Mixed connective tissue disease

Common Name(s)

Mixed connective tissue disease

Mixed connective tissue disease (MCTD) is a rare autoimmune disorder that is characterized by features commonly seen in three different connective tissue disorders: systemic lupus erythematosus, scleroderma, and polymyositis. Some affected people may also have symptoms of rheumatoid arthritis. Although MCTD can affect people of all ages, it appears to be most common in women under age 30. Signs and symptoms vary but may include Raynaud's phenomenon; arthritis; heart, lung and skin abnormalities; kidney disease; muscle weakness, and dysfunction of the esophagus. The cause of MCTD is currently unknown. There is no cure but certain medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids and immunosuppresive drugs may help manage the symptoms.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mixed connective tissue disease" for support, advocacy or research.

Logo
Raynaud's & Scleroderma Ireland

• To improve the lives of patients, their families and carers by providing support, advice and information. • To increase the awareness of Raynaud’s and Scleroderma amongst healthcare professionals, Government and Statutory agencies and the general public. • To work in partnership with appropriate healthcare professionals and agencies to promote and co-ordinate the attainment of the objectives of the strategy. • Maintain a working environment that fosters communication, teamwork and diversity among all members of staff- permanent, temporary and voluntary

Last Updated: 6 May 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mixed connective tissue disease" for support, advocacy or research.

Logo
Raynaud's & Scleroderma Ireland

• To improve the lives of patients, their families and carers by providing support, advice and information. • To increase the awareness of Raynaud’s and Scleroderma amongst healthcare professionals, Government and Statutory agencies and the general public. • To work in partnership with appropriate healthcare professionals and agencies to promote and co-ordinate the attainment of the objectives of the strategy. • Maintain a working environment that fosters communication, teamwork and diversity among all members of staff- permanent, temporary and voluntary

http://www.irishraynauds.com

Last Updated: 6 May 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Mixed connective tissue disease" returned 131 free, full-text research articles on human participants. First 3 results:

Associations between anti-Ro52 antibodies and lung fibrosis in mixed connective tissue disease.
 

Author(s): Ragnar Gunnarsson, Fadi El-Hage, Trond Mogens Aaløkken, Silje Reiseter, May Brit Lund, Torhild Garen, , Øyvind Molberg

Journal: Rheumatology (Oxford). 2016 Jan;55(1):103-8.

 

MCTD is a chronic, immune-mediated disorder defined by the combined presence of serum anti-RNP antibodies and distinct clinical features, including progressive lung fibrosis. The aim of the study was to evaluate the potential impact of anti-SSA (i.e. Ro52 and Ro60) and anti-SSB autoantibodies ...

Last Updated: 15 Dec 2015

Go To URL
Associations between circulating endostatin levels and vascular organ damage in systemic sclerosis and mixed connective tissue disease: an observational study.
 

Author(s): Silje Reiseter, Øyvind Molberg, Ragnar Gunnarsson, May Brit Lund, Trond Mogens Aalokken, Pål Aukrust, Thor Ueland, Torhild Garen, Cathrine Brunborg, Annika Michelsen, Aurelija Abraityte, Anna-Maria Hoffmann-Vold

Journal:

 

Systemic sclerosis (SSc) and mixed connective tissue disease (MCTD) are chronic immune-mediated disorders complicated by vascular organ damage. The aim of this study was to examine the serum levels of the markers of neoangiogenesis: endostatin and vascular endothelial growth factor ...

Last Updated: 28 Aug 2015

Go To URL
Mixed Connective Tissue Disease and Papillary Thyroid Cancer: A Case Report.
 

Author(s): Supat Thongpooswan, Rachel Tushabe, Jeffrey Song, Paul Kim, Adriana Abrudescu

Journal:

 

Mixed connective tissue disease (MCTD) is a connective tissue disorder characterized by high titers of distinct antibodies: U1 ribonucleoprotein with clinical features seen in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), dermatomyositis (DM), polymyositis, and scleroderma. ...

Last Updated: 6 Aug 2015

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Mixed connective tissue disease" returned 20 free, full-text review articles on human participants. First 3 results:

Scleroderma renal crisis in a case of mixed connective tissue disease.
 

Author(s): Mukul Vij, Vinita Agrawal, Manoj Jain

Journal: Saudi J Kidney Dis Transpl. 2014 Jul;25(4):844-8.

 

Mixed connective tissue disease (MCTD) is an overlap syndrome first defined in 1972 by Sharp et al. In this original study, the portrait emerged of a connective tissue disorder sharing features of systemic lupus erythematosus, systemic sclerosis (scleroderma) and polymyositis. Scleroderma ...

Last Updated: 27 Jun 2014

Go To URL
Two cases of mixed connective tissue disease complicated with thrombotic thrombocytopenic purpura.
 

Author(s): Eiji Suzuki, Takashi Kanno, Tomoyuki Asano, Akito Tsutsumi, Hiroko Kobayashi, Hiroshi Watanabe, Hiromasa Ohira

Journal: Fukushima J Med Sci. 2013 ;59(1):49-55.

 

Thrombotic thrombocytopenic purpura (TTP) is a rare complication of connective tissue diseases. Here, we describe 2 patients with mixed connective tissue disease (MCTD) who had pericardial effusion and TTP. They had moderately low to normal ADAMTS13 activity and no ADAMTS13 neutralizing ...

Last Updated: 11 Jul 2013

Go To URL
Prevalence of pulmonary hypertension in an unselected, mixed connective tissue disease cohort: results of a nationwide, Norwegian cross-sectional multicentre study and review of current literature.
 

Author(s): Ragnar Gunnarsson, Arne K Andreassen, Øyvind Molberg, Åse Stavland Lexberg, Kari Time, Alvilde Sofie Strand Dhainaut, Liv-Turid Bertelsen, Øyvind Palm, Karen Irgens, Andrea Becker-Merok, Jan Leidulf Nordeide, Villy Johnsen, Sonja Pedersen, Anne Prøven, Lamya Samir Noori Garabet, Torhild Garen, Trond Mogens Aaløkken, Inge-Margrethe Gilboe, Jan Tore Gran

Journal: Rheumatology (Oxford). 2013 Jul;52(7):1208-13.

 

The aim of this study was to assess the overall prevalence of pulmonary hypertension (PH) in an unselected MCTD cohort and review the current knowledge with a systematic database search.

Last Updated: 19 Jun 2013

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Characteristics and Disease Progression of Mixed Connective Tissue Disease and Systemic Lupus Erythematosus
 

Status: Recruiting

Condition Summary: Mixed Connective Tissue Disease (MCTD); Systemic Lupus Erythematosus (SLE)

 

Last Updated: 13 May 2016

Go to URL
Rituximab Versus Cyclophosphamide in Connective Tissue Disease-ILD
 

Status: Recruiting

Condition Summary: Interstitial Lung Disease; Scleroderma; Idiopathic Inflammatory Myositis; Mixed Connective Tissue Disease

 

Last Updated: 6 May 2015

Go to URL
Role of Mesenchymal Stem Cells in Fat Grafting
 

Status: Not yet recruiting

Condition Summary: Romberg's Disease; Craniofacial Microsomia; Lipodystrophy; Mixed Connective Tissue Disease

 

Last Updated: 9 Jul 2015

Go to URL