Merkel cell cancer

Common Name(s)

Merkel cell cancer

Merkel cell carcinoma (MCC) is a rare type of skin cancer that usually appears as a single, painless, lump on sun-exposed skin. It is typically red or violet in color. It is considered fast-growing and can spread quickly to surrounding tissues, nearby lymph nodes, or more distant parts of the body. Merkel cell polyomavirus has been detected in about 80% of the tumors tested. It is thought that this virus can cause somatic mutations leading to MCC when the immune system is weakened. Other risk factors for developing MCC include ultraviolet radiation and being over 50 years of age. Treatment should begin early and depends on the location and size of the cancer, and the extent to which it has spread.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Merkel cell cancer" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Merkel cell cancer" returned 12 free, full-text research articles on human participants. First 3 results:

Assessment of cancer cell line representativeness using microarrays for Merkel cell carcinoma.
 

Author(s): Kenneth Daily, Amy Coxon, Jonathan S Williams, Chyi-Chia R Lee, Daniel G Coit, Klaus J Busam, Isaac Brownell

Journal: J. Invest. Dermatol.. 2015 Apr;135(4):1138-46.

 

When using cell lines to study cancer, phenotypic similarity to the original tumor is paramount. Yet, little has been done to characterize how closely Merkel cell carcinoma (MCC) cell lines model native tumors. To determine their similarity to MCC tumor samples, we characterized MCC ...

Last Updated: 19 Mar 2015

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Molecular pathological findings of Merkel cell polyomavirus in lung cancer: a possible etiopathogenetic link?
 

Author(s): Katerina M Antoniou, Ismini Lasithiotaki, Emmanouil Symvoulakis, Stavros P Derdas, Anna Psaraki, Demetrios A Spandidos, Efstathios N Stathopoulos, Nikolaos M Siafakas, George Sourvinos

Journal: Int. J. Cancer. 2013 Dec;133(12):3016-7.

 

Last Updated: 14 Oct 2013

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Gene expression analysis in Merkel cell polyomavirus-positive non-small cell lung cancer from Japanese patients.
 

Author(s): Yumiko Hashida, Masayuki Imajoh, Masanori Daibata

Journal: Int. J. Cancer. 2013 Dec;133(12):3014-5.

 

Last Updated: 14 Oct 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Merkel cell cancer" returned 4 free, full-text review articles on human participants. First 3 results:

The role of Merkel cell polyomavirus and other human polyomaviruses in emerging hallmarks of cancer.
 

Author(s): Ugo Moens, Kashif Rasheed, Ibrahim Abdulsalam, Baldur Sveinbjørnsson

Journal:

 

Polyomaviruses are non-enveloped, dsDNA viruses that are common in mammals, including humans. All polyomaviruses encode the large T-antigen and small t-antigen proteins that share conserved functional domains, comprising binding motifs for the tumor suppressors pRb and p53, and for ...

Last Updated: 14 Apr 2015

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Immunobiology of Merkel cell carcinoma: implications for immunotherapy of a polyomavirus-associated cancer.
 

Author(s): Shailender Bhatia, Olga Afanasiev, Paul Nghiem

Journal: Curr Oncol Rep. 2011 Dec;13(6):488-97.

 

Merkel cell carcinoma (MCC) is an aggressive skin malignancy with a high mortality rate and an increasing incidence. The recent discovery of Merkel cell polyomavirus has revolutionized our understanding of MCC pathogenesis. Viral oncoproteins appear to play a critical role in tumor ...

Last Updated: 10 Nov 2011

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Merkel cell carcinoma: a virus-induced human cancer.
 

Author(s): Yuan Chang, Patrick S Moore

Journal: Annu Rev Pathol. 2012 ;7():123-44.

 

Merkel cell polyomavirus (MCV) is the first polyomavirus directly linked to human cancer, and its recent discovery helps to explain many of the enigmatic features of Merkel cell carcinoma (MCC). MCV is clonally integrated into MCC tumor cells, which then require continued MCV oncoprotein ...

Last Updated: 8 Feb 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pembrolizumab in Treating Patients With Advanced Merkel Cell Cancer
 

Status: Recruiting

Condition Summary: Recurrent Merkel Cell Carcinoma; Stage IIIA Merkel Cell Carcinoma; Stage IIIB Merkel Cell Carcinoma; Stage IV Merkel Cell Carcinoma

 

Last Updated: 28 Jan 2016

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Study of aNK (Activated NK-92, Formerly Neukoplast) Infusions in Patients With Unresectable Stage III (IIIB) or Distant Metastatic (IV) Merkel Cell Carcinoma (MCC)
 

Status: Recruiting

Condition Summary: Stage IIIB Merkel Cell Carcinoma; Stage IV Merkel Cell Carcinoma

 

Last Updated: 23 Nov 2015

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Cabozantinib in Recurrent/Metastatic Merkel Cell Carcinoma
 

Status: Recruiting

Condition Summary: Merkel Cell Carcinoma; Skin Cancer

 

Last Updated: 29 Jul 2015

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