Microvillus inclusion disease

Common Name(s)

Microvillus inclusion disease, Congenital microvillous atrophy

Microvillus inclusion disease is an intestinal disorder characterized by severe, watery diarrhea and an inability of the intestines to absorb nutrients. Symptoms typically develop in the first days (early-onset) or first months (late-onset) of life. Without adequate water and nutrients, children with this condition can become dehydrated, suffer from malnutrition, and fail to grow and develop normally. Management is difficult and relies on total parenteral nutrition. The advent of intestinal transplantation has improved the outlook for these patients. Microvillus inclusion disease is inherited in an autosomal recessive manner.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Microvillus inclusion disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Microvillus inclusion disease" returned 16 free, full-text research articles on human participants. First 3 results:

Abnormal Rab11-Rab8-vesicles cluster in enterocytes of patients with microvillus inclusion disease.
 

Author(s): Georg F Vogel, Andreas R Janecke, Iris M Krainer, Karin Gutleben, Barbara Witting, Sally G Mitton, Sahar Mansour, Antje Ballauff, Joseph T Roland, Amy C Engevik, Ernest Cutz, Thomas Müller, James R Goldenring, Lukas A Huber, Michael W Hess

Journal: Traffic. 2017 07;18(7):453-464.

 

Microvillus inclusion disease (MVID) is a congenital enteropathy characterized by accumulation of vesiculo-tubular endomembranes in the subapical cytoplasm of enterocytes, historically termed "secretory granules." However, neither their identity nor pathophysiological significance ...

Last Updated: 31 Dec 1969

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The zebrafish goosepimples/myosin Vb mutant exhibits cellular attributes of human microvillus inclusion disease.
 

Author(s): Jaydeep Sidhaye, Clyde Savio Pinto, Shweta Dharap, Tressa Jacob, Shobha Bhargava, Mahendra Sonawane

Journal: Mech. Dev.. 2016 11;142():62-74.

 

Microvillus inclusion disease (MVID) is a life-threatening enteropathy characterised by malabsorption and incapacitating fluid loss due to chronic diarrhoea. Histological analysis has revealed that enterocytes in MVID patients exhibit reduction of microvilli, presence of microvillus ...

Last Updated: 31 Dec 1969

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Identification of intestinal ion transport defects in microvillus inclusion disease.
 

Author(s): Dmitri V Kravtsov, Md Kaimul Ahsan, Vandana Kumari, Sven C D van Ijzendoorn, Miguel Reyes-Mugica, Anoop Kumar, Tarunmeet Gujral, Pradeep K Dudeja, Nadia A Ameen

Journal: Am. J. Physiol. Gastrointest. Liver Physiol.. 2016 Jul;311(1):G142-55.

 

Loss of function mutations in the actin motor myosin Vb (Myo5b) lead to microvillus inclusion disease (MVID) and death in newborns and children. MVID results in secretory diarrhea, brush border (BB) defects, villus atrophy, and microvillus inclusions (MVIs) in enterocytes. How loss ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Microvillus inclusion disease" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.