Microscopic polyangiitis

Common Name(s)

Microscopic polyangiitis

Microscopic polyangiitis (MPA) is a rare disorder that causes redness and swelling (inflammation) of the small tubes that carry blood to areas of the body - specifically, small arteries (arterioles), capillaries, and small veins (venules). Inflammation of these small tubes can make them narrow, causing poor blood flow to a specific area or organ in the body. Typically, MPA affects the skin, nerves, gastrointestinal tract (esophagus, stomach and intestines), lungs and joints. The symptoms of MPA depend on which of these organ systems are affected. Symptoms may include feeling tired (fatigue), fever, weight loss, rash, joint pain, loss of appetite, cough, shortness of breath, abdominal pain, and numbness.

MPA is rare and can affect a person at any age, but usually affects people in their 40s and 50s. Your doctor can diagnose MPA based on your symptoms, a physical exam, blood tests and images (x-rays, MRI or CT) of the affected area. In some cases, removal and examination of the affected area (biopsy) may be needed to confirm the diagnosis. Some people with MPA will have a positive blood test, known as antineutrophil cytoplasmic antibody (ANCA). However, not everyone with MPA will have a positive ANCA.

Treatment of MPA depends on which tissue or organs are affected and may include medications that control your immune system (immunosuppressive medications) or that treat the inflammation (steroids). The goal of treatment is to stop the inflammation (remission) and to keep it from coming back (maintain remission). However, even after MPA is treated and a person is in remission, symptoms can still return (relapse or flare). If you have been diagnosed with MPA, talk to your doctor to discuss the most current treatment options. Support groups are a good source of additional information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Microscopic polyangiitis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Microscopic polyangiitis" returned 84 free, full-text research articles on human participants. First 3 results:

Microscopic polyangiitis associated with primary biliary cirrhosis, Sjogren's syndrome and Hashimoto's thyroiditis.
 

Author(s): I Ben Ghorbel, N Bel Feki, T Ben Salem, A Hamzaoui, M Khanfir, M Lamloum, M Miled, M H Houman

Journal: Saudi J Kidney Dis Transpl. 2015 Mar;26(2):359-62.

 

The association between microscopic polyangiitis (MPA) and primary biliary cirrhosis (PBC) has seldom been reported. We describe here a patient who presented with sensorimotor neuropathy along with hypothyroidism, renal failure and liver dysfunction. Detection of antinuclear antibodies ...

Last Updated: 12 Mar 2015

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Pleuritis clinically diagnosed as aspergillosis during the course of microscopic polyangiitis.
 

Author(s): Yasutaka Kimoto, Kensuke Oryoji, Ayumi Uchino, Shigeru Yoshizawa, Hiroaki Niiro, Hiroshi Tsukamoto, Takahiko Horiuchi

Journal: Intern. Med.. 2014 ;53(24):2821-4.

 

Pleural aspergillosis is a rare fungal infection. We herein report a case of pleuritis clinically diagnosed as aspergillosis without apparent Aspergillus lung lesions. A 75-year-old man receiving immunosuppressive therapy due to microscopic polyangiitis was admitted for treatment ...

Last Updated: 16 Dec 2014

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Cardiac small vessel vasculitis in a case of microscopic polyangiitis.
 

Author(s): Michiko Yoshida, Izaya Nakaya, Tsutomu Sakuma, Jun Soma

Journal: Intern. Med.. 2014 ;53(22):2655-6.

 

Last Updated: 17 Nov 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Microscopic polyangiitis" returned 8 free, full-text review articles on human participants. First 3 results:

Cyclophosphamide as induction therapy for Wegener's granulomatosis and microscopic polyangiitis.
 

Author(s): C A Langford

Journal: Clin. Exp. Immunol.. 2011 May;164 Suppl 1():31-4.

 

The introduction of cyclophosphamide (CyP) as a treatment for Wegener's granulomatosis (WG) and microscopic polyangiitis (MPA) has been among the most significant contributions in vasculitis. Prior to the introduction of CyP, WG was a uniformly fatal disease, with mortality occurring ...

Last Updated: 30 Mar 2011

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Overall survival, renal survival and relapse in patients with microscopic polyangiitis: a systematic review of current evidence.
 

Author(s): Luis Corral-Gudino, María Borao-Cengotita-Bengoa, Javier Del Pino-Montes, José L Lerma-Márquez

Journal: Rheumatology (Oxford). 2011 Aug;50(8):1414-23.

 

There are limited data on the long-term prognosis of microscopic polyangiitis (MPA). A systematic review was performed to estimate the survival, renal survival and relapse rates in patients with MPA.

Last Updated: 12 Jul 2011

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Microscopic polyangiitis.
 

Author(s): Sharon A Chung, Philip Seo

Journal: Rheum. Dis. Clin. North Am.. 2010 Aug;36(3):545-58.

 

In 1923, Friedrich Wohlwill described two patients with a "microscopic form of periarteritis nodosa," which was distinct from the classical form. This disease, now known as microscopic polyangiitis (MPA), is a primary systemic vasculitis characterized by inflammation of the small-caliber ...

Last Updated: 6 Aug 2010

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Longitudinal Protocol for Granulomatosis With Polyangiitis (Wegener's) and Microscopic Polyangiitis
 

Status: Recruiting

Condition Summary: Granulomatosis With Polyangiitis; Microscopic Polyangiitis; Wegener's

 

Last Updated: 13 Feb 2015

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Last Updated: 17 Aug 2015

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Observation Study of Clinical Manifestation and Outcome in Chinese Patients With Pulmonary Vasculitis
 

Status: Not yet recruiting

Condition Summary: ANCA-associated Vasculitis; Granulomatosis With Polyangiitis; Microscopic Polyangiitis; EosinphilicGranulomatosis With Polyangiitis

 

Last Updated: 27 Apr 2014

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