Multicentric Castleman’s Disease

Common Name(s)

Multicentric Castleman’s Disease

Multicentric CastlemanÕs disease is a type of Castleman's disease that affects more than a single group of lymph nodes. It can also affect other organs containing lymphoid tissue. People with multicentric Castleman's disease often have serious infections, fevers, weight loss, fatigue, night sweats, and nerve damage that can cause weakness and numbness. Blood tests may indicate anemia and high levels of antibodies in the blood (hypergammaglobulinemia). They may also experience loss of appetite, nausea, vomiting, and enlarged liver and spleen. Multicentric Castleman disease can weaken the immune system, making it hard to fight infection. Infections in people with multicentric Castleman's disease can be very serious and may even be fatal. Multicentric Castleman's disease acts very much like lymphoma. In fact, about 20% of people with this disease eventually develop lymphoma. Treatment may involve surgery, chemotherapy or radiation therapy.  
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multicentric Castleman’s Disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Multicentric Castleman’s Disease" returned 70 free, full-text research articles on human participants. First 3 results:

Successful Treatment of TAFRO Syndrome, a Variant of Multicentric Castleman's Disease, with Cyclosporine A: Possible Pathogenetic Contribution of Interleukin-2.
 

Author(s): Yoshinobu Konishi, Satoshi Takahashi, Katsuyuki Nishi, Taro Sakamaki, Sachiko Mitani, Hitomi Kaneko, Chisato Mizutani, Naoya Ukyo, Hirokazu Hirata, Mitsuru Tsudo

Journal: Tohoku J. Exp. Med.. 2015 ;236(4):289-95.

 

Multicentric Castleman's disease is a systemic inflammatory disorder characterized by lymphadenopathy and excessive interleukin-6 production. A unique clinicopathologic variant of multicentric Castleman's disease, TAFRO (i.e., thrombocytopenia, anasarca, fever, renal failure or reticulin ...

Last Updated: 7 Aug 2015

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Efficacy of bortezomib and thalidomide in the recrudescent form of multicentric mixed-type Castleman's disease.
 

Author(s): Q Lin, B Fang, H Huang, F Yu, X Chai, Y Zhang, J Zhou, Q Xia, Y Li, Y Song

Journal:

 

Last Updated: 21 Mar 2015

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Multicentric Castleman's disease with voltage-gated potassium channel antibody-positive limbic encephalitis: a case report.
 

Author(s): Vikram R Rao, Leland E Lim, Dean Fong, Nina I Garga, Karen L Parko

Journal:

 

Castleman's disease is a rare lymphoproliferative disorder which occurs in localized and multicentric forms and can mimic lymphoma. Despite its well-known association with certain autoimmune diseases, including paraneoplastic pemphigus and myasthenia gravis, Castleman's disease has ...

Last Updated: 18 Apr 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Multicentric Castleman’s Disease" returned 6 free, full-text review articles on human participants. First 3 results:

[Hyaline-vascular Multicentric Castleman's Disease in an immunocompetent patient].
 

Author(s): Sergio Armando Zapata-Bonilla, Roberto López Vargas, Aldo Alfonso Scherling-Ocampo, Ana Lilia Morales Leyte, Liliana García Ilizaliturri

Journal: Gac Med Mex. ;151(5):648-54.

 

A previously healthy, immunocompetent 67-year-old female presented with a one-month history of general symptoms, weight loss, night fevers, and bilateral lower extremity edema. On admission she had severe anemia, acute kidney injury, and multiple lymphadenopathies. An excisional biopsy ...

Last Updated: 3 Nov 2015

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Mixed-type multicentric Castleman's disease developing during a 17-year follow-up of sarcoidosis.
 

Author(s): Nobuyasu Awano, Minoru Inomata, Keisuke Kondoh, Kohta Satake, Hiroyuki Kamiya, Atsuko Moriya, Tsunehiro Ando, Toshio Kumasaka, Tamiko Takemura, Kengo Takeuchi, Soichiro Ikushima

Journal: Intern. Med.. 2012 ;51(21):3061-6.

 

Multicentric Castleman's Disease (MCD) is a systemic disease characterized by generalized lymphadenopathy and the proliferation of plasma cells. The development of MCD in a patient with preexisting sarcoidosis has not been previously reported. We herein describe a case of MCD developing ...

Last Updated: 5 Nov 2012

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HIV-associated multicentric Castleman's disease.
 

Author(s): Justin Stebbing, Liron Pantanowitz, Farshid Dayyani, Ryan J Sullivan, Mark Bower, Bruce J Dezube

Journal: Am. J. Hematol.. 2008 Jun;83(6):498-503.

 

Multicentric Castleman's disease (MCD), a relatively rare lymphoproliferative disorder that presents with heterogenous symptoms including fevers, anemia, and multifocal lymphadenopathy, is today most commonly observed in individuals infected with human immunodeficiency virus type-1 ...

Last Updated: 8 May 2008

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Tocilizumab for KSHV-Associated Multicentric Castleman Disease
 

Status: Recruiting

Condition Summary: Castleman Disease; Castleman's Disease; Giant Lymph Node Hyperplasia

 

Last Updated: 13 Feb 2016

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Specimen Collections From Patients With HIV Infection, KSHV Infection, Viral-Related Pre-malignant Lesions and Cancer
 

Status: Recruiting

Condition Summary: HIV; Kaposi's Sarcoma; Lymphomas; Multicentric Castleman's Disease; Primary Effusion Lymphoma

 

Last Updated: 10 Mar 2016

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Virotherapy and Natural History Study of KHSV-Associated Multricentric Castleman s Disease With Correlates of Disease Activity
 

Status: Recruiting

Condition Summary: Lymphoproliferative Disorder; HHV-8; Malignancy; HIV

 

Last Updated: 15 Dec 2015

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