Morphea

Common Name(s)

Morphea

Morphea (mor-FEE-ah) comes from a Greek word that means ÒformÓ or Òstructure.Ó The word refers to local patches of scleroderma. The first signs of the disease are reddish patches of skin that thicken into firm, oval-shaped areas. The center of each patch becomes ivory colored with violet borders. These patches sweat very little and have little hair growth. Patches appear most often on the chest, stomach, and back. Sometimes they appear on the face, arms, and legs.  In most cases, morphea improves spontaneously over time (typically 3 to 5 years); however, patients are often left with patches of darkened or discolored skin and, in rare cases, muscle damage.  The cause of this condition is unknown. Morphea can be either localized or generalized.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Morphea" for support, advocacy or research.

International Scleroderma Network

Our mission is to provide stellar worldwide research, support, education and awareness for scleroderma and related illnesses.

Last Updated: 18 Apr 2010

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Morphea" for support, advocacy or research.

International Scleroderma Network

Our mission is to provide stellar worldwide research, support, education and awareness for scleroderma and related illnesses.

http://www.sclero.org/

Last Updated: 18 Apr 2010

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Morphea" returned 42 free, full-text research articles on human participants. First 3 results:

Hypopigmented micropapules in apparently quiescent morphea lesions: a manifestation of disease activity.
 

Author(s): Maria Teresa García-Romero, Glenn Taylor, Ronald Laxer, Elena Pope

Journal:

 

We present two young patients with morphea or localized scleroderma undergoing systemic treatment, who developed papular lesions on pre-existing sclerotic plaques. Histology was compatible with a papular presentation of morphea and other entities in the differential diagnosis were ...

Last Updated: 11 Sep 2013

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Morphea and Parry-Romberg syndrome associated with a mixed movement disorder.
 

Author(s): Ruth H Walker, John K Fink

Journal: Parkinsonism Relat. Disord.. 2013 Dec;19(12):1169-70.

 

Last Updated: 9 Dec 2013

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Correlation between soluble interleukin-2 receptor levels and modified Rodnan total skin thickness scores in a patient with generalized morphea: a case report.
 

Author(s): Noriaki Nakai, Eri Hotta, Jun Asai, Norito Katoh

Journal: Allergol Int. 2013 Sep;62(3):391-3.

 

Last Updated: 26 Aug 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Morphea" returned 2 free, full-text review articles on human participants. First 3 results:

Morphea: evidence-based recommendations for treatment.
 

Author(s): Nicole M Fett

Journal: Indian J Dermatol Venereol Leprol. ;78(2):135-41.

 

Morphea is a rare fibrosing disorder of the skin. Evidence-based treatment strategies in morphea are lacking. This review summarizes the available data on morphea treatment and provides therapeutic strategies based on morphea subtypes. The Cochrane Library, Medline and Embase from ...

Last Updated: 16 Mar 2012

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[Unilateral generalized morphea: a case and literature review].
 

Author(s): Antonia M Fernández Rodríguez, Myriam Gandia Martínez, Natalia Navas García

Journal: Reumatol Clin. ;7(6):404-6.

 

Localized scleroderma is a connective tissue disorder generally involving de entire dermis and usually limited to the subcutaneous tissue; however, it may progress to large indurated plaques, growth retardation, muscle atrophy, and even to flexion deformities or poorly healing ulcers. ...

Last Updated: 14 Nov 2011

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Morphea in Adults and Children (MAC) Cohort Study: A Morphea Registry and DNA Repository
 

Status: Recruiting

Condition Summary: Scleroderma, Localized; Morphea; Frontal Linear Scleroderma en Coup de Sabre; Scleroderma, Circumscribed; Scleroderma, Linear

 

Last Updated: 8 Mar 2013

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Treatment Study Comparing UVA-1 Phototherapy Versus Placebo Treatment for Morphea
 

Status: Recruiting

Condition Summary: Scleroderma, Localized; Morphea; Scleroderma, Circumscribed

 

Last Updated: 22 Feb 2013

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Genetic Variants in Linear Localized Scleroderma
 

Status: Not yet recruiting

Condition Summary: Morphea

 

Last Updated: 20 Aug 2014

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