Multiple myeloma

Common Name(s)

Multiple myeloma

Multiple myeloma is a cancer of the plasma cells in the bone marrow. Plasma cells help the body fight infection by producing proteins called antibodies. In multiple myeloma, plasma cells grow out of control in the bone marrow and form tumors in the areas of solid bone. The growth of these bone tumors makes it harder for the bone marrow to make healthy blood cells and platelets. This disease may also harm other tissues and organs, such as the kidneys. Multiple myeloma mainly affects older adults. Although the exact cause is unknown, there are several known risk factors that can increase a person's chance of getting this disease.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple myeloma" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

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Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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International Myeloma Foundation

To improve the quality of life of myeloma patients while working towards prevention and a cure

Last Updated: 19 Feb 2013

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple myeloma" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

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Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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International Myeloma Foundation

To improve the quality of life of myeloma patients while working towards prevention and a cure

http://www.myeloma.org

Last Updated: 19 Feb 2013

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Multiple myeloma" returned 3400 free, full-text research articles on human participants. First 3 results:

Case 8-2015: A Man with Multiple Myeloma, Skin Tightness, Arthralgias, and Edema.
 

Author(s): Fredrick Wigley, Rosalynn M Nazarian

Journal: N. Engl. J. Med.. 2015 Jun;372(25):2466.

 

Last Updated: 18 Jun 2015

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Treatment of relapsed multiple myeloma.
 

Author(s): A Keith Stewart, Antonio Palumbo

Journal: N. Engl. J. Med.. 2015 Apr;372(18):1774-5.

 

Last Updated: 30 Apr 2015

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[Survival prognosis factors in multiple myeloma].
 

Author(s): Mohamed Younes, Haifa Hachfi, Ferdaous Hammouda, Kaouthar Younes, Sameh Ben Hammouda, Mahbouba Jguirim, Saoussen Zrour, Ismail Béjia, Mongi Touzi, Naceur Bergaoui

Journal: Tunis Med. 2014 Jun;92(6):399-405.

 

Outcome in multiple myeloma (MM) is very heterogeneous in survival and therapeutic response, constantly fatale despite her therapy progress.

Last Updated: 6 Mar 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Multiple myeloma" returned 364 free, full-text review articles on human participants. First 3 results:

New criteria for response assessment: role of minimal residual disease in multiple myeloma.
 

Author(s): Bruno Paiva, Jacques J M van Dongen, Alberto Orfao

Journal: Blood. 2015 May;125(20):3059-68.

 

Assessment of minimal residual disease (MRD) is becoming standard diagnostic care for potentially curable neoplasms such as acute lymphoblastic leukemia. In multiple myeloma (MM), the majority of patients will inevitably relapse despite achievement of progressively higher complete ...

Last Updated: 15 May 2015

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[Cutaneous involvement in multiple myeloma. Report of one case].
 

Author(s): Camila O Peña, Ximena T Valladares, Ana María H Gray, María Elena C Cabrera

Journal: Rev Med Chil. 2014 Dec;142(12):1603-6.

 

Cutaneous involvement in multiple myeloma (MM) is extremely rare. It may correspond to plasmocytomas, secondary amyloidosis, paraneoplastic syndromes or drug reactions. We report a 75-year-old female with skin lesions, corresponding to extramedullary plasmacytomas (EPs), as a manifestation ...

Last Updated: 19 Feb 2015

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The European medicines agency review of pomalidomide in combination with low-dose dexamethasone for the treatment of adult patients with multiple myeloma: summary of the scientific assessment of the committee for medicinal products for human use.
 

Author(s): Zahra Hanaizi, Beatriz Flores, Robert Hemmings, Jorge Camarero, Arantxa Sancho-Lopez, Tomas Salmonson, Christian Gisselbrecht, Edward Laane, Francesco Pignatti

Journal: Oncologist. 2015 Mar;20(3):329-34.

 

On August 5, 2013, a marketing authorization valid throughout the European Union (EU) was issued for pomalidomide in combination with dexamethasone for the treatment of adult patients with relapsed and refractory multiple myeloma (MM) who have received at least two prior treatment ...

Last Updated: 6 Mar 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Denosumab Compared to Zoledronic Acid in the Treatment of Bone Disease in Subjects With Multiple Myeloma
 

Status: Recruiting

Condition Summary: Cancer; Hematologic Malignancies; Multiple Myeloma; Oncology; Bone Metastases; Multiple Myeloma Bone Lesions

 

Last Updated: 19 Aug 2015

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Combination Study of Pomalidomide, Marizomib, and Dexamethasone in Relapsed or Refractory Multiple Myeloma
 

Status: Recruiting

Condition Summary: Multiple Myeloma in Relapse; Refractory Multiple Myeloma

 

Last Updated: 11 May 2015

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Study of High Dose Carfilzomib in Multiple Myeloma Patients Who Have Progressed On Standard Dose Carfilzomib
 

Status: Recruiting

Condition Summary: Relapse Multiple Myeloma; Refractory Multiple Myeloma

 

Last Updated: 21 Oct 2014

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