Multiple sclerosis

Common Name(s)

Multiple sclerosis, MS

Multiple sclerosis (MS) is an autoimmune disorder that causes damage to the body’s central nervous system (CNS). In a person with MS, the immune system attacks part of the body, specifically myelin, mistaking it for something foreign (from outside the body). Myelin is a fatty substance that covers and protects the nerves. When myelin is damaged, the brain cannot send signals and communicate with the rest of the body. The symptoms depend on the location of the nerves which have damaged myelin. Symptoms may include numbness or weakness in the limbs, partial or complete loss of vision, pain in the body, electric-shock sensations with certain neck movements, lack of coordination, slurred speech, fatigue, dizziness, and problems with the bowel and bladder.

Many people with MS have periods of new symptoms (relapse) that are then followed by periods of improvement in symptoms (remission). This form of MS, which is the most common form, is called relapsing-remitting course. The exact cause of MS is unknown. Researchers believe genetics and environmental factors, such as smoking, diet, or infections during childhood, may play a role.

In order to diagnose this condition, your doctor will take a detailed medical history and perform a physical examination. Your doctor may also perform various tests, such as blood tests, imaging tests, or collect fluid from your spine (spinal tap) to both rule out other conditions and find evidence of MS. Although there is no cure for MS, there are medications and therapies available to help control the symptoms and slow the progression. Talk with your doctor to decide which treatment plan is best for you. Support groups are also a good resource for support and additional information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple sclerosis" for support, advocacy or research.

Logo
Multiple Sclerosis Association of America

MSAA's mission is to enrich the quality of life for everyone affected by multiple sclerosis. MSAA also serves to promote greater understanding of multiple sclerosis and the diverse needs and challenges of people with MS.

Last Updated: 5 May 2015

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Multiple Sclerosis Foundation

The mission of the Multiple Sclerosis Foundation, Inc. is to provide programs and support services to those persons affected by MS that help them maintain their health, safety, self-sufficiency, and personal well-being; and to heighten public awareness of multiple sclerosis in order to elicit financial support for the MSF’s programs and services and promote understanding for those diagnosed with the illness.

Last Updated: 5 May 2015

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National Multiple Sclerosis Society

The mission of the National Multiple Sclerosis Society is to mobilize people and resources so everyone affected by MS can live their best lives as we stop MS in its tracks, restore what has been lost, and end MS forever. Our vision is a world free of MS.

Last Updated: 20 Jun 2016

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APS Foundation of America, Inc.

The APS Foundation of America, Inc. is dedicated to fostering and facilitating joint efforts in the areas of education, public awareness, research and patient services in an effective and ethical manner.

Last Updated: 12 Aug 2013

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Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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The Myelin Project

We are an international 501(c)(3) non-profit organization funding medical research and raising awareness for rare brain diseases.

Last Updated: 13 Nov 2012

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United Spinal Association

United Spinal Association’s mission is to improve the quality of life of all people living with spinal cord injuries and disorders (SCI/D). United Spinal never loses sight of our founders' grassroots efforts to provide a voice to the disability community and to transform the public’s perception of wheelchair users. Now the largest non-profit organization dedicated to helping people living with SCI/D, United Spinal is committed to providing active-lifestyle information, peer support and advocacy that empowers individuals to achieve their highest potential in all facets of life.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple sclerosis" for support, advocacy or research.

Logo
Multiple Sclerosis Association of America

MSAA's mission is to enrich the quality of life for everyone affected by multiple sclerosis. MSAA also serves to promote greater understanding of multiple sclerosis and the diverse needs and challenges of people with MS.

http://www.msassociation.org

Last Updated: 5 May 2015

View Details
Multiple Sclerosis Foundation

The mission of the Multiple Sclerosis Foundation, Inc. is to provide programs and support services to those persons affected by MS that help them maintain their health, safety, self-sufficiency, and personal well-being; and to heighten public awareness of multiple sclerosis in order to elicit financial support for the MSF’s programs and services and promote understanding for those diagnosed with the illness.

http://www.msfocus.org

Last Updated: 5 May 2015

View Details
National Multiple Sclerosis Society

The mission of the National Multiple Sclerosis Society is to mobilize people and resources so everyone affected by MS can live their best lives as we stop MS in its tracks, restore what has been lost, and end MS forever. Our vision is a world free of MS.

https://www.nationalmssociety.org

Last Updated: 20 Jun 2016

View Details
APS Foundation of America, Inc.

The APS Foundation of America, Inc. is dedicated to fostering and facilitating joint efforts in the areas of education, public awareness, research and patient services in an effective and ethical manner.

http://www.apsfa.org

Last Updated: 12 Aug 2013

View Details
Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

View Details
HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

View Details
The Myelin Project

We are an international 501(c)(3) non-profit organization funding medical research and raising awareness for rare brain diseases.

http://www.myelin.org

Last Updated: 13 Nov 2012

View Details
United Spinal Association

United Spinal Association’s mission is to improve the quality of life of all people living with spinal cord injuries and disorders (SCI/D). United Spinal never loses sight of our founders' grassroots efforts to provide a voice to the disability community and to transform the public’s perception of wheelchair users. Now the largest non-profit organization dedicated to helping people living with SCI/D, United Spinal is committed to providing active-lifestyle information, peer support and advocacy that empowers individuals to achieve their highest potential in all facets of life.

http://www.unitedspinal.org

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

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General Resources

Resources for People Living with MS & Their Families

Family Matters, Library & Educational Programs, Find Support, Insurance & Financial Information, Living with Advanced MS, Employment, Resources for Specific Populations, Find Programs & Services in Your Area

Updated 20 Jun 2016

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Resources for People Living with MS & Their Families

Family Matters, Library & Educational Programs, Find Support, Insurance & Financial Information, Living with Advanced MS, Employment, Resources for Specific Populations, Find Programs & Services in Your Area

Updated 20 Jun 2016

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Multiple sclerosis" returned 5007 free, full-text research articles on human participants. First 3 results:

Assessment of Serum Nitrogen Species and Inflammatory Parameters in Relapsing-Remitting Multiple Sclerosis Patients Treated with Different Therapeutic Approaches.
 

