Multiple sclerosis

Common Name(s)

Multiple sclerosis, MS

Multiple sclerosis (MS) is an autoimmune disorder that causes damage to the body’s central nervous system (CNS). In a person with MS, the immune system attacks part of the body, specifically myelin, mistaking it for something foreign (from outside the body). Myelin is a fatty substance that covers and protects the nerves. When myelin is damaged, the brain cannot send signals and communicate with the rest of the body. The symptoms depend on the location of the nerves which have damaged myelin. Symptoms may include numbness or weakness in the limbs, partial or complete loss of vision, pain in the body, electric-shock sensations with certain neck movements, lack of coordination, slurred speech, fatigue, dizziness, and problems with the bowel and bladder.

Many people with MS have periods of new symptoms (relapse) that are then followed by periods of improvement in symptoms (remission). This form of MS, which is the most common form, is called relapsing-remitting course. The exact cause of MS is unknown. Researchers believe genetics and environmental factors, such as smoking, diet, or infections during childhood, may play a role.

In order to diagnose this condition, your doctor will take a detailed medical history and perform a physical examination. Your doctor may also perform various tests, such as blood tests, imaging tests, or collect fluid from your spine (spinal tap) to both rule out other conditions and find evidence of MS. Although there is no cure for MS, there are medications and therapies available to help control the symptoms and slow the progression. Talk with your doctor to decide which treatment plan is best for you. Support groups are also a good resource for support and additional information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple sclerosis" for support, advocacy or research.

Logo
Multiple Sclerosis Association of America

MSAA's mission is to enrich the quality of life for everyone affected by multiple sclerosis. MSAA also serves to promote greater understanding of multiple sclerosis and the diverse needs and challenges of people with MS.

Last Updated: 5 May 2015

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Multiple Sclerosis Foundation

The mission of the Multiple Sclerosis Foundation, Inc. is to provide programs and support services to those persons affected by MS that help them maintain their health, safety, self-sufficiency, and personal well-being; and to heighten public awareness of multiple sclerosis in order to elicit financial support for the MSF’s programs and services and promote understanding for those diagnosed with the illness.

Last Updated: 5 May 2015

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National Multiple Sclerosis Society

The mission of the National Multiple Sclerosis Society is to mobilize people and resources so everyone affected by MS can live their best lives as we stop MS in its tracks, restore what has been lost, and end MS forever. Our vision is a world free of MS.

Last Updated: 20 Jun 2016

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APS Foundation of America, Inc.

The APS Foundation of America, Inc. is dedicated to fostering and facilitating joint efforts in the areas of education, public awareness, research and patient services in an effective and ethical manner.

Last Updated: 12 Aug 2013

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Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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The Myelin Project

We are an international 501(c)(3) non-profit organization funding medical research and raising awareness for rare brain diseases.

Last Updated: 13 Nov 2012

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United Spinal Association

United Spinal Association’s mission is to improve the quality of life of all people living with spinal cord injuries and disorders (SCI/D). United Spinal never loses sight of our founders' grassroots efforts to provide a voice to the disability community and to transform the public’s perception of wheelchair users. Now the largest non-profit organization dedicated to helping people living with SCI/D, United Spinal is committed to providing active-lifestyle information, peer support and advocacy that empowers individuals to achieve their highest potential in all facets of life.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple sclerosis" for support, advocacy or research.

Logo
Multiple Sclerosis Association of America

MSAA's mission is to enrich the quality of life for everyone affected by multiple sclerosis. MSAA also serves to promote greater understanding of multiple sclerosis and the diverse needs and challenges of people with MS.

http://www.msassociation.org

Last Updated: 5 May 2015

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Multiple Sclerosis Foundation

The mission of the Multiple Sclerosis Foundation, Inc. is to provide programs and support services to those persons affected by MS that help them maintain their health, safety, self-sufficiency, and personal well-being; and to heighten public awareness of multiple sclerosis in order to elicit financial support for the MSF’s programs and services and promote understanding for those diagnosed with the illness.

http://www.msfocus.org

Last Updated: 5 May 2015

View Details
National Multiple Sclerosis Society

The mission of the National Multiple Sclerosis Society is to mobilize people and resources so everyone affected by MS can live their best lives as we stop MS in its tracks, restore what has been lost, and end MS forever. Our vision is a world free of MS.

https://www.nationalmssociety.org

Last Updated: 20 Jun 2016

View Details
APS Foundation of America, Inc.

