programs and services and promote understanding for those diagnosed with the illness.

Last Updated: 25 Mar 2013

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National Multiple Sclerosis Society

To end the devastating effects of MS

Last Updated: 24 Nov 2009

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The Myelin Project

We are an international 501(c)(3) non-profit organization funding medical research and raising awareness for rare brain diseases.

Last Updated: 13 Nov 2012

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United Spinal Association

United Spinal Association’s mission is to improve the quality of life of all people living with spinal cord injuries and disorders (SCI/D). United Spinal never loses sight of our founders' grassroots efforts to provide a voice to the disability community and to transform the public’s perception of wheelchair users. Now the largest non-profit organization dedicated to helping people living with SCI/D, United Spinal is committed to providing active-lifestyle information, peer support and advocacy that empowers individuals to achieve their highest potential in all facets of life.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple Sclerosis" for support, advocacy or research.

APS Foundation of America, Inc.

The APS Foundation of America, Inc. is dedicated to fostering and facilitating joint efforts in the areas of education, public awareness, research and patient services in an effective and ethical manner.

http://www.apsfa.org

Last Updated: 12 Aug 2013

View Details
Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2013

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 3 Oct 2013

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Multiple Sclerosis Association of America

MSAA's mission is to enrich the quality of life for everyone affected by multiple sclerosis. MSAA also serves to promote greater understanding of multiple sclerosis and the diverse needs and challenges of people with MS.

http://www.msassociation.org

Last Updated: 13 Feb 2013

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Multiple Sclerosis Foundation

The mission of the Multiple Sclerosis Foundation, Inc. is to provide programs and support services to those persons affected by MS that help them maintain their health, safety, self-sufficiency, and personal well-being; and to heighten public awareness of multiple sclerosis in order to elicit financial support for the MSF’s programs and services and promote understanding for those diagnosed with the illness.

http://www.msfocus.org

Last Updated: 25 Mar 2013

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National Multiple Sclerosis Society

To end the devastating effects of MS

http://www.nmss.org

Last Updated: 24 Nov 2009

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The Myelin Project

We are an international 501(c)(3) non-profit organization funding medical research and raising awareness for rare brain diseases.

http://www.myelin.org

Last Updated: 13 Nov 2012

View Details
United Spinal Association

United Spinal Association’s mission is to improve the quality of life of all people living with spinal cord injuries and disorders (SCI/D). United Spinal never loses sight of our founders' grassroots efforts to provide a voice to the disability community and to transform the public’s perception of wheelchair users. Now the largest non-profit organization dedicated to helping people living with SCI/D, United Spinal is committed to providing active-lifestyle information, peer support and advocacy that empowers individuals to achieve their highest potential in all facets of life.

http://www.unitedspinal.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Multiple Sclerosis" returned 3800 free, full-text research articles on human participants. First 3 results:

Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial.
 

Author(s): Jeremy Chataway, Nadine Schuerer, Ali Alsanousi, Dennis Chan, David MacManus, Kelvin Hunter, Val Anderson, Charles R M Bangham, Shona Clegg, Casper Nielsen, Nick C Fox, David Wilkie, Jennifer M Nicholas, Virginia L Calder, John Greenwood, Chris Frost, Richard Nicholas

Journal: Lancet. 2014 Jun;383(9936):2213-21.

 

Secondary progressive multiple sclerosis, for which no satisfactory treatment presently exists, accounts for most of the disability in patients with multiple sclerosis. Simvastatin, which is widely used for treatment of vascular disease, with its excellent safety profile, has immunomodulatory ...

Last Updated: 30 Jun 2014

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Modifying disability in progressive multiple sclerosis.
 

Author(s): Jacqueline Palace, Neil Robertson

Journal: Lancet. 2014 Jun;383(9936):2189-91.

 

Last Updated: 30 Jun 2014

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[Development of a computer-aided diagnostic system for detecting multiple sclerosis using magnetic resonance images].
 

Author(s): Susumu Tachinaga, Yuuki Hiura, Ikuo Kawashita, Yasuhiko Okura, Takayuki Ishida

Journal: Nihon Hoshasen Gijutsu Gakkai Zasshi. 2014 Mar;70(3):223-9.

 

It is of key importance to be able to evaluate the temporal changes seen in multiple sclerosis (MS) lesions in terms of location, shape, and area for estimating MS progression. The purpose of our study was to develop an automated method for detecting potential MS regions based on ...

Last Updated: 20 Mar 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Multiple Sclerosis" returned 495 free, full-text review articles on human participants. First 3 results:

Management of psoriasis vulgaris and multiple sclerosis with fumaric acid.
 

Author(s): Spyridon Gkalpakiotis, Petr Arenberger, Petra Gkalpakioti, Eva Meluzinova, Devika Chandran, Monika Arenbergerova

Journal: J. Am. Acad. Dermatol.. 2014 Mar;70(3):e60-1.

 

Last Updated: 17 Feb 2014

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Neuroendocrine immunoregulation in multiple sclerosis.
 

Author(s): Nathalie Deckx, Wai-Ping Lee, Zwi N Berneman, Nathalie Cools

Journal: Clin. Dev. Immunol.. 2013 ;2013():705232.

 

Currently, it is generally accepted that multiple sclerosis (MS) is a complex multifactorial disease involving genetic and environmental factors affecting the autoreactive immune responses that lead to damage of myelin. In this respect, intrinsic or extrinsic factors such as emotional, ...

Last Updated: 2 Jan 2014

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Clinical, MRI, and CSF markers of disability progression in multiple sclerosis.
 

Author(s): Alberto Gajofatto, Massimiliano Calabrese, Maria Donata Benedetti, Salvatore Monaco

Journal: Dis. Markers. 2013 ;35(6):687-99.

 

Multiple sclerosis (MS) is a chronic disorder of the central nervous system (CNS) in which the complex interplay between inflammation and neurodegeneration determines varying degrees of neurological disability. For this reason, it is very difficult to express an accurate prognosis ...

Last Updated: 10 Dec 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Estriol Treatment in Multiple Sclerosis (MS): Effect on Cognition
 

Status: Recruiting

Condition Summary: Relapsing-remitting Multiple Sclerosis; Secondary-progressive Multiple Sclerosis; Primary-progressive Multiple Sclerosis

 

Last Updated: 17 Jul 2013

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A Trial to Compare the Effectiveness of Two Rehabilitation Programs for Multiple Sclerosis Patients
 

Status: Recruiting

Condition Summary: Primary Progressive Multiple Sclerosis,; Secondary Progressive Multiple Sclerosis; Relapsing-remitting Multiple Sclerosis,; Demyelinating Autoimmune Diseases,; Nervous System Diseases

 

Last Updated: 20 Jan 2014

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A Phase 2b/3 Study to Compare Efficacy and Safety of Masitinib to Placebo in the Treatment of Patients With Primary Progressive or Relapse-free Secondary Progressive Multiple Sclerosis
 

Status: Recruiting

Condition Summary: Multiple Sclerosis, Secondary Progressive; Multiple Sclerosis, Primary Progressive; Multiple Sclerosis, Relapse Free

 

Last Updated: 13 Aug 2013

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