Microscopic polyangiitis

Common Name(s)

Microscopic polyangiitis

Microscopic polyangiitis (MPA) is a rare disorder that causes redness and swelling (inflammation) of the small tubes that carry blood to areas of the body - specifically, small arteries (arterioles), capillaries, and small veins (venules). Inflammation of these small tubes can make them narrow, causing poor blood flow to a specific area or organ in the body. Typically, MPA affects the skin, nerves, gastrointestinal tract (esophagus, stomach and intestines), lungs and joints. The symptoms of MPA depend on which of these organ systems are affected. Symptoms may include feeling tired (fatigue), fever, weight loss, rash, joint pain, loss of appetite, cough, shortness of breath, abdominal pain, and numbness.

MPA is rare and can affect a person at any age, but usually affects people in their 40s and 50s. Your doctor can diagnose MPA based on your symptoms, a physical exam, blood tests and images (x-rays, MRI or CT) of the affected area. In some cases, removal and examination of the affected area (biopsy) may be needed to confirm the diagnosis. Some people with MPA will have a positive blood test, known as antineutrophil cytoplasmic antibody (ANCA). However, not everyone with MPA will have a positive ANCA.

Treatment of MPA depends on which tissue or organs are affected and may include medications that control your immune system (immunosuppressive medications) or that treat the inflammation (steroids). The goal of treatment is to stop the inflammation (remission) and to keep it from coming back (maintain remission). However, even after MPA is treated and a person is in remission, symptoms can still return (relapse or flare). If you have been diagnosed with MPA, talk to your doctor to discuss the most current treatment options. Support groups are a good source of additional information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Microscopic polyangiitis" for support, advocacy or research.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Microscopic polyangiitis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Microscopic polyangiitis" returned 110 free, full-text research articles on human participants. First 3 results:

[Skin ulcers revealing microscopic polyangiitis].
 

Author(s): Naziha Khammassi, Amel Chakroun

Journal:

 

Last Updated: 5 Feb 2016

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Different responses to treatment across classified diseases and severities in Japanese patients with microscopic polyangiitis and granulomatosis with polyangiitis: a nationwide prospective inception cohort study.
 

Author(s): Ken-ei Sada, Masahiro Yamamura, Masayoshi Harigai, Takao Fujii, Yoshinari Takasaki, Koichi Amano, Shouichi Fujimoto, Eri Muso, Yohko Murakawa, Yoshihiro Arimura, Hirofumi Makino,

Journal:

 

This study aims to elucidate the prognosis and the effectiveness of current treatments for Japanese patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA).

Last Updated: 3 Nov 2015

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Clinical presentation and long-term outcome of 144 patients with microscopic polyangiitis in a monocentric German cohort.
 

Author(s): Jan H Schirmer, Marvin N Wright, Reinhard Vonthein, Kristine Herrmann, Bernhard Nölle, Marcus Both, Frank O Henes, Andreas Arlt, Wolfgang L Gross, Susanne Schinke, Eva Reinhold-Keller, Frank Moosig, Julia U Holle

Journal: Rheumatology (Oxford). 2016 Jan;55(1):71-9.

 

To evaluate the clinical presentation and long-term outcome of a vasculitis centre cohort of patients with microscopic polyangiitis (MPA) with respect to organ manifestations, treatment, chronic damage and mortality.

Last Updated: 15 Dec 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Microscopic polyangiitis" returned 10 free, full-text review articles on human participants. First 3 results:

Current therapy of granulomatosis with polyangiitis and microscopic polyangiitis: the role of rituximab.
 

Author(s): Duvuru Geetha, Cees Kallenberg, John H Stone, Alan D Salama, Gerald B Appel, George Duna, Paul Brunetta, David Jayne

Journal: J. Nephrol.. 2015 Feb;28(1):17-27.

 

Granulomatosis with polyangiitis and microscopic polyangiitis are anti-neutrophil cytoplasmic antibody-associated vasculitides (AAVs) that are prone to cycles of remission and relapse. The introduction of cytotoxic therapy has changed the prognosis for these diseases from typically ...

Last Updated: 16 Apr 2015

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Cyclophosphamide as induction therapy for Wegener's granulomatosis and microscopic polyangiitis.
 

Author(s): C A Langford

Journal: Clin. Exp. Immunol.. 2011 May;164 Suppl 1():31-4.

 

The introduction of cyclophosphamide (CyP) as a treatment for Wegener's granulomatosis (WG) and microscopic polyangiitis (MPA) has been among the most significant contributions in vasculitis. Prior to the introduction of CyP, WG was a uniformly fatal disease, with mortality occurring ...

Last Updated: 30 Mar 2011

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Overall survival, renal survival and relapse in patients with microscopic polyangiitis: a systematic review of current evidence.
 

Author(s): Luis Corral-Gudino, María Borao-Cengotita-Bengoa, Javier Del Pino-Montes, José L Lerma-Márquez

Journal: Rheumatology (Oxford). 2011 Aug;50(8):1414-23.

 

There are limited data on the long-term prognosis of microscopic polyangiitis (MPA). A systematic review was performed to estimate the survival, renal survival and relapse rates in patients with MPA.

Last Updated: 12 Jul 2011

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Longitudinal Protocol for Granulomatosis With Polyangiitis (Wegener's) and Microscopic Polyangiitis
 

Status: Recruiting

Condition Summary: Granulomatosis With Polyangiitis; Microscopic Polyangiitis; Wegener's

 

Last Updated: 10 May 2016

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Observation Study of Clinical Manifestation and Outcome in Chinese Patients With Pulmonary Vasculitis
 

Status: Not yet recruiting

Condition Summary: ANCA-associated Vasculitis; Granulomatosis With Polyangiitis; Microscopic Polyangiitis; EosinphilicGranulomatosis With Polyangiitis

 

Last Updated: 27 Apr 2014

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Pediatric Vasculitis Initiative
 

Status: Recruiting

Condition Summary: Wegeners Granulomatosis (Granulomatosis With Polyangiitis); Microscopic Polyangiitis; Churg Strauss Syndrome (Eosinophilic Granulomatosis With Polyangiitis); Polyarteritis Nodosa; Takayasu Arteritis; Primary CNS Vasculitis; Unclassified Vasculitis

 

Last Updated: 19 Aug 2016

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