Multiple sclerosis

Common Name(s)

Multiple sclerosis, MS

Multiple sclerosis (MS) is an autoimmune disorder that causes damage to the body’s central nervous system (CNS). In a person with MS, the immune system attacks part of the body, specifically myelin, mistaking it for something foreign (from outside the body). Myelin is a fatty substance that covers and protects the nerves. When myelin is damaged, the brain cannot send signals and communicate with the rest of the body. The symptoms depend on the location of the nerves which have damaged myelin. Symptoms may include numbness or weakness in the limbs, partial or complete loss of vision, pain in the body, electric-shock sensations with certain neck movements, lack of coordination, slurred speech, fatigue, dizziness, and problems with the bowel and bladder.

Many people with MS have periods of new symptoms (relapse) that are then followed by periods of improvement in symptoms (remission). This form of MS, which is the most common form, is called relapsing-remitting course. The exact cause of MS is unknown. Researchers believe genetics and environmental factors, such as smoking, diet, or infections during childhood, may play a role.

In order to diagnose this condition, your doctor will take a detailed medical history and perform a physical examination. Your doctor may also perform various tests, such as blood tests, imaging tests, or collect fluid from your spine (spinal tap) to both rule out other conditions and find evidence of MS. Although there is no cure for MS, there are medications and therapies available to help control the symptoms and slow the progression. Talk with your doctor to decide which treatment plan is best for you. Support groups are also a good resource for support and additional information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple sclerosis" for support, advocacy or research.

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Multiple Sclerosis Association of America

MSAA's mission is to enrich the quality of life for everyone affected by multiple sclerosis. MSAA also serves to promote greater understanding of multiple sclerosis and the diverse needs and challenges of people with MS.

Last Updated: 5 May 2015

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Multiple Sclerosis Foundation

The mission of the Multiple Sclerosis Foundation, Inc. is to provide programs and support services to those persons affected by MS that help them maintain their health, safety, self-sufficiency, and personal well-being; and to heighten public awareness of multiple sclerosis in order to elicit financial support for the MSF’s programs and services and promote understanding for those diagnosed with the illness.

Last Updated: 5 May 2015

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National Multiple Sclerosis Society

To end the devastating effects of MS

Last Updated: 5 May 2015

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APS Foundation of America, Inc.

The APS Foundation of America, Inc. is dedicated to fostering and facilitating joint efforts in the areas of education, public awareness, research and patient services in an effective and ethical manner.

Last Updated: 12 Aug 2013

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Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 27 Apr 2015

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The Myelin Project

We are an international 501(c)(3) non-profit organization funding medical research and raising awareness for rare brain diseases.

Last Updated: 13 Nov 2012

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United Spinal Association

United Spinal Association’s mission is to improve the quality of life of all people living with spinal cord injuries and disorders (SCI/D). United Spinal never loses sight of our founders' grassroots efforts to provide a voice to the disability community and to transform the public’s perception of wheelchair users. Now the largest non-profit organization dedicated to helping people living with SCI/D, United Spinal is committed to providing active-lifestyle information, peer support and advocacy that empowers individuals to achieve their highest potential in all facets of life.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple sclerosis" for support, advocacy or research.

Logo
Multiple Sclerosis Association of America

MSAA's mission is to enrich the quality of life for everyone affected by multiple sclerosis. MSAA also serves to promote greater understanding of multiple sclerosis and the diverse needs and challenges of people with MS.

http://www.msassociation.org

Last Updated: 5 May 2015

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Multiple Sclerosis Foundation

The mission of the Multiple Sclerosis Foundation, Inc. is to provide programs and support services to those persons affected by MS that help them maintain their health, safety, self-sufficiency, and personal well-being; and to heighten public awareness of multiple sclerosis in order to elicit financial support for the MSF’s programs and services and promote understanding for those diagnosed with the illness.

http://www.msfocus.org

Last Updated: 5 May 2015

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Logo
National Multiple Sclerosis Society

To end the devastating effects of MS

http://www.nmss.org

Last Updated: 5 May 2015

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APS Foundation of America, Inc.

The APS Foundation of America, Inc. is dedicated to fostering and facilitating joint efforts in the areas of education, public awareness, research and patient services in an effective and ethical manner.

http://www.apsfa.org

Last Updated: 12 Aug 2013

View Details
Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

View Details
HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 27 Apr 2015

View Details
The Myelin Project

We are an international 501(c)(3) non-profit organization funding medical research and raising awareness for rare brain diseases.

http://www.myelin.org

Last Updated: 13 Nov 2012

View Details
United Spinal Association

United Spinal Association’s mission is to improve the quality of life of all people living with spinal cord injuries and disorders (SCI/D). United Spinal never loses sight of our founders' grassroots efforts to provide a voice to the disability community and to transform the public’s perception of wheelchair users. Now the largest non-profit organization dedicated to helping people living with SCI/D, United Spinal is committed to providing active-lifestyle information, peer support and advocacy that empowers individuals to achieve their highest potential in all facets of life.

http://www.unitedspinal.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Multiple sclerosis" returned 4086 free, full-text research articles on human participants. First 3 results:

Correlation between brain volume loss and clinical and MRI outcomes in multiple sclerosis.
 

