Morphea

Common Name(s)

Morphea

Morphea (mor-FEE-ah) comes from a Greek word that means ÒformÓ or Òstructure.Ó The word refers to local patches of scleroderma. The first signs of the disease are reddish patches of skin that thicken into firm, oval-shaped areas. The center of each patch becomes ivory colored with violet borders. These patches sweat very little and have little hair growth. Patches appear most often on the chest, stomach, and back. Sometimes they appear on the face, arms, and legs.  In most cases, morphea improves spontaneously over time (typically 3 to 5 years); however, patients are often left with patches of darkened or discolored skin and, in rare cases, muscle damage.  The cause of this condition is unknown. Morphea can be either localized or generalized.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Morphea" for support, advocacy or research.

International Scleroderma Network

Our mission is to provide stellar worldwide research, support, education and awareness for scleroderma and related illnesses.

Last Updated: 18 Apr 2010

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Morphea" for support, advocacy or research.

International Scleroderma Network

Our mission is to provide stellar worldwide research, support, education and awareness for scleroderma and related illnesses.

http://www.sclero.org/

Last Updated: 18 Apr 2010

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Morphea" returned 71 free, full-text research articles on human participants. First 3 results:

Effects of UVA1 Phototherapy on Expression of Human Endogenous Retroviral Sequence (HERV)-K10 gag in Morphea: A Preliminary Study.
 

Author(s): Michał Jacek Kowalczyk, Ewa Teresiak-Mikołajczak, Aleksandra Dańczak-Pazdrowska, Ryszard Żaba, Zygmunt Adamski, Agnieszka Osmola-Mańkowska

Journal:

 

BACKGROUND Morphea, also known as localized scleroderma, is a rare autoimmune connective tissue disease characterized by skin fibrosis. UVA1 phototherapy is an important asset in the reduction of clinical manifestations in morphea. There are studies claiming that UV light modulates ...

Last Updated: 31 Dec 1969

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Correspondence: The association between morphea profunda and monoclonal gammopathy: A case series.
 

Author(s): Justin Endo, Nicole Strickland, Simer Grewal, Travis Vandergriff, Thomas Keenan, B Jack Longley, Heidi Jacobe

Journal:

 

It is known that eosinophilic fasciitis can be associated with monoclonal gammopathy. There is clinical similarity between eosinophilic fasciitis and morphea profunda, but it is unclear whether morphea profunda might be associated with monoclonal gammopathy. The temporal quantification ...

Last Updated: 31 Dec 1969

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[Morphea or juvenile localised scleroderma: Case report].
 

Author(s): Alexis Strickler, Silvanna Gallo, Pedro Jaramillo, Gonzalo de Toro

Journal: Rev Chil Pediatr. ;87(4):279-83.

 

Morphea or juvenile localised scleroderma (JLS) is an autoimmune, inflammatory, chronic, slowly progressive connective tissue disease of unknown cause that preferably affects skin and underlying tissues.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Morphea" returned 4 free, full-text review articles on human participants. First 3 results:

Cyclosporine Reduces Sclerosis in Morphea: A Retrospective Study in 12 Patients and a Literature Review.
 

Author(s): Gabor Bali, Julia Frühauf, Nora Wutte, Elisabeth Aberer

Journal: Dermatology (Basel). 2016 ;232(4):503-10.

 

The treatment of severe morphea is challenging, and treatment experience concerning the use of immunosuppressive agents for this condition is limited.

Last Updated: 31 Dec 1969

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Practice and Educational Gaps in Lupus, Dermatomyositis, and Morphea.
 

Author(s): Nicole M Fett, David Fiorentino, Victoria P Werth

Journal: Dermatol Clin. 2016 Jul;34(3):243-50.

 

Patients with skin-predominant lupus erythematosus, dermatomyositis, and morphea should be evaluated, treated, and followed by dermatologists who can take primary responsibility for their care. Many academic centers have specialized centers with dermatologists who care for these patients. ...

Last Updated: 31 Dec 1969

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Morphea: evidence-based recommendations for treatment.
 

Author(s): Nicole M Fett

Journal: Indian J Dermatol Venereol Leprol. ;78(2):135-41.

 

Morphea is a rare fibrosing disorder of the skin. Evidence-based treatment strategies in morphea are lacking. This review summarizes the available data on morphea treatment and provides therapeutic strategies based on morphea subtypes. The Cochrane Library, Medline and Embase from ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pilot Study Evaluating the Efficacy of a Topical PDE4 Inhibitor for Morphea
 

Status: Not yet recruiting

Condition Summary: Morphea

 

Last Updated: 20 Nov 2017

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Genetic Variants in Linear Localized Scleroderma
 

Status: Recruiting

Condition Summary: Morphea

 

Last Updated: 4 Feb 2016

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Morphea in Adults and Children (MAC) Cohort Study: A Morphea Registry and DNA Repository
 

Status: Recruiting

Condition Summary: Scleroderma, Localized; Morphea; Frontal Linear Scleroderma en Coup de Sabre; Scleroderma, Circumscribed; Scleroderma, Linear

 

Last Updated: 2 Dec 2014

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