Monkeypox

Common Name(s)

Monkeypox

Monkeypox is a virus that is very dangerous to humans. It is similar in symptoms to smallpox, and occurs sporadically in parts of Africa. Human monkepox first appeared in 1970 in the Democratic Republic of Congo, and since then has been reported in rural areas of the Congo Basin and western African. The disease can be spread through direct contact with the blood, bodily fluids, or rashes of infected animals, and also through transmission from human-to-human, through close contact. Signs and symptoms of monkeypox include fever, intense headache, swelling of the lymph node, muscle ache, and an intense lack of energy. Symptoms can then progress to skin eruptions on the palms of the hands and soles of the feet. Symptoms of monkeypox typically last 14 to 21 days, and the disease can be fatal.

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Condition Specific Organizations

Following organizations serve the condition "Monkeypox" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Monkeypox" returned 97 free, full-text research articles on human participants. First 3 results:

Mapping monkeypox transmission risk through time and space in the Congo Basin.
 

Author(s): Yoshinori Nakazawa, R Ryan Lash, Darin S Carroll, Inger K Damon, Kevin L Karem, Mary G Reynolds, Jorge E Osorio, Tonie E Rocke, Jean M Malekani, Jean-Jacques Muyembe, Pierre Formenty, A Townsend Peterson

Journal:

 

Monkeypox is a major public health concern in the Congo Basin area, with changing patterns of human case occurrences reported in recent years. Whether this trend results from better surveillance and detection methods, reduced proportions of vaccinated vs. non-vaccinated human populations, ...

Last Updated: 16 Sep 2013

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Pathogen-host associations and predicted range shifts of human monkeypox in response to climate change in central Africa.
 

Author(s): Henri A Thomassen, Trevon Fuller, Salvi Asefi-Najafabady, Julia A G Shiplacoff, Prime M Mulembakani, Seth Blumberg, Sara C Johnston, Neville K Kisalu, Timothée L Kinkela, Joseph N Fair, Nathan D Wolfe, Robert L Shongo, Matthew LeBreton, Hermann Meyer, Linda L Wright, Jean-Jacques Muyembe, Wolfgang Buermann, Emile Okitolonda, Lisa E Hensley, James O Lloyd-Smith, Thomas B Smith, Anne W Rimoin

Journal:

 

Climate change is predicted to result in changes in the geographic ranges and local prevalence of infectious diseases, either through direct effects on the pathogen, or indirectly through range shifts in vector and reservoir species. To better understand the occurrence of monkeypox ...

Last Updated: 12 Aug 2013

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Comparison of host cell gene expression in cowpox, monkeypox or vaccinia virus-infected cells reveals virus-specific regulation of immune response genes.
 

Author(s): Daniel Bourquain, Piotr Wojtek Dabrowski, Andreas Nitsche

Journal:

 

Animal-borne orthopoxviruses, like monkeypox, vaccinia and the closely related cowpox virus, are all capable of causing zoonotic infections in humans, representing a potential threat to human health. The disease caused by each virus differs in terms of symptoms and severity, but little ...

Last Updated: 18 Mar 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Monkeypox" returned 8 free, full-text review articles on human participants. First 3 results:

Comparative pathology of smallpox and monkeypox in man and macaques.
 

Author(s): J A Cann, P B Jahrling, L E Hensley, V Wahl-Jensen

Journal: J. Comp. Pathol.. 2013 Jan;148(1):6-21.

 

In the three decades since the eradication of smallpox and cessation of routine vaccination, the collective memory of the devastating epidemics caused by this orthopoxvirus has waned, and the human population has become increasingly susceptible to a disease that remains high on the ...

Last Updated: 29 Jan 2013

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Whither monkeypox vaccination.
 

Author(s): Anne W Rimoin, Barney S Graham

Journal: Vaccine. 2011 Dec;29 Suppl 4():D60-4.

 

Monkeypox (MPX) is a virulent orthopoxvirus that is endemic in some regions of Central Africa. MPX incidence has been rising since the cessation of routine smallpox immunization. While it causes significant disease, there is limited person-to-person spread, the incidence is still ...

Last Updated: 10 Apr 2012

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Monkeypox virus and insights into its immunomodulatory proteins.
 

Author(s): Jessica R Weaver, Stuart N Isaacs

Journal: Immunol. Rev.. 2008 Oct;225():96-113.

 

Monkeypox is a disease that is endemic in Central and Western Africa. However, in 2003, there was an outbreak in the United States, representing the first documented monkeypox cases in the Western hemisphere. Although monkeypox virus is less fatal and not as transmissible as variola ...

Last Updated: 7 Oct 2008

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Tecovirimat (ST-246) Treatment for Orthopox Virus Exposure
 

Status: Available

Condition Summary: Smallpox; Monkeypox

 

Last Updated: 4 Mar 2014

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