Multicentric Castleman’s Disease

Common Name(s)

Multicentric Castleman’s Disease

Multicentric CastlemanÕs disease is a type of Castleman's disease that affects more than a single group of lymph nodes. It can also affect other organs containing lymphoid tissue. People with multicentric Castleman's disease often have serious infections, fevers, weight loss, fatigue, night sweats, and nerve damage that can cause weakness and numbness. Blood tests may indicate anemia and high levels of antibodies in the blood (hypergammaglobulinemia). They may also experience loss of appetite, nausea, vomiting, and enlarged liver and spleen. Multicentric Castleman disease can weaken the immune system, making it hard to fight infection. Infections in people with multicentric Castleman's disease can be very serious and may even be fatal. Multicentric Castleman's disease acts very much like lymphoma. In fact, about 20% of people with this disease eventually develop lymphoma. Treatment may involve surgery, chemotherapy or radiation therapy.  
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multicentric Castleman’s Disease" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Multicentric Castleman’s Disease" returned 58 free, full-text research articles on human participants. First 3 results:

Rapid multiorgan failure due to large B-cell lymphoma arising in human herpesvirus-8-associated multicentric Castleman's disease in a patient with human immunodeficiency virus infection.
 

Author(s): Yoshihiko Ogawa, Dai Watanabe, Kazuyuki Hirota, Motoko Ikuma, Keishiro Yajima, Daisuke Kasai, Kiyoshi Mori, Yasunori Ota, Yasuharu Nishida, Tomoko Uehira, Masayuki Mano, Takahisa Yamane, Takuma Shirasaka

Journal: Intern. Med.. 2014 ;53(24):2805-9.

 

A 46-year-old man presented with a high-grade fever, multiple lymphadenopathies, hepatosplenomegaly and human immunodeficiency virus (HIV) seropositivity, without severe immunosuppression. We suspected human herpesvirus-8 (HHV-8)-associated multicentric Castleman's disease (MCD) based ...

Last Updated: 16 Dec 2014

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The first report of adolescent TAFRO syndrome, a unique clinicopathologic variant of multicentric Castleman's disease.
 

Author(s): Ikuko Kubokawa, Akihiro Yachie, Akira Hayakawa, Satoshi Hirase, Nobuyuki Yamamoto, Takeshi Mori, Tomoko Yanai, Yasuhiro Takeshima, Eiryu Kyo, Goichi Kageyama, Hiroshi Nagai, Keiichiro Uehara, Masaru Kojima, Kazumoto Iijima

Journal:

 

TAFRO syndrome is a unique clinicopathologic variant of multicentric Castleman's disease that has recently been identified in Japan. It is characterized by a constellation of symptoms: Thrombocytopenia, Anasarca, reticulin Fibrosis of the bone marrow, Renal dysfunction and Organomegaly ...

Last Updated: 11 Jul 2014

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Successful treatment of iatrogenic multicentric Castleman's disease arising due to recrudescence of HHV-8 in a liver transplant patient.
 

Author(s): D J Speicher, M M Sehu, P Mollee, L Shen, N W Johnson, J L Faoagali

Journal: Am. J. Transplant.. 2014 May;14(5):1207-13.

 

We describe the case of a 59-year-old HIV-negative male who developed multicentric Castleman's disease (MCD) 1 year postliver transplantation due to recrudescence of a pretransplant human herpesvirus-8 (HHV-8) infection. He presented with fevers, dry cough, weight loss and drenching ...

Last Updated: 22 Apr 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Multicentric Castleman’s Disease" returned 4 free, full-text review articles on human participants. First 3 results:

Mixed-type multicentric Castleman's disease developing during a 17-year follow-up of sarcoidosis.
 

Author(s): Nobuyasu Awano, Minoru Inomata, Keisuke Kondoh, Kohta Satake, Hiroyuki Kamiya, Atsuko Moriya, Tsunehiro Ando, Toshio Kumasaka, Tamiko Takemura, Kengo Takeuchi, Soichiro Ikushima

Journal: Intern. Med.. 2012 ;51(21):3061-6.

 

Multicentric Castleman's Disease (MCD) is a systemic disease characterized by generalized lymphadenopathy and the proliferation of plasma cells. The development of MCD in a patient with preexisting sarcoidosis has not been previously reported. We herein describe a case of MCD developing ...

Last Updated: 5 Nov 2012

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Multicentric Castleman's disease, non-Hodgkin's lymphoma, and Kaposi's sarcoma: a rare simultaneous occurrence.
 

Author(s): Sanya Sukpanichnant, Apichati Sivayathorn, Sukon Visudhiphan, Weerapan Ngowthammatas

Journal: Asian Pac. J. Allergy Immunol.. 2002 Jun;20(2):127-33.

 

A rare simultaneous occurrence of multicentric Castleman's disease, non-Hodgkin's lymphoma, and Kaposi's sarcoma was diagnosed in a 70-year-old man who presented with fever, polyarthralgia, weight loss, vascular purpura, anemia, generalized lymphadenopathy, and hepatosplenomegaly. ...

Last Updated: 29 Oct 2002

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Absence of gallium uptake in multicentric Castleman's disease of plasma cell type.
 

Author(s): C S Chim, F P Choi, G C Ooi, Y L Kwong

Journal: Haematologica. 2001 Apr;86(4):442-3.

 

Multicentric Castleman's disease (MCD) of plasma cell type is a reactive lymphoproliferative disease. While 67Ga scanning is useful in the detection of malignant lymphomas, its role in reactive lymphadenopathy is unknown. We report the absence of 67Ga uptake in three patients with ...

Last Updated: 30 Apr 2001

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Tocilizumab for KSHV-Associated Multicentric Castleman Disease
 

Status: Recruiting

Condition Summary: Castleman Disease; Castleman's Disease; Giant Lymph Node Hyperplasia

 

Last Updated: 3 Mar 2015

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Specimen Collections From Patients With HIV Infection, KSHV Infection, Viral-Related Pre-malignant Lesions and Cancer
 

Status: Recruiting

Condition Summary: HIV; Kaposi's Sarcoma; Lymphomas; Multicentric Castleman's Disease; Primary Effusion Lymphoma

 

Last Updated: 22 Apr 2015

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Dose-escalation Study of Oral CX-4945
 

Status: Recruiting

Condition Summary: Advanced Solid Tumors; Breast Cancer; Inflammatory Breast Cancer; Castleman's Disease; Multiple Myeloma

 

Last Updated: 13 Jun 2011

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