Microcephaly

Common Name(s)

Microcephaly

Microcephaly is a neurological condition in which a person's head is significantly smaller than normal for their age and sex, based on standardized charts. This condition, which most often occurs because the brain fails to grow at a normal rate, can be present at birth or it may develop in the first few years of life.  Conditions that affect brain growth and can cause microcephaly include infections, genetic disorders, severe malnutrition and other environmental factors. Some children with microcephaly will be of normal intelligence and development. However, many children with microcephaly experience complications such as developmental delays, difficulties with balance and coordination, short stature, hyperactivity, mental retardation, seizures or other neurological abnormalities.  While there's no treatment for microcephaly, early intervention may help enhance development and improve quality of life.
 

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Condition Specific Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Microcephaly" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Microcephaly" returned 253 free, full-text research articles on human participants. First 3 results:

Prevalence and Clinical Attributes of Congenital Microcephaly - New York, 2013-2015.
 

Author(s): Krishika A Graham, Deborah J Fox, Achala Talati, Cristian Pantea, Laura Brady, Sondra L Carter, Eric Friedenberg, Neil M Vora, Marilyn L Browne, Christopher T Lee

Journal:

 

Congenital Zika virus infection can cause microcephaly and other severe fetal neurological anomalies (1). To inform microcephaly surveillance efforts and assess ascertainment sources, the New York State Department of Health and the New York City Department of Health and Mental Hygiene ...

Last Updated: 9 Feb 2017

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Preliminary Report of Microcephaly Potentially Associated with Zika Virus Infection During Pregnancy - Colombia, January-November 2016.
 

Author(s): Esther Liliana Cuevas, Van T Tong, Nathaly Rozo, Diana Valencia, Oscar Pacheco, Suzanne M Gilboa, Marcela Mercado, Christina M Renquist, Maritza González, Elizabeth C Ailes, Carolina Duarte, Valerie Godoshian, Christina L Sancken, Angelica Maria Rico Turca, Dinorah L Calles, Martha Ayala, Paula Morgan, Erika Natalia Tolosa Perez, Hernan Quijada Bonilla, Ruben Caceres Gomez, Ana Carolina Estupiñan, Maria Luz Gunturiz, Dana Meaney-Delman, Denise J Jamieson, Margaret A Honein, Martha Lucia Ospina Martínez

Journal:

 

In Colombia, approximately 105,000 suspected cases of Zika virus disease (diagnosed based on clinical symptoms, regardless of laboratory confirmation) were reported during August 9, 2015-November 12, 2016, including nearly 20,000 in pregnant women (1,2). Zika virus infection during ...

Last Updated: 15 Dec 2016

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A novel splice-site mutation in the ASPM gene underlies autosomal recessive primary microcephaly.
 

Author(s): Jamil A Hashmi, Khalid M Al-Harbi, Khushnooda Ramzan, Alia M Albalawi, Amir Mehmood, Mohammed I Samman, Sulman Basit

Journal: Ann Saudi Med. ;36(6):391-396.

 

Autosomal recessive primary microcephaly (MCPH) is a clinically and genetically heterogeneous disorder. Patients with MCPH exhibit reduced occipito-frontal head circumference and non-progressive intellectual disability. To date, 17 genes have been known as an underlying cause of MCPH ...

Last Updated: 6 Dec 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Microcephaly" returned 22 free, full-text review articles on human participants. First 3 results:

Zika Virus-Induced Microcephaly and Its Possible Molecular Mechanism.
 

Author(s): Md Imam Faizan, Mohd Abdullah, Sher Ali, Irshad H Naqvi, Anwar Ahmed, Shama Parveen

Journal: Intervirology. 2016 ;59(3):152-158.

 

Zika virus is an arthropod-borne re-emerging pathogen associated with the global pandemic of 2015-2016. The devastating effect of Zika viral infection is reflected by its neurological manifestations such as microcephaly in newborns. This scenario evoked our interest to uncover the ...

Last Updated: 12 Jan 2017

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Available Evidence of Association between Zika Virus and Microcephaly.
 

Author(s): Jing Wu, Da-Yong Huang, Jun-Tao Ma, Ying-Hua Ma, Yi-Fei Hu

Journal: Chin. Med. J.. 2016 10;129(19):2347-56.

 

To clarify the possible association between the Zika virus (ZIKV) and microcephaly and understand where we are in terms of research and the debate on the causation between mild maternal clinical features and severe fetal microcephaly.

Last Updated: 20 Sep 2016

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Zika virus infection during pregnancy and microcephaly occurrence: a review of literature and Brazilian data.
 

Author(s): Newton Sérgio De Carvalho, Beatriz Freitas De Carvalho, Cyllian Arias Fugaça, Bruna Dóris, Evellyn Silverio Biscaia

Journal: Braz J Infect Dis. ;20(3):282-9.

 

In November of 2015, the Ministry of Health of Brazil published an announcement confirming the relationship between Zika virus and the microcephaly outbreak in the Northeast, suggesting that infected pregnant women might have transmitted the virus to their fetuses. The objectives ...

Last Updated: 24 May 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Microcephaly Genetic Deficiency in Neural Progenitors
 

Status: Recruiting

Condition Summary: Microcephaly

 

Last Updated: 28 Nov 2016

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Neurodevelopment Outcome of Newborns Exposed to Zika Virus (ZIKV) in Utero
 

Status: Recruiting

Condition Summary: Microcephaly; Mental Retardation

 

Last Updated: 21 Oct 2016

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Zika Virus Infection's Pregnancy Consequences in French Department of America
 

Status: Recruiting

Condition Summary: Incidence of ZIKV Infection on Fetus During the Pregnancy

 

Last Updated: 26 Sep 2016

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