Multicentric Castleman’s Disease

Common Name(s)

Multicentric Castleman’s Disease

Multicentric CastlemanÕs disease is a type of Castleman's disease that affects more than a single group of lymph nodes. It can also affect other organs containing lymphoid tissue. People with multicentric Castleman's disease often have serious infections, fevers, weight loss, fatigue, night sweats, and nerve damage that can cause weakness and numbness. Blood tests may indicate anemia and high levels of antibodies in the blood (hypergammaglobulinemia). They may also experience loss of appetite, nausea, vomiting, and enlarged liver and spleen. Multicentric Castleman disease can weaken the immune system, making it hard to fight infection. Infections in people with multicentric Castleman's disease can be very serious and may even be fatal. Multicentric Castleman's disease acts very much like lymphoma. In fact, about 20% of people with this disease eventually develop lymphoma. Treatment may involve surgery, chemotherapy or radiation therapy.  
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multicentric Castleman’s Disease" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Multicentric Castleman’s Disease" returned 53 free, full-text research articles on human participants. First 3 results:

Multicentric Castleman's disease in a Ghanaian adult.
 

Author(s): Y A Dei-Adomakoh, C Segbefia, I Ekem, A Taylor

Journal: Ghana Med J. 2013 Jun;47(2):92-5.

 

Castleman's disease is a rare cause of lymphoid hyperplasia that may result in localized symptoms or an aggressive, multisystem disorder that can mimic other diseases like lymphoma or tuberculosis. We describe a case of a 55-year-old Ghanaian male who was successfully diagnosed and ...

Last Updated: 22 Aug 2013

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Successful treatment of a patient with multicentric Castleman's disease who presented with thrombocytopenia, ascites, renal failure and myelofibrosis using tocilizumab, an anti-interleukin-6 receptor antibody.
 

Author(s): Hiroshi Kawabata, Shin-ichi Kotani, Yumi Matsumura, Tadakazu Kondo, Tatsuya Katsurada, Hironori Haga, Norimitsu Kadowaki, Akifumi Takaori-Kondo

Journal: Intern. Med.. 2013 ;52(13):1503-7.

 

We herein describe an unusual case of multicentric Castleman's disease accompanied by thrombocytopenia, ascites, renal failure and myelofibrosis in a Japanese woman. The patient was initially diagnosed as having myelodysplastic syndrome with myelofibrosis. The general condition of ...

Last Updated: 1 Jul 2013

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A case of multicentric castleman's disease of mixed-type, which showed constellation of symptoms, i.e., thrombocytopenia, anasarca, anemia, fever, myelofibrosis, and lymphadenopathy.
 

Author(s): Nobuyasu Awano, Minoru Inomata, Yui Sonoda, Keisuke Kondoh, Ryu Ono, Atsuko Moriya, Tsunehiro Ando, Toshio Kumasaka, Tamiko Takemura, Kengo Takeuchi, Soichiro Ikushima

Journal: J Clin Exp Hematop. 2013 ;53(1):101-5.

 

Last Updated: 26 Jun 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Multicentric Castleman’s Disease" returned 4 free, full-text review articles on human participants. First 3 results:

Mixed-type multicentric Castleman's disease developing during a 17-year follow-up of sarcoidosis.
 

Author(s): Nobuyasu Awano, Minoru Inomata, Keisuke Kondoh, Kohta Satake, Hiroyuki Kamiya, Atsuko Moriya, Tsunehiro Ando, Toshio Kumasaka, Tamiko Takemura, Kengo Takeuchi, Soichiro Ikushima

Journal: Intern. Med.. 2012 ;51(21):3061-6.

 

Multicentric Castleman's Disease (MCD) is a systemic disease characterized by generalized lymphadenopathy and the proliferation of plasma cells. The development of MCD in a patient with preexisting sarcoidosis has not been previously reported. We herein describe a case of MCD developing ...

Last Updated: 5 Nov 2012

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Multicentric Castleman's disease, non-Hodgkin's lymphoma, and Kaposi's sarcoma: a rare simultaneous occurrence.
 

Author(s): Sanya Sukpanichnant, Apichati Sivayathorn, Sukon Visudhiphan, Weerapan Ngowthammatas

Journal: Asian Pac. J. Allergy Immunol.. 2002 Jun;20(2):127-33.

 

A rare simultaneous occurrence of multicentric Castleman's disease, non-Hodgkin's lymphoma, and Kaposi's sarcoma was diagnosed in a 70-year-old man who presented with fever, polyarthralgia, weight loss, vascular purpura, anemia, generalized lymphadenopathy, and hepatosplenomegaly. ...

Last Updated: 29 Oct 2002

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Absence of gallium uptake in multicentric Castleman's disease of plasma cell type.
 

Author(s): C S Chim, F P Choi, G C Ooi, Y L Kwong

Journal: Haematologica. 2001 Apr;86(4):442-3.

 

Multicentric Castleman's disease (MCD) of plasma cell type is a reactive lymphoproliferative disease. While 67Ga scanning is useful in the detection of malignant lymphomas, its role in reactive lymphadenopathy is unknown. We report the absence of 67Ga uptake in three patients with ...

Last Updated: 30 Apr 2001

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Pomalidomide Combined With Modified DA-EPOCH and Rituximab in KSHV-Associated Lymphomas
 

Status: Recruiting

Condition Summary: Large Cell Lymphoma Arising in KSHV-associated Multicentric Castleman Disease; Primary Effusion Lymphoma

 

Last Updated: 27 Aug 2014

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Tocilizumab for KSHV-Associated Multicentric Castleman Disease
 

Status: Recruiting

Condition Summary: Castleman Disease; Castleman's Disease; Giant Lymph Node Hyperplasia

 

Last Updated: 26 Aug 2014

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Specimen Collections From Patients With HIV Infection, KSHV Infection, Viral-Related Pre-malignant Lesions and Cancer
 

Status: Recruiting

Condition Summary: HIV; Kaposi's Sarcoma; Lymphomas; Multicentric Castleman's Disease; Primary Effusion Lymphoma

 

Last Updated: 7 Jun 2014

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