Motor neuron disease

Common Name(s)

Motor neuron disease

Description for this condition is not yet available.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Motor neuron disease" for support, advocacy or research.

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The ALS Association - Evergreen Chapter

Leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig's Disease and their families to live fuller lives by providing them with compassionate care and support.

Last Updated: 12 Jun 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Motor neuron disease" for support, advocacy or research.

Logo
The ALS Association - Evergreen Chapter

Leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig's Disease and their families to live fuller lives by providing them with compassionate care and support.

http://www.alsa-ec.org

Last Updated: 12 Jun 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Motor neuron disease" returned 227 free, full-text research articles on human participants. First 3 results:

Inhibition of Cytohesins Protects against Genetic Models of Motor Neuron Disease.
 

Author(s): Jinbin Zhai, Lei Zhang, Jelena Mojsilovic-Petrovic, Xiaoying Jian, Jeffrey Thomas, Kengo Homma, Anton Schmitz, Michael Famulok, Hidenori Ichijo, Yair Argon, Paul A Randazzo, Robert G Kalb

Journal: J. Neurosci.. 2015 Jun;35(24):9088-105.

 

Mutant genes that underlie Mendelian forms of amyotrophic lateral sclerosis (ALS) and biochemical investigations of genetic disease models point to potential driver pathophysiological events involving endoplasmic reticulum (ER) stress and autophagy. Several steps in these cell biological ...

Last Updated: 18 Jun 2015

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Low signal intensity of motor cortex in SWI sequence: a radiological marker for motor neuron disease?
 

Author(s): Afonso Celso Pedrotti Liberato, Victor Hugo Rocha Marussi, José Luiz Pedroso, Acary Souza Bulle Oliveira, Orlando G Barsottini, Lázaro Luiz Faria do Amaral

Journal: Arq Neuropsiquiatr. 2015 Apr;73(4):362-3.

 

Last Updated: 21 May 2015

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A novel mutation P112H in the TARDBP gene associated with frontotemporal lobar degeneration without motor neuron disease and abundant neuritic amyloid plaques.
 

Author(s): Fermin Moreno, Gil D Rabinovici, Anna Karydas, Zachary Miller, Sandy Chan Hsu, Andrea Legati, Jamie Fong, Daniel Schonhaut, Hermann Esselmann, Christa Watson, Melanie L Stephens, Joel Kramer, Jens Wiltfang, William W Seeley, Bruce L Miller, Giovanni Coppola, Lea Tenenholz Grinberg

Journal:

 

Although TDP-43 is the main constituent of the ubiquitinated cytoplasmic inclusions in the most common forms of frontotemporal lobar degeneration, TARDBP mutations are not a common cause of familial frontotemporal dementia, especially in the absence of motor neuron disease.

Last Updated: 9 Apr 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Motor neuron disease" returned 22 free, full-text review articles on human participants. First 3 results:

Human-induced pluripotent stem cells pave the road for a better understanding of motor neuron disease.
 

Author(s): Beate Winner, Maria C Marchetto, Jürgen Winkler, Fred H Gage

Journal: Hum. Mol. Genet.. 2014 Sep;23(R1):R27-34.

 

While motor neuron diseases are currently incurable, induced pluripotent stem cell research has uncovered some disease-relevant phenotypes. We will discuss strategies to model different aspects of motor neuron disease and the specific neurons involved in the disease. We will then ...

Last Updated: 22 Aug 2014

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SMN control of RNP assembly: from post-transcriptional gene regulation to motor neuron disease.
 

Author(s): Darrick K Li, Sarah Tisdale, Francesco Lotti, Livio Pellizzoni

Journal: Semin. Cell Dev. Biol.. 2014 Aug;32():22-9.

 

At the post-transcriptional level, expression of protein-coding genes is controlled by a series of RNA regulatory events including nuclear processing of primary transcripts, transport of mature mRNAs to specific cellular compartments, translation and ultimately, turnover. These processes ...

Last Updated: 23 Jul 2014

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Spinal muscular atrophy: a motor neuron disorder or a multi-organ disease?
 

Author(s): Monir Shababi, Christian L Lorson, Sabine S Rudnik-Schöneborn

Journal: J. Anat.. 2014 Jan;224(1):15-28.

 

Spinal muscular atrophy (SMA) is an autosomal recessive disorder that is the leading genetic cause of infantile death. SMA is characterized by loss of motor neurons in the ventral horn of the spinal cord, leading to weakness and muscle atrophy. SMA occurs as a result of homozygous ...

Last Updated: 11 Dec 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Safety and Efficacy on Spasticity Symptoms of a Cannabis Sativa Extract in Motor Neuron Disease
 

Status: Recruiting

Condition Summary: Motor Neuron Disease; Amyotrophic Lateral Sclerosis (ALS)

 

Last Updated: 24 Jan 2013

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Cell Therapy for Motor Neuron Disease/Amyotrophic Lateral Sclerosis
 

Status: Recruiting

Condition Summary: Motor Neuron Disease/Amyotrophic Lateral Sclerosis

 

Last Updated: 13 Sep 2014

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Genetic Study of Familial and Sporadic ALS/Motor Neuron Disease, Miyoshi Myopathy and Other Neuromuscular Disorders
 

Status: Recruiting

Condition Summary: Amyotrophic Lateral Sclerosis; Frontotemporal Dementia; PLS; Motor Neuron Disease; Lou Gehrigs Disease; Familial Disease; Amyotrophic Lateral Sclerosis, Sporadic; Muscular Dystrophy; Miyoshi Myopathy

 

Last Updated: 31 Jul 2015

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