Ankylosing spondylitis

Common Name(s)

Ankylosing spondylitis, AS, Bechterew disease, Marie Strumpell disease

Ankylosing spondylitis (AS) is an inflammatory joint disease that primarily affects the spine. As ankylosing spondylitis progresses, the vertebrae in the spine fuse together (ankylosis), causing the spine to be less flexible and may result in a hunched-forward posture. Signs and symptoms of ankylosing spondylitis may include pain and stiffness in your lower back and hips. Affected areas can include the joints between the base of your spine and pelvis, the joints between the vertebrae, the hip joints, and the shoulder joints.

Up to 40 percent of individuals with ankylosing spondylitis will have eye inflammation that may cause eye pain, sensitivity to light and blurred vision. Other less common complications include restricted lung function and heart inflammation. Risk factors of ankylosing spondylitis include gender and age, as men develop ankylosing spondylitis more often than women and onset of symptoms typically occurs in late adolescence and early adulthood. The exact cause of ankylosing spondylitis is unknown, but it is believed that both genetic and environmental factors play a role. One genetic factor is the HLA-B gene, which provides instructions for making a protein that helps the immune system distinguish the body’s own proteins from foreign invaders (such as viruses and bacteria). Individuals who have the HLA-B27 variation of the HLA-B gene are at greater risk of developing ankylosing spondylitis.

Your doctor may use a physical exam along with imaging tests and lab tests to diagnosis the condition. There is no cure for ankylosing spondylitis, but there are treatment options that can help decrease your pain and reduce your symptoms. Support groups are good resources for additional information. Contact a doctor if you or someone in your family has been diagnosed with ankylosing spondylitis to discuss the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ankylosing spondylitis" for support, advocacy or research.

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

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Kickas.org

KickAs.org strives to provide the means for ankylosing spondylitis sufferers worldwide to share with, and learn from, the experiences of others coping with ankylosing spondylitis and related conditions in a safe and supportive environment.

Last Updated: 24 Nov 2009

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stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

Last Updated: 5 Mar 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ankylosing spondylitis" for support, advocacy or research.

Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

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Kickas.org

KickAs.org strives to provide the means for ankylosing spondylitis sufferers worldwide to share with, and learn from, the experiences of others coping with ankylosing spondylitis and related conditions in a safe and supportive environment.

http://www.kickas.org

Last Updated: 24 Nov 2009

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stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

http://www.stopcaidnow.org

Last Updated: 5 Mar 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ankylosing spondylitis" returned 1448 free, full-text research articles on human participants. First 3 results:

Comparison of Sagittal Spinopelvic Alignment in Patients With Ankylosing Spondylitis and Thoracolumbar Fracture.
 

Author(s): Tao Pan, Bang-Ping Qian, Yong Qiu

Journal: Medicine (Baltimore). 2016 Jan;95(4):e2585.

 

This article is a comparative study. The aim of the study is to investigate the difference of sagittal alignment of the pelvis and spine between patients with thoracolumbar kyphosis secondary to ankylosing spondylitis (AS) and thoracolumbar fracture, and to evaluate the role of sacropelvic ...

Last Updated: 30 Jan 2016

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[Clinical analysis of 31 ankylosing spondylitis patients with malignancies].
 

Author(s): Lan Gao, Yong Fan, Zhuo-li Zhang

Journal: Beijing Da Xue Xue Bao. 2015 Dec;47(6):962-5.

 

To investigate the clinical features of patients with ankylosing spondylitis (AS) and malignancies.

Last Updated: 18 Dec 2015

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Effect of Tumor Necrosis Factor Inhibitor Therapy on Osteoclasts Precursors in Ankylosing Spondylitis.
 

Author(s): Inês P Perpétuo, Rita Raposeiro, Joana Caetano-Lopes, Elsa Vieira-Sousa, Raquel Campanilho-Marques, Cristina Ponte, Helena Canhão, Mari Ainola, João E Fonseca

Journal:

 

Ankylosing Spondylitis (AS) is characterized by excessive local bone formation and concomitant systemic bone loss. Tumor necrosis factor (TNF) plays a central role in the inflammation of axial skeleton and enthesis of AS patients. Despite reduction of inflammation and systemic bone ...

Last Updated: 17 Dec 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ankylosing spondylitis" returned 106 free, full-text review articles on human participants. First 3 results:

Do Anti-TNF Blockers Increase the Risk of Lung Involvement in Patients with Ankylosing Spondylitis or Psoriatic Arthritis? A Systematic Review.
 

Author(s): Fabiola Atzeni, Elisabetta Grillo, Ignazio F Masala, Piercarlo Sarzi-Puttini, Gareth T Jones

Journal: Isr. Med. Assoc. J.. ;18(3-4):154-5.

 

Lung involvement is a well-recognized extra-articular manifestation of ankylosing spondylitis (AS). Anecdotal reports suggest that the use of anti-TNF drugs may be related to lung disease and pulmonary fibrosis. To examine the association between anti-TNF drugs and the development ...

Last Updated: 27 May 2016

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Concurrent Intervention With Exercises and Stabilized Tumor Necrosis Factor Inhibitor Therapy Reduced the Disease Activity in Patients With Ankylosing Spondylitis: A Meta-Analysis.
 

Author(s): Hui Liang, Wen-Rong Li, Hua Zhang, Xu Tian, Wei Wei, Chun-Mei Wang

Journal: Medicine (Baltimore). 2015 Dec;94(50):e2254.

 

Since the use of tumor necrosis factor (TNF) inhibitor therapy is becoming wider, the effects of concurrent intervention with exercises and stabilized TNF inhibitors therapy in patients with ankylosing spondylitis (AS) are different. The study aimed to objectively evaluate whether ...

Last Updated: 19 Dec 2015

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Endoplasmic reticulum aminopeptidases in the pathogenesis of ankylosing spondylitis.
 

Author(s): Tony J Kenna, Philip C Robinson, Nigil Haroon

Journal: Rheumatology (Oxford). 2015 Sep;54(9):1549-56.

 

There has been significant progress in our understanding of the pathogenesis of AS. The advent of genome-wide association studies has increased the known loci associated with AS to more than 40. The endoplasmic reticulum resident aminopeptidases (ERAP) 1 and 2 were identified in this ...

Last Updated: 15 Aug 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

European Ankylosing Spondylitis Infliximab Cohort (EASIC) Follow up Registration Study
 

Status: Not yet recruiting

Condition Summary: Ankylosing Spondylitis

 

Last Updated: 27 Jan 2011

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Genetic Determinants of Ankylosing Spondylitis Severity - Longitudinal Study
 

Status: Recruiting

Condition Summary: Ankylosing Spondylitis

 

Last Updated: 26 May 2016

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