Author(s): Natalia Niedziela, Monika Adamczyk-Sowa, Jacek T Niedziela, Bogdan Mazur, Ewa Kluczewska, Paweł Sowa, Mariusz Gąsior

Journal: Biomed Res Int. 2016 ;2016():4570351.

 

The role of nitric oxide and its reactive derivatives (NO x ) is well known in the pathogenesis of multiple sclerosis, which is an inflammatory disease while NO x seems to be important in coordinating inflammatory response. The purpose of the present study was to assess serum NO x ...

Last Updated: 12 Jan 2017

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Bone mineral density in patients with multiple sclerosis, hereditary ataxia or hereditary spastic paraplegia after at least 10 years of disease - a case control study.
 

Author(s): Cecilia Smith Simonsen, Elisabeth Gulowsen Celius, Cathrine Brunborg, Chantal Tallaksen, Erik Fink Eriksen, Trygve Holmøy, Stine Marit Moen

Journal:

 

Although disability is considered the main cause of low bone mineral density (BMD) in multiple sclerosis (MS), other factors related to the disease process or treatment could also be involved. The aim of this study was to assess whether patients with MS are more likely to develop ...

Last Updated: 6 Dec 2016

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A regional consensus recommendation on brain atrophy as an outcome measure in multiple sclerosis.
 

Author(s): Raed Alroughani, Dirk Deleu, Khalid El Salem, Jasem Al-Hashel, K John Alexander, Mohamed Assem Abdelrazek, Adel Aljishi, Jaber Alkhaboori, Faisal Al Azri, Nahida Al Zadjali, Majed Hbahbih, Tag Eldin Sokrab, Mohamed Said, Àlex Rovira

Journal:

 

Multiple sclerosis (MS) is a chronic autoimmune disease characterized by inflammatory and neurodegenerative processes leading to irreversible neurological impairment. Brain atrophy occurs early in the course of the disease at a rate greater than the general population. Brain volume ...

Last Updated: 24 Nov 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Multiple sclerosis" returned 764 free, full-text review articles on human participants. First 3 results:

Plasmatic microRNA as Potential Biomarkers of Multiple Sclerosis: Literature Review.
 

Author(s): Magdalena J Kacperska, Jakub Walenczak, Bartłomiej Tomasik

Journal: Adv Clin Exp Med. ;25(4):775-9.

 

There is ongoing research with the goal of finding precise and sensitive biomarkers of multiple sclerosis (MS). Recently, researchers have paid particular attention to small, non-encoding, single stranded endogenous microRNA molecules (miR, miRNA). At first these molecules were thought ...

Last Updated: 16 Sep 2016

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Guidelines for the use of magnetic resonance imaging in diagnosing and monitoring the treatment of multiple sclerosis: recommendations of the Swedish Multiple Sclerosis Association and the Swedish Neuroradiological Society.
 

Author(s): M Vågberg, M Axelsson, R Birgander, J Burman, C Cananau, Y Forslin, T Granberg, M Gunnarsson, A von Heijne, L Jönsson, V D Karrenbauer, E-M Larsson, T Lindqvist, J Lycke, L Lönn, E Mentesidou, S Müller, P Nilsson, F Piehl, A Svenningsson, M Vrethem, J Wikström

Journal: Acta Neurol. Scand.. 2017 Jan;135(1):17-24.

 

Multiple sclerosis (MS) is associated with inflammatory lesions in the brain and spinal cord. The detection of such inflammatory lesions using magnetic resonance imaging (MRI) is important in the consideration of the diagnosis and differential diagnoses of MS, as well as in the monitoring ...

Last Updated: 25 Aug 2016

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Multiple sclerosis: clinical profiling and data collection as prerequisite for personalized medicine approach.
 

Author(s): Tjalf Ziemssen, Raimar Kern, Katja Thomas

Journal:

 

Multiple sclerosis (MS) is a highly heterogeneous disease as it can present inter-individually as well as intra-individually, with different disease phenotypes emerging during different stages in the long-term disease course. In addition to advanced immunological, genetic and magnetic ...

Last Updated: 3 Aug 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase 2 Study of Ublituximab in Patients With Relapsing Forms of Multiple Sclerosis
 

Status: Recruiting

Condition Summary: Multiple Sclerosis

 

Last Updated: 9 Jan 2017

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Oral Ponesimod Versus Teriflunomide In Relapsing MUltiple Sclerosis
 

Status: Recruiting

Condition Summary: Multiple Sclerosis

 

Last Updated: 16 Jan 2017

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Use of an Electronic Diary by People With Multiple Sclerosis
 

Status: Not yet recruiting

Condition Summary: Multiple Sclerosis

 

Last Updated: 2 Aug 2015

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