Multiple sclerosis

Common Name(s)

Multiple sclerosis, MS

Multiple sclerosis (MS) is a disorder that affects the central nervous system (CNS), specifically the brain and spinal cord. A fatty tissue called myelin surrounds and protects the nerve fibers of the CNS. Myelin insulates the nerves and allows them to transmit electrical impulses from the brain to other parts of the body. In MS, myelin is lost in multiple areas, and sometimes the nerve fiber itself is damaged or broken. When myelin or the nerve fiber is destroyed or damaged, the nerve’s ability to conduct electrical impulses to and from the brain is disrupted; therefore, nerve signals cannot be transmitted. The disruption of the electrical impulses causes the symptoms associated with MS. There is no cure for MS at present, but research is ongoing. If you or a family member has been diagnosed with MS, talk with your doctor and specialists about the most current treatment and management options. A comprehensive care plan should be reviewed often as symptoms change over time and new treatments become available. Support organizations are a good source of information and may help connect you with specialists as well as other families living with MS.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple sclerosis" for support, advocacy or research.

APS Foundation of America, Inc.

The APS Foundation of America, Inc. is dedicated to fostering and facilitating joint efforts in the areas of education, public awareness, research and patient services in an effective and ethical manner.

Last Updated: 12 Aug 2013

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Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 27 Apr 2015

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Multiple Sclerosis Association of America

MSAA's mission is to enrich the quality of life for everyone affected by multiple sclerosis. MSAA also serves to promote greater understanding of multiple sclerosis and the diverse needs and challenges of people with MS.

Last Updated: 13 Feb 2013

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Multiple Sclerosis Foundation

The mission of the Multiple Sclerosis Foundation, Inc. is to provide programs and support services to those persons affected by MS that help them maintain their health, safety, self-sufficiency, and personal well-being; and to heighten public awareness of multiple sclerosis in order to elicit financial support for the MSF’s programs and services and promote understanding for those diagnosed with the illness.

Last Updated: 25 Mar 2013

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National Multiple Sclerosis Society

To end the devastating effects of MS

Last Updated: 24 Nov 2009

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The Myelin Project

We are an international 501(c)(3) non-profit organization funding medical research and raising awareness for rare brain diseases.

Last Updated: 13 Nov 2012

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United Spinal Association

United Spinal Association’s mission is to improve the quality of life of all people living with spinal cord injuries and disorders (SCI/D). United Spinal never loses sight of our founders' grassroots efforts to provide a voice to the disability community and to transform the public’s perception of wheelchair users. Now the largest non-profit organization dedicated to helping people living with SCI/D, United Spinal is committed to providing active-lifestyle information, peer support and advocacy that empowers individuals to achieve their highest potential in all facets of life.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple sclerosis" for support, advocacy or research.

APS Foundation of America, Inc.

The APS Foundation of America, Inc. is dedicated to fostering and facilitating joint efforts in the areas of education, public awareness, research and patient services in an effective and ethical manner.

http://www.apsfa.org

Last Updated: 12 Aug 2013

View Details
Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 27 Apr 2015

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Multiple Sclerosis Association of America

MSAA's mission is to enrich the quality of life for everyone affected by multiple sclerosis. MSAA also serves to promote greater understanding of multiple sclerosis and the diverse needs and challenges of people with MS.

http://www.msassociation.org

Last Updated: 13 Feb 2013

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Multiple Sclerosis Foundation

The mission of the Multiple Sclerosis Foundation, Inc. is to provide programs and support services to those persons affected by MS that help them maintain their health, safety, self-sufficiency, and personal well-being; and to heighten public awareness of multiple sclerosis in order to elicit financial support for the MSF’s programs and services and promote understanding for those diagnosed with the illness.

http://www.msfocus.org

Last Updated: 25 Mar 2013

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National Multiple Sclerosis Society

To end the devastating effects of MS

http://www.nmss.org

Last Updated: 24 Nov 2009

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The Myelin Project

We are an international 501(c)(3) non-profit organization funding medical research and raising awareness for rare brain diseases.

http://www.myelin.org

Last Updated: 13 Nov 2012

View Details
United Spinal Association

United Spinal Association’s mission is to improve the quality of life of all people living with spinal cord injuries and disorders (SCI/D). United Spinal never loses sight of our founders' grassroots efforts to provide a voice to the disability community and to transform the public’s perception of wheelchair users. Now the largest non-profit organization dedicated to helping people living with SCI/D, United Spinal is committed to providing active-lifestyle information, peer support and advocacy that empowers individuals to achieve their highest potential in all facets of life.

http://www.unitedspinal.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Multiple sclerosis" returned 4041 free, full-text research articles on human participants. First 3 results:

Mycophenolate mofetil in the treatment of multiple sclerosis: a preliminary report.
 

