Monilethrix

Common Name(s)

Monilethrix

Monilethrix is a rare condition caused by a defect in the hair shaft resulting in hair which appears dry, dull, and brittle, and which breaks spontaneously or with mild trauma.  The age of onset, severity, and course may vary from person to person.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Monilethrix" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Monilethrix" returned 18 free, full-text research articles on human participants. First 3 results:

Monilethrix: a typical case report with microscopic and dermatoscopic findings.
 

Author(s): Elisa Fontenelle de Oliveira, Ana Luiza Cotta de Alencar Araripe

Journal: An Bras Dermatol. ;90(1):126-7.

 

Monilethrix is a rare hereditary condition generally considered to be an autosomal dominant disorder with variable penetrance. A case of a 6-year-old girl without a familial background for this disease is reported. The diagnosis was made by optic microscopy and dermoscopy. A therapeutic ...

Last Updated: 12 Feb 2015

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Mutation detection of type II hair cortex keratin gene KRT86 in a Chinese Han family with congenital monilethrix.
 

Author(s): Zhen-zhen Ye, Xu Nan, Hong-shan Zhao, Xue-rong Chen, Qing-hua Song

Journal: Chin. Med. J.. 2013 Aug;126(16):3103-6.

 

Monilethrix is an autosomal dominant hair disorder characterized clinically by alopecia and follicular papules. In this study, we collected a Han monilethrix family to detect the mutations in patients and investigated the correlation between the genotype and phenotype of monilethrix.

Last Updated: 28 Aug 2013

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More than one gene involved in monilethrix: intracellular but also extracellular players.
 

Author(s): Jurgen Schweizer

Journal: J. Invest. Dermatol.. 2006 Jun;126(6):1216-9.

 

Monilethrix, an autosomal dominant human hair disorder, is caused by mutations in three type II hair cortex keratins. Rare cases of the disease with non-vertical transmission have now been found to overlap with localized autosomal recessive hypotrichosis. The underlying gene, desmoglein ...

Last Updated: 16 May 2006

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Monilethrix" returned 1 free, full-text review articles on human participants. First 3 results:

A mutational hotspot in the 2B domain of human hair basic keratin 6 (hHb6) in monilethrix patients.
 

Author(s): B P Korge, E Healy, C S Munro, C P√ľnter, M Birch-Machin, S C Holmes, S Darlington, H Hamm, A G Messenger, J L Rees, H Traupe

Journal: J. Invest. Dermatol.. 1998 Nov;111(5):896-9.

 

Monilethrix is an inherited hair dystrophy in which affected, fragile, hairs have an unique beaded morphology. Ultrastructural studies suggest a defect in filament structure in the cortex of the hair, and the hard keratins of hair and nail are thus candidate genes. In several families ...

Last Updated: 18 Nov 1998

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.