Ankylosing Spondylitis

Common Name(s)

Ankylosing Spondylitis

Ankylosing spondylitis is a type of arthritis of the spine. It causes swelling between the vertebrae and in the joints between the spine and pelvis. This autoimmune disease is more common and more severe in men than in women.  It is likely caused by a combination of genetic and environmental factors, most of which have not yet been identified. Researchers have found variations in several genes that influence the risk of developing this disorder. These genes include HLA-B, ERAP1, IL1A, and IL23R. Early symptoms of ankylosing spondylitis include back pain and stiffness. These problems often start in late adolescence or early adulthood. Over time, ankylosing spondylitis can fuse the vertebrae together, limiting movement. Symptoms can worsen, improve, or stop altogether. The disease has no cure, but medicines can relieve the pain, swelling and other symptoms. Exercise can also help.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ankylosing Spondylitis" for support, advocacy or research.

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

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Kickas.org

KickAs.org strives to provide the means for ankylosing spondylitis sufferers worldwide to share with, and learn from, the experiences of others coping with ankylosing spondylitis and related conditions in a safe and supportive environment.

Last Updated: 24 Nov 2009

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stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

Last Updated: 5 Mar 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ankylosing Spondylitis" for support, advocacy or research.

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

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Kickas.org

KickAs.org strives to provide the means for ankylosing spondylitis sufferers worldwide to share with, and learn from, the experiences of others coping with ankylosing spondylitis and related conditions in a safe and supportive environment.

http://www.kickas.org

Last Updated: 24 Nov 2009

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stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

http://www.stopcaidnow.org

Last Updated: 5 Mar 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ankylosing Spondylitis" returned 1143 free, full-text research articles on human participants. First 3 results:

The VEGF and BMP-2 levels in patients with ankylosing spondylitis and the relationship to treatment with tumour necrosis factor alpha inhibitors.
 

Author(s): Marian Tošovský, Petr Bradna, Ctirad Andrýs, Kateřina Andrýsová, Eva Cermáková, Tomáš Soukup

Journal: Acta Medica (Hradec Kralove). 2014 ;57(2):56-61.

 

Ankylosing spondylitis (AS) is an inflammatory rheumatic disease characterized by the development of osteoproductive changes in the spine which could possibly result in ankylosis. Treatment with tumour necrosis factor alpha (TNFα) inhibitors has proved to be an important step forward ...

Last Updated: 26 Sep 2014

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Ankylosing spondylitis is associated with the anthrax toxin receptor 2 gene (ANTXR2).
 

Author(s): T Karaderi, S M Keidel, J J Pointon, L H Appleton, M A Brown, D M Evans, B P Wordsworth

Journal: Ann. Rheum. Dis.. 2014 Nov;73(11):2054-8.

 

ANTXR2 variants have been associated with ankylosing spondylitis (AS) in two previous genome-wide association studies (GWAS) (p∼9×10(-8)). However, a genome-wide significant association (p<5×10(-8)) was not observed. We conducted a more comprehensive analysis of ANTXR2 in an independent ...

Last Updated: 7 Oct 2014

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Ankylosing spondylitis and rheumatoid arthritis: serum levels of TNF-α and Its soluble receptors during the course of therapy with etanercept and infliximab.
 

Author(s): Martin Schulz, Helmut Dotzlaw, Gunther Neeck

Journal: Biomed Res Int. 2014 ;2014():675108.

 

The effects of the TNF- α blockers infliximab or etanercept on the levels of TNF- α , TNF-receptor 1 (TNF-R1), and TNF-receptor 2 (TNF-R2), as well as the levels of the inflammation markers CRP and IL-6, were measured in ankylosing spondylitis (AS) and rheumatoid arthritis (RA) ...

Last Updated: 30 Apr 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ankylosing Spondylitis" returned 79 free, full-text review articles on human participants. First 3 results:

Adipokines, biomarkers of endothelial activation, and metabolic syndrome in patients with ankylosing spondylitis.
 

Author(s): Fernanda Genre, Raquel López-Mejías, José A Miranda-Filloy, Begoña Ubilla, Beatriz Carnero-López, Ricardo Blanco, Trinitario Pina, Carlos González-Juanatey, Javier Llorca, Miguel A González-Gay

Journal: Biomed Res Int. 2014 ;2014():860651.

 

Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease associated with accelerated atherosclerosis and increased risk of cardiovascular (CV) disease. AS patients also display a high prevalence of features clustered under the name of metabolic syndrome (MeS). Anti-TNF- ...

Last Updated: 23 Apr 2014

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Ankylosing spondylitis: an update.
 

Author(s): Vera Golder, Lionel Schachna

Journal: Aust Fam Physician. 2013 Nov;42(11):780-4.

 

Ankylosing spondylitis (AS) affects one in 200 individuals and is usually diagnosed many years after onset of symptoms. Chronic back pain is common and recognition of early disease requires clinical experience and a high index of suspicion. Further, inflammatory markers are not invariably ...

Last Updated: 12 Nov 2013

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Variables related to work productivity loss in patients with ankylosing spondylitis.
 

Author(s): Renata Frauendorf, Marcelo de Medeiros Pinheiro, Rozana Mesquita Ciconelli

Journal: Rev Bras Reumatol. ;53(3):303-9.

 

The work productivity loss due to ankylosing spondylitis (AS) has become subject of interest because of its socioeconomic impact. In addition to physical limitations, other variables seem to affect the productivity of those patients, who often withdraw early from the labor force. ...

Last Updated: 20 Sep 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

European Ankylosing Spondylitis Infliximab Cohort (EASIC) Follow up Registration Study
 

Status: Not yet recruiting

Condition Summary: Ankylosing Spondylitis

 

Last Updated: 27 Jan 2011

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Genetic Determinants of Ankylosing Spondylitis Severity - Longitudinal Study
 

Status: Recruiting

Condition Summary: Ankylosing Spondylitis

 

Last Updated: 3 Dec 2014

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