Multicentric Castleman’s Disease

Common Name(s)

Multicentric Castleman’s Disease

Multicentric CastlemanÕs disease is a type of Castleman's disease that affects more than a single group of lymph nodes. It can also affect other organs containing lymphoid tissue. People with multicentric Castleman's disease often have serious infections, fevers, weight loss, fatigue, night sweats, and nerve damage that can cause weakness and numbness. Blood tests may indicate anemia and high levels of antibodies in the blood (hypergammaglobulinemia). They may also experience loss of appetite, nausea, vomiting, and enlarged liver and spleen. Multicentric Castleman disease can weaken the immune system, making it hard to fight infection. Infections in people with multicentric Castleman's disease can be very serious and may even be fatal. Multicentric Castleman's disease acts very much like lymphoma. In fact, about 20% of people with this disease eventually develop lymphoma. Treatment may involve surgery, chemotherapy or radiation therapy.  
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multicentric Castleman’s Disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Multicentric Castleman’s Disease" returned 68 free, full-text research articles on human participants. First 3 results:

Efficacy of bortezomib and thalidomide in the recrudescent form of multicentric mixed-type Castleman's disease.
 

Author(s): Q Lin, B Fang, H Huang, F Yu, X Chai, Y Zhang, J Zhou, Q Xia, Y Li, Y Song

Journal:

 

Last Updated: 21 Mar 2015

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Multicentric Castleman's disease with impaired lymphocytic apoptosis.
 

Author(s): Hiroyuki Minemura, Kazuhiko Ikeda, Yoshinori Tanino, Yuko Hashimoto, Takefumi Nikaido, Atsuro Fukuhara, Hiroshi Yokouchi, Suguru Sato, Mishie Tanino, Teruaki Oka, Akira Hebisawa, Hiroyuki Suzuki, Kazuei Ogawa, Yasuchika Takeishi, Mitsuru Munakata

Journal: Allergol Int. 2015 Jan;64(1):112-4.

 

Last Updated: 9 Jan 2015

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Rapid multiorgan failure due to large B-cell lymphoma arising in human herpesvirus-8-associated multicentric Castleman's disease in a patient with human immunodeficiency virus infection.
 

Author(s): Yoshihiko Ogawa, Dai Watanabe, Kazuyuki Hirota, Motoko Ikuma, Keishiro Yajima, Daisuke Kasai, Kiyoshi Mori, Yasunori Ota, Yasuharu Nishida, Tomoko Uehira, Masayuki Mano, Takahisa Yamane, Takuma Shirasaka

Journal: Intern. Med.. 2014 ;53(24):2805-9.

 

A 46-year-old man presented with a high-grade fever, multiple lymphadenopathies, hepatosplenomegaly and human immunodeficiency virus (HIV) seropositivity, without severe immunosuppression. We suspected human herpesvirus-8 (HHV-8)-associated multicentric Castleman's disease (MCD) based ...

Last Updated: 16 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Multicentric Castleman’s Disease" returned 5 free, full-text review articles on human participants. First 3 results:

Mixed-type multicentric Castleman's disease developing during a 17-year follow-up of sarcoidosis.
 

Author(s): Nobuyasu Awano, Minoru Inomata, Keisuke Kondoh, Kohta Satake, Hiroyuki Kamiya, Atsuko Moriya, Tsunehiro Ando, Toshio Kumasaka, Tamiko Takemura, Kengo Takeuchi, Soichiro Ikushima

Journal: Intern. Med.. 2012 ;51(21):3061-6.

 

Multicentric Castleman's Disease (MCD) is a systemic disease characterized by generalized lymphadenopathy and the proliferation of plasma cells. The development of MCD in a patient with preexisting sarcoidosis has not been previously reported. We herein describe a case of MCD developing ...

Last Updated: 5 Nov 2012

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HIV-associated multicentric Castleman's disease.
 

Author(s): Justin Stebbing, Liron Pantanowitz, Farshid Dayyani, Ryan J Sullivan, Mark Bower, Bruce J Dezube

Journal: Am. J. Hematol.. 2008 Jun;83(6):498-503.

 

Multicentric Castleman's disease (MCD), a relatively rare lymphoproliferative disorder that presents with heterogenous symptoms including fevers, anemia, and multifocal lymphadenopathy, is today most commonly observed in individuals infected with human immunodeficiency virus type-1 ...

Last Updated: 8 May 2008

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Multicentric Castleman's disease, non-Hodgkin's lymphoma, and Kaposi's sarcoma: a rare simultaneous occurrence.
 

Author(s): Sanya Sukpanichnant, Apichati Sivayathorn, Sukon Visudhiphan, Weerapan Ngowthammatas

Journal: Asian Pac. J. Allergy Immunol.. 2002 Jun;20(2):127-33.

 

A rare simultaneous occurrence of multicentric Castleman's disease, non-Hodgkin's lymphoma, and Kaposi's sarcoma was diagnosed in a 70-year-old man who presented with fever, polyarthralgia, weight loss, vascular purpura, anemia, generalized lymphadenopathy, and hepatosplenomegaly. ...

Last Updated: 29 Oct 2002

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Tocilizumab for KSHV-Associated Multicentric Castleman Disease
 

Status: Recruiting

Condition Summary: Castleman Disease; Castleman's Disease; Giant Lymph Node Hyperplasia

 

Last Updated: 2 Feb 2016

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Specimen Collections From Patients With HIV Infection, KSHV Infection, Viral-Related Pre-malignant Lesions and Cancer
 

Status: Recruiting

Condition Summary: HIV; Kaposi's Sarcoma; Lymphomas; Multicentric Castleman's Disease; Primary Effusion Lymphoma

 

Last Updated: 7 Nov 2015

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Virotherapy and Natural History Study of KHSV-Associated Multricentric Castleman s Disease With Correlates of Disease Activity
 

Status: Recruiting

Condition Summary: Lymphoproliferative Disorder; HHV-8; Malignancy; HIV

 

Last Updated: 15 Dec 2015

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