Monkeypox

Common Name(s)

Monkeypox

Monkeypox is a virus that is very dangerous to humans. It is similar in symptoms to smallpox, and occurs sporadically in parts of Africa. Human monkepox first appeared in 1970 in the Democratic Republic of Congo, and since then has been reported in rural areas of the Congo Basin and western African. The disease can be spread through direct contact with the blood, bodily fluids, or rashes of infected animals, and also through transmission from human-to-human, through close contact. Signs and symptoms of monkeypox include fever, intense headache, swelling of the lymph node, muscle ache, and an intense lack of energy. Symptoms can then progress to skin eruptions on the palms of the hands and soles of the feet. Symptoms of monkeypox typically last 14 to 21 days, and the disease can be fatal.

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Condition Specific Organizations

Following organizations serve the condition "Monkeypox" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Monkeypox" returned 100 free, full-text research articles on human participants. First 3 results:

Evasion of the Innate Immune Type I Interferon System by Monkeypox Virus.
 

Author(s): William D Arndt, Samantha Cotsmire, Kelly Trainor, Heather Harrington, Kevin Hauns, Karen V Kibler, Trung P Huynh, Bertram L Jacobs

Journal: J. Virol.. 2015 Oct;89(20):10489-99.

 

The vaccinia virus (VACV) E3 protein has been shown to be important for blocking activation of the cellular innate immune system and allowing viral replication to occur unhindered. Mutation or deletion of E3L severely affects viral host range and pathogenesis. While the monkeypox ...

Last Updated: 23 Sep 2015

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A phylogeographic investigation of African monkeypox.
 

Author(s): Yoshinori Nakazawa, Matthew R Mauldin, Ginny L Emerson, Mary G Reynolds, R Ryan Lash, Jinxin Gao, Hui Zhao, Yu Li, Jean-Jacques Muyembe, Placide Mbala Kingebeni, Okito Wemakoy, Jean Malekani, Kevin L Karem, Inger K Damon, Darin S Carroll

Journal:

 

Monkeypox is a zoonotic disease caused by a virus member of the genus Orthopoxvirus and is endemic to Central and Western African countries. Previous work has identified two geographically disjuct clades of monkeypox virus based on the analysis of a few genomes coupled with epidemiological ...

Last Updated: 28 Apr 2015

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Genetic studies of the susceptibility of classical and wild-derived inbred mouse strains to monkeypox virus.
 

Author(s): Patricia L Earl, Jeffrey L Americo, Bernard Moss

Journal: Virology. 2015 Jul;481():161-5.

 

Previously, we screened 38 inbred mouse strains for susceptibility to monkeypox virus (MPXV) and focused on wild-derived CAST mice because of their extreme vulnerability. Here, we provide further analysis of inbred mouse strains. NZW/Lac and C58 mice exhibited more weight loss than ...

Last Updated: 18 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Monkeypox" returned 9 free, full-text review articles on human participants. First 3 results:

Human monkeypox.
 

Author(s): Andrea M McCollum, Inger K Damon

Journal: Clin. Infect. Dis.. 2014 Jan;58(2):260-7.

 

Human monkeypox is a zoonotic Orthopoxvirus with a presentation similar to smallpox. Clinical differentiation of the disease from smallpox and varicella is difficult. Laboratory diagnostics are principal components to identification and surveillance of disease, and new tests are needed ...

Last Updated: 25 Dec 2013

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Comparative pathology of smallpox and monkeypox in man and macaques.
 

Author(s): J A Cann, P B Jahrling, L E Hensley, V Wahl-Jensen

Journal: J. Comp. Pathol.. 2013 Jan;148(1):6-21.

 

In the three decades since the eradication of smallpox and cessation of routine vaccination, the collective memory of the devastating epidemics caused by this orthopoxvirus has waned, and the human population has become increasingly susceptible to a disease that remains high on the ...

Last Updated: 29 Jan 2013

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Whither monkeypox vaccination.
 

Author(s): Anne W Rimoin, Barney S Graham

Journal: Vaccine. 2011 Dec;29 Suppl 4():D60-4.

 

Monkeypox (MPX) is a virulent orthopoxvirus that is endemic in some regions of Central Africa. MPX incidence has been rising since the cessation of routine smallpox immunization. While it causes significant disease, there is limited person-to-person spread, the incidence is still ...

Last Updated: 10 Apr 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Tecovirimat (ST-246) Treatment for Orthopox Virus Exposure
 

Status: Available

Condition Summary: Smallpox; Monkeypox

 

Last Updated: 28 Oct 2015

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