Ankylosing Spondylitis

Common Name(s)

Ankylosing Spondylitis

Ankylosing spondylitis is a type of arthritis of the spine. It causes swelling between the vertebrae and in the joints between the spine and pelvis. This autoimmune disease is more common and more severe in men than in women.  It is likely caused by a combination of genetic and environmental factors, most of which have not yet been identified. Researchers have found variations in several genes that influence the risk of developing this disorder. These genes include HLA-B, ERAP1, IL1A, and IL23R. Early symptoms of ankylosing spondylitis include back pain and stiffness. These problems often start in late adolescence or early adulthood. Over time, ankylosing spondylitis can fuse the vertebrae together, limiting movement. Symptoms can worsen, improve, or stop altogether. The disease has no cure, but medicines can relieve the pain, swelling and other symptoms. Exercise can also help.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ankylosing Spondylitis" for support, advocacy or research.

Logo
Kickas.org

KickAs.org strives to provide the means for ankylosing spondylitis sufferers worldwide to share with, and learn from, the experiences of others coping with ankylosing spondylitis and related conditions in a safe and supportive environment.

Last Updated: 24 Nov 2009

View Details
stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

Last Updated: 5 Mar 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ankylosing Spondylitis" for support, advocacy or research.

Logo
Kickas.org

KickAs.org strives to provide the means for ankylosing spondylitis sufferers worldwide to share with, and learn from, the experiences of others coping with ankylosing spondylitis and related conditions in a safe and supportive environment.

http://www.kickas.org

Last Updated: 24 Nov 2009

View Details
stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

http://www.stopcaidnow.org

Last Updated: 5 Mar 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ankylosing Spondylitis" returned 1120 free, full-text research articles on human participants. First 3 results:

Long-lasting unspecific intestinal inflammation in ankylosing spondylitis evolving into Crohn's disease.
 

Author(s): Antonio Tursi, Cosimo Damiano Inchingolo

Journal: J Gastrointestin Liver Dis. 2013 Dec;22(4):472-3.

 

Last Updated: 26 Dec 2013

Go To URL
Transcriptome network analysis reveals potential candidate genes for ankylosing spondylitis.
 

Author(s): Z-Q Zhu, J-S Tang, X-J Cao

Journal: Eur Rev Med Pharmacol Sci. 2013 Dec;17(23):3178-85.

 

Ankylosing spondylitis (AS) is a chronic, inflammatory arthritis and autoimmune disease.

Last Updated: 16 Dec 2013

Go To URL
[Toxoplasma uveitis in a patient with ankylosing spondylitis].
 

Author(s): Hülya Deveci, Şenol Kobak

Journal: Turkiye Parazitol Derg. 2013 ;37(3):216-8.

 

In this paper, a posterior uveitis case was reported in a patient who was being followed and under treatment for Ankylosing Spondylitis. Toxoplasma antibodies were investigated and anti-toxoplasma IgG was positive. Systematic treatment (Sulfamethoxazole/Trimethoprim and Clindamycin) ...

Last Updated: 6 Nov 2013

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ankylosing Spondylitis" returned 73 free, full-text review articles on human participants. First 3 results:

The link between ankylosing spondylitis, Crohn's disease, Klebsiella, and starch consumption.
 

Author(s): Taha Rashid, Clyde Wilson, Alan Ebringer

Journal: Clin. Dev. Immunol.. 2013 ;2013():872632.

 

Both ankylosing spondylitis (AS) and Crohn's disease (CD) are chronic and potentially disabling interrelated conditions, which have been included under the group of spondyloarthropathies. The results of a large number of studies support the idea that an enteropathic pathogen, Klebsiella ...

Last Updated: 19 Jun 2013

Go To URL
Association between IL-1RN gene polymorphisms and susceptibility to ankylosing spondylitis: a large Human Genome Epidemiology review and meta-analysis.
 

Author(s): G X Jin, J Z Duan, W L Guo, L Li, S Q Cui, H Wang

Journal:

 

We made a Human Genome Epidemiology review and meta-analysis to examine a possible association between interleukin-1 receptor antagonist (IL-1RN) polymorphisms and susceptibility to ankylosing spondylitis (AS). Studies of IL-1RN polymorphisms and susceptibility to AS were found by ...

Last Updated: 14 Jun 2013

Go To URL
Treating spondyloarthritis, including ankylosing spondylitis and psoriatic arthritis, to target: recommendations of an international task force.
 

Author(s): Josef S Smolen, Jürgen Braun, Maxime Dougados, Paul Emery, Oliver Fitzgerald, Philip Helliwell, Arthur Kavanaugh, Tore K Kvien, Robert Landewé, Thomas Luger, Philip Mease, Ignazio Olivieri, John Reveille, Christopher Ritchlin, Martin Rudwaleit, Monika Schoels, Joachim Sieper, Martinus de Wit, Xenofon Baraliakos, Neil Betteridge, Ruben Burgos-Vargas, Eduardo Collantes-Estevez, Atul Deodhar, Dirk Elewaut, Laure Gossec, Merryn Jongkees, Mara Maccarone, Kurt Redlich, Filip van den Bosch, James Cheng-Chung Wei, Kevin Winthrop, Désirée van der Heijde

Journal: Ann. Rheum. Dis.. 2014 Jan;73(1):6-16.

 

Therapeutic targets have been defined for diseases like diabetes, hypertension or rheumatoid arthritis and adhering to them has improved outcomes. Such targets are just emerging for spondyloarthritis (SpA).

Last Updated: 5 Dec 2013

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Pilot Open Label Clinical Trial With Abatacept in Ankylosing Spondylitis
 

Status: Recruiting

Condition Summary: Ankylosing Spondylitis

 

Last Updated: 25 Feb 2008

Go to URL
Open Label Clinical Trial With Rituximab (MabThera ®) in Ankylosing Spondylitis
 

Status: Not yet recruiting

Condition Summary: Ankylosing Spondylitis

 

Last Updated: 7 Feb 2007

Go to URL