Multiple myeloma

Common Name(s)

Multiple myeloma

Multiple myeloma is a cancer of the plasma cells in the bone marrow. Plasma cells help the body fight infection by producing proteins called antibodies. In multiple myeloma, plasma cells grow out of control in the bone marrow and form tumors in the areas of solid bone. The growth of these bone tumors makes it harder for the bone marrow to make healthy blood cells and platelets. This disease may also harm other tissues and organs, such as the kidneys. Multiple myeloma mainly affects older adults. Although the exact cause is unknown, there are several known risk factors that can increase a person's chance of getting this disease.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple myeloma" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

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International Myeloma Foundation

To improve the quality of life of myeloma patients while working towards prevention and a cure

Last Updated: 19 Feb 2013

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple myeloma" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

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International Myeloma Foundation

To improve the quality of life of myeloma patients while working towards prevention and a cure

http://www.myeloma.org

Last Updated: 19 Feb 2013

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Multiple myeloma" returned 3096 free, full-text research articles on human participants. First 3 results:

Managing adverse events of multiple myeloma and anti-multiple myeloma treatment: a perspective on carfilzomib.
 

Author(s): David S Siegel

Journal: Oncology (Williston Park, N.Y.). 2013 Dec;27 Suppl 3():2-3.

 

Last Updated: 4 Sep 2014

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Analysis of free serum light chains in patients suffering from multiple myeloma complicated by light-chain amyloidosis.
 

Author(s): Lidia Usnarska-Zubkiewicz, Jadwiga Hołojda, Jakub Dębski, Anna Zubkiewicz-Zarębska, Ewa Zagocka, Kazimierz Kuliczkowski

Journal: Adv Clin Exp Med. ;23(4):531-8.

 

AL amyloidosis is an acquired systemic disease in which a pathologic amorphous substance produced as a result of abnormal protein metabolism is deposited in the extracellular space of various tissues.

Last Updated: 29 Aug 2014

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The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma.
 

Author(s): Siobhan V Glavey, Salomon Manier, Alessandro Natoni, Antonio Sacco, Michele Moschetta, Michaela R Reagan, Laura S Murillo, Ilyas Sahin, Ping Wu, Yuji Mishima, Yu Zhang, Wenjing Zhang, Yong Zhang, Gareth Morgan, Lokesh Joshi, Aldo M Roccaro, Irene M Ghobrial, Michael E O'Dwyer

Journal: Blood. 2014 Sep;124(11):1765-76.

 

Glycosylation is a stepwise procedure of covalent attachment of oligosaccharide chains to proteins or lipids, and alterations in this process, especially increased sialylation, have been associated with malignant transformation and metastasis. The role of altered sialylation in multiple ...

Last Updated: 12 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Multiple myeloma" returned 332 free, full-text review articles on human participants. First 3 results:

Overview and management of cardiac and pulmonary adverse events in patients with relapsed and/or refractory multiple myeloma treated with single-agent carfilzomib.
 

Author(s): Michael Wang, Jie Cheng

Journal: Oncology (Williston Park, N.Y.). 2013 Dec;27 Suppl 3():24-30.

 

Cardiac events and pulmonary complications are commonly seen in patients with multiple myeloma (MM), most of whom are over 60 years of age at the time of their diagnosis. These events and complications may be consequences of age-related comorbidities, or effects of the disease itself ...

Last Updated: 4 Sep 2014

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Incidence and management of renal adverse events in patients with relapsed and/or refractory multiple myeloma treated with single-agent carfilzomib.
 

Author(s): Jatin J Shah

Journal: Oncology (Williston Park, N.Y.). 2013 Dec;27 Suppl 3():19-23.

 

Patients with multiple myeloma (MM) frequently experience renal dysfunction owing to patient-specific risk factors, the pathophysiology of MM, and treatment-related adverse events. The presence of renal complications in patients with MM may be associated with advanced disease and ...

Last Updated: 4 Sep 2014

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Management of hematologic adverse events in patients with relapsed and/or refractory multiple myeloma treated with single-agent carfilzomib.
 

Author(s): Ajay K Nooka

Journal: Oncology (Williston Park, N.Y.). 2013 Dec;27 Suppl 3():11-8.

 

Hematologic adverse events (AEs) are commonly encountered in patients with multiple myeloma (MM) owing to the nature of the disease and the adverse effects related to myeloma treatment. Immunomodulatory drugs (eg, thalidomide, lenalidomide, and pomalidomide) and the proteasome inhibitor ...

Last Updated: 4 Sep 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Ohio State University Multiple Myeloma and Amyloidosis Data Registry and Sample Resource
 

Status: Recruiting

Condition Summary: Plasma Cell Dyscrasias; Monoclonal Gammopathy of Undetermined Significance; AL Amyloidosis; Multiple Myeloma

 

Last Updated: 14 Oct 2014

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A Phase 1 Study Evaluating CB-5083 in Patients With Relapsed/Refractory Multiple Myeloma
 

Status: Recruiting

Condition Summary: Relapsed Multiple Myeloma; Refractory Multiple Myeloma; Multiple Myeloma

 

Last Updated: 11 Sep 2014

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Lenalidomide and Low-Dose Dexamethasone in Patients With Previously Treated Multiple Myeloma and Kidney Dysfunction
 

Status: Recruiting

Condition Summary: Multiple Myeloma; Plasma Cell Neoplasm

 

Last Updated: 9 Jul 2014

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