Microcephaly

Common Name(s)

Microcephaly

Microcephaly is a neurological condition in which a person's head is significantly smaller than normal for their age and sex, based on standardized charts. This condition, which most often occurs because the brain fails to grow at a normal rate, can be present at birth or it may develop in the first few years of life.  Conditions that affect brain growth and can cause microcephaly include infections, genetic disorders, severe malnutrition and other environmental factors. Some children with microcephaly will be of normal intelligence and development. However, many children with microcephaly experience complications such as developmental delays, difficulties with balance and coordination, short stature, hyperactivity, mental retardation, seizures or other neurological abnormalities.  While there's no treatment for microcephaly, early intervention may help enhance development and improve quality of life.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Microcephaly" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Microcephaly" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Microcephaly" returned 251 free, full-text research articles on human participants. First 3 results:

Preliminary Report of Microcephaly Potentially Associated with Zika Virus Infection During Pregnancy - Colombia, January-November 2016.
 

Author(s): Esther Liliana Cuevas, Van T Tong, Nathaly Rozo, Diana Valencia, Oscar Pacheco, Suzanne M Gilboa, Marcela Mercado, Christina M Renquist, Maritza González, Elizabeth C Ailes, Carolina Duarte, Valerie Godoshian, Christina L Sancken, Angelica Maria Rico Turca, Dinorah L Calles, Martha Ayala, Paula Morgan, Erika Natalia Tolosa Perez, Hernan Quijada Bonilla, Ruben Caceres Gomez, Ana Carolina Estupiñan, Maria Luz Gunturiz, Dana Meaney-Delman, Denise J Jamieson, Margaret A Honein, Martha Lucia Ospina Martínez

Journal:

 

In Colombia, approximately 105,000 suspected cases of Zika virus disease (diagnosed based on clinical symptoms, regardless of laboratory confirmation) were reported during August 9, 2015-November 12, 2016, including nearly 20,000 in pregnant women (1,2). Zika virus infection during ...

Last Updated: 15 Dec 2016

Go To URL
Description of 13 Infants Born During October 2015-January 2016 With Congenital Zika Virus Infection Without Microcephaly at Birth - Brazil.
 

Author(s): Vanessa van der Linden, André Pessoa, William Dobyns, A James Barkovich, Hélio van der Linden Júnior, Epitacio Leite Rolim Filho, Erlane Marques Ribeiro, Mariana de Carvalho Leal, Pablo Picasso de Araújo Coimbra, Maria de Fátima Viana Vasco Aragão, Islane Verçosa, Camila Ventura, Regina Coeli Ramos, Danielle Di Cavalcanti Sousa Cruz, Marli Tenório Cordeiro, Vivian Maria Ribeiro Mota, Mary Dott, Christina Hillard, Cynthia A Moore

Journal:

 

Congenital Zika virus infection can cause microcephaly and severe brain abnormalities (1). Congenital Zika syndrome comprises a spectrum of clinical features (2); however, as is the case with most newly recognized teratogens, the earliest documented clinical presentation is expected ...

Last Updated: 1 Dec 2016

Go To URL
Hearing Loss in Infants with Microcephaly and Evidence of Congenital Zika Virus Infection - Brazil, November 2015-May 2016.
 

Author(s): Mariana C Leal, Lilian F Muniz, Tamires S A Ferreira, Cristiane M Santos, Luciana C Almeida, Vanessa Van Der Linden, Regina C F Ramos, Laura C Rodrigues, Silvio S Caldas Neto

Journal:

 

Congenital infection with Zika virus causes microcephaly and other brain abnormalities (1). Hearing loss associated with other congenital viral infections is well described; however, little is known about hearing loss in infants with congenital Zika virus infection. A retrospective ...

Last Updated: 2 Sep 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Microcephaly" returned 18 free, full-text review articles on human participants. First 3 results:

Microcephaly and Zika virus: a clinical and epidemiological analysis of the current outbreak in Brazil.
 

Author(s): Magda Lahorgue Nunes, Celia Regina Carlini, Daniel Marinowic, Felipe Kalil Neto, Humberto Holmer Fiori, Marcelo Comerlato Scotta, Pedro Luis Ávila Zanella, Ricardo Bernardi Soder, Jaderson Costa da Costa

Journal: J Pediatr (Rio J). ;92(3):230-40.

 

This study aimed to critically review the literature available regarding the Zika virus outbreak in Brazil and its possible association with microcephaly cases.

Last Updated: 29 May 2016

Go To URL
Measuring head circumference: Update on infant microcephaly.
 

Author(s): Susan R Harris

Journal: Can Fam Physician. 2015 Aug;61(8):680-4.

 

To provide an evidence-based update emphasizing the importance of measuring head circumference (HC) in infants, with a focus on microcephaly.

Last Updated: 26 Oct 2015

Go To URL
Molecular genetics of human primary microcephaly: an overview.
 

Author(s): Muhammad Faheem, Muhammad Imran Naseer, Mahmood Rasool, Adeel G Chaudhary, Taha A Kumosani, Asad Muhammad Ilyas, Peter Pushparaj, Farid Ahmed, Hussain A Algahtani, Mohammad H Al-Qahtani, Hasan Saleh Jamal

Journal: BMC Med Genomics. 2015 ;8 Suppl 1():S4.

 

Autosomal recessive primary microcephaly (MCPH) is a neurodevelopmental disorder that is characterised by microcephaly present at birth and non-progressive mental retardation. Microcephaly is the outcome of a smaller but architecturally normal brain; the cerebral cortex exhibits a ...

Last Updated: 8 May 2015

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Zika and Microcephaly: Case-control Study
 

Status: Recruiting

Condition Summary: Microcephaly

 

Last Updated: 16 Jun 2016

Go to URL
Microcephaly Genetic Deficiency in Neural Progenitors
 

Status: Recruiting

Condition Summary: Microcephaly

 

Last Updated: 28 Nov 2016

Go to URL
Neurodevelopment Outcome of Newborns Exposed to Zika Virus (ZIKV) in Utero
 

Status: Recruiting

Condition Summary: Microcephaly; Mental Retardation

 

Last Updated: 21 Oct 2016

Go to URL