Multiple Sclerosis

Common Name(s)

Multiple Sclerosis

Multiple sclerosis (MS) is a disorder that affects the central nervous system (CNS), specifically the brain and spinal cord.  A fatty tissue called myelin surrounds and protects the nerve fibers of the CNS.  Myelin insulates the nerves and allows them to transmit electrical impulses from the brain to other parts of the body.  In MS, myelin is lost in multiple areas, and sometimes the nerve fiber itself is damaged or broken.  When myelin or the nerve fiber is destroyed or damaged, the nerveÕs ability to conduct electrical impulses to and from the brain is disrupted; therefore, nerve signals cannot be transmitted.  The disruption of the electrical impulses causes the symptoms associated with MS.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple Sclerosis" for support, advocacy or research.

APS Foundation of America, Inc.

The APS Foundation of America, Inc. is dedicated to fostering and facilitating joint efforts in the areas of education, public awareness, research and patient services in an effective and ethical manner.

Last Updated: 12 Aug 2013

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Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2013

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 3 Oct 2013

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Multiple Sclerosis Association of America

MSAA's mission is to enrich the quality of life for everyone affected by multiple sclerosis. MSAA also serves to promote greater understanding of multiple sclerosis and the diverse needs and challenges of people with MS.

Last Updated: 13 Feb 2013

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Multiple Sclerosis Foundation

The mission of the Multiple Sclerosis Foundation, Inc. is to provide programs and support services to those persons affected by MS that help them maintain their health, safety, self-sufficiency, and personal well-being; and to heighten public awareness of multiple sclerosis in order to elicit financial support for the MSF’s programs and services and promote understanding for those diagnosed with the illness.

Last Updated: 25 Mar 2013

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National Multiple Sclerosis Society

To end the devastating effects of MS

Last Updated: 24 Nov 2009

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The Myelin Project

We are an international 501(c)(3) non-profit organization funding medical research and raising awareness for rare brain diseases.

Last Updated: 13 Nov 2012

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United Spinal Association

United Spinal Association’s mission is to improve the quality of life of all people living with spinal cord injuries and disorders (SCI/D). United Spinal never loses sight of our founders' grassroots efforts to provide a voice to the disability community and to transform the public’s perception of wheelchair users. Now the largest non-profit organization dedicated to helping people living with SCI/D, United Spinal is committed to providing active-lifestyle information, peer support and advocacy that empowers individuals to achieve their highest potential in all facets of life.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple Sclerosis" for support, advocacy or research.

APS Foundation of America, Inc.

The APS Foundation of America, Inc. is dedicated to fostering and facilitating joint efforts in the areas of education, public awareness, research and patient services in an effective and ethical manner.

http://www.apsfa.org

Last Updated: 12 Aug 2013

View Details
Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2013

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 3 Oct 2013

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Multiple Sclerosis Association of America

MSAA's mission is to enrich the quality of life for everyone affected by multiple sclerosis. MSAA also serves to promote greater understanding of multiple sclerosis and the diverse needs and challenges of people with MS.

http://www.msassociation.org

Last Updated: 13 Feb 2013

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Multiple Sclerosis Foundation

The mission of the Multiple Sclerosis Foundation, Inc. is to provide programs and support services to those persons affected by MS that help them maintain their health, safety, self-sufficiency, and personal well-being; and to heighten public awareness of multiple sclerosis in order to elicit financial support for the MSF’s programs and services and promote understanding for those diagnosed with the illness.

http://www.msfocus.org

Last Updated: 25 Mar 2013

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National Multiple Sclerosis Society

To end the devastating effects of MS

http://www.nmss.org

Last Updated: 24 Nov 2009

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The Myelin Project

We are an international 501(c)(3) non-profit organization funding medical research and raising awareness for rare brain diseases.

http://www.myelin.org

Last Updated: 13 Nov 2012

View Details
United Spinal Association

United Spinal Association’s mission is to improve the quality of life of all people living with spinal cord injuries and disorders (SCI/D). United Spinal never loses sight of our founders' grassroots efforts to provide a voice to the disability community and to transform the public’s perception of wheelchair users. Now the largest non-profit organization dedicated to helping people living with SCI/D, United Spinal is committed to providing active-lifestyle information, peer support and advocacy that empowers individuals to achieve their highest potential in all facets of life.

http://www.unitedspinal.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Multiple Sclerosis" returned 3897 free, full-text research articles on human participants. First 3 results:

Stabilometric assessment of context dependent balance recovery in persons with multiple sclerosis: a randomized controlled study.
 

