Migraine

Common Name(s)

Migraine

A migraine is a severe headache that can cause intense throbbing or a pulsing sensation in your head. Environmental and genetic factors may play a role in causing migraines. Migraine headaches often begin in childhood, adolescence or early adulthood and may consist of four stages, prodrome, aura, headache, and postdrome.

Prodrome may occur one or two days before a migraine and are subtle changes in food craving, activity, irritability, neck stiffness, depression, constipation, and uncontrollable yawning. Aura may occur before or during migraine headaches. Symptoms of aura may include vision loss, bright spots, and speech problems (apshasia). During the migraine attack symptoms may include throbbing pain in sides of your head, sensitivity to light, sound, and sometimes smells, nausea, vomiting, blurred vision, and lightheadedness. Postdrome is the last phase that occurs after a migraine attack where you may feel drained and washed out.

Migraine headache triggers may include, food, caffeinated and alcoholic drinks, stress, sensory stimuli, changes in wake-sleep pattern, physical factors, changes in the environment, hormonal changes in women, and medications. Risk factors may include family history, age, sex, and hormonal changes. Your doctor may diagnose your condition based on your medical history, symptoms and a physical and neurological examination. To rule out other possible causes for your pain your doctor may perform blood tests, computerized tomography (CT) scan, magnetic resonance imaging (MRI) and or a spinal tap (lumbar puncture). If you or someone you know suffers from migraines talk to your doctor to learn how to manage your condition.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Migraine" for support, advocacy or research.

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National Headache Foundation

The National Headache Foundation exists to enhance the healthcare of individuals with headache. It is a source of help to their families, physicians and allied healthcare professionals who treat them, and to the public. The NHF accomplishes its mission by providing educational and informational resources, supporting headache research, and advocating for the understanding of headache as a legitimate neurobiological disease.

Last Updated: 16 Mar 2015

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APS Foundation of America, Inc.

The APS Foundation of America, Inc. is dedicated to fostering and facilitating joint efforts in the areas of education, public awareness, research and patient services in an effective and ethical manner.

Last Updated: 12 Aug 2013

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 16 Mar 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Migraine" for support, advocacy or research.

Logo
National Headache Foundation

The National Headache Foundation exists to enhance the healthcare of individuals with headache. It is a source of help to their families, physicians and allied healthcare professionals who treat them, and to the public. The NHF accomplishes its mission by providing educational and informational resources, supporting headache research, and advocating for the understanding of headache as a legitimate neurobiological disease.

http://www.headaches.org

Last Updated: 16 Mar 2015

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APS Foundation of America, Inc.

The APS Foundation of America, Inc. is dedicated to fostering and facilitating joint efforts in the areas of education, public awareness, research and patient services in an effective and ethical manner.

http://www.apsfa.org

Last Updated: 12 Aug 2013

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 16 Mar 2015

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General Resources

Migraine Signs and Symptoms

A migraine is a throbbing or pulsating headache that is often one sided (unilateral) and associated with nausea; vomiting; sensitivity to light, sound, and smells; sleep disruption; and depression. Attacks are often recurrent and tend to become less

Updated 13 Nov 2012

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APS Foundation of America, Inc Fan Page

The APS Foundation of America, Inc. is the leading United States nonprofit health agency dedicated to bringing national awareness to Antiphospholipid Antibody Syndrome (APS).

Updated 13 Nov 2012

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Blogs

APS Friends & Support Forum

Are you looking for Support for Antiphospholipid Antibody Syndrome, APS, APLS, APLA, Hughes Syndrome, or Sticky Blood? Well you've come to the right place! This is an private forum for people who have Antiphospholipid Antibody Syndrome, friends, fam

Updated 13 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Migraine" returned 1384 free, full-text research articles on human participants. First 3 results:

Amitriptyline and aerobic exercise or amitriptyline alone in the treatment of chronic migraine: a randomized comparative study.
 

