Mixed connective tissue disease

Common Name(s)

Mixed connective tissue disease

Mixed connective tissue disease (MCTD) is a autoimmune disorder that causes overlapping features of three connective tissue disorders: lupus, scleroderma, and polymyositis. MCTD may also have features of rheumatoid arthritis. This condition is most often diagnosed in women in their 20's and 30's. Occasionally, children are affected. At this time the cause of this condition is unknown.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mixed connective tissue disease" for support, advocacy or research.

Logo
Raynaud's & Scleroderma Ireland

• To improve the lives of patients, their families and carers by providing support, advice and information. • To increase the awareness of Raynaud’s and Scleroderma amongst healthcare professionals, Government and Statutory agencies and the general public. • To work in partnership with appropriate healthcare professionals and agencies to promote and co-ordinate the attainment of the objectives of the strategy. • Maintain a working environment that fosters communication, teamwork and diversity among all members of staff- permanent, temporary and voluntary

Last Updated: 6 May 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mixed connective tissue disease" for support, advocacy or research.

Logo
Raynaud's & Scleroderma Ireland

• To improve the lives of patients, their families and carers by providing support, advice and information. • To increase the awareness of Raynaud’s and Scleroderma amongst healthcare professionals, Government and Statutory agencies and the general public. • To work in partnership with appropriate healthcare professionals and agencies to promote and co-ordinate the attainment of the objectives of the strategy. • Maintain a working environment that fosters communication, teamwork and diversity among all members of staff- permanent, temporary and voluntary

http://www.irishraynauds.com

Last Updated: 6 May 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Mixed connective tissue disease" returned 113 free, full-text research articles on human participants. First 3 results:

Cutaneous mucinosis in mixed connective tissue disease.
 

Author(s): Maria Helena Sampaio Favarato, Sofia Silveira de Castro Miranda, Maria Teresa Correia Caleiro, Ana Paula Luppino Assad, Ilana Halpern, Ricardo Fuller

Journal: An Bras Dermatol. ;88(4):635-8.

 

Cutaneous mucinosis is a group of conditions involving an accumulation of mucin or glycosaminoglycan in the skin and its annexes. It is described in some connective tissue diseases but never in association with mixed connective tissue disease. This report concerns two cases of cutaneous ...

Last Updated: 26 Sep 2013

Go To URL
Immunogenicity of influenza H1N1 vaccination in mixed connective tissue disease: effect of disease and therapy.
 

Author(s): Renata Miossi, Ricardo Fuller, Júlio C B Moraes, Ana Cristina M Ribeiro, Carla G S Saad, Nadia E Aikawa, Joao L Miraglia, Maria A Ishida, Eloisa Bonfa, M Teresa C Caleiro

Journal: Clinics (Sao Paulo). 2013 ;68(2):129-34.

 

To assess the potential acute effects regarding the immunogenicity and safety of non-adjuvanted influenza A H1N1/2009 vaccine in patients with mixed connective tissue disease and healthy controls.

Last Updated: 25 Mar 2013

Go To URL
Rapidly progressive respiratory failure in mixed connective tissue disease: report of an autopsy case.
 

Author(s): Yasutaka Watanabe, Shinichiro Koyama, Masato Moriguchi, Chihiro Miwa, Mamoru Shiraishi, Motoko Nomura, Mitsuhiro Nokubi, Chihiro Terai, Yoshinori Kawabata

Journal: Intern. Med.. 2012 ;51(24):3415-9.

 

A 64-year-old woman presented with exertional dyspnea. The case was diagnosed as mixed connective tissue disease (MCTD) due to presence of swollen fingers, Raynaud's phenomenon, muscle weakness, positive anti-U1RNP antibody, pericarditis and interstitial pneumonia. Although the histology ...

Last Updated: 21 Dec 2012

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Mixed connective tissue disease" returned 16 free, full-text review articles on human participants. First 3 results:

Two cases of mixed connective tissue disease complicated with thrombotic thrombocytopenic purpura.
 

Author(s): Eiji Suzuki, Takashi Kanno, Tomoyuki Asano, Akito Tsutsumi, Hiroko Kobayashi, Hiroshi Watanabe, Hiromasa Ohira

Journal: Fukushima J Med Sci. 2013 ;59(1):49-55.

 

Thrombotic thrombocytopenic purpura (TTP) is a rare complication of connective tissue diseases. Here, we describe 2 patients with mixed connective tissue disease (MCTD) who had pericardial effusion and TTP. They had moderately low to normal ADAMTS13 activity and no ADAMTS13 neutralizing ...

Last Updated: 11 Jul 2013

Go To URL
Epstein-Barr virus-negative, CD5-positive diffuse large B-cell lymphoma developing after treatment with oral tacrolimus for mixed connective tissue disease : a case report and review of the literature.
 

Author(s): Yasunobu Sekiguchi, Asami Shimada, Hidenori Imai, Mutsumi Wakabayashi, Keiji Sugimoto, Noriko Nakamura, Tomonori Sawada, Norio Komatsu, Masaaki Noguchi

Journal: J Clin Exp Hematop. 2012 ;52(3):211-8.

 

A 69-year-old woman, who had been diagnosed as having Sjögren's syndrome at 37 years old and mixed connective tissue disease at 42 years old, was under treatment with oral prednisolone. In 2009, she was diagnosed as having active systemic lupus erythematosus, and started on treatment ...

Last Updated: 27 Dec 2012

Go To URL
Ovarian stimulation and embryo banking for fertility preservation in a woman with severe mixed connective tissue disease: Is it safe?
 

Author(s): Vasileios D Sioulas, Clarisa R Gracia

Journal: J. Assist. Reprod. Genet.. 2012 Mar;29(3):271-5.

 

To report the first case of using assisted reproductive technologies (ART) for fertility preservation in a patient with mixed connective tissue disease (MCTD), secondary pulmonary hypertension (PH) and antiphospholipid syndrome (APS).

Last Updated: 28 Feb 2012

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Characteristics and Disease Progression of Mixed Connective Tissue Disease and Systemic Lupus Erythematosus
 

Status: Recruiting

Condition Summary: Mixed Connective Tissue Disease (MCTD); Systemic Lupus Erythematosus (SLE)

 

Last Updated: 10 Feb 2014

Go to URL
Rituximab Versus Cyclophosphamide in Connective Tissue Disease-ILD
 

Status: Not yet recruiting

Condition Summary: Interstitial Lung Disease; Scleroderma; Idiopathic Inflammatory Myositis; Mixed Connective Tissue Disease

 

Last Updated: 24 May 2013

Go to URL
The CARRA Registry
 

Status: Recruiting

Condition Summary: Juvenile Idiopathic Arthritis; Systemic Lupus Erythematosus; Mixed Connective Tissue Disease; Juvenile Ankylosing Spondylitis; Juvenile Dermatomyositis; Localized Scleroderma; Systemic Sclerosis; Vasculitis; Sarcoid; Fibromyalgia, Primary; Auto-inflammatory Disease; Idiopathic Uveitis Idiopathic

 

Last Updated: 17 Mar 2014

Go to URL