The APS Foundation of America, Inc. is dedicated to fostering and facilitating joint efforts in the areas of education, public awareness, research and patient services in an effective and ethical manner.

http://www.apsfa.org

Last Updated: 12 Aug 2013

View Details
Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

View Details
HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

View Details
The Myelin Project

We are an international 501(c)(3) non-profit organization funding medical research and raising awareness for rare brain diseases.

http://www.myelin.org

Last Updated: 13 Nov 2012

View Details
United Spinal Association

United Spinal Association’s mission is to improve the quality of life of all people living with spinal cord injuries and disorders (SCI/D). United Spinal never loses sight of our founders' grassroots efforts to provide a voice to the disability community and to transform the public’s perception of wheelchair users. Now the largest non-profit organization dedicated to helping people living with SCI/D, United Spinal is committed to providing active-lifestyle information, peer support and advocacy that empowers individuals to achieve their highest potential in all facets of life.

http://www.unitedspinal.org

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

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General Resources

Resources for People Living with MS & Their Families

Family Matters, Library & Educational Programs, Find Support, Insurance & Financial Information, Living with Advanced MS, Employment, Resources for Specific Populations, Find Programs & Services in Your Area

Updated 20 Jun 2016

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Resources for People Living with MS & Their Families

Family Matters, Library & Educational Programs, Find Support, Insurance & Financial Information, Living with Advanced MS, Employment, Resources for Specific Populations, Find Programs & Services in Your Area

Updated 20 Jun 2016

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Multiple sclerosis" returned 5213 free, full-text research articles on human participants. First 3 results:

Mediterranean diet adherence and risk of multiple sclerosis: a case-control study.
 

Author(s): Fatemeh Sedaghat, Mahsa Jessri, Maryam Behrooz, Mostafa Mirghotbi, Bahram Rashidkhani

Journal: Asia Pac J Clin Nutr. 2016 ;25(2):377-84.

 

We conducted a hospital-based, case-control study to examine the association between Mediterranean diet (MD) and the risk of multiple sclerosis (MS) in Iran.

Last Updated: 25 May 2016

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Validation of the Brazilian version of the neurological fatigue index for multiple sclerosis.
 

Author(s): Josiane Lopes, Edson Lopes Lavado, Damacio Ramón Kaimen-Maciel

Journal: Arq Neuropsiquiatr. 2016 Apr;74(4):320-8.

 

The Neurological Fatigue Index for Multiple Sclerosis (NFI-MS) is a new fatigue assessment instrument. The aim of this study was to cross-culturally adapt and assess the psychometric properties of the Brazilian version of the NFI-MS (NFI-MS/BR).

Last Updated: 21 Apr 2016

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Allelic imbalance of multiple sclerosis susceptibility genes IKZF3 and IQGAP1 in human peripheral blood.
 

Author(s): Pankaj K Keshari, Hanne F Harbo, Kjell-Morten Myhr, Jan H Aarseth, Steffan D Bos, Tone Berge

Journal:

 

Multiple sclerosis is a chronic inflammatory, demyelinating disease of the central nervous system. Recent genome-wide studies have revealed more than 110 single nucleotide polymorphisms as associated with susceptibility to multiple sclerosis, but their functional contribution to disease ...

Last Updated: 15 Apr 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Multiple sclerosis" returned 766 free, full-text review articles on human participants. First 3 results:

Albumin and multiple sclerosis.
 

Author(s): Steven M LeVine

Journal:

 

Leakage of the blood-brain barrier (BBB) is a common pathological feature in multiple sclerosis (MS). Following a breach of the BBB, albumin, the most abundant protein in plasma, gains access to CNS tissue where it is exposed to an inflammatory milieu and tissue damage, e.g., demyelination. ...

Last Updated: 12 Apr 2016

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Systematic reviews in paediatric multiple sclerosis and Creutzfeldt-Jakob disease exemplify shortcomings in methods used to evaluate therapies in rare conditions.
 

Author(s): Steffen Unkel, Christian Röver, Nigel Stallard, Norbert Benda, Martin Posch, Sarah Zohar, Tim Friede

Journal:

 

Randomized controlled trials (RCTs) are the gold standard design of clinical research to assess interventions. However, RCTs cannot always be applied for practical or ethical reasons. To investigate the current practices in rare diseases, we review evaluations of therapeutic interventions ...

Last Updated: 22 Feb 2016

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Systematic review and meta-analysis of interventions for depression and anxiety in persons with multiple sclerosis.
 

Author(s): K M Fiest, J R Walker, C N Bernstein, L A Graff, R Zarychanski, A M Abou-Setta, S B Patten, J Sareen, J M Bolton, J J Marriott, J D Fisk, A Singer, R A Marrie,

Journal: Mult Scler Relat Disord. 2016 Jan;5():12-26.

 

Depression and anxiety are common in persons with multiple sclerosis (MS), and adversely affect fatigue, medication adherence, and quality of life. Though effective treatments for depression and anxiety exist in the general population, their applicability in the MS population has ...

Last Updated: 9 Feb 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase 2 Study of Ublituximab in Patients With Relapsing Forms of Multiple Sclerosis
 

Status: Recruiting

Condition Summary: Multiple Sclerosis

 

Last Updated: 21 Aug 2016

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Oral Ponesimod Versus Teriflunomide In Relapsing MUltiple Sclerosis
 

Status: Recruiting

Condition Summary: Multiple Sclerosis

 

Last Updated: 10 Nov 2016

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Use of an Electronic Diary by People With Multiple Sclerosis
 

Status: Not yet recruiting

Condition Summary: Multiple Sclerosis

 

Last Updated: 2 Aug 2015

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