Morphea

Common Name(s)

Morphea

Morphea (mor-FEE-ah) comes from a Greek word that means ÒformÓ or Òstructure.Ó The word refers to local patches of scleroderma. The first signs of the disease are reddish patches of skin that thicken into firm, oval-shaped areas. The center of each patch becomes ivory colored with violet borders. These patches sweat very little and have little hair growth. Patches appear most often on the chest, stomach, and back. Sometimes they appear on the face, arms, and legs.  In most cases, morphea improves spontaneously over time (typically 3 to 5 years); however, patients are often left with patches of darkened or discolored skin and, in rare cases, muscle damage.  The cause of this condition is unknown. Morphea can be either localized or generalized.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Morphea" for support, advocacy or research.

International Scleroderma Network

Our mission is to provide stellar worldwide research, support, education and awareness for scleroderma and related illnesses.

Last Updated: 18 Apr 2010

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Morphea" for support, advocacy or research.

International Scleroderma Network

Our mission is to provide stellar worldwide research, support, education and awareness for scleroderma and related illnesses.

http://www.sclero.org/

Last Updated: 18 Apr 2010

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Morphea" returned 54 free, full-text research articles on human participants. First 3 results:

A case of radiation-induced generalized morphea with prominent mucin deposition and tenderness.
 

Author(s): Koichi Yanaba, Yoshinori Umezawa, Hidemi Nakagawa

Journal:

 

Radiation-induced morphea is a rare complication of radiation therapy. The affected areas are generally restricted to the radiation field or to the nearby surrounding area.

Last Updated: 11 May 2015

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Headaches as a presenting symptom of linear morphea en coup de sabre.
 

Author(s): Ingrid Polcari, Amanda Moon, Erin F Mathes, Elaine S Gilmore, Amy S Paller

Journal: Pediatrics. 2014 Dec;134(6):e1715-9.

 

Linear morphea en coup de sabre (ECDS) is a form of localized scleroderma that predominantly affects the pediatric population, with a median age of 10 years at presentation. The existence of neurologic findings in association with ECDS has been well described in the literature. Here ...

Last Updated: 2 Dec 2014

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Major histocompatibility complex class I and class II alleles may confer susceptibility to or protection against morphea: findings from the Morphea in Adults and Children cohort.
 

Author(s): Heidi Jacobe, Chul Ahn, Frank C Arnett, John D Reveille

Journal: Arthritis Rheumatol. 2014 Nov;66(11):3170-7.

 

To determine the HLA class I and class II alleles of the human major histocompatibility complex showing an association with morphea (localized scleroderma) in the Morphea in Adults and Children (MAC) cohort, using a nested case-control association study.

Last Updated: 27 Oct 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Morphea" returned 2 free, full-text review articles on human participants. First 3 results:

Morphea: evidence-based recommendations for treatment.
 

Author(s): Nicole M Fett

Journal: Indian J Dermatol Venereol Leprol. ;78(2):135-41.

 

Morphea is a rare fibrosing disorder of the skin. Evidence-based treatment strategies in morphea are lacking. This review summarizes the available data on morphea treatment and provides therapeutic strategies based on morphea subtypes. The Cochrane Library, Medline and Embase from ...

Last Updated: 16 Mar 2012

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[Unilateral generalized morphea: a case and literature review].
 

Author(s): Antonia M Fernández Rodríguez, Myriam Gandia Martínez, Natalia Navas García

Journal: Reumatol Clin. ;7(6):404-6.

 

Localized scleroderma is a connective tissue disorder generally involving de entire dermis and usually limited to the subcutaneous tissue; however, it may progress to large indurated plaques, growth retardation, muscle atrophy, and even to flexion deformities or poorly healing ulcers. ...

Last Updated: 14 Nov 2011

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Molecular Effects of Topical Calcipotriene on Morphea
 

Status: Recruiting

Condition Summary: Morphea; Localized Scleroderma

 

Last Updated: 25 Sep 2015

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Morphea in Adults and Children (MAC) Cohort Study: A Morphea Registry and DNA Repository
 

Status: Recruiting

Condition Summary: Scleroderma, Localized; Morphea; Frontal Linear Scleroderma en Coup de Sabre; Scleroderma, Circumscribed; Scleroderma, Linear

 

Last Updated: 2 Dec 2014

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Treatment Study Comparing UVA-1 Phototherapy Versus Placebo Treatment for Morphea
 

Status: Recruiting

Condition Summary: Scleroderma, Localized; Morphea; Scleroderma, Circumscribed

 

Last Updated: 2 Dec 2014

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