Merkel cell cancer

Common Name(s)

Merkel cell cancer

Merkel cell carcinoma (MCC) is a rare type of skin cancer that usually appears as a single, painless, lump on sun-exposed skin. It is typically red or violet in color. It is considered fast-growing and can spread quickly to surrounding tissues, nearby lymph nodes, or more distant parts of the body. Merkel cell polyomavirus has been detected in about 80% of the tumors tested. It is thought that this virus can cause somatic mutations leading to MCC when the immune system is weakened. Other risk factors for developing MCC include ultraviolet radiation and being over 50 years of age. Treatment should begin early and depends on the location and size of the cancer, and the extent to which it has spread.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Merkel cell cancer" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Merkel cell cancer" returned 5 free, full-text research articles on human participants. First 3 results:

Merkel cell polyomavirus and non-small cell lung cancer.
 

Author(s): M Shuda, H Feng, P S Moore, Y Chang

Journal: Br. J. Cancer. 2013 Jun;108(12):2623.

 

Last Updated: 26 Jun 2013

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Integrated and mutated forms of Merkel cell polyomavirus in non-small cell lung cancer.
 

Author(s): Y Hashida, M Imajoh, M Daibata

Journal: Br. J. Cancer. 2013 Jun;108(12):2624.

 

Last Updated: 26 Jun 2013

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Neuroembolization of metastatic Merkel cell cancer to the face for treatment of Kasabach-Merritt syndrome.
 

Author(s): Jason Huang Lee, Sudipta Roychowdhury, Michael J Nissenblatt

Journal:

 

Kasabach-Merritt syndrome is defined as a consumptive thrombocytopenia in the presence of a highly vascular tumor. Multiple treatment options, including transarterial embolization, have been described. We demonstrate that transarterial embolization is a viable option in the treatment ...

Last Updated: 18 Jan 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Merkel cell cancer" returned 3 free, full-text review articles on human participants. First 3 results:

Immunobiology of Merkel cell carcinoma: implications for immunotherapy of a polyomavirus-associated cancer.
 

Author(s): Shailender Bhatia, Olga Afanasiev, Paul Nghiem

Journal: Curr Oncol Rep. 2011 Dec;13(6):488-97.

 

Merkel cell carcinoma (MCC) is an aggressive skin malignancy with a high mortality rate and an increasing incidence. The recent discovery of Merkel cell polyomavirus has revolutionized our understanding of MCC pathogenesis. Viral oncoproteins appear to play a critical role in tumor ...

Last Updated: 10 Nov 2011

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Merkel cell carcinoma: a virus-induced human cancer.
 

Author(s): Yuan Chang, Patrick S Moore

Journal: Annu Rev Pathol. 2012 ;7():123-44.

 

Merkel cell polyomavirus (MCV) is the first polyomavirus directly linked to human cancer, and its recent discovery helps to explain many of the enigmatic features of Merkel cell carcinoma (MCC). MCV is clonally integrated into MCC tumor cells, which then require continued MCV oncoprotein ...

Last Updated: 8 Feb 2012

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Merkel cell cancer of the skin.
 

Author(s): D Pectasides, M Pectasides, T Economopoulos

Journal: Ann. Oncol.. 2006 Oct;17(10):1489-95.

 

Merkel cell carcinoma (MCC) is a rare malignant cutaneous tumor of the elderly with rapidly growing skin nodules found predominantly on sun-exposed areas of the body. The vast majority of patients present with localized disease, while up to 30% have regional lymph node metastases. ...

Last Updated: 28 Sep 2006

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pembrolizumab in Treating Patients With Advanced Merkel Cell Cancer
 

Status: Recruiting

Condition Summary: Recurrent Merkel Cell Carcinoma; Stage IIIA Merkel Cell Carcinoma; Stage IIIB Merkel Cell Carcinoma; Stage IV Merkel Cell Carcinoma

 

Last Updated: 27 Jul 2015

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Study of Neukoplast (NK-92) Infusions in Patients With Unresectable Stage III (IIIB) or Distant Metastatic (IV) Merkel Cell Carcinoma (MCC)
 

Status: Not yet recruiting

Condition Summary: Stage IIIB Merkel Cell Carcinoma; Stage IV Merkel Cell Carcinoma

 

Last Updated: 4 Jun 2015

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Cabozantinib in Recurrent/Metastatic Merkel Cell Carcinoma
 

Status: Recruiting

Condition Summary: Merkel Cell Carcinoma; Skin Cancer

 

Last Updated: 29 Jul 2015

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