Ankylosing Spondylitis

Common Name(s)

Ankylosing Spondylitis

Ankylosing spondylitis is a type of arthritis of the spine. It causes swelling between the vertebrae and in the joints between the spine and pelvis. This autoimmune disease is more common and more severe in men than in women.  It is likely caused by a combination of genetic and environmental factors, most of which have not yet been identified. Researchers have found variations in several genes that influence the risk of developing this disorder. These genes include HLA-B, ERAP1, IL1A, and IL23R. Early symptoms of ankylosing spondylitis include back pain and stiffness. These problems often start in late adolescence or early adulthood. Over time, ankylosing spondylitis can fuse the vertebrae together, limiting movement. Symptoms can worsen, improve, or stop altogether. The disease has no cure, but medicines can relieve the pain, swelling and other symptoms. Exercise can also help.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ankylosing Spondylitis" for support, advocacy or research.

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

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Kickas.org

KickAs.org strives to provide the means for ankylosing spondylitis sufferers worldwide to share with, and learn from, the experiences of others coping with ankylosing spondylitis and related conditions in a safe and supportive environment.

Last Updated: 24 Nov 2009

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stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

Last Updated: 5 Mar 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ankylosing Spondylitis" for support, advocacy or research.

Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

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Kickas.org

KickAs.org strives to provide the means for ankylosing spondylitis sufferers worldwide to share with, and learn from, the experiences of others coping with ankylosing spondylitis and related conditions in a safe and supportive environment.

http://www.kickas.org

Last Updated: 24 Nov 2009

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stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

http://www.stopcaidnow.org

Last Updated: 5 Mar 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ankylosing Spondylitis" returned 1152 free, full-text research articles on human participants. First 3 results:

Xinfeng capsule improves pulmonary function in ankylosing spondylitis patients via NF-ΚB-iNOS-NO signaling pathway.
 

Author(s): Jian Liu, Yajun Qi, Li Zheng, Yunxiang Cao, Lei Wan, Wenfang Ye, Li Fang

Journal: J Tradit Chin Med. 2014 Dec;34(6):657-65.

 

To study changes in the nuclear factor-κB p65 (NF-κB p65)-inducible nitric oxide synthase (iNOS)-nitric oxide (NO) signaling pathway and the effects of Xinfeng capsules (XFC) in patients with ankylosing spondylitis (AS).

Last Updated: 26 Jan 2015

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The VEGF and BMP-2 levels in patients with ankylosing spondylitis and the relationship to treatment with tumour necrosis factor alpha inhibitors.
 

Author(s): Marian Tošovský, Petr Bradna, Ctirad Andrýs, Kateřina Andrýsová, Eva Cermáková, Tomáš Soukup

Journal: Acta Medica (Hradec Kralove). 2014 ;57(2):56-61.

 

Ankylosing spondylitis (AS) is an inflammatory rheumatic disease characterized by the development of osteoproductive changes in the spine which could possibly result in ankylosis. Treatment with tumour necrosis factor alpha (TNFα) inhibitors has proved to be an important step forward ...

Last Updated: 26 Sep 2014

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Ankylosing spondylitis is associated with the anthrax toxin receptor 2 gene (ANTXR2).
 

Author(s): T Karaderi, S M Keidel, J J Pointon, L H Appleton, M A Brown, D M Evans, B P Wordsworth

Journal: Ann. Rheum. Dis.. 2014 Nov;73(11):2054-8.

 

ANTXR2 variants have been associated with ankylosing spondylitis (AS) in two previous genome-wide association studies (GWAS) (p∼9×10(-8)). However, a genome-wide significant association (p<5×10(-8)) was not observed. We conducted a more comprehensive analysis of ANTXR2 in an independent ...

Last Updated: 7 Oct 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ankylosing Spondylitis" returned 81 free, full-text review articles on human participants. First 3 results:

Comparative efficacy and safety of biosimilar infliximab and other biological treatments in ankylosing spondylitis: systematic literature review and meta-analysis.
 

Author(s): Petra Baji, Márta Péntek, Sándor Szántó, Pál Géher, László Gulácsi, Orsolya Balogh, Valentin Brodszky

Journal: Eur J Health Econ. 2014 May;15 Suppl 1():S45-52.

 

To compare the efficacy and safety of infliximab-biosimilar with other biological drugs for the treatment of active ankylosing spondylitis (AS).

Last Updated: 6 Jun 2014

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Adipokines, biomarkers of endothelial activation, and metabolic syndrome in patients with ankylosing spondylitis.
 

Author(s): Fernanda Genre, Raquel López-Mejías, José A Miranda-Filloy, Begoña Ubilla, Beatriz Carnero-López, Ricardo Blanco, Trinitario Pina, Carlos González-Juanatey, Javier Llorca, Miguel A González-Gay

Journal: Biomed Res Int. 2014 ;2014():860651.

 

Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease associated with accelerated atherosclerosis and increased risk of cardiovascular (CV) disease. AS patients also display a high prevalence of features clustered under the name of metabolic syndrome (MeS). Anti-TNF- ...

Last Updated: 23 Apr 2014

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Measurement and treatment of radiographic progression in ankylosing spondylitis: lessons learned from observational studies and clinical trials.
 

Author(s): Grant H Louie, Michael M Ward

Journal: Curr Opin Rheumatol. 2014 Mar;26(2):145-50.

 

One of the major goals of treatment of ankylosing spondylitis is to prevent or slow the development of spinal new bone formation. Recent observational studies are compared with the results from clinical trials for the effects of tumor necrosis factor-alpha inhibitors (TNFi) and NSAIDs ...

Last Updated: 4 Feb 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

European Ankylosing Spondylitis Infliximab Cohort (EASIC) Follow up Registration Study
 

Status: Not yet recruiting

Condition Summary: Ankylosing Spondylitis

 

Last Updated: 27 Jan 2011

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Genetic Determinants of Ankylosing Spondylitis Severity - Longitudinal Study
 

Status: Recruiting

Condition Summary: Ankylosing Spondylitis

 

Last Updated: 3 Dec 2014

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