Membranous nephropathy

Common Name(s)

Membranous nephropathy

Membranous nephropathy is a kidney disease characterized by inflammation of the structures inside the kidney that help filter wastes and fluids. When the glomerular basement membrane becomes thickened, it does not work normally, allowing large amounts of protein to be lost in the urine. Symptoms develop gradually and may include swelling, fatigue, weight gain, and high blood pressure. In many cases, the underlying cause of membranous nephropathy is not known. Some cases are associated with other conditions (lupus), infections (hepatitis B and C), cancer or as a side effect of certain medications. The goal of treatment is to reduce symptoms and slow the progression of the disease.  
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Membranous nephropathy" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

Last Updated: 30 Jan 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Membranous nephropathy" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

http://www.nephcure.org

Last Updated: 30 Jan 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Membranous nephropathy" returned 244 free, full-text research articles on human participants. First 3 results:

Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy.
 

Author(s): Catherine Meyer-Schwesinger, Gérard Lambeau, Rolf A K Stahl

Journal: N. Engl. J. Med.. 2015 Mar;372(11):1074-5.

 

Last Updated: 12 Mar 2015

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An unusual presentation of venous thrombosis in a child with idiopathic membranous nephropathy.
 

Author(s): Sreekanth Burri, Manjusha Yadla, Pradeep Deshpande, Rama Enaganti, Ramesh Chada, Nimmagadda Laxmi NarasimhaMoorthy, Nethikoppula Anil Kumar

Journal: Saudi J Kidney Dis Transpl. 2015 Mar;26(2):355-8.

 

Venous thrombosis is one of the major complications associated with nephrotic syndrome. Among the primary glomerular diseases, membranous nephropathy is associated with a high incidence of thrombotic events. Although this is well described in adults, there is paucity of the literature ...

Last Updated: 12 Mar 2015

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Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy.
 

Author(s): Nicola M Tomas, Laurence H Beck, Catherine Meyer-Schwesinger, Barbara Seitz-Polski, Hong Ma, Gunther Zahner, Guillaume Dolla, Elion Hoxha, Udo Helmchen, Anne-Sophie Dabert-Gay, Delphine Debayle, Michael Merchant, Jon Klein, David J Salant, Rolf A K Stahl, Gérard Lambeau

Journal: N. Engl. J. Med.. 2014 Dec;371(24):2277-87.

 

Idiopathic membranous nephropathy is an autoimmune disease. In approximately 70% of patients, it is associated with autoantibodies against the phospholipase A2 receptor 1 (PLA2R1). Antigenic targets in the remaining patients are unknown.

Last Updated: 19 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Membranous nephropathy" returned 36 free, full-text review articles on human participants. First 3 results:

Rituximab in primary membranous nephropathy: first-line therapy, why not?
 

Author(s): Paolo Cravedi, Giuseppe Remuzzi, Piero Ruggenenti

Journal: Nephron Clin Pract. 2014 ;128(3-4):261-9.

 

The ideal treatment of patients with primary membranous nephropathy (MN) and persistent nephrotic syndrome (NS) is still a matter of debate. This is a major issue since these patients may progress to end-stage kidney disease (ESKD) in 5-10 years. Steroids, alkylating agents, and calcineurin ...

Last Updated: 12 Feb 2015

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Anti-phospholipase A2 receptor antibodies and the pathogenesis of membranous nephropathy.
 

Author(s): Pierre Ronco, Hanna Debiec

Journal: Nephron Clin Pract. 2014 ;128(3-4):232-7.

 

Since the early 2000s, considerable advances have been achieved in the understanding of molecular pathomechanisms of human membranous nephropathy (MN), inspired by studies of Heymann nephritis, a faithful experimental model. These studies led to the identification of neutral endopeptidase, ...

Last Updated: 9 Feb 2015

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[New physiopathological roles for the PLA2R1 receptor in cancer and membranous nephropathy].
 

Author(s): Christophe A Girard, Barbara Seitz-Polski, Guillaume Dolla, Arnaud Augert, David Vindrieux, David Bernard, Gérard Lambeau

Journal: Med Sci (Paris). 2014 May;30(5):519-25.

 

PLA2R1 is a large transmembrane receptor of 180-kDa that belongs to the superfamily of C-type lectins. It was discovered because of its high affinity for secreted phospholipases A2 (sPLA2), enzymes that play a key role in lipid mediator synthesis. Early PLA2R1 physiological roles ...

Last Updated: 18 Jun 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

MEmbranous Nephropathy Trial Of Rituximab
 

Status: Recruiting

Condition Summary: Idiopathic Membranous Nephropathy

 

Last Updated: 23 Apr 2015

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Sequential Therapy With Tacrolimus and Rituximab in Primary Membranous Nephropathy
 

Status: Recruiting

Condition Summary: MEMBRANOUS NEPHROPATHY

 

Last Updated: 21 Nov 2014

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Clinical Study of QingReMoShen Granule to Treat Idiopathic Membranous Nephropathy
 

Status: Recruiting

Condition Summary: Idiopathic Membranous Nephropathy

 

Last Updated: 18 May 2013

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