Membranous nephropathy

Common Name(s)

Membranous nephropathy

Membranous nephropathy is a kidney disease characterized by inflammation of the structures inside the kidney that help filter wastes and fluids. When the glomerular basement membrane becomes thickened, it does not work normally, allowing large amounts of protein to be lost in the urine. Symptoms develop gradually and may include swelling, fatigue, weight gain, and high blood pressure. In many cases, the underlying cause of membranous nephropathy is not known. Some cases are associated with other conditions (lupus), infections (hepatitis B and C), cancer or as a side effect of certain medications. The goal of treatment is to reduce symptoms and slow the progression of the disease.  
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Membranous nephropathy" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

Last Updated: 30 Jan 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Membranous nephropathy" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

http://www.nephcure.org

Last Updated: 30 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Membranous nephropathy" returned 327 free, full-text research articles on human participants. First 3 results:

Clinical Features and Outcomes in Patients With Membranous Nephropathy and Crescent Formation.
 

Author(s): Jia Wang, Ping Zhu, Zhao Cui, Zhen Qu, Yi-miao Zhang, Fang Wang, Xin Wang, Jin-wei Wang, Sai-nan Zhu, Gang Liu, Fu-de Zhou, Ming-hui Zhao

Journal: Medicine (Baltimore). 2015 Dec;94(50):e2294.

 

Cases of membranous nephropathy (MN) with crescent formation, in the absence of lupus, hepatitis B virus infection, anti-glomerular basement membrane (GBM) nephritis, or antineutrophil cytoplasmic antibody (ANCA), are on record. Clinical presentation and treatment outcomes in these ...

Last Updated: 19 Dec 2015

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Membranous nephropathy and severe acute kidney injury following influenza vaccination.
 

Author(s): Chinmay Patel, Hitesh H Shah

Journal: Saudi J Kidney Dis Transpl. 2015 Nov;26(6):1289-93.

 

Immunization with influenza vaccine remains an important global health strategy to prevent outbreaks and epidemics of seasonal influenza. Influenza vaccine has rarely been associated with vasculitis, acute kidney injury (AKI) and nephrotic syndrome (NS). Glomerular diseases following ...

Last Updated: 20 Nov 2015

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Clinical and Immunologic Characteristics of Patients With ANCA-Associated Glomerulonephritis Combined With Membranous Nephropathy: A Retrospective Cohort Study in a Single Chinese Center.
 

Author(s): Rong Zou, Gang Liu, Zhao Cui, Min Chen, Ming-Hui Zhao

Journal: Medicine (Baltimore). 2015 Sep;94(37):e1472.

 

The concurrent antineutrophil cytoplasmic antibody-associated glomerulonephritis (ANCA-GN) and membranous nephropathy (MN) have been increasingly documented, mainly in case studies and case series; however, the differences of clinical and pathologic characteristics as well as outcomes ...

Last Updated: 17 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Membranous nephropathy" returned 42 free, full-text review articles on human participants. First 3 results:

Rituximab in primary membranous nephropathy: first-line therapy, why not?
 

Author(s): Paolo Cravedi, Giuseppe Remuzzi, Piero Ruggenenti

Journal: Nephron Clin Pract. 2014 ;128(3-4):261-9.

 

The ideal treatment of patients with primary membranous nephropathy (MN) and persistent nephrotic syndrome (NS) is still a matter of debate. This is a major issue since these patients may progress to end-stage kidney disease (ESKD) in 5-10 years. Steroids, alkylating agents, and calcineurin ...

Last Updated: 12 Feb 2015

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Anti-phospholipase A2 receptor antibodies and the pathogenesis of membranous nephropathy.
 

Author(s): Pierre Ronco, Hanna Debiec

Journal: Nephron Clin Pract. 2014 ;128(3-4):232-7.

 

Since the early 2000s, considerable advances have been achieved in the understanding of molecular pathomechanisms of human membranous nephropathy (MN), inspired by studies of Heymann nephritis, a faithful experimental model. These studies led to the identification of neutral endopeptidase, ...

Last Updated: 9 Feb 2015

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Prevalence of cancer in membranous nephropathy: a systematic review and meta-analysis of observational studies.
 

Author(s): Napat Leeaphorn, Pogsathorn Kue-A-Pai, Natanong Thamcharoen, Patompong Ungprasert, Michael B Stokes, Eric L Knight

Journal: Am. J. Nephrol.. 2014 ;40(1):29-35.

 

The association between membranous nephropathy (MN) and cancer has been well documented. However, the true prevalence and characteristics of cancer associated with MN have not been well described.

Last Updated: 6 Aug 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Sequential Therapy With Tacrolimus and Rituximab in Primary Membranous Nephropathy
 

Status: Recruiting

Condition Summary: MEMBRANOUS NEPHROPATHY

 

Last Updated: 17 Sep 2015

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Acthar for Treatment of Proteinuria in Membranous Nephropathy Patients
 

Status: Recruiting

Condition Summary: Proteinuria; Idiopathic Membranous Nephropathy

 

Last Updated: 30 Oct 2015

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Role of Anti-mouse PLA2R1 ELISA in Membranous Nephropathy
 

Status: Recruiting

Condition Summary: Membranous Nephropathy

 

Last Updated: 29 Sep 2015

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