Migraine

Common Name(s)

Migraine

Migraine is the most common type of chronic, episodic headache, as summarized by {7:Featherstone (1985)}. One locus for migraine with or without aura (MGR1) has been identified on chromosome 4q24. Other loci for migraine have been identified on 6p21.1-p12.2 (MGR3; {607498}), 14q21.2-q22.3 (MGR4; {607501}), 19p13 (MGR5; {607508}), 1q31 (MGR6; {607516}), 15q11-q13 (MGR7; {609179}), 5q21 (with or without aura, MGR8, {609570}; with aura, MGR9, {609670}), 17p13 (MGR10; {610208}), 18q12 (MGR11; {610209}), 10q22-q23 (MGR12; {611706}), and the X chromosome (MGR2; {300125}). Mutation in the KCNK18 gene ({613655}) on chromosome 10q25 causes migraine with aura (MGR13; {613656}). A subtype of autosomal dominant migraine with aura (MA), familial hemiplegic migraine (FHM; see {141500}), is caused by mutation in the CACNA1A gene ({601011}) on chromosome 19p13 (FHM1; {141500}), by mutation in the ATP1A2 gene ({182340}) on chromosome 1q21 (FHM2; {602481}), or by mutation in the SCN1A gene ({182389}) on chromosome 2q24 (FHM3; {609634}). Another locus for FHM has been mapped to chromosome 1q31 (FHM4; see {607516}). There is evidence that a polymorphism in the estrogen receptor gene (ESR1; {133430.0005}) and a polymorphism in the TNF gene ({191160.0004}) may confer susceptibility to migraine. A polymorphism in the endothelin receptor type A gene (EDNRA; {131243.0001}) may confer resistance to migraine.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Migraine" for support, advocacy or research.

APS Foundation of America, Inc.

The APS Foundation of America, Inc. is dedicated to fostering and facilitating joint efforts in the areas of education, public awareness, research and patient services in an effective and ethical manner.

Last Updated: 12 Aug 2013

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 3 Oct 2013

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National Headache Foundation

The National Headache Foundation exists to enhance the healthcare of individuals with headache. It is a source of help to their families, physicians and allied healthcare professionals who treat them, and to the public. The NHF accomplishes its mission by providing educational and informational resources, supporting headache research, and advocating for the understanding of headache as a legitimate neurobiological disease.

Last Updated: 20 Feb 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Migraine" for support, advocacy or research.

APS Foundation of America, Inc.

The APS Foundation of America, Inc. is dedicated to fostering and facilitating joint efforts in the areas of education, public awareness, research and patient services in an effective and ethical manner.

http://www.apsfa.org

Last Updated: 12 Aug 2013

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 3 Oct 2013

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National Headache Foundation

The National Headache Foundation exists to enhance the healthcare of individuals with headache. It is a source of help to their families, physicians and allied healthcare professionals who treat them, and to the public. The NHF accomplishes its mission by providing educational and informational resources, supporting headache research, and advocating for the understanding of headache as a legitimate neurobiological disease.

http://www.headaches.org

Last Updated: 20 Feb 2013

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General Resources

Migraine Signs and Symptoms

A migraine is a throbbing or pulsating headache that is often one sided (unilateral) and associated with nausea; vomiting; sensitivity to light, sound, and smells; sleep disruption; and depression. Attacks are often recurrent and tend to become less

Updated 13 Nov 2012

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APS Foundation of America, Inc Fan Page

The APS Foundation of America, Inc. is the leading United States nonprofit health agency dedicated to bringing national awareness to Antiphospholipid Antibody Syndrome (APS).

Updated 13 Nov 2012

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Blogs

APS Friends & Support Forum

Are you looking for Support for Antiphospholipid Antibody Syndrome, APS, APLS, APLA, Hughes Syndrome, or Sticky Blood? Well you've come to the right place! This is an private forum for people who have Antiphospholipid Antibody Syndrome, friends, fam

Updated 13 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Migraine" returned 1329 free, full-text research articles on human participants. First 3 results:

Making modern migraine medieval: men of science, Hildegard of Bingen and the life of a retrospective diagnosis.
 

