Migraine

Common Name(s)

Migraine

Migraine is the most common type of chronic, episodic headache, as summarized by {7:Featherstone (1985)}. One locus for migraine with or without aura (MGR1) has been identified on chromosome 4q24. Other loci for migraine have been identified on 6p21.1-p12.2 (MGR3; {607498}), 14q21.2-q22.3 (MGR4; {607501}), 19p13 (MGR5; {607508}), 1q31 (MGR6; {607516}), 15q11-q13 (MGR7; {609179}), 5q21 (with or without aura, MGR8, {609570}; with aura, MGR9, {609670}), 17p13 (MGR10; {610208}), 18q12 (MGR11; {610209}), 10q22-q23 (MGR12; {611706}), and the X chromosome (MGR2; {300125}). Mutation in the KCNK18 gene ({613655}) on chromosome 10q25 causes migraine with aura (MGR13; {613656}). A subtype of autosomal dominant migraine with aura (MA), familial hemiplegic migraine (FHM; see {141500}), is caused by mutation in the CACNA1A gene ({601011}) on chromosome 19p13 (FHM1; {141500}), by mutation in the ATP1A2 gene ({182340}) on chromosome 1q21 (FHM2; {602481}), or by mutation in the SCN1A gene ({182389}) on chromosome 2q24 (FHM3; {609634}). Another locus for FHM has been mapped to chromosome 1q31 (FHM4; see {607516}). There is evidence that a polymorphism in the estrogen receptor gene (ESR1; {133430.0005}) and a polymorphism in the TNF gene ({191160.0004}) may confer susceptibility to migraine. A polymorphism in the endothelin receptor type A gene (EDNRA; {131243.0001}) may confer resistance to migraine.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Migraine" for support, advocacy or research.

APS Foundation of America, Inc.

The APS Foundation of America, Inc. is dedicated to fostering and facilitating joint efforts in the areas of education, public awareness, research and patient services in an effective and ethical manner.

Last Updated: 12 Aug 2013

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 3 Oct 2013

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National Headache Foundation

The National Headache Foundation exists to enhance the healthcare of individuals with headache. It is a source of help to their families, physicians and allied healthcare professionals who treat them, and to the public. The NHF accomplishes its mission by providing educational and informational resources, supporting headache research, and advocating for the understanding of headache as a legitimate neurobiological disease.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Migraine" for support, advocacy or research.

APS Foundation of America, Inc.

The APS Foundation of America, Inc. is dedicated to fostering and facilitating joint efforts in the areas of education, public awareness, research and patient services in an effective and ethical manner.

http://www.apsfa.org

Last Updated: 12 Aug 2013

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 3 Oct 2013

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National Headache Foundation

The National Headache Foundation exists to enhance the healthcare of individuals with headache. It is a source of help to their families, physicians and allied healthcare professionals who treat them, and to the public. The NHF accomplishes its mission by providing educational and informational resources, supporting headache research, and advocating for the understanding of headache as a legitimate neurobiological disease.

http://www.headaches.org

Last Updated: 20 Feb 2013

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General Resources

Migraine Signs and Symptoms

A migraine is a throbbing or pulsating headache that is often one sided (unilateral) and associated with nausea; vomiting; sensitivity to light, sound, and smells; sleep disruption; and depression. Attacks are often recurrent and tend to become less

Updated 13 Nov 2012

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APS Foundation of America, Inc Fan Page

The APS Foundation of America, Inc. is the leading United States nonprofit health agency dedicated to bringing national awareness to Antiphospholipid Antibody Syndrome (APS).

Updated 13 Nov 2012

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Blogs

APS Friends & Support Forum

Are you looking for Support for Antiphospholipid Antibody Syndrome, APS, APLS, APLA, Hughes Syndrome, or Sticky Blood? Well you've come to the right place! This is an private forum for people who have Antiphospholipid Antibody Syndrome, friends, fam

Updated 13 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Migraine" returned 1382 free, full-text research articles on human participants. First 3 results:

A comparative study of psychiatric comorbidity, quality of life and disability in patients with migraine and tension type headache.
 

