Migraine

Common Name(s)

Migraine

A migraine is a severe headache that can cause intense throbbing or a pulsing sensation in your head. Environmental and genetic factors may play a role in causing migraines. Migraine headaches often begin in childhood, adolescence or early adulthood and may consist of four stages, prodrome, aura, headache, and postdrome.

Prodrome may occur one or two days before a migraine and are subtle changes in food craving, activity, irritability, neck stiffness, depression, constipation, and uncontrollable yawning. Aura may occur before or during migraine headaches. Symptoms of aura may include vision loss, bright spots, and speech problems (apshasia). During the migraine attack symptoms may include throbbing pain in sides of your head, sensitivity to light, sound, and sometimes smells, nausea, vomiting, blurred vision, and lightheadedness. Postdrome is the last phase that occurs after a migraine attack where you may feel drained and washed out.

Migraine headache triggers may include, food, caffeinated and alcoholic drinks, stress, sensory stimuli, changes in wake-sleep pattern, physical factors, changes in the environment, hormonal changes in women, and medications. Risk factors may include family history, age, sex, and hormonal changes. Your doctor may diagnose your condition based on your medical history, symptoms and a physical and neurological examination. To rule out other possible causes for your pain your doctor may perform blood tests, computerized tomography (CT) scan, magnetic resonance imaging (MRI) and or a spinal tap (lumbar puncture). If you or someone you know suffers from migraines talk to your doctor to learn how to manage your condition.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Migraine" for support, advocacy or research.

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National Headache Foundation

The National Headache Foundation exists to enhance the healthcare of individuals with headache. It is a source of help to their families, physicians and allied healthcare professionals who treat them, and to the public. The NHF accomplishes its mission by providing educational and informational resources, supporting headache research, and advocating for the understanding of headache as a legitimate neurobiological disease.

Last Updated: 16 Mar 2015

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APS Foundation of America, Inc.

The APS Foundation of America, Inc. is dedicated to fostering and facilitating joint efforts in the areas of education, public awareness, research and patient services in an effective and ethical manner.

Last Updated: 12 Aug 2013

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Migraine" for support, advocacy or research.

Logo
National Headache Foundation

The National Headache Foundation exists to enhance the healthcare of individuals with headache. It is a source of help to their families, physicians and allied healthcare professionals who treat them, and to the public. The NHF accomplishes its mission by providing educational and informational resources, supporting headache research, and advocating for the understanding of headache as a legitimate neurobiological disease.

http://www.headaches.org

Last Updated: 16 Mar 2015

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APS Foundation of America, Inc.

The APS Foundation of America, Inc. is dedicated to fostering and facilitating joint efforts in the areas of education, public awareness, research and patient services in an effective and ethical manner.

http://www.apsfa.org

Last Updated: 12 Aug 2013

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

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General Resources

Migraine Signs and Symptoms

A migraine is a throbbing or pulsating headache that is often one sided (unilateral) and associated with nausea; vomiting; sensitivity to light, sound, and smells; sleep disruption; and depression. Attacks are often recurrent and tend to become less

Updated 13 Nov 2012

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APS Foundation of America, Inc Fan Page

The APS Foundation of America, Inc. is the leading United States nonprofit health agency dedicated to bringing national awareness to Antiphospholipid Antibody Syndrome (APS).

Updated 13 Nov 2012

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Blogs

APS Friends & Support Forum

Are you looking for Support for Antiphospholipid Antibody Syndrome, APS, APLS, APLA, Hughes Syndrome, or Sticky Blood? Well you've come to the right place! This is an private forum for people who have Antiphospholipid Antibody Syndrome, friends, fam

Updated 13 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Migraine" returned 1771 free, full-text research articles on human participants. First 3 results:

The effect of foetal growth restriction on the development of migraine and tension-type headache in adulthood. The HUNT Study.
 

Author(s): Sigrid Børte, Bendik S Winsvold, Synne Øien Stensland, Milada Cvancarova Småstuen, John-Anker Zwart

Journal:

 

There is little knowledge about how factors early in life affect the development of migraine and tension-type headache. We aimed to examine whether growth restriction in utero is associated with development of migraine and frequent tension-type headache in adults.

Last Updated: 14 Apr 2017

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Treatment of Pediatric Migraine.
 

Author(s): Scott W Powers, Christopher S Coffey, Andrew D Hershey

Journal: N. Engl. J. Med.. 2017 04;376(14):1388-9.

 

Last Updated: 5 Apr 2017

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Unveiling the relative efficacy, safety and tolerability of prophylactic medications for migraine: pairwise and network-meta analysis.
 

Author(s): Aijie He, Dehua Song, Lei Zhang, Chen Li

Journal: J Headache Pain. 2017 Dec;18(1):26.

 

A large number patients struggle with migraine which is classified as a chronic disorder. The relative efficacy, safety and tolerability of prophylactic medications for migraine play a key role in managing this disease.

Last Updated: 21 Feb 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Migraine" returned 326 free, full-text review articles on human participants. First 3 results:

Genetic and biochemical changes of the serotonergic system in migraine pathobiology.
 

Author(s): Claudia Francesca Gasparini, Robert Anthony Smith, Lyn Robyn Griffiths

Journal: J Headache Pain. 2017 Dec;18(1):20.

 

Migraine is a brain disorder characterized by a piercing headache which affects one side of the head, located mainly at the temples and in the area around the eye. Migraine imparts substantial suffering to the family in addition to the sufferer, particularly as it affects three times ...

Last Updated: 14 Feb 2017

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The association between brain-derived neurotrophic factor gene polymorphism and migraine: a meta-analysis.
 

Author(s): Xiaoying Cai, Xiaolei Shi, Ximeng Zhang, Aiwu Zhang, Minying Zheng, Yannan Fang

Journal: J Headache Pain. 2017 Dec;18(1):13.

 

Migraine is a recurrent headache disease related to genetic variants. The brain-derived neurotrophic factor (BDNF) gene rs6265 (Val66Met) and rs2049046 polymorphism has been found to be associated with migraine. However, their roles in this disorder are not well established. Then ...

Last Updated: 2 Feb 2017

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Vestibular Migraine: Clinical Challenges and Opportunities for Multidisciplinarity.
 

Author(s): Isabel Luzeiro, Leonel Luís, Freire Gonçalves, Isabel Pavão Martins

Journal: Behav Neurol. 2016 ;2016():6179805.

 

Migraine and vertigo are two very prevalent conditions in general population. The coexistence of both in the same subject is a significant clinical challenge, since it is not always possible to understand whether they are causally related or associated by chance, requiring different ...

Last Updated: 13 Jan 2017

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pain Processing in Adults With Migraines
 

Status: Recruiting

Condition Summary: Migraines

 

Last Updated: 12 Sep 2016

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Nutrition for Migraine Prevention
 

Status: Recruiting

Condition Summary: Migraine Disorders

 

Last Updated: 10 May 2016

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Efficacy and Safety of IONIS-PKKRx for Preventive Treatment of Chronic Migraine
 

Status: Not yet recruiting

Condition Summary: Chronic Migraine

 

Last Updated: 10 Apr 2017

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