Author(s): Katherine Foxhall

Journal: Med Hist. 2014 Jul;58(3):354-74.

 

Charles Singer's retrospective diagnosis of Hildegard of Bingen as a migraine sufferer, first made in 1913, has become commonly accepted. This article uses Hildegard as a case study to shift our focus from a polarised debate about the merits or otherwise of retrospective diagnosis, ...

Last Updated: 21 Jul 2014

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3D-neuronavigation in vivo through a patient's brain during a spontaneous migraine headache.
 

Author(s): Alexandre F DaSilva, Thiago D Nascimento, Tiffany Love, Marcos F DosSantos, Ilkka K Martikainen, Chelsea M Cummiford, Misty DeBoer, Sarah R Lucas, MaryCatherine A Bender, Robert A Koeppe, Theodore Hall, Sean Petty, Eric Maslowski, Yolanda R Smith, Jon-Kar Zubieta

Journal:

 

A growing body of research, generated primarily from MRI-based studies, shows that migraine appears to occur, and possibly endure, due to the alteration of specific neural processes in the central nervous system. However, information is lacking on the molecular impact of these changes, ...

Last Updated: 25 Jun 2014

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Effect of qilongtoutong granule on calcitonin gene-related peptide, beta-endorphin, serotonin, dopamine, and noradrenalin in migraine model rats and mice.
 

Author(s): Xiaofang Wu, Meikui Zhang, Huai Huang

Journal: J Tradit Chin Med. 2014 Apr;34(2):188-93.

 

To study the effect of Qilongtoutong granule (QLTT) on plasma calcitonin gene-related peptide (CGRP), beta-endorphin (beta-EP), 5-HT, dopamine (DA), noradrenalin (NE), and blood viscosity in migraine model rats and mice.

Last Updated: 2 May 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Migraine" returned 257 free, full-text review articles on human participants. First 3 results:

Chronic migraine.
 

Author(s): Todd J Schwedt

Journal:

 

Chronic migraine is a disabling neurologic condition that affects 2% of the general population. Patients with chronic migraine have headaches on at least 15 days a month, with at least eight days a month on which their headaches and associated symptoms meet diagnostic criteria for ...

Last Updated: 25 Mar 2014

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Hormonal contraception in women with migraine: is progestogen-only contraception a better choice?
 

Author(s): Rossella E Nappi, Gabriele S Merki-Feld, Erica Terreno, Alice Pellegrinelli, Michele Viana

Journal:

 

A significant number of women with migraine has to face the choice of reliable hormonal contraception during their fertile life. Combined hormonal contraceptives (CHCs) may be used in the majority of women with headache and migraine. However, they carry a small, but significant vascular ...

Last Updated: 24 Jan 2014

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Tonabersat for migraine prophylaxis: a systematic review.
 

Author(s): Yue Cao, Ou Jin Zheng

Journal: Pain Physician. ;17(1):1-8.

 

Randomized clinical trials assessing the efficacy and tolerability of tonabersat compared with placebo as prophylaxis for migraine were systematically reviewed in this study. By analyzing all available data, we aimed to establish an overall estimate of any association in order to ...

Last Updated: 23 Jan 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Efficacy and Safety of Intra-oral Topical Ketoprofen for the Treatment of Acute Migraine
 

Status: Not yet recruiting

Condition Summary: Migraine Disorders; Migraine Headache; Migraine; Acute Migraine

 

Last Updated: 4 Jun 2011

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Impact of a Nurse for Migraine Management: the IMPACT Project
 

Status: Recruiting

Condition Summary: Migraine Without Aura; Migraine With Aura; Chronic Migraine

 

Last Updated: 2 Mar 2013

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Intravenous Ketorolac and Metoclopramide for Pediatric Migraine in the Emergency Department
 

Status: Recruiting

Condition Summary: Probable Migraine; Migraine With Aura; Migraine Without Aura

 

Last Updated: 9 Sep 2013

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