Minimal change disease

Common Name(s)

Minimal change disease

Minimal change disease is a kidney disorder that can lead to nephrotic syndrome, although the nephrons of the kidney look normal under a regular microscope. The most common symptom is swelling around the eyes, face, abdomen, and legs. Other features include poor appetite, weight gain, and a foamy appearance of the urine. The cause of minimal change disease is unknown, but it may occur following an allergic reaction, immunization, or viral infection. Treatment may involve the use of steroids such as prednisone. Children often respond better to this therapy than adults. Those who experience repeated relapses may benefit from the use of cytotoxic therapy, including cyclophosphamide, cyclosporine or chlorambucil.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Minimal change disease" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

Last Updated: 30 Jan 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Minimal change disease" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

http://www.nephcure.org

Last Updated: 30 Jan 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Minimal change disease" returned 52 free, full-text research articles on human participants. First 3 results:

Rifampicin-induced minimal change disease is improved after cessation of rifampicin without steroid therapy.
 

Author(s): Dong Hyuk Park, Sul A Lee, Hyeon Joo Jeong, Tae-Hyun Yoo, Shin-Wook Kang, Hyung Jung Oh

Journal: Yonsei Med. J.. 2015 Mar;56(2):582-5.

 

There are several reports to demonstrate that rifampicin, a major anti-tuberculosis agent, is associated with some adverse renal effects, with a few cases of rifampicin-induced minimal change disease (MCD). In the present case, a 68-year-old female presented with nausea, vomiting, ...

Last Updated: 16 Feb 2015

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A case of minimal change disease complicated by acute kidney injury in systemic lupus erythematosus.
 

Author(s): Koh-Wei Wong

Journal: Saudi J Kidney Dis Transpl. 2014 Nov;25(6):1308-11.

 

Last Updated: 14 Nov 2014

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A higher frequency of CD4⁺CXCR5⁺ T follicular helper cells in adult patients with minimal change disease.
 

Author(s): Nan Zhang, Pingwei Zhao, Amrita Shrestha, Li Zhang, Zhihui Qu, Mingyuan Liu, Songling Zhang, Yanfang Jiang

Journal: Biomed Res Int. 2014 ;2014():836157.

 

T follicular helper (TFH) cells are involved in the humoral immune responses. This study is aimed at examining the frequencies of different subsets of CD4(+)CXCR5(+) TFH cells in adult patients with minimal change disease (MCD).

Last Updated: 22 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Minimal change disease" returned 9 free, full-text review articles on human participants. First 3 results:

Rituximab in adult minimal change disease and focal segmental glomerulosclerosis.
 

Author(s): Andreas Kronbichler, Annette Bruchfeld

Journal: Nephron Clin Pract. 2014 ;128(3-4):277-82.

 

Treatment of nephrotic syndrome due to minimal change disease and focal segmental glomerulosclerosis remains a challenge since steroid dependence, steroid resistance and a relapsing disease course exhibits a high cumulative steroid dosage. The necessity of using alternative steroid-sparing ...

Last Updated: 9 Feb 2015

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The treatment of minimal change disease in adults.
 

Author(s): Jonathan Hogan, Jai Radhakrishnan

Journal: J. Am. Soc. Nephrol.. 2013 Apr;24(5):702-11.

 

Minimal change disease (MCD) is the etiology of 10%-25% of cases of nephrotic syndrome in adults. The mainstay of treatment for adult MCD, oral glucocorticoids, is based on two randomized controlled trials and extensive observational data in adults, and this treatment leads to remission ...

Last Updated: 1 May 2013

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New insights into human minimal change disease: lessons from animal models.
 

Author(s): Sumant S Chugh, Lionel C Clement, Camille Macé

Journal: Am. J. Kidney Dis.. 2012 Feb;59(2):284-92.

 

The pathogenesis of minimal change disease (MCD), considered to be the simplest form of nephrotic syndrome, has been one of the major unsolved mysteries in kidney disease. In this review, recent landmark studies that have led to the unraveling of MCD are discussed. A recent study ...

Last Updated: 16 Jan 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Tacrolimus Versus Prednisolone for the Treatment of Minimal Change Disease
 

Status: Recruiting

Condition Summary: Minimal Change Disease

 

Last Updated: 1 May 2015

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Nephrotic Syndrome Study Network
 

Status: Recruiting

Condition Summary: Minimal Change Disease (MCD); Membranous Nephropathy; Glomerulosclerosis, Focal Segmental

 

Last Updated: 26 May 2015

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A Study to Evaluate the Effect of Tacrolimus and Corticosteroid Combination Therapy in Patients With Minimal Change Nephrotic Syndrome
 

Status: Recruiting

Condition Summary: Minimal Change Nephrotic Syndrome (MCNS); MCNS

 

Last Updated: 7 Jan 2013

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