Multiple myeloma

Common Name(s)

Multiple myeloma

Multiple myeloma is a cancer of the plasma cells in the bone marrow. Plasma cells help the body fight infection by producing proteins called antibodies. In multiple myeloma, plasma cells grow out of control in the bone marrow and form tumors in the areas of solid bone. The growth of these bone tumors makes it harder for the bone marrow to make healthy blood cells and platelets. This disease may also harm other tissues and organs, such as the kidneys. Multiple myeloma mainly affects older adults. Although the exact cause is unknown, there are several known risk factors that can increase a person's chance of getting this disease.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple myeloma" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

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International Myeloma Foundation

To improve the quality of life of myeloma patients while working towards prevention and a cure

Last Updated: 19 Feb 2013

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple myeloma" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

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International Myeloma Foundation

To improve the quality of life of myeloma patients while working towards prevention and a cure

http://www.myeloma.org

Last Updated: 19 Feb 2013

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Multiple myeloma" returned 3052 free, full-text research articles on human participants. First 3 results:

Merkel cell carcinoma presenting as right leg edema in a multiple myeloma patient.
 

Author(s): Claire M Noell, Elizabeth Rose, Lee T Nesbitt

Journal: J. Am. Acad. Dermatol.. 2014 Aug;71(2):e50-2.

 

Last Updated: 19 Jul 2014

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The occurrence of Al amyloidosis (light-chain amyloidosis) in patients with multiple myeloma in Lower Silesia Region, Poland.
 

Author(s): Lidia Usnarska-Zubkiewicz, Jadwiga Hołojda, Michał Jeleń, Anna Zubkiewicz-Zarębska, Jakub Dębski, Kazimierz Kuliczkowski

Journal: Adv Clin Exp Med. ;23(2):235-44.

 

The incidence of amyloidosis is difficult to determine because the disease is often undiagnosed or diagnosed incorrectly. In Polish studies, there are no statistics and analyses of the factors that may influence the development of amyloidosis in patients with multiple myeloma.

Last Updated: 10 Jun 2014

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Electroacupuncture for thalidomide/bortezomib-induced peripheral neuropathy in multiple myeloma: a feasibility study.
 

Author(s): M Kay Garcia, Lorenzo Cohen, Ying Guo, Yuhong Zhou, Bing You, Joseph Chiang, Robert Z Orlowski, Donna Weber, Jatin Shah, Raymond Alexanian, Sheeba Thomas, Jorge Romaguera, Liang Zhang, Maria Badillo, Yiming Chen, Qi Wei, Richard Lee, Kay Delasalle, Vivian Green, Michael Wang

Journal:

 

This single-arm study evaluated feasibility, safety, and initial efficacy of electroacupuncture for thalidomide/bortezomib-induced peripheral neuropathy (PN) in cancer patients with multiple myeloma.

Last Updated: 4 Jun 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Multiple myeloma" returned 320 free, full-text review articles on human participants. First 3 results:

Evolution of carfilzomib dose and schedule in patients with multiple myeloma: a historical overview.
 

Author(s): Andrzej J Jakubowiak

Journal: Cancer Treat. Rev.. 2014 Jul;40(6):781-90.

 

Carfilzomib is a proteasome inhibitor that binds selectively and irreversibly to its target. In July 2012, carfilzomib received accelerated approval in the United States for the treatment of relapsed and refractory multiple myeloma. Based on emerging preclinical data and clinical ...

Last Updated: 13 May 2014

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Expert panel consensus statement on the optimal use of pomalidomide in relapsed and refractory multiple myeloma.
 

Author(s): M A Dimopoulos, X Leleu, A Palumbo, P Moreau, M Delforge, M Cavo, H Ludwig, G J Morgan, F E Davies, P Sonneveld, S A Schey, S Zweegman, M Hansson, K Weisel, M V Mateos, T Facon, J F S Miguel

Journal: Leukemia. 2014 Aug;28(8):1573-85.

 

In this report, a panel of European myeloma experts discuss the role of pomalidomide in the treatment of relapsed and refractory multiple myeloma (RRMM). Based on the available evidence, the combination of pomalidomide and low-dose dexamethasone is a well-tolerated and effective treatment ...

Last Updated: 7 Aug 2014

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Staging and prognostication of multiple myeloma.
 

Author(s): Rafael Fonseca, Jorge Monge, Meletios A Dimopoulos

Journal: Expert Rev Hematol. 2014 Feb;7(1):21-31.

 

Multiple myeloma (MM) is a heterogeneous disease that, over the past 15 years, has seen an increased understanding of its biology and of novel therapeutic options. Distinctive subtypes of the disease have been described, each with different outcomes and clinic-pathological features. ...

Last Updated: 3 Feb 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Ohio State University Multiple Myeloma and Amyloidosis Data Registry and Sample Resource
 

Status: Recruiting

Condition Summary: Plasma Cell Dyscrasias; Monoclonal Gammopathy of Undetermined Significance; AL Amyloidosis; Multiple Myeloma

 

Last Updated: 14 Oct 2014

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A Phase 1 Study Evaluating CB-5083 in Patients With Relapsed/Refractory Multiple Myeloma
 

Status: Recruiting

Condition Summary: Relapsed Multiple Myeloma; Refractory Multiple Myeloma; Multiple Myeloma

 

Last Updated: 11 Sep 2014

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Lenalidomide and Low-Dose Dexamethasone in Patients With Previously Treated Multiple Myeloma and Kidney Dysfunction
 

Status: Recruiting

Condition Summary: Multiple Myeloma; Plasma Cell Neoplasm

 

Last Updated: 9 Jul 2014

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