Microcephaly

Common Name(s)

Microcephaly

Microcephaly is a neurological condition in which a person's head is significantly smaller than normal for their age and sex, based on standardized charts. This condition, which most often occurs because the brain fails to grow at a normal rate, can be present at birth or it may develop in the first few years of life.  Conditions that affect brain growth and can cause microcephaly include infections, genetic disorders, severe malnutrition and other environmental factors. Some children with microcephaly will be of normal intelligence and development. However, many children with microcephaly experience complications such as developmental delays, difficulties with balance and coordination, short stature, hyperactivity, mental retardation, seizures or other neurological abnormalities.  While there's no treatment for microcephaly, early intervention may help enhance development and improve quality of life.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Microcephaly" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Microcephaly" returned 232 free, full-text research articles on human participants. First 3 results:

Zika Virus Associated with Microcephaly.
 

Author(s): Jernej Mlakar, Misa Korva, Nataša Tul, Mara Popović, Mateja Poljšak-Prijatelj, Jerica Mraz, Marko Kolenc, Katarina Resman Rus, Tina Vesnaver Vipotnik, Vesna Fabjan Vodušek, Alenka Vizjak, Jože Pižem, Miroslav Petrovec, Tatjana Avšič Županc

Journal: N. Engl. J. Med.. 2016 Mar;374(10):951-8.

 

A widespread epidemic of Zika virus (ZIKV) infection was reported in 2015 in South and Central America and the Caribbean. A major concern associated with this infection is the apparent increased incidence of microcephaly in fetuses born to mothers infected with ZIKV. In this report, ...

Last Updated: 11 Mar 2016

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Zika Virus and Microcephaly.
 

Author(s): Eric J Rubin, Michael F Greene, Lindsey R Baden

Journal: N. Engl. J. Med.. 2016 Mar;374(10):984-5.

 

Last Updated: 11 Mar 2016

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Possible Association Between Zika Virus Infection and Microcephaly - Brazil, 2015.
 

Author(s): Lavinia Schuler-Faccini, Erlane M Ribeiro, Ian M L Feitosa, Dafne D G Horovitz, Denise P Cavalcanti, André Pessoa, Maria Juliana R Doriqui, Joao Ivanildo Neri, Joao Monteiro de Pina Neto, Hector Y C Wanderley, Mirlene Cernach, Antonette S El-Husny, Marcos V S Pone, Cassio L C Serao, Maria Teresa V Sanseverino,

Journal:

 

In early 2015, an outbreak of Zika virus, a flavivirus transmitted by Aedes mosquitoes, was identified in northeast Brazil, an area where dengue virus was also circulating. By September, reports of an increase in the number of infants born with microcephaly in Zika virus-affected ...

Last Updated: 29 Jan 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Microcephaly" returned 17 free, full-text review articles on human participants. First 3 results:

Measuring head circumference: Update on infant microcephaly.
 

Author(s): Susan R Harris

Journal: Can Fam Physician. 2015 Aug;61(8):680-4.

 

To provide an evidence-based update emphasizing the importance of measuring head circumference (HC) in infants, with a focus on microcephaly.

Last Updated: 26 Oct 2015

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Molecular genetics of human primary microcephaly: an overview.
 

Author(s): Muhammad Faheem, Muhammad Imran Naseer, Mahmood Rasool, Adeel G Chaudhary, Taha A Kumosani, Asad Muhammad Ilyas, Peter Pushparaj, Farid Ahmed, Hussain A Algahtani, Mohammad H Al-Qahtani, Hasan Saleh Jamal

Journal: BMC Med Genomics. 2015 ;8 Suppl 1():S4.

 

Autosomal recessive primary microcephaly (MCPH) is a neurodevelopmental disorder that is characterised by microcephaly present at birth and non-progressive mental retardation. Microcephaly is the outcome of a smaller but architecturally normal brain; the cerebral cortex exhibits a ...

Last Updated: 8 May 2015

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Molecular and cellular basis of autosomal recessive primary microcephaly.
 

Author(s): Marine Barbelanne, William Y Tsang

Journal: Biomed Res Int. 2014 ;2014():547986.

 

Autosomal recessive primary microcephaly (MCPH) is a rare hereditary neurodevelopmental disorder characterized by a marked reduction in brain size and intellectual disability. MCPH is genetically heterogeneous and can exhibit additional clinical features that overlap with related ...

Last Updated: 30 Dec 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Zika and Microcephaly: Case-control Study
 

Status: Recruiting

Condition Summary: Microcephaly

 

Last Updated: 16 Jun 2016

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Microcephaly Genetic Deficiency in Neural Progenitors
 

Status: Recruiting

Condition Summary: Microcephaly

 

Last Updated: 24 Feb 2016

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Fetal and Maternal Head Circumference During Pregnancy in Israeli Population
 

Status: Recruiting

Condition Summary: Maternal-Fetal Relations; Microcephaly

 

Last Updated: 11 Feb 2016

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