Mixed connective tissue disease

Common Name(s)

Mixed connective tissue disease

Mixed connective tissue disease (MCTD) is a rare autoimmune disorder that is characterized by features commonly seen in three different connective tissue disorders: systemic lupus erythematosus, scleroderma, and polymyositis. Some affected people may also have symptoms of rheumatoid arthritis. Although MCTD can affect people of all ages, it appears to be most common in women under age 30. Signs and symptoms vary but may include Raynaud's phenomenon; arthritis; heart, lung and skin abnormalities; kidney disease; muscle weakness, and dysfunction of the esophagus. The cause of MCTD is currently unknown. There is no cure but certain medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids and immunosuppresive drugs may help manage the symptoms.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mixed connective tissue disease" for support, advocacy or research.

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Raynaud's & Scleroderma Ireland

• To improve the lives of patients, their families and carers by providing support, advice and information. • To increase the awareness of Raynaud’s and Scleroderma amongst healthcare professionals, Government and Statutory agencies and the general public. • To work in partnership with appropriate healthcare professionals and agencies to promote and co-ordinate the attainment of the objectives of the strategy. • Maintain a working environment that fosters communication, teamwork and diversity among all members of staff- permanent, temporary and voluntary

Last Updated: 6 May 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mixed connective tissue disease" for support, advocacy or research.

Logo
Raynaud's & Scleroderma Ireland

• To improve the lives of patients, their families and carers by providing support, advice and information. • To increase the awareness of Raynaud’s and Scleroderma amongst healthcare professionals, Government and Statutory agencies and the general public. • To work in partnership with appropriate healthcare professionals and agencies to promote and co-ordinate the attainment of the objectives of the strategy. • Maintain a working environment that fosters communication, teamwork and diversity among all members of staff- permanent, temporary and voluntary

http://www.irishraynauds.com

Last Updated: 6 May 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Mixed connective tissue disease" returned 133 free, full-text research articles on human participants. First 3 results:

Barriers and facilitators for mental healthcare in pediatric lupus and mixed connective tissue disease: a qualitative study of youth and parent perspectives.
 

Author(s): Andrea M Knight, Michelle E Vickery, Alexander G Fiks, Frances K Barg

Journal:

 

Untreated mental health problems may result in poor outcomes for youth with systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD). We investigated perceptions, barriers and facilitators for mental healthcare of these youth.

Last Updated: 24 Nov 2015

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Associations between anti-Ro52 antibodies and lung fibrosis in mixed connective tissue disease.
 

Author(s): Ragnar Gunnarsson, Fadi El-Hage, Trond Mogens Aaløkken, Silje Reiseter, May Brit Lund, Torhild Garen, , Øyvind Molberg

Journal: Rheumatology (Oxford). 2016 Jan;55(1):103-8.

 

MCTD is a chronic, immune-mediated disorder defined by the combined presence of serum anti-RNP antibodies and distinct clinical features, including progressive lung fibrosis. The aim of the study was to evaluate the potential impact of anti-SSA (i.e. Ro52 and Ro60) and anti-SSB autoantibodies ...

Last Updated: 15 Dec 2015

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Associations between circulating endostatin levels and vascular organ damage in systemic sclerosis and mixed connective tissue disease: an observational study.
 

Author(s): Silje Reiseter, Øyvind Molberg, Ragnar Gunnarsson, May Brit Lund, Trond Mogens Aalokken, Pål Aukrust, Thor Ueland, Torhild Garen, Cathrine Brunborg, Annika Michelsen, Aurelija Abraityte, Anna-Maria Hoffmann-Vold

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Systemic sclerosis (SSc) and mixed connective tissue disease (MCTD) are chronic immune-mediated disorders complicated by vascular organ damage. The aim of this study was to examine the serum levels of the markers of neoangiogenesis: endostatin and vascular endothelial growth factor ...

Last Updated: 28 Aug 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Mixed connective tissue disease" returned 22 free, full-text review articles on human participants. First 3 results:

Melkersson-Rosenthal syndrome as an early manifestation of mixed connective tissue disease.
 

Author(s): Dorota Jasinska, Jerzy Boczon

Journal:

 

We aim to illustrate the potential viability of MCTD as an underlying aetiology of Melkersson-Rosenthal syndrome. The case is probably the first description available in the literature of the Melkersson-Rosenthal as an early manifestation of mixed connective tissue disease.

Last Updated: 24 Dec 2015

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Autoimmune hepatitis as a presenting manifestation of mixed connective tissue disease in a child. Case report and review of the literature.
 

Author(s): Katarina Sedej, Nataša Toplak, Marina Praprotnik, Boštjan Luzar, Jernej Brecelj, Tadej Avčin

Journal:

 

Liver disease is rare in the course of mixed connective tissue disease. Most commonly liver steatosis or elevated liver function tests are reported and only a few cases of mixed connective tissue disease associated with autoimmune hepatitis were described.

Last Updated: 11 Nov 2015

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Scleroderma renal crisis in a case of mixed connective tissue disease.
 

Author(s): Mukul Vij, Vinita Agrawal, Manoj Jain

Journal: Saudi J Kidney Dis Transpl. 2014 Jul;25(4):844-8.

 

Mixed connective tissue disease (MCTD) is an overlap syndrome first defined in 1972 by Sharp et al. In this original study, the portrait emerged of a connective tissue disorder sharing features of systemic lupus erythematosus, systemic sclerosis (scleroderma) and polymyositis. Scleroderma ...

Last Updated: 27 Jun 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Characteristics and Disease Progression of Mixed Connective Tissue Disease and Systemic Lupus Erythematosus
 

Status: Recruiting

Condition Summary: Mixed Connective Tissue Disease (MCTD); Systemic Lupus Erythematosus (SLE)

 

Last Updated: 14 Nov 2016

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Safety and Efficacy of Adipose Derived Stem Cells in Refractory Rheumatoid Arthritis, Systemic Lupus Erythematosus or Sharp's Syndrome
 

Status: Recruiting

Condition Summary: Systemic Lupus Erythematosus; Rheumatoid Arthritis; Sharp's Syndrome

 

Last Updated: 18 Apr 2016

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Rituximab Versus Cyclophosphamide in Connective Tissue Disease-ILD
 

Status: Recruiting

Condition Summary: Interstitial Lung Disease; Scleroderma; Idiopathic Inflammatory Myositis; Mixed Connective Tissue Disease

 

Last Updated: 6 May 2015

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