Microcephaly

Common Name(s)

Microcephaly

Microcephaly is a neurological condition in which a person's head is significantly smaller than normal for their age and sex, based on standardized charts. This condition, which most often occurs because the brain fails to grow at a normal rate, can be present at birth or it may develop in the first few years of life.  Conditions that affect brain growth and can cause microcephaly include infections, genetic disorders, severe malnutrition and other environmental factors. Some children with microcephaly will be of normal intelligence and development. However, many children with microcephaly experience complications such as developmental delays, difficulties with balance and coordination, short stature, hyperactivity, mental retardation, seizures or other neurological abnormalities.  While there's no treatment for microcephaly, early intervention may help enhance development and improve quality of life.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Microcephaly" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Microcephaly" returned 344 free, full-text research articles on human participants. First 3 results:

Zika Virus infection and microcephaly: anxiety burden for women.
 

Author(s): Ikenna Desmond Ebuenyi, Soumitra Sudip Bhuyan, Luchuo Engelbert Bain

Journal:

 

The re-emergence of Zika virus in Brazil and other contiguous countries is a source of anxiety for pregnant women on account of its association with microcephaly. Adverse pregnancy outcome has huge mental health implications. It is essential for health providers to incorporate psychosocial ...

Last Updated: 31 Dec 1969

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Zika virus infection and microcephaly: Evidence regarding geospatial associations.
 

Author(s): João Ricardo Nickenig Vissoci, Thiago Augusto Hernandes Rocha, Núbia Cristina da Silva, Rejane Christine de Sousa Queiroz, Erika Bárbara Abreu Fonseca Thomaz, Pedro Vasconcelos Maia Amaral, Adriana Lein, Maria Dos Remédios Freitas Carvalho Branco, José Aquino, Zulimar Márita Ribeiro Rodrigues, Antônio Augusto Moura da Silva, Catherine Staton

Journal:

 

Although the Zika virus (ZIKV) epidemic ceased to be a public health emergency by the end of 2016, studies to improve knowledge about this emerging disease are still needed, especially those investigating a causal relationship between ZIKV in pregnant women and microcephaly in neonates. ...

Last Updated: 31 Dec 1969

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Microcephaly caused by congenital Zika virus infection and viral detection in maternal urine during pregnancy.
 

Author(s): Vanessa Couras Regadas, Márcio de Castro E Silva, Lucas Giansante Abud, Luiz Mario Pereira Lopes Labadessa, Rafael Gouvêa Gomes de Oliveira, Cecília Hissae Miyake, Rodolfo Mendes Queiroz

Journal: Rev Assoc Med Bras (1992). 2018 Jan;64(1):11-14.

 

Currently Latin America is undergoing a major epidemic of Zika virus, which is transmitted by Aedes mosquitoes. Concern for Zika virus infection has been increasing as it is suspected of causing brain defects in newborns such as microcephaly and, more recently, potential neurological ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Microcephaly" returned 31 free, full-text review articles on human participants. First 3 results:

Severe congenital microcephaly with 16p13.11 microdeletion combined with NDE1 mutation, a case report and literature review.
 

Author(s): Li Tan, Bo Bi, Peiwei Zhao, Xiaonan Cai, Chunhui Wan, Jianbo Shao, Xuelian He

Journal:

 

Microcephaly is a disorder characterized by severe impairment in brain development, reduced brain and head size. Congenital severe microcephaly is very rare, and NDE1 deletion and genetic mutations are important contributors.

Last Updated: 31 Dec 1969

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Microcephaly Prevalence in Infants Born to Zika Virus-Infected Women: A Systematic Review and Meta-Analysis.
 

Author(s): Antonio Victor Campos Coelho, Sergio Crovella

Journal:

 

Zika virus is an emergent flavivirus transmitted by genus mosquitoes that recently reached the Americas and was soon implicated in an increase of microcephaly incidence. The objective of the present study is to systematically review the published data and perform a meta-analysis ...

Last Updated: 31 Dec 1969

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How does Zika virus cause microcephaly?
 

Author(s): Zhexing Wen, Hongjun Song, Guo-Li Ming

Journal: Genes Dev.. 2017 05;31(9):849-861.

 

The re-emergence of Zika virus (ZIKV), a mosquito-borne and sexually transmitted flavivirus circulating in >70 countries and territories, poses a significant global threat to public health due to its ability to cause severe developmental defects in the human brain, such as microcephaly. ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Guangzhou Surveillance and Clinical Study in Microcephaly (GSCSM)
 

Status: Recruiting

Condition Summary: Microcephaly

 

Last Updated: 27 Aug 2018

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Neurodevelopment Outcome of Newborns Exposed to Zika Virus (ZIKV) in Utero
 

Status: Recruiting

Condition Summary: Microcephaly; Mental Retardation

 

Last Updated: 21 Oct 2016

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Vertical Exposure to Zika Virus and Its Consequences for Child Neurodevelopment (ZIKVIRUSIFF)
 

Status: Recruiting

Condition Summary: ZIKA VIRUS INFECTION; Child Development; Microcephaly

 

Last Updated: 2 May 2018

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