Author(s): Ernst-Wilhelm Radue, Frederik Barkhof, Ludwig Kappos, Till Sprenger, Dieter A Häring, Ana de Vera, Philipp von Rosenstiel, Jeremy R Bright, Gordon Francis, Jeffrey A Cohen

Journal: Neurology. 2015 Feb;84(8):784-93.

 

We investigated the determinants and clinical correlations of MRI-detected brain volume loss (BVL) among patients with relapsing-remitting multiple sclerosis from the phase 3 trials of fingolimod: FREEDOMS, FREEDOMS II, and TRANSFORMS.

Last Updated: 25 Feb 2015

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Mycophenolate mofetil in the treatment of multiple sclerosis: a preliminary report.
 

Author(s): Lekha Pandit, Sharik Mustafa, Chaithra Malli, Anitha D'Cunha

Journal: Neurol India. ;62(6):646-8.

 

Mycophenolate mofetil (MMF) is an affordable and tolerable drug reported to be beneficial in the treatment of multiple sclerosis (MS).

Last Updated: 16 Jan 2015

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Natalizumab treatment for multiple sclerosis.
 

Author(s): Maria Lucia Brito Ferreira

Journal: Arq Neuropsiquiatr. 2014 Dec;72(12):911-2.

 

Last Updated: 18 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Multiple sclerosis" returned 572 free, full-text review articles on human participants. First 3 results:

Vision and vision-related outcome measures in multiple sclerosis.
 

Author(s): Laura J Balcer, David H Miller, Stephen C Reingold, Jeffrey A Cohen

Journal: Brain. 2015 Jan;138(Pt 1):11-27.

 

Visual impairment is a key manifestation of multiple sclerosis. Acute optic neuritis is a common, often presenting manifestation, but visual deficits and structural loss of retinal axonal and neuronal integrity can occur even without a history of optic neuritis. Interest in vision ...

Last Updated: 7 Jan 2015

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Modifiable environmental factors in multiple sclerosis.
 

Author(s): Yara Dadalti Fragoso

Journal: Arq Neuropsiquiatr. 2014 Nov;72(11):889-94.

 

Potential environmental modifiable factors involved in multiple sclerosis (MS) include low adherence to treatment, smoking, obesity, low levels of liposoluble vitamins A and D, high consumption of salt, and a sedentary lifestyle. Chronic tobacco use, obesity, sedentarism and insufficient ...

Last Updated: 21 Nov 2014

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Immune surveillance of the central nervous system in multiple sclerosis--relevance for therapy and experimental models.
 

Author(s): Rehana Z Hussain, Liat Hayardeny, Petra C Cravens, Felix Yarovinsky, Todd N Eagar, Benjamine Arellano, Krystin Deason, Cyd Castro-Rojas, Olaf Stüve

Journal: J. Neuroimmunol.. 2014 Nov;276(1-2):9-17.

 

Treatment of central nervous system (CNS) autoimmune disorders frequently involves the reduction, or depletion of immune-competent cells. Alternatively, immune cells are being sequestered away from the target organ by interfering with their movement from secondary lymphoid organs, ...

Last Updated: 2 Dec 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Estriol Treatment in Multiple Sclerosis (MS): Effect on Cognition
 

Status: Recruiting

Condition Summary: Relapsing-remitting Multiple Sclerosis; Secondary-progressive Multiple Sclerosis; Primary-progressive Multiple Sclerosis

 

Last Updated: 17 Sep 2014

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Rotating Frame Relaxation Imaging in Patients With Multiple Sclerosis
 

Status: Recruiting

Condition Summary: Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Multiple Sclerosis, Chronic Progressive

 

Last Updated: 25 Mar 2015

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A Trial to Compare the Effectiveness of Two Rehabilitation Programs for Multiple Sclerosis Patients
 

Status: Recruiting

Condition Summary: Primary Progressive Multiple Sclerosis,; Secondary Progressive Multiple Sclerosis; Relapsing-remitting Multiple Sclerosis,; Demyelinating Autoimmune Diseases,; Nervous System Diseases

 

Last Updated: 20 Jan 2014

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