Multiple myeloma

Common Name(s)

Multiple myeloma

Multiple myeloma is a cancer of the plasma cells in the bone marrow. Plasma cells help the body fight infection by producing proteins called antibodies. In multiple myeloma, plasma cells grow out of control in the bone marrow and form tumors in the areas of solid bone. The growth of these bone tumors makes it harder for the bone marrow to make healthy blood cells and platelets. This disease may also harm other tissues and organs, such as the kidneys. Multiple myeloma mainly affects older adults. Although the exact cause is unknown, there are several known risk factors that can increase a person's chance of getting this disease.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple myeloma" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

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Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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International Myeloma Foundation

To improve the quality of life of myeloma patients while working towards prevention and a cure

Last Updated: 19 Feb 2013

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple myeloma" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

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Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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International Myeloma Foundation

To improve the quality of life of myeloma patients while working towards prevention and a cure

http://www.myeloma.org

Last Updated: 19 Feb 2013

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Multiple myeloma" returned 4033 free, full-text research articles on human participants. First 3 results:

Genome-wide association study identifies variation at 6q25.1 associated with survival in multiple myeloma.
 

Author(s): David C Johnson, Niels Weinhold, Jonathan S Mitchell, Bowang Chen, Martin Kaiser, Dil B Begum, Jens Hillengass, Uta Bertsch, Walter A Gregory, David Cairns, Graham H Jackson, Asta Försti, Jolanta Nickel, Per Hoffmann, Markus M Nöethen, Owen W Stephens, Bart Barlogie, Faith E Davis, Kari Hemminki, Hartmut Goldschmidt, Richard S Houlston, Gareth J Morgan

Journal:

 

Survival following a diagnosis of multiple myeloma (MM) varies between patients and some of these differences may be a consequence of inherited genetic variation. In this study, to identify genetic markers associated with MM overall survival (MM-OS), we conduct a meta-analysis of ...

Last Updated: 8 Jan 2016

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Profound impact of sample processing delay on gene expression of multiple myeloma plasma cells.
 

Author(s): Tobias Meißner, Anja Seckinger, Kari Hemminki, Uta Bertsch, Asta Foersti, Mathias Haenel, Jan Duering, Hans Salwender, Hartmut Goldschmidt, Gareth J Morgan, Dirk Hose, Niels Weinhold

Journal:

 

Gene expression profiling (GEP) has significantly contributed to the elucidation of the molecular heterogeneity of multiple myeloma plasma cells (MMPC) and only recently it has been recommended for risk stratification. Prior to GEP MMPC need to be enriched resulting in an inability ...

Last Updated: 30 Dec 2015

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Risk of Early Mortality in Patients With Newly Diagnosed Multiple Myeloma.
 

Author(s): Pei Hsu, Ting-Wei Lin, Jyh-Pyng Gau, Yuan-Bin Yu, Liang-Tsai Hsiao, Cheng-Hwai Tzeng, Po-Min Chen, Tzeon-Jye Chiou, Jin-Hwang Liu, Yao-Chung Liu, Chia-Jen Liu

Journal: Medicine (Baltimore). 2015 Dec;94(50):e2305.

 

The overall survival of patients with multiple myeloma (MM) has been improved greatly over the last 2 decades with the broader use of novel drugs and autologous tandem transplantation. However, more than one tenth of myeloma patients still die shortly after diagnosis. We therefore ...

Last Updated: 19 Dec 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Multiple myeloma" returned 408 free, full-text review articles on human participants. First 3 results:

Multiple myeloma: Diagnosis and management issues in patients with pre-existing chronic kidney disease.
 

Author(s): Srilatha Vadlamudi, Siva Nagendra Reddy Annapareddy

Journal: Saudi J Kidney Dis Transpl. 2016 Jan;27(1):9-14.

 

Multiple myeloma is one of the most common malignancies encountered in clinical practice. Renal involvement in myeloma is a well-recognized entity. Although rare, another special situation that a nephrologist can encounter is myeloma occurring in a patient with preexisting chronic ...

Last Updated: 20 Jan 2016

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Molecular mechanisms in multiple myeloma drug resistance.
 

Author(s): Nicholas Nikesitch, Silvia C W Ling

Journal: J. Clin. Pathol.. 2016 Feb;69(2):97-101.

 

Multiple myeloma (MM) is predominantly an incurable malignancy despite high-dose chemotherapy, autologous stem cell transplant and novel agents. MM is a genetically heterogeneous disease and the complexity increases as the disease progresses to a more aggressive stage. MM arises from ...

Last Updated: 22 Jan 2016

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Interpretation of cytogenetic results in multiple myeloma for clinical practice.
 

Author(s): A M Rajan, S V Rajkumar

Journal:

 

The interpretation of cytogenetic abnormalities in multiple myeloma (MM) is often a challenging task. MM is characterized by several cytogenetic abnormalities that occur at various time points in the disease course. The interpretation of cytogenetic results in MM is complicated by ...

Last Updated: 31 Oct 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Early Patient Access Single Named Patient Program for the Use of Ulocuplumab for the Treatment of Multiple Myeloma
 

Status: Available

Condition Summary: Relapsed Multiple Myeloma; Refractory Multiple Myeloma

 

Last Updated: 26 Jan 2016

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Study of Pomalidomide, Cyclophosphamide, Dexamethasone in Relapsed/Refractory Multiple Myeloma
 

Status: Recruiting

Condition Summary: Multiple Myeloma in Relapse; Multiple Myeloma, Refractory

 

Last Updated: 6 Jan 2016

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Total Marrow Irradiation With High Dose Melphalan Prior to Autologous Transplant for Relapsed or Refractory Multiple Myeloma (BMT-03)
 

Status: Recruiting

Condition Summary: Multiple Myeloma, Relapsed; Multiple Myeloma, Refractory to Standard Treatment

 

Last Updated: 2 Dec 2015

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