Author(s): Lekha Pandit, Sharik Mustafa, Chaithra Malli, Anitha D'Cunha

Journal: Neurol India. ;62(6):646-8.

 

Mycophenolate mofetil (MMF) is an affordable and tolerable drug reported to be beneficial in the treatment of multiple sclerosis (MS).

Last Updated: 16 Jan 2015

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Natalizumab treatment for multiple sclerosis.
 

Author(s): Maria Lucia Brito Ferreira

Journal: Arq Neuropsiquiatr. 2014 Dec;72(12):911-2.

 

Last Updated: 18 Dec 2014

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Natalizumab treatment for multiple sclerosis: updates and considerations for safer treatment in JCV positive patients.
 

Author(s): Luiz Henrique da Silva Nali, Lenira Moraes, Maria Cristina Domingues Fink, Dagoberto Callegaro, Camila Malta Romano, Augusto Cesar Penalva de Oliveira

Journal: Arq Neuropsiquiatr. 2014 Dec;72(12):960-5.

 

Natalizumab is currently one of the best options for treatment of patients with Multiple Sclerosis who have failed traditional prior therapies. However, prolonged use, prior immunosuppressive therapy and anti-JCV antibody status have been associated with increased risk of developing ...

Last Updated: 18 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Multiple sclerosis" returned 564 free, full-text review articles on human participants. First 3 results:

Vision and vision-related outcome measures in multiple sclerosis.
 

Author(s): Laura J Balcer, David H Miller, Stephen C Reingold, Jeffrey A Cohen

Journal: Brain. 2015 Jan;138(Pt 1):11-27.

 

Visual impairment is a key manifestation of multiple sclerosis. Acute optic neuritis is a common, often presenting manifestation, but visual deficits and structural loss of retinal axonal and neuronal integrity can occur even without a history of optic neuritis. Interest in vision ...

Last Updated: 7 Jan 2015

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Modifiable environmental factors in multiple sclerosis.
 

Author(s): Yara Dadalti Fragoso

Journal: Arq Neuropsiquiatr. 2014 Nov;72(11):889-94.

 

Potential environmental modifiable factors involved in multiple sclerosis (MS) include low adherence to treatment, smoking, obesity, low levels of liposoluble vitamins A and D, high consumption of salt, and a sedentary lifestyle. Chronic tobacco use, obesity, sedentarism and insufficient ...

Last Updated: 21 Nov 2014

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Immune surveillance of the central nervous system in multiple sclerosis--relevance for therapy and experimental models.
 

Author(s): Rehana Z Hussain, Liat Hayardeny, Petra C Cravens, Felix Yarovinsky, Todd N Eagar, Benjamine Arellano, Krystin Deason, Cyd Castro-Rojas, Olaf Stüve

Journal: J. Neuroimmunol.. 2014 Nov;276(1-2):9-17.

 

Treatment of central nervous system (CNS) autoimmune disorders frequently involves the reduction, or depletion of immune-competent cells. Alternatively, immune cells are being sequestered away from the target organ by interfering with their movement from secondary lymphoid organs, ...

Last Updated: 2 Dec 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Estriol Treatment in Multiple Sclerosis (MS): Effect on Cognition
 

Status: Recruiting

Condition Summary: Relapsing-remitting Multiple Sclerosis; Secondary-progressive Multiple Sclerosis; Primary-progressive Multiple Sclerosis

 

Last Updated: 17 Sep 2014

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Rotating Frame Relaxation Imaging in Patients With Multiple Sclerosis
 

Status: Recruiting

Condition Summary: Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Multiple Sclerosis, Chronic Progressive

 

Last Updated: 25 Mar 2015

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A Trial to Compare the Effectiveness of Two Rehabilitation Programs for Multiple Sclerosis Patients
 

Status: Recruiting

Condition Summary: Primary Progressive Multiple Sclerosis,; Secondary Progressive Multiple Sclerosis; Relapsing-remitting Multiple Sclerosis,; Demyelinating Autoimmune Diseases,; Nervous System Diseases

 

Last Updated: 20 Jan 2014

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