Merkel cell cancer

Common Name(s)

Merkel cell cancer

Merkel cell carcinoma is a rare type of skin cancer that appears as a painless, hardened, red to purplish bump.  It occurs primarily in sun-exposed skin of the head and neck, though it can also occur on the skin of the arms, legs, and trunk.  It is considered fast-growing (aggressive), meaning that it can spread quickly to surrounding tissues, nearby lymph nodes, or more distant parts of the body.  Merkel cell carcinoma is diagnosed by biopsy, when some of the tissue is removed and examined under a microscope.  In 2007, approximately 1500 people in the United States were diagnosed with this type of cancer.  Treatment depends on the size of the cancer and the extent to which it has spread as determined by imaging studies.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Merkel cell cancer" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Merkel cell cancer" returned 4 free, full-text research articles on human participants. First 3 results:

Merkel cell polyomavirus and non-small cell lung cancer.
 

Author(s): M Shuda, H Feng, P S Moore, Y Chang

Journal: Br. J. Cancer. 2013 Jun;108(12):2623.

 

Last Updated: 26 Jun 2013

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Integrated and mutated forms of Merkel cell polyomavirus in non-small cell lung cancer.
 

Author(s): Y Hashida, M Imajoh, M Daibata

Journal: Br. J. Cancer. 2013 Jun;108(12):2624.

 

Last Updated: 26 Jun 2013

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Detection of Merkel cell polyomavirus with a tumour-specific signature in non-small cell lung cancer.
 

Author(s): Y Hashida, M Imajoh, Y Nemoto, M Kamioka, A Taniguchi, T Taguchi, M Kume, K Orihashi, M Daibata

Journal: Br. J. Cancer. 2013 Feb;108(3):629-37.

 

We searched for a viral aetiology for non-small cell lung cancer (NSCLC), focusing on Merkel cell polyomavirus (MCPyV).

Last Updated: 20 Feb 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Merkel cell cancer" returned 3 free, full-text review articles on human participants. First 3 results:

Immunobiology of Merkel cell carcinoma: implications for immunotherapy of a polyomavirus-associated cancer.
 

Author(s): Shailender Bhatia, Olga Afanasiev, Paul Nghiem

Journal: Curr Oncol Rep. 2011 Dec;13(6):488-97.

 

Merkel cell carcinoma (MCC) is an aggressive skin malignancy with a high mortality rate and an increasing incidence. The recent discovery of Merkel cell polyomavirus has revolutionized our understanding of MCC pathogenesis. Viral oncoproteins appear to play a critical role in tumor ...

Last Updated: 10 Nov 2011

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Merkel cell carcinoma: a virus-induced human cancer.
 

Author(s): Yuan Chang, Patrick S Moore

Journal: Annu Rev Pathol. 2012 ;7():123-44.

 

Merkel cell polyomavirus (MCV) is the first polyomavirus directly linked to human cancer, and its recent discovery helps to explain many of the enigmatic features of Merkel cell carcinoma (MCC). MCV is clonally integrated into MCC tumor cells, which then require continued MCV oncoprotein ...

Last Updated: 8 Feb 2012

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Merkel cell cancer of the skin.
 

Author(s): D Pectasides, M Pectasides, T Economopoulos

Journal: Ann. Oncol.. 2006 Oct;17(10):1489-95.

 

Merkel cell carcinoma (MCC) is a rare malignant cutaneous tumor of the elderly with rapidly growing skin nodules found predominantly on sun-exposed areas of the body. The vast majority of patients present with localized disease, while up to 30% have regional lymph node metastases. ...

Last Updated: 28 Sep 2006

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Interleukin-12 Gene and in Vivo Electroporation-Mediated Plasmid DNA Vaccine Therapy in Treating Patients With Merkel Cell Cancer
 

Status: Recruiting

Condition Summary: Recurrent Neuroendocrine Carcinoma of the Skin; Stage I Neuroendocrine Carcinoma of the Skin; Stage II Neuroendocrine Carcinoma of the Skin; Stage III Neuroendocrine Carcinoma of the Skin; Stage IV Neuroendocrine Carcinoma of the Skin

 

Last Updated: 20 Nov 2014

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Pembrolizumab in Treating Patients With Advanced Merkel Cell Cancer
 

Status: Recruiting

Condition Summary: Recurrent Merkel Cell Carcinoma; Stage III Merkel Cell Carcinoma; Stage IV Merkel Cell Carcinoma

 

Last Updated: 3 Dec 2014

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Cabozantinib in Recurrent/Metastatic Merkel Cell Carcinoma
 

Status: Recruiting

Condition Summary: Merkel Cell Carcinoma; Skin Cancer

 

Last Updated: 8 Oct 2014

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