Minimal change disease

Common Name(s)

Minimal change disease

Minimal change disease is a kidney disorder that can lead to nephrotic syndrome, although the nephrons of the kidney look normal under a regular microscope. The most common symptom is swelling around the eyes, face, abdomen, and legs. Other features include poor appetite, weight gain, and a foamy appearance of the urine. The cause of minimal change disease is unknown, but it may occur following an allergic reaction, immunization, or viral infection. Treatment may involve the use of steroids such as prednisone. Children often respond better to this therapy than adults. Those who experience repeated relapses may benefit from the use of cytotoxic therapy, including cyclophosphamide, cyclosporine or chlorambucil.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Minimal change disease" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

Last Updated: 30 Jan 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Minimal change disease" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

http://www.nephcure.org

Last Updated: 30 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Minimal change disease" returned 63 free, full-text research articles on human participants. First 3 results:

Minimal change disease in horseshoe kidney.
 

Author(s): Yosr Chaabouni, Rahma Guesmi, Yosr Hentati, Khaoula Kammoun, Mohamed Ben Hmida, Zeineb Mnif, Tahya Boudawara, Jamil Hachicha

Journal:

 

The horseshoe kidney is a frequent urological birth defect. The most frequent complications are urinary tract infections, stones and hydronephrosis. The occurrence of glomerular disease in horseshoe kidney is rare. Therefore, we report the first case of minimal change disease occurring ...

Last Updated: 10 Jul 2017

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Complete Remission of Minimal Change Disease Following an Improvement of Lung Mycobacterium avium Infection.
 

Author(s): Aoi Yamashiro, Takahiro Uchida, Seigo Ito, Naoki Oshima, Takashi Oda, Hiroo Kumagai

Journal: Intern. Med.. ;55(18):2669-72.

 

A 46-year-old woman suddenly developed peripheral edema. Her massive proteinuria, hypoproteinemia, and renal biopsy findings yielded the diagnosis of minimal change disease (MCD). In addition, lung Mycobacterium avium infection was diagnosed according to a positive culture of her ...

Last Updated: 16 Sep 2016

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Flexible Spectral Imaging Color Enhancement and Probe-based Confocal Laser Endomicroscopy in Minimal Change Esophageal Reflux Disease.
 

Author(s): Rapat Pittayanon, Surasak Aumkaew, Rungsun Rerknimitr, Naruemon Wisedopas, Pinit Kullavanijaya

Journal: Korean J Gastroenterol. 2016 Jul;68(1):29-35.

 

Although flexible spectral imaging color enhancement (FICE) can facilitate the diagnosis of minimal change esophageal reflux disease (MERD), the complicated diagnostic criteria cause suboptimal inter-observer agreement. Confocal laser endomicroscopy (CLE) yields good diagnostic results ...

Last Updated: 22 Jul 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Minimal change disease" returned 8 free, full-text review articles on human participants. First 3 results:

Minimal change disease in a patient with myasthenia gravis: A case report.
 

Author(s): Jun-Li Tsai, Shang-Feng Tsai

Journal: Medicine (Baltimore). 2016 Sep;95(39):e5008.

 

Myasthenia gravis superimposed with proteinuria is a very rare disorder with only 39 cases reported so far. Of these cases, the most commonly associated disorder is minimal change disease. Myasthenia gravis and minimal change disease are both related to the dysfunction of T lymphocytes ...

Last Updated: 30 Sep 2016

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The treatment of minimal change disease in adults.
 

Author(s): Jonathan Hogan, Jai Radhakrishnan

Journal: J. Am. Soc. Nephrol.. 2013 Apr;24(5):702-11.

 

Minimal change disease (MCD) is the etiology of 10%-25% of cases of nephrotic syndrome in adults. The mainstay of treatment for adult MCD, oral glucocorticoids, is based on two randomized controlled trials and extensive observational data in adults, and this treatment leads to remission ...

Last Updated: 1 May 2013

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New insights into human minimal change disease: lessons from animal models.
 

Author(s): Sumant S Chugh, Lionel C Clement, Camille Macé

Journal: Am. J. Kidney Dis.. 2012 Feb;59(2):284-92.

 

The pathogenesis of minimal change disease (MCD), considered to be the simplest form of nephrotic syndrome, has been one of the major unsolved mysteries in kidney disease. In this review, recent landmark studies that have led to the unraveling of MCD are discussed. A recent study ...

Last Updated: 16 Jan 2012

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Tacrolimus Versus Prednisolone for the Treatment of Minimal Change Disease
 

Status: Recruiting

Condition Summary: Minimal Change Disease

 

Last Updated: 3 Mar 2017

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Active Vitamin D And Reduced Dose Prednisolone for Treatment in Minimal Change Nephropathy
 

Status: Not yet recruiting

Condition Summary: Minimal Change Disease; Nephrotic Syndrome

 

Last Updated: 4 Jul 2017

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