Minimal change disease

Common Name(s)

Minimal change disease

Minimal change disease is a kidney disorder that can lead to nephrotic syndrome, although the nephrons of the kidney look normal under a regular microscope. The most common symptom is swelling around the eyes, face, abdomen, and legs. Other features include poor appetite, weight gain, and a foamy appearance of the urine. The cause of minimal change disease is unknown, but it may occur following an allergic reaction, immunization, or viral infection. Treatment may involve the use of steroids such as prednisone. Children often respond better to this therapy than adults. Those who experience repeated relapses may benefit from the use of cytotoxic therapy, including cyclophosphamide, cyclosporine or chlorambucil.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Minimal change disease" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

Last Updated: 30 Jan 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Minimal change disease" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

http://www.nephcure.org

Last Updated: 30 Jan 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Minimal change disease" returned 48 free, full-text research articles on human participants. First 3 results:

Urinary peptide profiling to differentiate between minimal change disease and focal segmental glomerulosclerosis.
 

Author(s): Vanessa Pérez, Meritxell Ibernón, Dolores López, María Cruz Pastor, Maruja Navarro, Maribel Navarro-Muñoz, Josep Bonet, Ramón Romero

Journal:

 

Minimal change disease (MCD) and primary focal segmental glomerulosclerosis (FSGS) are the main causes of primary idiopathic nephrotic syndrome in children and adults, with diagnosis being essential for the appropriate choice of therapy and requiring renal biopsy. However, the presence ...

Last Updated: 5 Feb 2014

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Reliability and minimal detectable change of physical performance measures in individuals with pre-manifest and manifest Huntington disease.
 

Author(s): Lori Quinn, Hanan Khalil, Helen Dawes, Nora E Fritz, Deb Kegelmeyer, Anne D Kloos, Jonathan W Gillard, Monica Busse,

Journal: Phys Ther. 2013 Jul;93(7):942-56.

 

Clinical intervention trials in people with Huntington disease (HD) have been limited by a lack of reliable and appropriate outcome measures.

Last Updated: 2 Jul 2013

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Two new families with hereditary minimal change disease.
 

Author(s): Hassib Chehade, Francois Cachat, Eric Girardin, Samuel Rotman, Antonio Jorge Correia, Florence Fellmann, Olivier Bonny

Journal:

 

Steroid-sensitive idiopathic nephrotic syndrome (SSINS) is most often encountered in sporadic cases of minimal change disease (MCD). Only rare cases of familial forms of MCD have been reported and most of them only in one generation. The scarcity of data has precluded unraveling the ...

Last Updated: 5 Apr 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Minimal change disease" returned 8 free, full-text review articles on human participants. First 3 results:

The treatment of minimal change disease in adults.
 

Author(s): Jonathan Hogan, Jai Radhakrishnan

Journal: J. Am. Soc. Nephrol.. 2013 Apr;24(5):702-11.

 

Minimal change disease (MCD) is the etiology of 10%-25% of cases of nephrotic syndrome in adults. The mainstay of treatment for adult MCD, oral glucocorticoids, is based on two randomized controlled trials and extensive observational data in adults, and this treatment leads to remission ...

Last Updated: 1 May 2013

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New insights into human minimal change disease: lessons from animal models.
 

Author(s): Sumant S Chugh, Lionel C Clement, Camille Macé

Journal: Am. J. Kidney Dis.. 2012 Feb;59(2):284-92.

 

The pathogenesis of minimal change disease (MCD), considered to be the simplest form of nephrotic syndrome, has been one of the major unsolved mysteries in kidney disease. In this review, recent landmark studies that have led to the unraveling of MCD are discussed. A recent study ...

Last Updated: 16 Jan 2012

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Minimal change disease as a modifiable podocyte paracrine disorder.
 

Author(s): Changli Wei, Jochen Reiser

Journal: Nephrol. Dial. Transplant.. 2011 Jun;26(6):1776-7.

 

Last Updated: 6 Jun 2011

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Tacrolimus Versus Prednisolone for the Treatment of Minimal Change Disease
 

Status: Recruiting

Condition Summary: Minimal Change Disease

 

Last Updated: 26 Sep 2013

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A Study to Evaluate the Effect of Tacrolimus and Corticosteroid Combination Therapy in Patients With Minimal Change Nephrotic Syndrome
 

Status: Recruiting

Condition Summary: Minimal Change Nephrotic Syndrome (MCNS); MCNS

 

Last Updated: 7 Jan 2013

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Nephrotic Syndrome Study Network
 

Status: Recruiting

Condition Summary: Minimal Change Disease (MCD); Membranous Nephropathy; Glomerulosclerosis, Focal Segmental

 

Last Updated: 2 Dec 2014

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