Mixed connective tissue disease

Common Name(s)

Mixed connective tissue disease

Mixed connective tissue disease (MCTD) is a rare autoimmune disorder that is characterized by features commonly seen in three different connective tissue disorders: systemic lupus erythematosus, scleroderma, and polymyositis. Some affected people may also have symptoms of rheumatoid arthritis. Although MCTD can affect people of all ages, it appears to be most common in women under age 30. Signs and symptoms vary but may include Raynaud's phenomenon; arthritis; heart, lung and skin abnormalities; kidney disease; muscle weakness, and dysfunction of the esophagus. The cause of MCTD is currently unknown. There is no cure but certain medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids and immunosuppresive drugs may help manage the symptoms.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mixed connective tissue disease" for support, advocacy or research.

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Raynaud's & Scleroderma Ireland

• To improve the lives of patients, their families and carers by providing support, advice and information. • To increase the awareness of Raynaud’s and Scleroderma amongst healthcare professionals, Government and Statutory agencies and the general public. • To work in partnership with appropriate healthcare professionals and agencies to promote and co-ordinate the attainment of the objectives of the strategy. • Maintain a working environment that fosters communication, teamwork and diversity among all members of staff- permanent, temporary and voluntary

Last Updated: 6 May 2014

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mixed connective tissue disease" for support, advocacy or research.

Logo
Raynaud's & Scleroderma Ireland

• To improve the lives of patients, their families and carers by providing support, advice and information. • To increase the awareness of Raynaud’s and Scleroderma amongst healthcare professionals, Government and Statutory agencies and the general public. • To work in partnership with appropriate healthcare professionals and agencies to promote and co-ordinate the attainment of the objectives of the strategy. • Maintain a working environment that fosters communication, teamwork and diversity among all members of staff- permanent, temporary and voluntary

http://www.irishraynauds.com

Last Updated: 6 May 2014

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General Resources

Mixed connective tissue disease (MCTD)

Mixed connective tissue disease is classified and considered as an “overlap” of three diseases, Systemic Lupus Erythematosus, Scleroderma, and Polymyositis. Patients with MCTD typically experience features of each of these three diseases. Read more

Updated 3 Mar 2018

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Mixed connective tissue disease" returned 128 free, full-text research articles on human participants. First 3 results:

[A case of mixed connective tissue disease positive for proteinase 3 antineutrophil cytoplasmic antibody in a patient with slowly progressive type 1 diabetes mellitus and chronic thyroiditis].
 

Author(s): Tohru Michitsuji, Yoshiro Horai, Ayaka Sako, Taro Asano, Nozomi Iwanaga, Yasumori Izumi, Atsushi Kawakami

Journal: Nihon Rinsho Meneki Gakkai Kaishi. 2017 ;40(6):467-470.

 

  A female in her sixties with slowly progressive type 1 diabetes mellitus (SPT1DM) and chronic thyroiditis was referred to our rheumatology department with swelling in her fingers. A prominent atherosclerotic lesion was revealed upon brain magnetic resonance imaging, and she was ...

Last Updated: 31 Dec 1969

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An unusual association between hemophagocytic lymphohistiocytosis, mixed connective tissue disease, and autoimmune hemolytic anemia: A case report.
 

Author(s): Amar H Kelkar, Anushi A Shah, Sherri L Yong, Zohair Ahmed

Journal: Medicine (Baltimore). 2017 Jul;96(28):e7488.

 

In the adult patient, hemophagocytic lymphohistiocytosis (HLH) is uncommon and frequently difficult to diagnose due to its nonspecific presentation and numerous complications.

Last Updated: 31 Dec 1969

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Pulmonary-Limited Granulomatosis with Polyangiitis Coexisting with Mixed Connective Tissue Disease.
 

Author(s): Masaru Ando, Akihiko Goto, Mari Yamasue, Yuko Usagawa, Hiroaki Oka, Takehiko Shigenaga, Jun-Ichi Kadota

Journal: Tohoku J. Exp. Med.. 2017 06;242(2):109-114.

 

Granulomatosis with polyangiitis (GPA) is a systemic disease characterized by necrotizing, granulomatous vasculitis of the upper and lower respiratory tracts and glomerulonephritis, and is classified as a classical or limited form. The classical form of GPA demonstrates the involvement ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Mixed connective tissue disease" returned 23 free, full-text review articles on human participants. First 3 results:

[Mixed connective tissue disease: prevalence and clinical characteristics in African black, study of 7 cases in Gabon and review of the literature].
 

Author(s): Landry Missounga, Josaphat Iba Ba, Ingrid Rosalie Nseng Nseng Ondo, Maria Ines Carine Nziengui Madjinou, Doris Malekou, Emeline Gracia Mouendou Mouloungui, Emmanuel Ecke Nzengue, Jean Bruno Boguikouma, Moussavou Kombila

Journal:

 

The literature reports that mixed connective tissue disease seems more frequent in the black population and among Asians. This study aims to determine the prevalence of mixed connective tissue disease (MCTD) among connective tissue disorders and all rheumatologic pathologies in a ...

Last Updated: 31 Dec 1969

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Protein-losing Gastroenteropathy Related to Mixed Connective Tissue Disease: A Case Report of a Successful Outcome and Literature Review.
 

Author(s): Yuya Kobayashi, Yasuhiro Shimojima, Yasufumi Kondo, Ryota Takamatsu, Daigo Miyazaki, Dai Kishida, Yoshiki Sekijima, Shu-Ichi Ikeda

Journal: Intern. Med.. 2017 ;56(15):2057-2062.

 

We herein report the case of a 44-year-old woman who developed protein-losing gastroenteropathy (PLGE) with hypoalbuminemia as the first manifestation of mixed connective tissue disease (MCTD). Albumin leakage from the stomach and intestinal tract was demonstrated by Tc-labeled human ...

Last Updated: 31 Dec 1969

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Melkersson-Rosenthal syndrome as an early manifestation of mixed connective tissue disease.
 

Author(s): Dorota Jasinska, Jerzy Boczon

Journal:

 

We aim to illustrate the potential viability of MCTD as an underlying aetiology of Melkersson-Rosenthal syndrome. The case is probably the first description available in the literature of the Melkersson-Rosenthal as an early manifestation of mixed connective tissue disease.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Characteristics and Disease Progression of Mixed Connective Tissue Disease and Systemic Lupus Erythematosus
 

Status: Recruiting

Condition Summary: Mixed Connective Tissue Disease (MCTD); Systemic Lupus Erythematosus (SLE)

 

Last Updated: 7 Aug 2017

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Rituximab Versus Cyclophosphamide in Connective Tissue Disease-ILD
 

Status: Recruiting

Condition Summary: Interstitial Lung Disease; Scleroderma; Idiopathic Inflammatory Myositis; Mixed Connective Tissue Disease

 

Last Updated: 7 Jun 2017

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New Orleans Pulmonary Hypertension Biobank
 

Status: Recruiting

Condition Summary: Pulmonary Hypertension; Systemic Sclerosis; Mixed Connective Tissue Disease; Heart Failure With Normal Ejection Fraction; Healthy

 

Last Updated: 11 Jan 2018

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