Multiple myeloma

Common Name(s)

Multiple myeloma

Multiple myeloma is a cancer of the plasma cells in the bone marrow. Plasma cells help the body fight infection by producing proteins called antibodies. In multiple myeloma, plasma cells grow out of control in the bone marrow and form tumors in the areas of solid bone. The growth of these bone tumors makes it harder for the bone marrow to make healthy blood cells and platelets. This disease may also harm other tissues and organs, such as the kidneys. Multiple myeloma mainly affects older adults. Although the exact cause is unknown, there are several known risk factors that can increase a person's chance of getting this disease.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple myeloma" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

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Ben's Friends

Our mission is to ensure that everyone in the world with a rare disease has a safe place to go and connect with others like them.

Last Updated: 11 Jul 2016

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Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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International Myeloma Foundation

To improve the quality of life of myeloma patients while working towards prevention and a cure

Last Updated: 19 Feb 2013

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple myeloma" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

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Ben's Friends

Our mission is to ensure that everyone in the world with a rare disease has a safe place to go and connect with others like them.

http://www.bensfriends.org

Last Updated: 11 Jul 2016

View Details
Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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International Myeloma Foundation

To improve the quality of life of myeloma patients while working towards prevention and a cure

http://www.myeloma.org

Last Updated: 19 Feb 2013

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Multiple myeloma" returned 4013 free, full-text research articles on human participants. First 3 results:

Risk of vertebral compression fractures in multiple myeloma patients: A finite-element study.
 

Author(s): D Anitha, Baum Thomas, Kirschke S Jan, Karupppasamy Subburaj

Journal: Medicine (Baltimore). 2017 Jan;96(2):e5825.

 

The purpose of this study was to develop and validate a finite element (FE) model to predict vertebral bone strength in vitro using multidetector computed tomography (MDCT) images in multiple myeloma (MM) patients, to serve as a complementing tool to assess fracture risk. In addition, ...

Last Updated: 12 Jan 2017

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Bortezomib combined with lenalidomide as the first-line treatment for the rare synchronous occurrence of multiple myeloma and pulmonary adenocarcinoma: A case report.
 

Author(s): Wenli Zuo, Xinghu Zhu, Jingke Yang, Zhenyang Mei, Mei Deng, Quande Lin, Yongping Song, Qingsong Yin

Journal: Medicine (Baltimore). 2017 Jan;96(1):e5787.

 

Simultaneous multiple myeloma (MM) and pulmonary adenocarcinoma is a rare occurrence, and thus, treatment is a challenge. This study reports on 1 such case of MM with concurrent lung cancer, where an accurate diagnosis was made and the patient underwent treatment for both cancers.

Last Updated: 10 Jan 2017

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History of autoimmune disease is associated with impaired survival in multiple myeloma and monoclonal gammopathy of undetermined significance: a population-based study.
 

Author(s): Ebba K Lindqvist, Ola Landgren, Sigrún H Lund, Ingemar Turesson, Malin Hultcrantz, Lynn Goldin, Magnus Björkholm, Sigurdur Y Kristinsson

Journal: Ann. Hematol.. 2017 Feb;96(2):261-269.

 

Multiple myeloma (MM) is a plasma cell disorder preceded by monoclonal gammopathy of undetermined significance (MGUS). Incidence of MM and MGUS is higher among patients with autoimmune disease. The aim of this study was to determine whether a history of autoimmunity has an impact ...

Last Updated: 3 Nov 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Multiple myeloma" returned 425 free, full-text review articles on human participants. First 3 results:

Bortezomib-based treatment for multiple myeloma patients with renal impairment: A systematic review and meta-analysis of observational studies.
 

Author(s): Wanqiu Zhu, Wenming Chen

Journal: Medicine (Baltimore). 2016 Nov;95(46):e5202.

 

Renal insufficiency is a common and severe complication of patients with multiple myeloma. The aim of this study was to evaluate bortezomib-based treatment for multiple myeloma patients with renal insufficiency.

Last Updated: 18 Nov 2016

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C3 glomerulonephritis in multiple myeloma: A case report and literature review.
 

Author(s): Guang Yin, Zhen Cheng, Cai-Hong Zeng, Zhi-Hong Liu

Journal: Medicine (Baltimore). 2016 Sep;95(37):e4843.

 

C3 glomerulonephritis (C3 GN) is a recently defined entity characterized by predominant C3 deposition in glomeruli due to abnormal activation of the alternative pathway of complement system. C3 GN has been reported to be associated with several systemic diseases. However, the association ...

Last Updated: 16 Sep 2016

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New Targets and New Agents in High-Risk Multiple Myeloma.
 

Author(s): Ajay K Nooka, Sagar Lonial

Journal: Am Soc Clin Oncol Educ Book. 2016 ;35():e431-41.

 

Advances in the treatment of multiple myeloma have resulted in dramatic improvements in outcomes for patients. The newly emerging profiling of mutations emerging as a consequence of large prospective sequencing studies such as the CoMMpass Study or other efforts from European investigators ...

Last Updated: 2 Jun 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Treatment of Chemotherapy Refractory Multiple Myeloma by CART-138
 

Status: Recruiting

Condition Summary: Multiple Myeloma

 

Last Updated: 26 Jan 2016

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Last Updated: 22 Aug 2016

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Last Updated: 13 May 2016

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