Migraine

Common Name(s)

Migraine

A migraine is a severe headache that can cause intense throbbing or a pulsing sensation in your head. Environmental and genetic factors may play a role in causing migraines. Migraine headaches often begin in childhood, adolescence or early adulthood and may consist of four stages, prodrome, aura, headache, and postdrome.

Prodrome may occur one or two days before a migraine and are subtle changes in food craving, activity, irritability, neck stiffness, depression, constipation, and uncontrollable yawning. Aura may occur before or during migraine headaches. Symptoms of aura may include vision loss, bright spots, and speech problems (apshasia). During the migraine attack symptoms may include throbbing pain in sides of your head, sensitivity to light, sound, and sometimes smells, nausea, vomiting, blurred vision, and lightheadedness. Postdrome is the last phase that occurs after a migraine attack where you may feel drained and washed out.

Migraine headache triggers may include, food, caffeinated and alcoholic drinks, stress, sensory stimuli, changes in wake-sleep pattern, physical factors, changes in the environment, hormonal changes in women, and medications. Risk factors may include family history, age, sex, and hormonal changes. Your doctor may diagnose your condition based on your medical history, symptoms and a physical and neurological examination. To rule out other possible causes for your pain your doctor may perform blood tests, computerized tomography (CT) scan, magnetic resonance imaging (MRI) and or a spinal tap (lumbar puncture). If you or someone you know suffers from migraines talk to your doctor to learn how to manage your condition.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Migraine" for support, advocacy or research.

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National Headache Foundation

The National Headache Foundation exists to enhance the healthcare of individuals with headache. It is a source of help to their families, physicians and allied healthcare professionals who treat them, and to the public. The NHF accomplishes its mission by providing educational and informational resources, supporting headache research, and advocating for the understanding of headache as a legitimate neurobiological disease.

Last Updated: 16 Mar 2015

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APS Foundation of America, Inc.

The APS Foundation of America, Inc. is dedicated to fostering and facilitating joint efforts in the areas of education, public awareness, research and patient services in an effective and ethical manner.

Last Updated: 12 Aug 2013

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Migraine" for support, advocacy or research.

Logo
National Headache Foundation

The National Headache Foundation exists to enhance the healthcare of individuals with headache. It is a source of help to their families, physicians and allied healthcare professionals who treat them, and to the public. The NHF accomplishes its mission by providing educational and informational resources, supporting headache research, and advocating for the understanding of headache as a legitimate neurobiological disease.

http://www.headaches.org

Last Updated: 16 Mar 2015

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APS Foundation of America, Inc.

The APS Foundation of America, Inc. is dedicated to fostering and facilitating joint efforts in the areas of education, public awareness, research and patient services in an effective and ethical manner.

http://www.apsfa.org

Last Updated: 12 Aug 2013

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

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General Resources

Migraine Signs and Symptoms

A migraine is a throbbing or pulsating headache that is often one sided (unilateral) and associated with nausea; vomiting; sensitivity to light, sound, and smells; sleep disruption; and depression. Attacks are often recurrent and tend to become less

Updated 13 Nov 2012

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APS Foundation of America, Inc Fan Page

The APS Foundation of America, Inc. is the leading United States nonprofit health agency dedicated to bringing national awareness to Antiphospholipid Antibody Syndrome (APS).

Updated 13 Nov 2012

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Blogs

APS Friends & Support Forum

Are you looking for Support for Antiphospholipid Antibody Syndrome, APS, APLS, APLA, Hughes Syndrome, or Sticky Blood? Well you've come to the right place! This is an private forum for people who have Antiphospholipid Antibody Syndrome, friends, fam

Updated 13 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Migraine" returned 1455 free, full-text research articles on human participants. First 3 results:

MAOA and TNF-β gene polymorphisms are associated with photophobia but not osmophobia in patients with migraine.
 

Author(s): Masakazu Ishii, Shino Usami, Hajime Hara, Atsuko Imagawa, Yutaka Masuda, Shuniichi Shimizu

Journal: Acta Neurol Taiwan. 2014 Jun;23(2):40-8.

 

Photophobia and osmophobia are typical symptoms associated with migraine, but the contributions of gene polymorphisms to these symptoms are not fully elucidated. We investigated whether the gene polymorphisms are involved in photophobia and osmophobia in patients with migraine.

Last Updated: 3 Jun 2015

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Congenital hypoplasia of bilateral internal carotid artery with migraine-like headache with aura.
 

Author(s): Zhi-Yong Zhang, Shoichiro Sato, Lei Liu, Shuang Xue, Zun-Jing Liu, Zhao-Hui Tian, Wei Liu, Kazunori Toyoda, Jin-Song Jiao

Journal: Chin. Med. J.. 2015 Feb;128(3):421-2.

 

Last Updated: 31 Jan 2015

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Therapeutic effect of intranasal evaporative cooling in patients with migraine: a pilot study.
 

Author(s): Jitka Vanderpol, Barbara Bishop, Manjit Matharu, Mark Glencorse

Journal:

 

Cryotherapy is the most common non-pharmacological pain-relieving method. The aim of this pilot study was to ascertain whether intranasal evaporative cooling may be an effective intervention in an acute migraine attack. Studies have previously demonstrated effectiveness of a variety ...

Last Updated: 3 Feb 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Migraine" returned 272 free, full-text review articles on human participants. First 3 results:

Development of onabotulinumtoxinA for chronic migraine.
 

Author(s): Scott M Whitcup, Catherine C Turkel, Ronald E DeGryse, Mitchell F Brin

Journal: Ann. N. Y. Acad. Sci.. 2014 Nov;1329():67-80.

 

Discovery of the neuromuscular effects of botulinum toxin began in the early 19th century and has continued to evolve. Currently, onabotulinumtoxinA is approved by the U.S. Food and Drug Administration for two cosmetic and eight medical indications, including chronic migraine (CM). ...

Last Updated: 17 Nov 2014

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Association between Helicobacter pylori infection and migraine: a meta-analysis.
 

Author(s): Jing Su, Xiao-Ying Zhou, Guo-Xin Zhang

Journal: World J. Gastroenterol.. 2014 Oct;20(40):14965-72.

 

To quantify the association between Helicobacter pylori (H. pylori) infection and migraine.

Last Updated: 30 Oct 2014

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Targeting TRP channels for novel migraine therapeutics.
 

Author(s): Gregory Dussor, J Yan, Jennifer Y Xie, Michael H Ossipov, David W Dodick, Frank Porreca

Journal: ACS Chem Neurosci. 2014 Nov;5(11):1085-96.

 

Migraine is increasingly understood to be a disorder of the brain. In susceptible individuals, a variety of "triggers" may influence altered central excitability, resulting in the activation and sensitization of trigeminal nociceptive afferents surrounding blood vessels (i.e., the ...

Last Updated: 21 Nov 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Efficacy and Safety of Intra-oral Topical Ketoprofen for the Treatment of Acute Migraine
 

Status: Not yet recruiting

Condition Summary: Migraine Disorders; Migraine Headache; Migraine; Acute Migraine

 

Last Updated: 4 Jun 2011

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The Impact of Triptan and Doxycycline on Neuroinflammatory Biomarkers in Acute Migraine
 

Status: Recruiting

Condition Summary: Migraine Disorders; Headache, Migraine; Migraine; Migraine Headache; Migraine With Aura; Migraine Without Aura; Headache Disorders, Primary

 

Last Updated: 20 Apr 2014

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Migraine and Body Composition
 

Status: Recruiting

Condition Summary: Migraine With and Without Aura; Chronic Migraine; Healthy Controls

 

Last Updated: 22 Jun 2015

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