Motor neuron disease

Common Name(s)

Motor neuron disease

Description for this condition is not yet available.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Motor neuron disease" for support, advocacy or research.

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The ALS Association - Evergreen Chapter

Leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig's Disease and their families to live fuller lives by providing them with compassionate care and support.

Last Updated: 12 Jun 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Motor neuron disease" for support, advocacy or research.

Logo
The ALS Association - Evergreen Chapter

Leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig's Disease and their families to live fuller lives by providing them with compassionate care and support.

http://www.alsa-ec.org

Last Updated: 12 Jun 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Motor neuron disease" returned 201 free, full-text research articles on human participants. First 3 results:

A rare case of tuberculosis with motor neuron disease.
 

Author(s): Jie Ren, Cheng Shen, Guowei Che

Journal:

 

Motor neuron disease (MND) is occasionally aggravated by chronic infection. A misdiagnosed case of tuberculosis with MND is illustrated in a 45-year-old woman who underwent successful VATS wedge excision, which is presented herein. MND in an adult is a rare clinical entity. In order ...

Last Updated: 26 Dec 2014

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Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy.
 

Author(s): Nikolai A Naryshkin, Marla Weetall, Amal Dakka, Jana Narasimhan, Xin Zhao, Zhihua Feng, Karen K Y Ling, Gary M Karp, Hongyan Qi, Matthew G Woll, Guangming Chen, Nanjing Zhang, Vijayalakshmi Gabbeta, Priya Vazirani, Anuradha Bhattacharyya, Bansri Furia, Nicole Risher, Josephine Sheedy, Ronald Kong, Jiyuan Ma, Anthony Turpoff, Chang-Sun Lee, Xiaoyan Zhang, Young-Choon Moon, Panayiota Trifillis, Ellen M Welch, Joseph M Colacino, John Babiak, Neil G Almstead, Stuart W Peltz, Loren A Eng, Karen S Chen, Jesse L Mull, Maureen S Lynes, Lee L Rubin, Paulo Fontoura, Luca Santarelli, Daniel Haehnke, Kathleen D McCarthy, Roland Schmucki, Martin Ebeling, Manaswini Sivaramakrishnan, Chien-Ping Ko, Sergey V Paushkin, Hasane Ratni, Irene Gerlach, Anirvan Ghosh, Friedrich Metzger

Journal: Science. 2014 Aug;345(6197):688-93.

 

Spinal muscular atrophy (SMA) is a genetic disease caused by mutation or deletion of the survival of motor neuron 1 (SMN1) gene. A paralogous gene in humans, SMN2, produces low, insufficient levels of functional SMN protein due to alternative splicing that truncates the transcript. ...

Last Updated: 8 Aug 2014

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A zebrafish model exemplifies the long preclinical period of motor neuron disease.
 

Author(s): Tennore M Ramesh, Pamela J Shaw, Jonathan McDearmid

Journal: J. Neurol. Neurosurg. Psychiatr.. 2014 Nov;85(11):1288-9.

 

Last Updated: 18 Oct 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Motor neuron disease" returned 19 free, full-text review articles on human participants. First 3 results:

SMN control of RNP assembly: from post-transcriptional gene regulation to motor neuron disease.
 

Author(s): Darrick K Li, Sarah Tisdale, Francesco Lotti, Livio Pellizzoni

Journal: Semin. Cell Dev. Biol.. 2014 Aug;32():22-9.

 

At the post-transcriptional level, expression of protein-coding genes is controlled by a series of RNA regulatory events including nuclear processing of primary transcripts, transport of mature mRNAs to specific cellular compartments, translation and ultimately, turnover. These processes ...

Last Updated: 23 Jul 2014

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Neurogenic and myogenic contributions to hereditary motor neuron disease.
 

Author(s): Katherine V Bricceno, Kenneth H Fischbeck, Barrington G Burnett

Journal: Neurodegener Dis. 2012 ;9(4):199-209.

 

Spinal muscular atrophy and spinal and bulbar muscular atrophy are characterized by lower motor neuron loss and muscle atrophy. Although it is accepted that motor neuron loss is a primary event in disease pathogenesis, inherent defects in muscle may also contribute to the disease ...

Last Updated: 15 May 2012

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Reviewing evidences on the management of patients with motor neuron disease.
 

Author(s): C N Lee

Journal: Hong Kong Med J. 2012 Feb;18(1):48-55.

 

To review evidences on the management of patients with motor neuron disease.

Last Updated: 3 Feb 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Safety and Efficacy on Spasticity Symptoms of a Cannabis Sativa Extract in Motor Neuron Disease
 

Status: Recruiting

Condition Summary: Motor Neuron Disease; Amyotrophic Lateral Sclerosis (ALS)

 

Last Updated: 24 Jan 2013

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Cell Therapy for Motor Neuron Disease/Amyotrophic Lateral Sclerosis
 

Status: Recruiting

Condition Summary: Motor Neuron Disease/Amyotrophic Lateral Sclerosis

 

Last Updated: 13 Sep 2014

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Genetic Study of Familial and Sporadic ALS/Motor Neuron Disease, Miyoshi Myopathy and Other Neuromuscular Disorders
 

Status: Recruiting

Condition Summary: Amyotrophic Lateral Sclerosis; Frontotemporal Dementia; PLS; Motor Neuron Disease; Lou Gehrigs Disease; Familial Disease; Amyotrophic Lateral Sclerosis, Sporadic; Muscular Dystrophy; Miyoshi Myopathy

 

Last Updated: 31 Jul 2015

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