Author(s): Davide Cattaneo, Johanna Jonsdottir, Alberto Regola, Roberta Carabalona

Journal:

 

Balance control relies on accurate perception of visual, somatosensory and vestibular cues. Sensory flow is impaired in Multiple Sclerosis (MS) and little is known about the ability of the sensory systems to adapt after neurological lesions reducing sensory impairment. The aims of ...

Last Updated: 21 Jun 2014

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Localisation of citrullinated proteins in normal appearing white matter and lesions in the central nervous system in multiple sclerosis.
 

Author(s): Claire M Bradford, Inês Ramos, Alison K Cross, Gail Haddock, Stephen McQuaid, Anthony P Nicholas, M Nicola Woodroofe

Journal: J. Neuroimmunol.. 2014 Aug;273(1-2):85-95.

 

Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disease, considered to be autoimmune in origin. Post-translational modification of central nervous system proteins, including glial fibrillary acidic protein (GFAP) and myelin basic protein (MBP), through citrullination ...

Last Updated: 15 Jul 2014

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Validity of the diagnostic criteria for chronic cerebrospinal venous insufficiency and association with multiple sclerosis.
 

Author(s): Fiona Costello, Jayesh Modi, David Lautner, Deepak Bhayana, James N Scott, W Jeptha Davenport, Jessie Trufyn, Richard Frayne, Viesha A Ciura, Mayank Goyal, Jean Mah, Michael D Hill

Journal: CMAJ. 2014 Aug;186(11):E418-26.

 

The chronic cerebrospinal venous insufficiency theory proposes that altered cerebral venous hemodynamics play a role in the pathophysiology of multiple sclerosis. We aimed to explore the validity of this hypothesis by assessing the diagnostic criteria for chronic cerebrospinal venous ...

Last Updated: 6 Aug 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Multiple Sclerosis" returned 515 free, full-text review articles on human participants. First 3 results:

Systematic literature review and validity evaluation of the Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Functional Composite (MSFC) in patients with multiple sclerosis.
 

Author(s): Sandra Meyer-Moock, You-Shan Feng, Mathias Maeurer, Franz-Werner Dippel, Thomas Kohlmann

Journal:

 

There are a number of instruments that describe severity and progression of multiple sclerosis and they are increasingly used as endpoints to assess the effectiveness of therapeutic interventions. We examined to what extent the psychometric properties of two accepted instruments--EDSS ...

Last Updated: 1 Apr 2014

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Islamic fasting and multiple sclerosis.
 

Author(s): Soodeh Razeghi Jahromi, Mohammad Ali Sahraian, Fereshteh Ashtari, Hormoz Ayromlou, Massoud Etemadifar, Majid Ghaffarpour, Ehsan Mohammadianinejad, Shahriar Nafissi, Alireza Nickseresht, Vahid Shaygannejad, Mansoreh Togha, Hamid Reza Torabi, Shadi Ziaie

Journal:

 

Month-long daytime Ramadan fasting pose s major challenges to multiple sclerosis (MS) patients in Muslim countries. Physicians should have practical knowledge on the implications of fasting on MS. We present a summary of database searches (Cochrane Database of Systematic Reviews, ...

Last Updated: 1 Apr 2014

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Chemokines and chemokine receptors in multiple sclerosis.
 

Author(s): Wenjing Cheng, Guangjie Chen

Journal: Mediators Inflamm.. 2014 ;2014():659206.

 

Multiple sclerosis is an autoimmune disease with classical traits of demyelination, axonal damage, and neurodegeneration. The migration of autoimmune T cells and macrophages from blood to central nervous system as well as the destruction of blood brain barrier are thought to be the ...

Last Updated: 18 Mar 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Estriol Treatment in Multiple Sclerosis (MS): Effect on Cognition
 

Status: Recruiting

Condition Summary: Relapsing-remitting Multiple Sclerosis; Secondary-progressive Multiple Sclerosis; Primary-progressive Multiple Sclerosis

 

Last Updated: 17 Sep 2014

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A Trial to Compare the Effectiveness of Two Rehabilitation Programs for Multiple Sclerosis Patients
 

Status: Recruiting

Condition Summary: Primary Progressive Multiple Sclerosis,; Secondary Progressive Multiple Sclerosis; Relapsing-remitting Multiple Sclerosis,; Demyelinating Autoimmune Diseases,; Nervous System Diseases

 

Last Updated: 20 Jan 2014

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A Phase 2b/3 Study to Compare Efficacy and Safety of Masitinib to Placebo in the Treatment of Patients With Primary Progressive or Relapse-free Secondary Progressive Multiple Sclerosis
 

Status: Recruiting

Condition Summary: Multiple Sclerosis, Secondary Progressive; Multiple Sclerosis, Primary Progressive; Multiple Sclerosis, Relapse Free

 

Last Updated: 13 Aug 2013

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