Author(s): Michelle Dias Santos Santiago, Deusvenir de Souza Carvalho, Alberto Alain Gabbai, Mariana Machado Pereira Pinto, Andrea Regina Correa Moutran, Thais Rodrigues Villa

Journal: Arq Neuropsiquiatr. 2014 Nov;72(11):851-5.

 

To compare the preventive treatment benefits of amitriptyline and aerobic exercise or amitriptyline alone in patients with chronic migraine.

Last Updated: 21 Nov 2014

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A comparative study of psychiatric comorbidity, quality of life and disability in patients with migraine and tension type headache.
 

Author(s): Sagar Chandra Bera, Sudhir K Khandelwal, Mamta Sood, Vinay Goyal

Journal: Neurol India. ;62(5):516-20.

 

To compare psychiatric co-morbidity, quality of life and disability between patients of migraine and tension type headache and healthy controls.

Last Updated: 12 Nov 2014

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Preventive effect of greater occipital nerve block on severity and frequency of migraine headache.
 

Author(s): Davood Kashipazha, Ali Nakhostin-Mortazavi, Seyyed Ehsan Mohammadianinejad, Mohammad Bahadoram, Sepideh Zandifar, Shahram Tarahomi

Journal:

 

Despite a favorable clinical experience, little evidence exists for the efficacy of greater occipital nerve block (GONB) in migraine treatment. Considering such a premise, we wished to evaluate the therapeutic efficacy of GONB in patients affected by migraine headaches.

Last Updated: 3 Nov 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Migraine" returned 254 free, full-text review articles on human participants. First 3 results:

Development of onabotulinumtoxinA for chronic migraine.
 

Author(s): Scott M Whitcup, Catherine C Turkel, Ronald E DeGryse, Mitchell F Brin

Journal: Ann. N. Y. Acad. Sci.. 2014 Nov;1329():67-80.

 

Discovery of the neuromuscular effects of botulinum toxin began in the early 19th century and has continued to evolve. Currently, onabotulinumtoxinA is approved by the U.S. Food and Drug Administration for two cosmetic and eight medical indications, including chronic migraine (CM). ...

Last Updated: 17 Nov 2014

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Obesity and headache/migraine: the importance of weight reduction through lifestyle modifications.
 

Author(s): Alberto Verrotti, Alessia Di Fonzo, Laura Penta, Sergio Agostinelli, Pasquale Parisi

Journal: Biomed Res Int. 2014 ;2014():420858.

 

The aim of this study is to determine a possible relationship between prevalence, frequency, and severity of migraine and obesity. All pertinent data from the literature have been critically examined and reviewed in order to assess the possible relationship between obesity and migraine, ...

Last Updated: 6 May 2014

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Migraine and estrogen.
 

Author(s): Nu Cindy Chai, B Lee Peterlin, Anne H Calhoun

Journal: Curr. Opin. Neurol.. 2014 Jun;27(3):315-24.

 

The aim is to systematically and critically review the relationship between migraine and estrogen, the predominant female sex hormone, with a focus on studies published in the last 18 months.

Last Updated: 5 May 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Efficacy and Safety of Intra-oral Topical Ketoprofen for the Treatment of Acute Migraine
 

Status: Not yet recruiting

Condition Summary: Migraine Disorders; Migraine Headache; Migraine; Acute Migraine

 

Last Updated: 4 Jun 2011

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Impact of a Nurse for Migraine Management: the IMPACT Project
 

Status: Recruiting

Condition Summary: Migraine Without Aura; Migraine With Aura; Chronic Migraine

 

Last Updated: 2 Mar 2013

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The Impact of Triptan and Doxycycline on Neuroinflammatory Biomarkers in Acute Migraine
 

Status: Recruiting

Condition Summary: Migraine Disorders; Headache, Migraine; Migraine; Migraine Headache; Migraine With Aura; Migraine Without Aura; Headache Disorders, Primary

 

Last Updated: 20 Apr 2014

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