Monilethrix

Common Name(s)

Monilethrix

Monilethrix is a rare condition caused by a defect in the hair shaft resulting in hair which appears dry, dull, and brittle, and which breaks spontaneously or with mild trauma.  The age of onset, severity, and course may vary from person to person.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Monilethrix" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Monilethrix" returned 20 free, full-text research articles on human participants. First 3 results:

Dermoscopy: A rapid bedside tool to assess monilethrix.
 

Author(s): Vinod Kumar Sharma, Minu Jose Chiramel, Ashwin Rao

Journal: Indian J Dermatol Venereol Leprol. ;82(1):73-4.

 

Last Updated: 5 Jan 2016

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Monilethrix: a typical case report with microscopic and dermatoscopic findings.
 

Author(s): Elisa Fontenelle de Oliveira, Ana Luiza Cotta de Alencar Araripe

Journal: An Bras Dermatol. ;90(1):126-7.

 

Monilethrix is a rare hereditary condition generally considered to be an autosomal dominant disorder with variable penetrance. A case of a 6-year-old girl without a familial background for this disease is reported. The diagnosis was made by optic microscopy and dermoscopy. A therapeutic ...

Last Updated: 12 Feb 2015

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An autosomal recessive mutation of DSG4 causes monilethrix through the ER stress response.
 

Author(s): Madoka Kato, Akira Shimizu, Yoko Yokoyama, Kyoichi Kaira, Yutaka Shimomura, Akemi Ishida-Yamamoto, Kiyoko Kamei, Fuminori Tokunaga, Osamu Ishikawa

Journal: J. Invest. Dermatol.. 2015 May;135(5):1253-60.

 

Monilethrix is a hair shaft anomaly characterized by beaded hair with periodic changes in hair thickness. Mutations in the desmoglein 4 (DSG4) gene reportedly underlie the autosomal recessive form of the disease. However, the pathogenesis and cellular basis for the DSG4 mutation-induced ...

Last Updated: 17 Apr 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Monilethrix" returned 1 free, full-text review articles on human participants. First 3 results:

A mutational hotspot in the 2B domain of human hair basic keratin 6 (hHb6) in monilethrix patients.
 

Author(s): B P Korge, E Healy, C S Munro, C P√ľnter, M Birch-Machin, S C Holmes, S Darlington, H Hamm, A G Messenger, J L Rees, H Traupe

Journal: J. Invest. Dermatol.. 1998 Nov;111(5):896-9.

 

Monilethrix is an inherited hair dystrophy in which affected, fragile, hairs have an unique beaded morphology. Ultrastructural studies suggest a defect in filament structure in the cortex of the hair, and the hard keratins of hair and nail are thus candidate genes. In several families ...

Last Updated: 18 Nov 1998

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.