Membranous nephropathy

Common Name(s)

Membranous nephropathy

Membranous nephropathy is a kidney disease characterized by inflammation of the structures inside the kidney that help filter wastes and fluids. When the glomerular basement membrane becomes thickened, it does not work normally, allowing large amounts of protein to be lost in the urine. Symptoms develop gradually and may include swelling, fatigue, weight gain, and high blood pressure. In many cases, the underlying cause of membranous nephropathy is not known. Some cases are associated with other conditions (lupus), infections (hepatitis B and C), cancer or as a side effect of certain medications. The goal of treatment is to reduce symptoms and slow the progression of the disease.  
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Membranous nephropathy" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

Last Updated: 30 Jan 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Membranous nephropathy" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

http://www.nephcure.org

Last Updated: 30 Jan 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Membranous nephropathy" returned 291 free, full-text research articles on human participants. First 3 results:

Protein Array-Based Detection of Proteins in Kidney Tissues from Patients with Membranous Nephropathy.
 

Author(s): Shuqiang Wang, Yang Lu, Quan Hong, Xiaodong Geng, Xu Wang, Wei Zheng, Chengcheng Song, Chunling Liu, Meng Fan, Yue Xi, Mandi Guo, Di Wu

Journal: Biomed Res Int. 2017 ;2017():7843584.

 

Membranous nephropathy (MN) is an autoimmune inflammatory disease in which proteins related with plenty of biological processes play an important role. However, the role of these proteins in the pathogenesis of MN is still unclear. This study aimed to screen differential proteins ...

Last Updated: 24 Mar 2017

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Different Effects of Tolvaptan in Patients with Idiopathic Membranous Nephropathy with Nephrotic Syndrome.
 

Author(s): Atsushi Tanaka, Tsukasa Nakamura, Eiichi Sato, Yoshihiko Ueda, Koichi Node

Journal: Intern. Med.. 2017 ;56(2):191-196.

 

This case report discusses the clinical indication for immunosuppressants in patients with idiopathic membranous nephropathy (IMN). Because this disease occasionally shows spontaneous remission, it is necessary to determine the predictive values for a therapeutic effect in order to ...

Last Updated: 16 Jan 2017

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HLA-DR, and not PLA2R, is expressed on the podocytes in kidney allografts in de novo membranous nephropathy.
 

Author(s): Jiqiu Wen, Kenan Xie, Mingchao Zhang, Jinsong Chen, Jiong Zhang, Dongrui Cheng, Xue Li, Shuming Ji, Zhihong Liu

Journal: Medicine (Baltimore). 2016 Sep;95(37):e4809.

 

Idiopathic membranous nephropathy (IMN) is known to be associated with antibodies acting on the M-type phospholipase A2 receptor (PLA2R) of the podocyte. However, the mechanism underlying de novo membranous nephropathy (dn MN) posttransplantation remains unclear. In this study, we ...

Last Updated: 16 Sep 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Membranous nephropathy" returned 39 free, full-text review articles on human participants. First 3 results:

Rituximab in Membranous Nephropathy: Not All Studies Are Created Equal.
 

Author(s): Paolo Cravedi

Journal: Nephron. 2017 ;135(1):46-50.

 

Many prospective studies and a recent randomized controlled trial have shown that the B-cell-depleting monoclonal antibody, rituximab, safely promotes the remission of nephrotic syndrome in approximately 65% of patients with membranous nephropathy (MN). Mechanistic studies have indicated ...

Last Updated: 27 Sep 2016

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Membranous Nephropathy with an Enhanced Granular Expression of Thrombospondin Type-1 Domain-containing 7A in a Pregnant Woman.
 

Author(s): Takamasa Iwakura, Yoshihide Fujigaki, Naoko Katahashi, Taichi Sato, Sayaka Ishigaki, Naoko Tsuji, Yoshitaka Naito, Shinsuke Isobe, Masashi Ono, Yukitoshi Sakao, Takayuki Tsuji, Naro Ohashi, Akihiko Kato, Hiroaki Miyajima, Hideo Yasuda

Journal: Intern. Med.. ;55(18):2663-8.

 

A 30-year-old woman with proteinuria first noted at 26 weeks of gestation was admitted to undergo further evaluation. A renal biopsy revealed membranous nephropathy (MN). There was no evidence of any secondary MN. Prednisolone was initiated 6 months after delivery. Four months later, ...

Last Updated: 16 Sep 2016

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Antiphospholipase A2 Receptor Autoantibodies: A Step Forward in the Management of Primary Membranous Nephropathy.
 

Author(s): Bogdan Obrisca, Gener Ismail, Roxana Jurubita, Catalin Baston, Andreea Andronesi, Gabriel Mircescu

Journal: Biomed Res Int. 2015 ;2015():249740.

 

Since the identification of PLA2R (M-type phospholipase A2 receptor) as the first human antigenic target in primary membranous nephropathy (MN), perpetual progress has been made in understanding the pathogenesis of this disease. Accumulating clinical data support a pathogenic role ...

Last Updated: 20 Nov 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Adrenocorticotropic Hormone in Membranous Nephropathy
 

Status: Not yet recruiting

Condition Summary: Membranous Nephropathy

 

Last Updated: 2 May 2017

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Sequential Therapy With Tacrolimus and Rituximab in Primary Membranous Nephropathy
 

Status: Recruiting

Condition Summary: MEMBRANOUS NEPHROPATHY

 

Last Updated: 18 Aug 2016

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Role of Anti-mouse PLA2R1 ELISA in Membranous Nephropathy
 

Status: Recruiting

Condition Summary: Membranous Nephropathy

 

Last Updated: 29 Sep 2015

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