Author(s): Sagar Chandra Bera, Sudhir K Khandelwal, Mamta Sood, Vinay Goyal

Journal: Neurol India. ;62(5):516-20.

 

To compare psychiatric co-morbidity, quality of life and disability between patients of migraine and tension type headache and healthy controls.

Last Updated: 12 Nov 2014

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Preventive effect of greater occipital nerve block on severity and frequency of migraine headache.
 

Author(s): Davood Kashipazha, Ali Nakhostin-Mortazavi, Seyyed Ehsan Mohammadianinejad, Mohammad Bahadoram, Sepideh Zandifar, Shahram Tarahomi

Journal:

 

Despite a favorable clinical experience, little evidence exists for the efficacy of greater occipital nerve block (GONB) in migraine treatment. Considering such a premise, we wished to evaluate the therapeutic efficacy of GONB in patients affected by migraine headaches.

Last Updated: 3 Nov 2014

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Dependency-like behaviors and pain coping styles in subjects with chronic migraine and medication overuse: results from a 1-year follow-up study.
 

Author(s): Bruno Biagianti, Licia Grazzi, Susanna Usai, Orsola Gambini

Journal:

 

Even after successful detoxification, 20-40% of subjects presenting chronic migraine with symptomatic medication overuse (CMwMO) relapse into medication overuse within one year. In this restrospective analysis on subjects referred to our center for detoxification, we investigated ...

Last Updated: 24 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Migraine" returned 259 free, full-text review articles on human participants. First 3 results:

Development of onabotulinumtoxinA for chronic migraine.
 

Author(s): Scott M Whitcup, Catherine C Turkel, Ronald E DeGryse, Mitchell F Brin

Journal: Ann. N. Y. Acad. Sci.. 2014 Nov;1329():67-80.

 

Discovery of the neuromuscular effects of botulinum toxin began in the early 19th century and has continued to evolve. Currently, onabotulinumtoxinA is approved by the U.S. Food and Drug Administration for two cosmetic and eight medical indications, including chronic migraine (CM). ...

Last Updated: 17 Nov 2014

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Obesity and headache/migraine: the importance of weight reduction through lifestyle modifications.
 

Author(s): Alberto Verrotti, Alessia Di Fonzo, Laura Penta, Sergio Agostinelli, Pasquale Parisi

Journal: Biomed Res Int. 2014 ;2014():420858.

 

The aim of this study is to determine a possible relationship between prevalence, frequency, and severity of migraine and obesity. All pertinent data from the literature have been critically examined and reviewed in order to assess the possible relationship between obesity and migraine, ...

Last Updated: 6 May 2014

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Migraine and estrogen.
 

Author(s): Nu Cindy Chai, B Lee Peterlin, Anne H Calhoun

Journal: Curr. Opin. Neurol.. 2014 Jun;27(3):315-24.

 

The aim is to systematically and critically review the relationship between migraine and estrogen, the predominant female sex hormone, with a focus on studies published in the last 18 months.

Last Updated: 5 May 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Efficacy and Safety of Intra-oral Topical Ketoprofen for the Treatment of Acute Migraine
 

Status: Not yet recruiting

Condition Summary: Migraine Disorders; Migraine Headache; Migraine; Acute Migraine

 

Last Updated: 4 Jun 2011

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Impact of a Nurse for Migraine Management: the IMPACT Project
 

Status: Recruiting

Condition Summary: Migraine Without Aura; Migraine With Aura; Chronic Migraine

 

Last Updated: 2 Mar 2013

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The Impact of Triptan and Doxycycline on Neuroinflammatory Biomarkers in Acute Migraine
 

Status: Recruiting

Condition Summary: Migraine Disorders; Headache, Migraine; Migraine; Migraine Headache; Migraine With Aura; Migraine Without Aura; Headache Disorders, Primary

 

Last Updated: 20 Apr 2014

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