Minimal change disease

Common Name(s)

Minimal change disease

Minimal change disease is a kidney disorder that can lead to nephrotic syndrome, although the nephrons of the kidney look normal under a regular microscope. The most common symptom is swelling around the eyes, face, abdomen, and legs. Other features include poor appetite, weight gain, and a foamy appearance of the urine. The cause of minimal change disease is unknown, but it may occur following an allergic reaction, immunization, or viral infection. Treatment may involve the use of steroids such as prednisone. Children often respond better to this therapy than adults. Those who experience repeated relapses may benefit from the use of cytotoxic therapy, including cyclophosphamide, cyclosporine or chlorambucil.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Minimal change disease" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

Last Updated: 30 Jan 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Minimal change disease" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

http://www.nephcure.org

Last Updated: 30 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Minimal change disease" returned 60 free, full-text research articles on human participants. First 3 results:

Renal manifestations of human brucellosis: First report of minimal change disease.
 

Author(s): Nikolaos Sabanis, Eleni Gavriilaki, Eleni Paschou, Eleni Tsotsiou, Asterios Kalaitzoglou, Christos Kavlakoudis, Sotirios Vasileiou

Journal: Saudi J Kidney Dis Transpl. 2016 May;27(3):590-4.

 

Human brucellosis is considered a great example of the complexity of clinical manifestations possibly affecting multiple organs or systems. Renal manifestations of human brucellosis have been documented in few case reports and one case series. Herein, we present a case of Nephrotic ...

Last Updated: 24 May 2016

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Predictors of Relapse in Adult-Onset Nephrotic Minimal Change Disease.
 

Author(s): Hajeong Lee, Kyung Don Yoo, Yun Kyu Oh, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim, Curie Ahn, Jin Suk Han, Chun Soo Lim

Journal: Medicine (Baltimore). 2016 Mar;95(12):e3179.

 

Minimal change disease (MCD) is a well-known benign primary glomerulonephritis because of its distinct rare tendency to progress to end-stage renal disease. However, factors associated with relapse in adults are not well known. We aimed to identify predictors of relapse in adult-onset ...

Last Updated: 26 Mar 2016

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Effective treatment with rituximab for the maintenance of remission in frequently relapsing minimal change disease.
 

Author(s): Eugenia Papakrivopoulou, Ali M Shendi, Alan D Salama, Maryam Khosravi, John O Connolly, Richard Trompeter

Journal: Nephrology (Carlton). 2016 Oct;21(10):893-900.

 

Treatment of frequently relapsing or steroid-dependent minimal change disease (MCD) in children and adults remains challenging. Glucocorticoids and/or other immunosuppressive agents are the mainstay of treatment, but patients often experience toxicity from prolonged exposure and may ...

Last Updated: 13 Sep 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Minimal change disease" returned 9 free, full-text review articles on human participants. First 3 results:

Minimal change disease in a patient with myasthenia gravis: A case report.
 

Author(s): Jun-Li Tsai, Shang-Feng Tsai

Journal: Medicine (Baltimore). 2016 Sep;95(39):e5008.

 

Myasthenia gravis superimposed with proteinuria is a very rare disorder with only 39 cases reported so far. Of these cases, the most commonly associated disorder is minimal change disease. Myasthenia gravis and minimal change disease are both related to the dysfunction of T lymphocytes ...

Last Updated: 30 Sep 2016

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Rituximab in adult minimal change disease and focal segmental glomerulosclerosis.
 

Author(s): Andreas Kronbichler, Annette Bruchfeld

Journal: Nephron Clin Pract. 2014 ;128(3-4):277-82.

 

Treatment of nephrotic syndrome due to minimal change disease and focal segmental glomerulosclerosis remains a challenge since steroid dependence, steroid resistance and a relapsing disease course exhibits a high cumulative steroid dosage. The necessity of using alternative steroid-sparing ...

Last Updated: 9 Feb 2015

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The treatment of minimal change disease in adults.
 

Author(s): Jonathan Hogan, Jai Radhakrishnan

Journal: J. Am. Soc. Nephrol.. 2013 Apr;24(5):702-11.

 

Minimal change disease (MCD) is the etiology of 10%-25% of cases of nephrotic syndrome in adults. The mainstay of treatment for adult MCD, oral glucocorticoids, is based on two randomized controlled trials and extensive observational data in adults, and this treatment leads to remission ...

Last Updated: 1 May 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Tacrolimus Versus Prednisolone for the Treatment of Minimal Change Disease
 

Status: Recruiting

Condition Summary: Minimal Change Disease

 

Last Updated: 3 Mar 2017

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A Study to Evaluate the Effect of Tacrolimus and Corticosteroid Combination Therapy in Patients With Minimal Change Nephrotic Syndrome
 

Status: Recruiting

Condition Summary: MCNS; Minimal Change Nephrotic Syndrome (MCNS)

 

Last Updated: 12 Jan 2017

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Myfortic® for Minimal Change Nephrotic Syndrome (MCNS): a Randomized Study
 

Status: Recruiting

Condition Summary: Nephrosis, Lipoid

 

Last Updated: 25 Oct 2016

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