Motor neuron disease

Common Name(s)

Motor neuron disease

Description for this condition is not yet available.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Motor neuron disease" for support, advocacy or research.

Logo
The ALS Association - Evergreen Chapter

Leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig's Disease and their families to live fuller lives by providing them with compassionate care and support.

Last Updated: 12 Jun 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Motor neuron disease" for support, advocacy or research.

Logo
The ALS Association - Evergreen Chapter

Leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig's Disease and their families to live fuller lives by providing them with compassionate care and support.

http://www.alsa-ec.org

Last Updated: 12 Jun 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Motor neuron disease" returned 242 free, full-text research articles on human participants. First 3 results:

A Temporal Association between Accumulated Petrol (Gasoline) Lead Emissions and Motor Neuron Disease in Australia.
 

Author(s): Mark A S Laidlaw, Dominic B Rowe, Andrew S Ball, Howard W Mielke

Journal:

 

The age standardised death rate from motor neuron disease (MND) has increased from 1.29 to 2.74 per 100,000, an increase of 112.4% between 1959 and 2013. It is clear that genetics could not have played a causal role in the increased rate of MND deaths over such a short time span. ...

Last Updated: 25 Dec 2015

Go To URL
Expanding Phenotype of VRK1 Mutations in Motor Neuron Disease.
 

Author(s): Thy P Nguyen, Suur Biliciler, Wojciech Wiszniewski, Kazim Sheikh

Journal: J Clin Neuromuscul Dis. 2015 Dec;17(2):69-71.

 

In the past decade, hereditary forms of motor neuron disease (spinal muscular atrophy and/or amyotrophic lateral sclerosis) are increasingly identified. As advanced genetic testing is performed, molecular diagnosis can be obtained. Identifying new gene mutations can lead to further ...

Last Updated: 20 Nov 2015

Go To URL
Loss of RAD-23 Protects Against Models of Motor Neuron Disease by Enhancing Mutant Protein Clearance.
 

Author(s): Angela M Jablonski, Todd Lamitina, Nicole F Liachko, Mariangela Sabatella, Jiayin Lu, Lei Zhang, Lyle W Ostrow, Preetika Gupta, Chia-Yen Wu, Shachee Doshi, Jelena Mojsilovic-Petrovic, Hannes Lans, Jiou Wang, Brian Kraemer, Robert G Kalb

Journal: J. Neurosci.. 2015 Oct;35(42):14286-306.

 

Misfolded proteins accumulate and aggregate in neurodegenerative disease. The existence of these deposits reflects a derangement in the protein homeostasis machinery. Using a candidate gene screen, we report that loss of RAD-23 protects against the toxicity of proteins known to aggregate ...

Last Updated: 22 Oct 2015

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Motor neuron disease" returned 23 free, full-text review articles on human participants. First 3 results:

Challenges in the Understanding and Treatment of Amyotrophic Lateral Sclerosis/Motor Neuron Disease.
 

Author(s): Jeffrey Rosenfeld, Michael J Strong

Journal: Neurotherapeutics. 2015 Apr;12(2):317-25.

 

With the acceleration in our understanding of ALS and the related motor neuron disease has come even greater challenges in reconciling all of the proposed pathogenic mechanisms and how this will translate into impactful treatments. Fundamental issues such as diagnostic definition(s) ...

Last Updated: 21 Apr 2015

Go To URL
Human-induced pluripotent stem cells pave the road for a better understanding of motor neuron disease.
 

Author(s): Beate Winner, Maria C Marchetto, J├╝rgen Winkler, Fred H Gage

Journal: Hum. Mol. Genet.. 2014 Sep;23(R1):R27-34.

 

While motor neuron diseases are currently incurable, induced pluripotent stem cell research has uncovered some disease-relevant phenotypes. We will discuss strategies to model different aspects of motor neuron disease and the specific neurons involved in the disease. We will then ...

Last Updated: 22 Aug 2014

Go To URL
SMN control of RNP assembly: from post-transcriptional gene regulation to motor neuron disease.
 

Author(s): Darrick K Li, Sarah Tisdale, Francesco Lotti, Livio Pellizzoni

Journal: Semin. Cell Dev. Biol.. 2014 Aug;32():22-9.

 

At the post-transcriptional level, expression of protein-coding genes is controlled by a series of RNA regulatory events including nuclear processing of primary transcripts, transport of mature mRNAs to specific cellular compartments, translation and ultimately, turnover. These processes ...

Last Updated: 23 Jul 2014

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Safety and Efficacy on Spasticity Symptoms of a Cannabis Sativa Extract in Motor Neuron Disease
 

Status: Recruiting

Condition Summary: Motor Neuron Disease; Amyotrophic Lateral Sclerosis (ALS)

 

Last Updated: 24 Jan 2013

Go to URL
Genetic Study of Familial and Sporadic ALS/Motor Neuron Disease, Miyoshi Myopathy and Other Neuromuscular Disorders
 

Status: Recruiting

Condition Summary: Amyotrophic Lateral Sclerosis; Frontotemporal Dementia; PLS; Motor Neuron Disease; Lou Gehrigs Disease; Familial Disease; Amyotrophic Lateral Sclerosis, Sporadic; Muscular Dystrophy; Miyoshi Myopathy

 

Last Updated: 25 Aug 2016

Go to URL
Phase 1 Dose Escalation and PK Study of Cu(II)ATSM in ALS/MND
 

Status: Not yet recruiting

Condition Summary: Amyotrophic Lateral Sclerosis; Motor Neuron Disease

 

Last Updated: 22 Aug 2016

Go to URL